Details for: SMAD7

Gene ID: 4092

Symbol: SMAD7

Ensembl ID: ENSG00000101665

Description: SMAD family member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.2018
    Cell Significance Index: -21.0300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 82.7146
    Cell Significance Index: -20.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.2478
    Cell Significance Index: -22.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.0485
    Cell Significance Index: -21.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.2796
    Cell Significance Index: -22.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6064
    Cell Significance Index: -12.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2990
    Cell Significance Index: -20.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.3758
    Cell Significance Index: -13.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.4337
    Cell Significance Index: 20.6200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.3092
    Cell Significance Index: 13.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1664
    Cell Significance Index: 33.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0248
    Cell Significance Index: 46.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8320
    Cell Significance Index: 43.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8268
    Cell Significance Index: 23.7000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7865
    Cell Significance Index: 17.0400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6371
    Cell Significance Index: 38.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5952
    Cell Significance Index: 64.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5252
    Cell Significance Index: 474.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5034
    Cell Significance Index: 81.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4191
    Cell Significance Index: 41.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4024
    Cell Significance Index: 51.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3719
    Cell Significance Index: 74.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3362
    Cell Significance Index: 120.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3275
    Cell Significance Index: 22.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2939
    Cell Significance Index: 58.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2359
    Cell Significance Index: 32.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2348
    Cell Significance Index: 103.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1875
    Cell Significance Index: 23.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1871
    Cell Significance Index: 13.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1306
    Cell Significance Index: 201.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1216
    Cell Significance Index: 3.0400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0959
    Cell Significance Index: 2.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0954
    Cell Significance Index: 18.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0922
    Cell Significance Index: 7.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0919
    Cell Significance Index: 16.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0914
    Cell Significance Index: 5.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0554
    Cell Significance Index: 75.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0366
    Cell Significance Index: 4.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0333
    Cell Significance Index: 23.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0266
    Cell Significance Index: 0.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0186
    Cell Significance Index: 35.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0156
    Cell Significance Index: 1.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0068
    Cell Significance Index: 12.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0066
    Cell Significance Index: 3.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0068
    Cell Significance Index: -1.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0099
    Cell Significance Index: -6.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0211
    Cell Significance Index: -15.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0214
    Cell Significance Index: -12.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0317
    Cell Significance Index: -14.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0324
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0523
    Cell Significance Index: -11.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0604
    Cell Significance Index: -17.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0619
    Cell Significance Index: -6.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0657
    Cell Significance Index: -9.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0683
    Cell Significance Index: -7.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1196
    Cell Significance Index: -3.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1270
    Cell Significance Index: -14.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1300
    Cell Significance Index: -3.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1334
    Cell Significance Index: -8.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1354
    Cell Significance Index: -6.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1414
    Cell Significance Index: -18.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1440
    Cell Significance Index: -7.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1575
    Cell Significance Index: -3.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1744
    Cell Significance Index: -2.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1755
    Cell Significance Index: -6.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1881
    Cell Significance Index: -11.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1964
    Cell Significance Index: -20.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1997
    Cell Significance Index: -12.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2004
    Cell Significance Index: -5.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2075
    Cell Significance Index: -9.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2271
    Cell Significance Index: -13.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2346
    Cell Significance Index: -18.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2702
    Cell Significance Index: -20.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2714
    Cell Significance Index: -16.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2726
    Cell Significance Index: -14.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2892
    Cell Significance Index: -4.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3473
    Cell Significance Index: -5.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3965
    Cell Significance Index: -11.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4204
    Cell Significance Index: -14.6100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4312
    Cell Significance Index: -18.7500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4361
    Cell Significance Index: -6.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4435
    Cell Significance Index: -14.5200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.4539
    Cell Significance Index: -2.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4548
    Cell Significance Index: -15.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4725
    Cell Significance Index: -12.6400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4761
    Cell Significance Index: -16.6800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4799
    Cell Significance Index: -12.6200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4832
    Cell Significance Index: -8.2800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.4926
    Cell Significance Index: -6.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4969
    Cell Significance Index: -18.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4995
    Cell Significance Index: -15.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5139
    Cell Significance Index: -10.0300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5151
    Cell Significance Index: -7.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5346
    Cell Significance Index: -11.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5578
    Cell Significance Index: -10.3100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5579
    Cell Significance Index: -5.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5734
    Cell Significance Index: -18.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SMAD7 is a 345-amino acid protein that belongs to the SMAD family, which is a key component of the TGF-β signaling pathway. SMAD7 is characterized by its ability to negatively regulate TGF-β signaling by binding to and inhibiting the activity of TGF-β receptors, thereby preventing the activation of SMAD2/3 and the subsequent transcription of target genes. However, SMAD7 also possesses a unique ability to positively regulate TGF-β signaling in certain contexts, such as in the regulation of epithelial-to-mesenchymal transition (EMT) and chondrocyte hypertrophy. **Pathways and Functions:** SMAD7's role in TGF-β signaling is mediated through its interaction with TGF-β receptors, which leads to the inhibition of SMAD2/3 activation. This negative regulation is critical in preventing excessive TGF-β signaling, which can lead to tissue fibrosis and cancer. However, SMAD7's positive regulatory role in TGF-β signaling is essential for maintaining immune homeostasis and preventing autoimmune diseases. SMAD7 has been shown to regulate the activity of various immune cells, including T cells, B cells, and dendritic cells, and plays a crucial role in the development and function of the immune system. In addition to its role in TGF-β signaling, SMAD7 has been implicated in various cellular processes, including cell differentiation, migration, and proliferation. SMAD7 has been shown to regulate the activity of various transcription factors, including BMPs and Wnt/β-catenin, and plays a critical role in the regulation of cellular morphology and tissue morphogenesis. **Clinical Significance:** SMAD7's role in regulating TGF-β signaling has significant implications for the treatment of various diseases, including cancer, fibrosis, and autoimmune disorders. Dysregulation of TGF-β signaling has been implicated in the development of various diseases, including cancer, where it can promote tumor growth and metastasis. SMAD7's negative regulatory role in TGF-β signaling makes it a potential therapeutic target for the treatment of cancer and other diseases. Furthermore, SMAD7's positive regulatory role in TGF-β signaling has been implicated in the regulation of immune homeostasis and the prevention of autoimmune diseases. SMAD7's ability to regulate the activity of immune cells makes it a potential therapeutic target for the treatment of autoimmune disorders. In conclusion, SMAD7 is a complex protein that plays a multifaceted role in regulating TGF-β signaling, with both negative and positive effects depending on the cellular context. Its significant impact on immune homeostasis, cellular differentiation, and tissue morphogenesis makes it a critical regulator of various cellular processes. Further research is needed to fully understand the mechanisms by which SMAD7 regulates TGF-β signaling and its role in various diseases.

Genular Protein ID: 2792474333

Symbol: SMAD7_HUMAN

Name: Mothers against decapentaplegic homolog 7

UniProtKB Accession Codes:

O15105 B7Z773 K7EQ10 O14740 Q6DK23

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 59 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 7 RefSeq 4 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9215638

Title: The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.

PubMed ID: 9215638

DOI: 10.1016/s0092-8674(00)80303-7

PubMed ID: 9256479

Title: Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.

PubMed ID: 9256479

DOI: 10.1073/pnas.94.17.9314

PubMed ID: 9335507

Title: Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.

PubMed ID: 9335507

DOI: 10.1038/39369

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9759503

Title: TGF-beta signal transduction.

PubMed ID: 9759503

DOI: 10.1146/annurev.biochem.67.1.753

PubMed ID: 10647776

Title: Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

PubMed ID: 10647776

DOI: 10.1016/s1359-6101(99)00012-x

PubMed ID: 9892009

Title: Roles of pathway-specific and inhibitory Smads in activin receptor signaling.

PubMed ID: 9892009

DOI: 10.1210/mend.13.1.0218

PubMed ID: 10708948

Title: The Smad pathway.

PubMed ID: 10708948

DOI: 10.1016/s1359-6101(99)00024-6

PubMed ID: 10708949

Title: TGF-beta signaling by Smad proteins.

PubMed ID: 10708949

DOI: 10.1016/s1359-6101(99)00025-8

PubMed ID: 11163210

Title: Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation.

PubMed ID: 11163210

DOI: 10.1016/s1097-2765(00)00134-9

PubMed ID: 11483516

Title: Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads.

PubMed ID: 11483516

DOI: 10.1093/emboj/20.15.4132

PubMed ID: 11278251

Title: Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation.

PubMed ID: 11278251

DOI: 10.1074/jbc.c100008200

PubMed ID: 12023024

Title: Phosphorylation regulation of the interaction between Smad7 and activin type I receptor.

PubMed ID: 12023024

DOI: 10.1016/s0014-5793(02)02718-7

PubMed ID: 12408818

Title: Control of Smad7 stability by competition between acetylation and ubiquitination.

PubMed ID: 12408818

DOI: 10.1016/s1097-2765(02)00639-1

PubMed ID: 14657019

Title: Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7.

PubMed ID: 14657019

DOI: 10.1093/emboj/cdg632

PubMed ID: 14718519

Title: GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor.

PubMed ID: 14718519

DOI: 10.1083/jcb.200307151

PubMed ID: 14993265

Title: Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation.

PubMed ID: 14993265

DOI: 10.1128/mcb.24.6.2251-2262.2004

PubMed ID: 16061177

Title: Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.

PubMed ID: 16061177

DOI: 10.1016/j.molcel.2005.06.028

PubMed ID: 16601693

Title: Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.

PubMed ID: 16601693

DOI: 10.1038/sj.emboj.7601057

PubMed ID: 17327236

Title: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.

PubMed ID: 17327236

DOI: 10.1074/jbc.m609279200

PubMed ID: 21791611

Title: TSC-22 promotes transforming growth factor beta-mediated cardiac myofibroblast differentiation by antagonizing Smad7 activity.

PubMed ID: 21791611

DOI: 10.1128/mcb.05448-11

PubMed ID: 16641086

Title: An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2.

PubMed ID: 16641086

DOI: 10.1074/jbc.m601493200

PubMed ID: 17934461

Title: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.

PubMed ID: 17934461

DOI: 10.1038/ng.2007.18

Sequence Information:

  • Length: 426
  • Mass: 46426
  • Checksum: 5B76EC986776C102
  • Sequence:
    • MFRTKRSALV RRLWRSRAPG GEDEEEGAGG GGGGGELRGE GATDSRAHGA GGGGPGRAGC 
CLGKAVRGAK GHHHPHPPAA GAGAAGGAEA DLKALTHSVL KKLKERQLEL LLQAVESRGG 
TRTACLLLPG RLDCRLGPGA PAGAQPAQPP SSYSLPLLLC KVFRWPDLRH SSEVKRLCCC 
ESYGKINPEL VCCNPHHLSR LCELESPPPP YSRYPMDFLK PTADCPDAVP SSAETGGTNY 
LAPGGLSDSQ LLLEPGDRSH WCVVAYWEEK TRVGRLYCVQ EPSLDIFYDL PQGNGFCLGQ 
LNSDNKSQLV QKVRSKIGCG IQLTREVDGV WVYNRSSYPI FIKSATLDNP DSRTLLVHKV 
FPGFSIKAFD YEKAYSLQRP NDHEFMQQPW TGFTVQISFV KGWGQCYTRQ FISSCPCWLE 
VIFNSR

Genular Protein ID: 2472692791

Symbol: B3KYA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KYA8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 238
  • Mass: 26904
  • Checksum: F7D2B026E146BCA1
  • Sequence:
    • MCGLSFMLFR ACLKMDLGVF ICVFISFSPL FKSTADCPDA VPSSAETGGT NYLAPGGLSD 
SQLLLEPGDR SHWCVVAYWE EKTRVGRLYC VQEPSLDIFY DLPQGNGFCL GQLNSDNKSQ 
LVQKVRSKIG CGIQLTREVD GVWVYNRSSY PIFIKSATLD NPDSRTLLVH KVFPGFSIKA 
FDYEKAYSLQ RPNDHEFMQQ PWTGFTVQIS FVKGWGQCYT RQFISSCPCW LEVIFNSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.