Details for: DNAJB9

Gene ID: 4189

Symbol: DNAJB9

Ensembl ID: ENSG00000128590

Description: DnaJ heat shock protein family (Hsp40) member B9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 241.1517
    Cell Significance Index: -37.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.6696
    Cell Significance Index: -38.4700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.5832
    Cell Significance Index: -41.4400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 85.6769
    Cell Significance Index: -40.4500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 77.3545
    Cell Significance Index: -39.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.3706
    Cell Significance Index: -40.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.6070
    Cell Significance Index: -38.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5270
    Cell Significance Index: -41.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4111
    Cell Significance Index: -27.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4455
    Cell Significance Index: -25.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4627
    Cell Significance Index: 70.6000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.4422
    Cell Significance Index: 15.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.1342
    Cell Significance Index: 58.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0129
    Cell Significance Index: 150.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.7107
    Cell Significance Index: 30.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3439
    Cell Significance Index: 63.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1088
    Cell Significance Index: 1001.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0857
    Cell Significance Index: 140.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0443
    Cell Significance Index: 48.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0070
    Cell Significance Index: 52.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8197
    Cell Significance Index: 49.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7760
    Cell Significance Index: 132.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7635
    Cell Significance Index: 83.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6580
    Cell Significance Index: 90.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6124
    Cell Significance Index: 99.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5990
    Cell Significance Index: 76.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.5655
    Cell Significance Index: 19.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5294
    Cell Significance Index: 27.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5212
    Cell Significance Index: 64.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4713
    Cell Significance Index: 208.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4441
    Cell Significance Index: 242.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4322
    Cell Significance Index: 11.5400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4053
    Cell Significance Index: 5.5300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3898
    Cell Significance Index: 2.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3699
    Cell Significance Index: 25.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3688
    Cell Significance Index: 8.5200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3560
    Cell Significance Index: 64.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3259
    Cell Significance Index: 62.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3111
    Cell Significance Index: 30.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2918
    Cell Significance Index: 20.6400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2730
    Cell Significance Index: 2.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2379
    Cell Significance Index: 3.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2336
    Cell Significance Index: 46.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1829
    Cell Significance Index: 4.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1446
    Cell Significance Index: 4.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1127
    Cell Significance Index: 2.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1071
    Cell Significance Index: 21.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1023
    Cell Significance Index: 2.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1008
    Cell Significance Index: 11.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0842
    Cell Significance Index: 30.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0644
    Cell Significance Index: 4.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0524
    Cell Significance Index: 0.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0438
    Cell Significance Index: 33.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0229
    Cell Significance Index: 1.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0032
    Cell Significance Index: 6.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0153
    Cell Significance Index: -3.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0218
    Cell Significance Index: -40.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0243
    Cell Significance Index: -37.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0245
    Cell Significance Index: -17.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0247
    Cell Significance Index: -15.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0249
    Cell Significance Index: -15.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0307
    Cell Significance Index: -3.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0319
    Cell Significance Index: -43.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0418
    Cell Significance Index: -23.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0439
    Cell Significance Index: -30.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0741
    Cell Significance Index: -33.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0744
    Cell Significance Index: -1.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0763
    Cell Significance Index: -9.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0867
    Cell Significance Index: -24.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1295
    Cell Significance Index: -14.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1942
    Cell Significance Index: -28.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2186
    Cell Significance Index: -7.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2353
    Cell Significance Index: -27.4200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2748
    Cell Significance Index: -7.6800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2959
    Cell Significance Index: -2.7300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3597
    Cell Significance Index: -7.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3685
    Cell Significance Index: -28.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3925
    Cell Significance Index: -40.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4025
    Cell Significance Index: -12.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4055
    Cell Significance Index: -26.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4117
    Cell Significance Index: -12.0900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4387
    Cell Significance Index: -5.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4408
    Cell Significance Index: -34.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4931
    Cell Significance Index: -30.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4998
    Cell Significance Index: -28.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5045
    Cell Significance Index: -33.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5419
    Cell Significance Index: -11.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5658
    Cell Significance Index: -34.6900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.6258
    Cell Significance Index: -4.2400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.6679
    Cell Significance Index: -7.2900
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.7190
    Cell Significance Index: -3.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7374
    Cell Significance Index: -21.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7504
    Cell Significance Index: -33.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7853
    Cell Significance Index: -19.6300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.8175
    Cell Significance Index: -7.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8307
    Cell Significance Index: -22.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8424
    Cell Significance Index: -34.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8450
    Cell Significance Index: -21.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8527
    Cell Significance Index: -43.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** DNAJB9 is a small heat shock protein (Hsp40) that belongs to the Hsp70 family of molecular chaperones. It is characterized by its ability to interact with other proteins, including Hsp70, and to regulate various cellular processes. Key features of DNAJB9 include: * **Molecular Chaperone Activity:** DNAJB9 facilitates the proper folding and degradation of proteins, thereby regulating cellular responses to stress and inflammation. * **Cellular Expression:** DNAJB9 is widely expressed in various cell types, including immune cells, such as B cells and plasma cells. * **Interactions with Other Proteins:** DNAJB9 interacts with other proteins, including Hsp70, to regulate cellular processes. * **Regulation of Immune Responses:** DNAJB9 plays a crucial role in regulating immune responses, including B cell differentiation and immunoglobulin production. **Pathways and Functions:** DNAJB9 is involved in various cellular pathways, including: * **B Cell Differentiation:** DNAJB9 regulates B cell differentiation and immunoglobulin production. * **Cellular Responses to Stimuli:** DNAJB9 is involved in regulating cellular responses to stimuli, including stress and inflammation. * **Cytoplasmic and Endoplasmic Reticulum Pathways:** DNAJB9 is localized to the cytoplasm and endoplasmic reticulum, where it regulates protein folding and degradation. * **Eradication Pathway:** DNAJB9 is involved in the eradication pathway, which regulates the degradation of misfolded proteins. * **Unfolded Protein Response (UPR):** DNAJB9 regulates the UPR, which is a cellular response to endoplasmic reticulum stress. **Clinical Significance:** Dysregulation of DNAJB9 has been implicated in various diseases, including: * **Autoimmune Disorders:** DNAJB9 dysregulation has been linked to autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. * **Cancer:** DNAJB9 expression is often upregulated in cancer cells, where it promotes tumor growth and metastasis. * **Infectious Diseases:** DNAJB9 plays a crucial role in regulating immune responses to infectious diseases, such as tuberculosis and HIV. In conclusion, DNAJB9 is a critical regulator of cellular homeostasis and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining human health. Further research is needed to fully understand the mechanisms by which DNAJB9 regulates cellular processes and to develop therapeutic strategies to target this gene in disease prevention and treatment.

Genular Protein ID: 4049281963

Symbol: DNJB9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UBS3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11836248

Title: Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress.

PubMed ID: 11836248

DOI: 10.1074/jbc.m112214200

PubMed ID: 18400946

Title: ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.

PubMed ID: 18400946

DOI: 10.1091/mbc.e07-07-0674

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 223
  • Mass: 25518
  • Checksum: 59E3E57FF8B378BC
  • Sequence:
    • MATPQSIFIF AICILMITEL ILASKSYYDI LGVPKSASER QIKKAFHKLA MKYHPDKNKS 
PDAEAKFREI AEAYETLSDA NRRKEYDTLG HSAFTSGKGQ RGSGSSFEQS FNFNFDDLFK 
DFGFFGQNQN TGSKKRFENH FQTRQDGGSS RQRHHFQEFS FGGGLFDDMF EDMEKMFSFS 
GFDSTNQHTV QTENRFHGSS KHCRTVTQRR GNMVTTYTDC SGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.