Details for: MDM4

Gene ID: 4194

Symbol: MDM4

Ensembl ID: ENSG00000198625

Description: MDM4 regulator of p53

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 432.8002
    Cell Significance Index: -67.3200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 254.4517
    Cell Significance Index: -64.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 161.6105
    Cell Significance Index: -76.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 158.9880
    Cell Significance Index: -64.5900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 141.1588
    Cell Significance Index: -72.6100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 113.9679
    Cell Significance Index: -76.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 67.8403
    Cell Significance Index: -64.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.0451
    Cell Significance Index: -72.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.9144
    Cell Significance Index: -72.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 18.9129
    Cell Significance Index: -58.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.8467
    Cell Significance Index: -74.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.7016
    Cell Significance Index: -40.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5086
    Cell Significance Index: 226.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.9890
    Cell Significance Index: 206.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0163
    Cell Significance Index: 400.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.9634
    Cell Significance Index: 54.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8206
    Cell Significance Index: 365.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6036
    Cell Significance Index: 174.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3184
    Cell Significance Index: 101.1800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1557
    Cell Significance Index: 64.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0953
    Cell Significance Index: 150.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0783
    Cell Significance Index: 64.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0605
    Cell Significance Index: 27.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0171
    Cell Significance Index: 183.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9467
    Cell Significance Index: 339.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8823
    Cell Significance Index: 104.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8454
    Cell Significance Index: 103.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7764
    Cell Significance Index: 343.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7650
    Cell Significance Index: 47.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7157
    Cell Significance Index: 19.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7040
    Cell Significance Index: 20.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6625
    Cell Significance Index: 18.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6497
    Cell Significance Index: 449.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6026
    Cell Significance Index: 329.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5432
    Cell Significance Index: 69.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5096
    Cell Significance Index: 32.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5028
    Cell Significance Index: 22.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4624
    Cell Significance Index: 417.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3841
    Cell Significance Index: 5.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3741
    Cell Significance Index: 27.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3592
    Cell Significance Index: 16.8800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2780
    Cell Significance Index: 5.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2310
    Cell Significance Index: 434.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1987
    Cell Significance Index: 33.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1848
    Cell Significance Index: 30.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1837
    Cell Significance Index: 3.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1794
    Cell Significance Index: 12.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1389
    Cell Significance Index: 17.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1327
    Cell Significance Index: 25.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0991
    Cell Significance Index: 44.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0984
    Cell Significance Index: 4.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0982
    Cell Significance Index: 3.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0907
    Cell Significance Index: 8.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0848
    Cell Significance Index: 156.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0826
    Cell Significance Index: 127.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0692
    Cell Significance Index: 43.9700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0477
    Cell Significance Index: 64.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0143
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0345
    Cell Significance Index: -25.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0421
    Cell Significance Index: -31.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0437
    Cell Significance Index: -32.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0451
    Cell Significance Index: -3.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0571
    Cell Significance Index: -35.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0937
    Cell Significance Index: -52.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1055
    Cell Significance Index: -5.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1499
    Cell Significance Index: -4.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1939
    Cell Significance Index: -40.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2029
    Cell Significance Index: -4.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2183
    Cell Significance Index: -11.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2252
    Cell Significance Index: -23.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2269
    Cell Significance Index: -65.2900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2595
    Cell Significance Index: -37.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2661
    Cell Significance Index: -11.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3472
    Cell Significance Index: -39.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3507
    Cell Significance Index: -5.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3738
    Cell Significance Index: -43.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4081
    Cell Significance Index: -46.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4099
    Cell Significance Index: -15.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4330
    Cell Significance Index: -9.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4990
    Cell Significance Index: -25.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5014
    Cell Significance Index: -7.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5111
    Cell Significance Index: -10.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5421
    Cell Significance Index: -56.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5830
    Cell Significance Index: -20.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6841
    Cell Significance Index: -18.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7151
    Cell Significance Index: -17.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7382
    Cell Significance Index: -8.8000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7399
    Cell Significance Index: -13.6800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7659
    Cell Significance Index: -17.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8586
    Cell Significance Index: -68.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9408
    Cell Significance Index: -19.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9772
    Cell Significance Index: -25.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0660
    Cell Significance Index: -65.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.0743
    Cell Significance Index: -8.7600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.1316
    Cell Significance Index: -16.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1809
    Cell Significance Index: -30.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3236
    Cell Significance Index: -37.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4082
    Cell Significance Index: -21.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.4161
    Cell Significance Index: -37.9500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.4972
    Cell Significance Index: -11.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MDM4 is a 14 kDa protein that belongs to the MDM family of proteins, which are known to regulate TP53 activity. MDM4 is highly expressed in various cell types, including immune cells such as B cells, T cells, and dendritic cells. The protein is characterized by its ability to bind to the N-terminal domain of TP53, inhibiting its transcriptional activity. MDM4 also has the ability to interact with other proteins, such as p53, p73, and p63, modulating their activity. **Pathways and Functions:** The MDM4-TP53 regulatory axis is a critical component of the cell cycle checkpoint system, which ensures genomic stability by preventing the propagation of damaged DNA. MDM4 regulates TP53 activity through several mechanisms, including: 1. **Negative regulation of TP53 transcription**: MDM4 binds to the N-terminal domain of TP53, preventing its transcriptional activation and thereby inhibiting the expression of TP53 target genes. 2. **Inhibition of p53-dependent cell cycle checkpoints**: MDM4 inhibits the activity of TP53-dependent cell cycle checkpoints, allowing cells to continue proliferating despite DNA damage. 3. **Regulation of TP53 degradation**: MDM4 interacts with the E3 ubiquitin ligase MDM2, modulating its activity and affecting TP53 degradation. The MDM4-TP53 axis also plays a role in regulating immune responses, including: 1. **Regulation of immune cell development**: MDM4 is involved in the development and differentiation of immune cells, such as B cells and T cells. 2. **Modulation of immune responses**: MDM4 regulates the activity of immune cells, such as dendritic cells and macrophages, influencing their ability to respond to pathogens and antigens. **Clinical Significance:** Dysregulation of the MDM4-TP53 axis has been implicated in various diseases, including: 1. **Cancer**: Mutations in MDM4 can lead to the overexpression of TP53, promoting tumorigenesis. 2. **Autoimmune diseases**: Dysregulation of the MDM4-TP53 axis can contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Immunodeficiency**: Mutations in MDM4 can lead to immunodeficiency, as the protein plays a critical role in regulating immune cell development and function. In conclusion, the MDM4-TP53 regulatory axis is a critical component of the cell cycle checkpoint system and plays a significant role in regulating immune responses. Dysregulation of this axis has been implicated in various diseases, highlighting the importance of understanding the complex interactions between MDM4 and TP53 in the context of immunology.

Genular Protein ID: 1705457047

Symbol: MDM4_HUMAN

Name: Protein Mdm4

UniProtKB Accession Codes:

O15151 Q2M2Y2 Q32SL2 Q6GS18 Q8IV83

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 39 PDBsum 39 PIRSF 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 7 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9226370

Title: Isolation and identification of the human homolog of a new p53-binding protein, Mdmx.

PubMed ID: 9226370

DOI: 10.1006/geno.1997.4775

PubMed ID: 16266988

Title: Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.

PubMed ID: 16266988

DOI: 10.1158/0008-5472.can-05-0450

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12761890

Title: Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells.

PubMed ID: 12761890

DOI: 10.1002/jcb.10535

PubMed ID: 10608892

Title: Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.

PubMed ID: 10608892

DOI: 10.1074/jbc.274.53.38189

PubMed ID: 16163388

Title: ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.

PubMed ID: 16163388

DOI: 10.1038/sj.emboj.7600812

PubMed ID: 16511572

Title: 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.

PubMed ID: 16511572

DOI: 10.1038/sj.emboj.7601010

PubMed ID: 19838211

Title: MdmX is a substrate for the deubiquitinating enzyme USP2a.

PubMed ID: 19838211

DOI: 10.1038/onc.2009.330

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32300648

Title: Germline mutation of MDM4, a major p53 regulator, in a familial syndrome of defective telomere maintenance.

PubMed ID: 32300648

DOI: 10.1126/sciadv.aay3511

Sequence Information:

  • Length: 490
  • Mass: 54864
  • Checksum: 415E6FA5A0C69857
  • Sequence:
    • MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI 
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL 
ALAQDHSMDI PSQDQLKQSA EESSTSRKRT TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ 
DETSRLDLGF EEWDVAGLPW WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF 
LNESVSEQLG VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS 
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP EKENEGNDVP 
DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS SESQETISSM GEQLDNLSEQ 
RTDTENMEDC QNLLKPCSLC EKRPRDGNII HGRTGHLVTC FHCARRLKKA GASCPICKKE 
IQLVIKVFIA

Genular Protein ID: 94731523

Symbol: A0A087WZ58_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WZ58

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 392
  • Mass: 43961
  • Checksum: B30F41BC9C422026
  • Sequence:
    • MTSFSTSAQC STSDSACRIS PGQINQDHSM DIPSQDQLKQ SAEESSTSRK RTTEDDIPTL 
PTSEHKCIHS REDEDLIENL AQDETSRLDL GFEEWDVAGL PWWFLGNLRS NYTPRSNGST 
DLQTNQDVGT AIVSDTTDDL WFLNESVSEQ LGVGIKVEAA DTEQTSEEVG KVSDKKVIEV 
GKNDDLEDSK SLSDDTDVEV TSEDEWQCTE CKKFNSPSKR YCFRCWALRK DWYSDCSKLT 
HSLSTSDITA IPEKENEGND VPDCRRTISA PVVRPKDAYI KKENSKLFDP CNSVEFLDLA 
HSSESQETIS SMGEQLDNLS EQRTDTENME DCQNLLKPCS LCEKRPRDGN IIHGRTGHLV 
TCFHCARRLK KAGASCPICK KEIQLVIKVF IA

Genular Protein ID: 798678987

Symbol: A0A087WUE3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WUE3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 116
  • Mass: 12801
  • Checksum: 6DF728DC35A2B420
  • Sequence:
    • MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI 
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTGD

Genular Protein ID: 578937645

Symbol: Q68DC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q68DC0

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 140
  • Mass: 15907
  • Checksum: 79EEF2BFB123B726
  • Sequence:
    • MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI 
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTAKCRGK 
FHFQKKNYRR RYPHTAYLRA

Genular Protein ID: 2912134789

Symbol: A0A087WTR9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WTR9

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 267
  • Mass: 29921
  • Checksum: AFF1C2134B2599C9
  • Sequence:
    • MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVIEVGKNDD 
LEDSKSLSDD TDVEVTSEDE WQCTECKKFN SPSKRYCFRC WALRKDWYSD CSKLTHSLST 
SDITAIPEKE NEGNDVPDCR RTISAPVVRP KDAYIKKENS KLFDPCNSVE FLDLAHSSES 
QETISSMGEQ LDNLSEQRTD TENMEDCQNL LKPCSLCEKR PRDGNIIHGR TGHLVTCFHC 
ARRLKKAGAS CPICKKEIQL VIKVFIA

Genular Protein ID: 2484436403

Symbol: Q59FS6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FS6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 3 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 233
  • Mass: 26480
  • Checksum: 195F80EBA539E7C6
  • Sequence:
    • PHLKQVNITN EMFLPSQVIE VGKNDDLEDS KSLSDDTDVE VTSEDEWQCT ECKKFNSPSK 
RYCFRCWALR KDWYSDCSKL THSLSTSDIT AIPEKENEGN DVPDCRRTIS APVVRPKDAY 
IKKENSKLFD PCNSVEFLDL AHSSESQETI SSMGEQLDNL SEQRTDTENM EDCQNLLKPC 
SLCEKRPRDG NIIHGRTGHL VTCFHCARRL KKAGASCPIC KKEIQLVIKV FIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.