Details for: MCM4

Gene ID: 4173

Symbol: MCM4

Ensembl ID: ENSG00000104738

Description: minichromosome maintenance complex component 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.2998
    Cell Significance Index: -11.4900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 31.7533
    Cell Significance Index: -12.9000
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.0585
    Cell Significance Index: -3.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.0588
    Cell Significance Index: -13.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6890
    Cell Significance Index: -15.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.8558
    Cell Significance Index: -15.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.3339
    Cell Significance Index: -10.2400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.9092
    Cell Significance Index: 19.3000
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 2.5472
    Cell Significance Index: 1.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4459
    Cell Significance Index: 241.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.3638
    Cell Significance Index: 63.2300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.1453
    Cell Significance Index: 13.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2563
    Cell Significance Index: 136.6500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1363
    Cell Significance Index: 8.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.0898
    Cell Significance Index: 27.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0769
    Cell Significance Index: 175.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9286
    Cell Significance Index: 12.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9252
    Cell Significance Index: 109.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.9125
    Cell Significance Index: 31.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8430
    Cell Significance Index: 22.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8032
    Cell Significance Index: 41.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7800
    Cell Significance Index: 90.9000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.7564
    Cell Significance Index: 6.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7376
    Cell Significance Index: 146.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6911
    Cell Significance Index: 43.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6605
    Cell Significance Index: 18.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6411
    Cell Significance Index: 6.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5487
    Cell Significance Index: 30.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4790
    Cell Significance Index: 13.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4214
    Cell Significance Index: 51.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3619
    Cell Significance Index: 25.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3592
    Cell Significance Index: 16.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3582
    Cell Significance Index: 23.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3521
    Cell Significance Index: 24.9000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3180
    Cell Significance Index: 2.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3163
    Cell Significance Index: 139.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2539
    Cell Significance Index: 45.7800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2507
    Cell Significance Index: 8.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2434
    Cell Significance Index: 219.8000
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.2407
    Cell Significance Index: 1.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2319
    Cell Significance Index: 6.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2308
    Cell Significance Index: 5.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2232
    Cell Significance Index: 5.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2230
    Cell Significance Index: 44.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2069
    Cell Significance Index: 112.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1526
    Cell Significance Index: 3.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1235
    Cell Significance Index: 77.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1000
    Cell Significance Index: 2.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0949
    Cell Significance Index: 34.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0911
    Cell Significance Index: 2.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0836
    Cell Significance Index: 1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0738
    Cell Significance Index: 8.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0664
    Cell Significance Index: 8.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0633
    Cell Significance Index: 12.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0541
    Cell Significance Index: 2.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0534
    Cell Significance Index: 7.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0431
    Cell Significance Index: 1.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0353
    Cell Significance Index: 6.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0217
    Cell Significance Index: 1.6200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0172
    Cell Significance Index: 1.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0096
    Cell Significance Index: 0.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0053
    Cell Significance Index: 3.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0012
    Cell Significance Index: -2.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -10.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -4.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0091
    Cell Significance Index: -13.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0096
    Cell Significance Index: -6.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0126
    Cell Significance Index: -8.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0184
    Cell Significance Index: -0.8600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0189
    Cell Significance Index: -10.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0217
    Cell Significance Index: -0.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0277
    Cell Significance Index: -12.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0284
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0316
    Cell Significance Index: -6.6600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0369
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0414
    Cell Significance Index: -4.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0423
    Cell Significance Index: -2.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0432
    Cell Significance Index: -12.4400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0851
    Cell Significance Index: -1.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0980
    Cell Significance Index: -1.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1161
    Cell Significance Index: -6.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1217
    Cell Significance Index: -9.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1403
    Cell Significance Index: -11.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1421
    Cell Significance Index: -14.8000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1427
    Cell Significance Index: -4.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1559
    Cell Significance Index: -10.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1675
    Cell Significance Index: -7.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1799
    Cell Significance Index: -11.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1857
    Cell Significance Index: -5.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1925
    Cell Significance Index: -7.2900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2236
    Cell Significance Index: -1.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2728
    Cell Significance Index: -5.6600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2805
    Cell Significance Index: -6.4800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2959
    Cell Significance Index: -4.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3215
    Cell Significance Index: -10.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3256
    Cell Significance Index: -10.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MCM4 is a highly conserved protein that belongs to the minichromosome maintenance complex family. It is characterized by its ability to bind to single-stranded DNA (ssDNA) and its involvement in the regulation of DNA replication initiation. MCM4 is also known to interact with other proteins, such as Orc1, to form the pre-replicative complex. Its expression is tightly regulated during the cell cycle, with peak expression during the G1/S transition. **Pathways and Functions:** MCM4 is involved in several key pathways, including: 1. **Activation of the pre-replicative complex**: MCM4 plays a critical role in the assembly and activation of the pre-replicative complex, which is a complex of proteins that binds to the origin of replication and initiates DNA replication. 2. **DNA replication licensing**: MCM4 is involved in the licensing of DNA replication, which ensures that only one round of replication occurs per cell cycle. 3. **Cell cycle regulation**: MCM4 is also involved in the regulation of cell cycle progression, with peak expression during the G1/S transition. 4. **DNA repair**: MCM4 has been shown to interact with proteins involved in DNA repair, such as BLM and WRN. **Clinical Significance:** MCM4 has been implicated in various diseases, including: 1. **Cancer**: MCM4 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: MCM4 has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Autoimmune diseases**: MCM4 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Reproductive disorders**: MCM4 has been shown to play a critical role in reproductive development and function, with abnormalities in MCM4 expression leading to infertility and miscarriage. **Implications for Immunology:** MCM4 has been shown to interact with various immune cells, including B cells and T cells. Its expression has been observed in immune cells involved in the regulation of the immune response, such as germinal center B cells. MCM4 has also been implicated in the regulation of immune tolerance, with alterations in MCM4 expression leading to immune dysregulation. In conclusion, MCM4 is a critical protein involved in DNA replication and cell cycle regulation. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative diseases, autoimmune diseases, and reproductive disorders. Further studies are needed to fully elucidate the role of MCM4 in immunology and its potential as a therapeutic target for various diseases.

Genular Protein ID: 4107789870

Symbol: MCM4_HUMAN

Name: DNA replication licensing factor MCM4

UniProtKB Accession Codes:

P33991 Q8NEH1 Q99658

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 EMDB 6 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7601140

Title: A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins.

PubMed ID: 7601140

DOI: 10.1111/j.1432-1033.1995.tb20660.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9465298

Title: The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11.

PubMed ID: 9465298

DOI: 10.1006/geno.1997.5076

PubMed ID: 9284934

Title: MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13.

PubMed ID: 9284934

DOI: 10.1159/000134594

PubMed ID: 8265339

Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.

PubMed ID: 8265339

DOI: 10.1093/nar/21.23.5289-a

PubMed ID: 9305914

Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.

PubMed ID: 9305914

DOI: 10.1074/jbc.272.39.24508

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16899510

Title: Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

PubMed ID: 16899510

DOI: 10.1091/mbc.e06-03-0241

PubMed ID: 17296731

Title: Identification and characterization of a novel component of the human minichromosome maintenance complex.

PubMed ID: 17296731

DOI: 10.1128/mcb.02384-06

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22354170

Title: MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.

PubMed ID: 22354170

DOI: 10.1172/jci60224

PubMed ID: 22354167

Title: Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.

PubMed ID: 22354167

DOI: 10.1172/jci61014

PubMed ID: 22499342

Title: Recessive mutations in MCM4/PRKDC cause a novel syndrome involving a primary immunodeficiency and a disorder of DNA repair.

PubMed ID: 22499342

DOI: 10.1136/jmedgenet-2012-100803

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25661590

Title: G364R mutation of MCM4 detected in human skin cancer cells affects DNA helicase activity of MCM4/6/7 complex.

PubMed ID: 25661590

DOI: 10.1093/jb/mvv015

PubMed ID: 27401717

Title: Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.

PubMed ID: 27401717

DOI: 10.1038/ncomms12135

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 32453425

Title: CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.

PubMed ID: 32453425

DOI: 10.1093/nar/gkaa429

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

Sequence Information:

  • Length: 863
  • Mass: 96558
  • Checksum: 96D9CA2A7D88D015
  • Sequence:
    • MSSPASTPSR RGSRRGRATP AQTPRSEDAR SSPSQRRRGE DSTSTGELQP MPTSPGVDLQ 
SPAAQDVLFS SPPQMHSSAI PLDFDVSSPL TYGTPSSRVE GTPRSGVRGT PVRQRPDLGS 
AQKGLQVDLQ SDGAAAEDIV ASEQSLGQKL VIWGTDVNVA ACKENFQRFL QRFIDPLAKE 
EENVGIDITE PLYMQRLGEI NVIGEPFLNV NCEHIKSFDK NLYRQLISYP QEVIPTFDMA 
VNEIFFDRYP DSILEHQIQV RPFNALKTKN MRNLNPEDID QLITISGMVI RTSQLIPEMQ 
EAFFQCQVCA HTTRVEMDRG RIAEPSVCGR CHTTHSMALI HNRSLFSDKQ MIKLQESPED 
MPAGQTPHTV ILFAHNDLVD KVQPGDRVNV TGIYRAVPIR VNPRVSNVKS VYKTHIDVIH 
YRKTDAKRLH GLDEEAEQKL FSEKRVELLK ELSRKPDIYE RLASALAPSI YEHEDIKKGI 
LLQLFGGTRK DFSHTGRGKF RAEINILLCG DPGTSKSQLL QYVYNLVPRG QYTSGKGSSA 
VGLTAYVMKD PETRQLVLQT GALVLSDNGI CCIDEFDKMN ESTRSVLHEV MEQQTLSIAK 
AGIICQLNAR TSVLAAANPI ESQWNPKKTT IENIQLPHTL LSRFDLIFLL LDPQDEAYDR 
RLAHHLVALY YQSEEQAEEE LLDMAVLKDY IAYAHSTIMP RLSEEASQAL IEAYVDMRKI 
GSSRGMVSAY PRQLESLIRL AEAHAKVRLS NKVEAIDVEE AKRLHREALK QSATDPRTGI 
VDISILTTGM SATSRKRKEE LAEALKKLIL SKGKTPALKY QQLFEDIRGQ SDIAITKDMF 
EEALRALADD DFLTVTGKTV RLL

Genular Protein ID: 53233551

Symbol: B4DLA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLA6

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 11 Gene3D 4 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 4 RefSeq 1 Rhea 2 RuleBase 2 SMART 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 823
  • Mass: 92723
  • Checksum: 85FE1F8514B88675
  • Sequence:
    • MPGHLPLRDV EARIPPPRGS CSRCQPRLEW TCRALLRRTC CFPALPKCIL QLSLLTLMLE 
GTPRSGVRGT PVRQRPDLGS AQKGLQVDLQ SDGAAAEDIV ASEQSLGQKL VIWGTDVNVA 
ACKENFQRFL QRFIDPLAKE EENVGIDITE PLYMQRLGEI NVIGEPFLNV NCEHIKSFDK 
NLYRQLISYP QEVIPTFDMA VNEIFFDRYP DSILEHQIQV RPFNALKTKN MRNLNPEDID 
QLITISGMVI RTSQLIPEMQ EAFFQCQVCA HTTRVEMDRG RIAEPSVCGR CHTTHSMALI 
HNRSLFSDKQ MIKLQESPED MPAGQTPHTV ILFAHNDLVD KVQPGDRVNV TGIYRAVPIR 
VNPRVSNVKS VYKTHIDVIH YRKTDAKRLH GLDEEAEQKL FSEKRVELLK ELSRKPDIYE 
RLASALAPSI YEHEDIKKGI LLQLFGGTRK DFSHTGGGKF RAEINILLCG DPGTSKSQLL 
QYVYNLVPRG QYTSGKGSSA VGLTAYVMKD PETRQLVLQT GALVLSDNGI CCIDEFDKMN 
ESTRSVLHEV MEQQTLSIAK AGIICQLNAR TSVLAAANPI ESQWNPKKTT IENIQLPHTL 
LSRFDLIFLM LDPQDEAYDR RLAHHLVALY YQSEEQAEEE LLDMAVLKDY IAYAHSTIMP 
RLSEEASQAL IEAYVDMRKI GSSRGMVSAY PRQLESLIRL AEAHAKVRLS NKVEAIDVEE 
AKRLHREALK QSATDPRTGI VDISILTTGM SATSRKRKEE LAEALKKLIL SKGKTPALKY 
QQLFEDIRGQ SDIAITKDMF EEALRALADD DFLTVTGKTV RLL

Genular Protein ID: 3497634655

Symbol: B3KMX0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KMX0

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 11 Gene3D 4 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 Rhea 2 RuleBase 2 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 863
  • Mass: 96604
  • Checksum: E58157D9009E551A
  • Sequence:
    • MSSPASTPSR RGSRRGRATP AQTPRSEDAR SSPSQRRRGE DSTSTGELQP MPTSPGVDLQ 
SPAAQDVLFS SPPQMHSSAI PLDFDVSSPL TYGTPSSRVE GTPRSGVRGT PVRQRPDLGS 
AQKGLQVDLQ SDGAAAEDIV ASEQSLGQKL VIWGTDVNVA ACKENFQRFL QRFIDPLAKE 
EENVGIDITE PLYMQRLGEI NVIGEPFLNV NCEHIKSFDK NLYRQLISYP QEVIPTFDMA 
VNEIFFDRYP DSILEHQIQV RPFNALKTKN MRNLNPEDID QLITISGMVI RTSQLIPEMQ 
EAFFQCQVCA HTTRVEMDRG RIAEPSVCGR CHTTHSMALI HNRSLFSDKQ MIKLQESPED 
MPAGQTPHTV ILFAHNDLVD KVQPGDRVNV TGIYRAVPIR VNPRVSNVKS VYKTHIDVIH 
YRKTDAKRLH GLDEEAEQKL FSEKRVELLK ELSRKPDIYE RLASALAPSI YEHEDIKKGI 
LLQLFGGTRK DFSHTGRGKF RAEINILLCG DPGTSKSQLL QYVYNLVPRG QYTSGKGSSA 
VGLTAYVMKD PETRQLVLQT GALVLSDNGI CCIDEFDRMN ESTRSVLHEV MEQQTLSIAK 
AGIICQLNAR TSVLAAANPI ESQWNPKKTT IENIQLPHTL LSRFDLIFLM LDPQDEAYDR 
RLAHHLVALY YQSEEQAEEE LLDMAVLKDY IAYAHSTIMP RLSEEASQAL IEAYVDMRKI 
GSSRGMVSAY PRQLESLIRL AEAHAKVRLS NKVEAIDVEE AKRLHREALK QSATDPRTGI 
VDISILTTGM SATSRKRKEE LAEALKKLIL SKGKTPALKY QQLFEDIRGQ SDIAITKDMF 
EEALRALADD DFLTVTGKTV RLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.