Details for: ME1

Gene ID: 4199

Symbol: ME1

Ensembl ID: ENSG00000065833

Description: malic enzyme 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 152.7538
    Cell Significance Index: -38.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.1122
    Cell Significance Index: -38.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.7198
    Cell Significance Index: -27.4200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2721
    Cell Significance Index: -24.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.7997
    Cell Significance Index: -38.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 6.8579
    Cell Significance Index: 183.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.0522
    Cell Significance Index: 104.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3276
    Cell Significance Index: 466.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0730
    Cell Significance Index: 394.5100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.8621
    Cell Significance Index: 45.4400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 1.7468
    Cell Significance Index: 2.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.5600
    Cell Significance Index: 2401.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4722
    Cell Significance Index: 55.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4262
    Cell Significance Index: 95.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4218
    Cell Significance Index: 62.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3822
    Cell Significance Index: 106.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3515
    Cell Significance Index: 484.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.3382
    Cell Significance Index: 2468.0300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.3327
    Cell Significance Index: 38.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2896
    Cell Significance Index: 255.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1249
    Cell Significance Index: 24.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9650
    Cell Significance Index: 95.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8965
    Cell Significance Index: 53.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8688
    Cell Significance Index: 784.4900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8476
    Cell Significance Index: 24.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7001
    Cell Significance Index: 76.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.6724
    Cell Significance Index: 914.3000
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.6639
    Cell Significance Index: 2.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5264
    Cell Significance Index: 14.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4919
    Cell Significance Index: 12.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4361
    Cell Significance Index: 197.9200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3804
    Cell Significance Index: 4.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3042
    Cell Significance Index: 4.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.2859
    Cell Significance Index: 6.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0825
    Cell Significance Index: 1.1000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0658
    Cell Significance Index: 0.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0608
    Cell Significance Index: 4.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0500
    Cell Significance Index: 9.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0430
    Cell Significance Index: 1.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0334
    Cell Significance Index: 62.9700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0270
    Cell Significance Index: 3.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0240
    Cell Significance Index: 15.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0033
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0042
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0097
    Cell Significance Index: -6.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0121
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0149
    Cell Significance Index: -11.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0300
    Cell Significance Index: -22.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0315
    Cell Significance Index: -17.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0346
    Cell Significance Index: -19.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0366
    Cell Significance Index: -26.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0391
    Cell Significance Index: -17.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0479
    Cell Significance Index: -6.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0658
    Cell Significance Index: -11.2400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0861
    Cell Significance Index: -1.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0876
    Cell Significance Index: -12.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0929
    Cell Significance Index: -19.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0983
    Cell Significance Index: -11.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1066
    Cell Significance Index: -30.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1161
    Cell Significance Index: -13.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1236
    Cell Significance Index: -12.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1349
    Cell Significance Index: -8.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1391
    Cell Significance Index: -17.8300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1640
    Cell Significance Index: -2.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2199
    Cell Significance Index: -4.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2415
    Cell Significance Index: -6.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2576
    Cell Significance Index: -33.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2593
    Cell Significance Index: -27.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2618
    Cell Significance Index: -29.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2966
    Cell Significance Index: -18.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3070
    Cell Significance Index: -18.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3395
    Cell Significance Index: -24.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3484
    Cell Significance Index: -11.1600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.3496
    Cell Significance Index: -2.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3651
    Cell Significance Index: -15.8800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3783
    Cell Significance Index: -29.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3929
    Cell Significance Index: -5.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4324
    Cell Significance Index: -22.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4389
    Cell Significance Index: -32.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4489
    Cell Significance Index: -23.5700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4574
    Cell Significance Index: -3.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4803
    Cell Significance Index: -22.4000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.4963
    Cell Significance Index: -6.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4977
    Cell Significance Index: -32.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5145
    Cell Significance Index: -26.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5164
    Cell Significance Index: -8.8500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.5408
    Cell Significance Index: -3.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5470
    Cell Significance Index: -25.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5842
    Cell Significance Index: -14.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6025
    Cell Significance Index: -19.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6157
    Cell Significance Index: -12.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6433
    Cell Significance Index: -12.7200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.6752
    Cell Significance Index: -9.4700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.6795
    Cell Significance Index: -8.4300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.6968
    Cell Significance Index: -13.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7110
    Cell Significance Index: -15.0900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7149
    Cell Significance Index: -22.6100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.7248
    Cell Significance Index: -9.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7406
    Cell Significance Index: -11.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7532
    Cell Significance Index: -24.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Metabolic Pathways:** ME1 is involved in carbohydrate and lipid metabolism, facilitating the conversion of malate to pyruvate, and playing a crucial role in the citric acid (TCA) cycle and respiratory electron transport. 2. **Cellular Stress Response:** ME1 is activated in response to cellular stress, including oxidative stress, which highlights its role in maintaining cellular homeostasis. 3. **Regulation of Gene Expression:** ME1 is regulated by various transcription factors, including PPARα, which activates gene expression and influences lipid metabolism. 4. **Protein Binding and Homotetramerization:** ME1 exhibits identical protein binding and homotetramerization properties, which contribute to its enzymatic activity and stability. **Pathways and Functions:** 1. **Carbohydrate Metabolic Process:** ME1 is involved in the conversion of malate to pyruvate, a key step in glucose metabolism. 2. **Lipid Metabolism:** ME1 regulates lipid metabolism by influencing the expression of genes involved in fatty acid synthesis and oxidation. 3. **Electron Transport Chain:** ME1 participates in the respiratory electron transport chain, facilitating the generation of ATP. 4. **Keap1-Nfe2L2 Pathway:** ME1 is activated in response to oxidative stress, which is mediated by the Keap1-Nfe2L2 pathway. 5. **Regulation of NadP Metabolic Process:** ME1 regulates NadP-dependent metabolic processes, including those involved in fatty acid synthesis and oxidation. **Clinical Significance:** 1. **Metabolic Disorders:** Abnormalities in ME1 expression or function may contribute to metabolic disorders, such as diabetes and lipid metabolism disorders. 2. **Cancer:** ME1's role in the Keap1-Nfe2L2 pathway and its involvement in cellular stress response may influence cancer development and progression. 3. **Neurological Disorders:** ME1's expression in dopaminergic neurons and astrocytes of the cerebral cortex may contribute to the pathogenesis of neurological disorders, such as Parkinson's disease and Alzheimer's disease. 4. **Cardiovascular Disease:** ME1's involvement in lipid metabolism and the regulation of NadP-dependent metabolic processes may influence the development of cardiovascular disease. In conclusion, the malic enzyme 1 gene plays a crucial role in regulating carbohydrate and lipid metabolism, as well as responding to cellular stress and chemical stimuli. Its involvement in the Keap1-Nfe2L2 pathway and its regulation of NadP-dependent metabolic processes highlight its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the clinical significance of ME1 in various diseases and disorders.

Genular Protein ID: 2574313000

Symbol: MAOX_HUMAN

Name: Malic enzyme 1

UniProtKB Accession Codes:

P48163 B4DZ70 Q16797 Q16855 Q53F72 Q5VWA2 Q9BWX8 Q9H1W3 Q9UIY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 18 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 5 SABIO-RK 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8187880

Title: Characterization of cytosolic malic enzyme in human tumor cells.

PubMed ID: 8187880

DOI: 10.1016/0014-5793(94)00386-6

PubMed ID: 7622060

Title: Cloning, sequencing and functional expression of a cDNA encoding a NADP-dependent malic enzyme from human liver.

PubMed ID: 7622060

DOI: 10.1016/0378-1119(95)00004-p

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8804575

Title: Nonidentity of the cDNA sequence of human breast cancer cell malic enzyme to that from the normal human cell.

PubMed ID: 8804575

DOI: 10.1007/bf01887116

PubMed ID: 7757881

Title: Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain.

PubMed ID: 7757881

DOI: 10.1016/1357-2725(94)00057-3

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 572
  • Mass: 64150
  • Checksum: EA4C8CB36F6C619C
  • Sequence:
    • MEPEAPRRRH THQRGYLLTR NPHLNKDLAF TLEERQQLNI HGLLPPSFNS QEIQVLRVVK 
NFEHLNSDFD RYLLLMDLQD RNEKLFYRVL TSDIEKFMPI VYTPTVGLAC QQYSLVFRKP 
RGLFITIHDR GHIASVLNAW PEDVIKAIVV TDGERILGLG DLGCNGMGIP VGKLALYTAC 
GGMNPQECLP VILDVGTENE ELLKDPLYIG LRQRRVRGSE YDDFLDEFME AVSSKYGMNC 
LIQFEDFANV NAFRLLNKYR NQYCTFNDDI QGTASVAVAG LLAALRITKN KLSDQTILFQ 
GAGEAALGIA HLIVMALEKE GLPKEKAIKK IWLVDSKGLI VKGRASLTQE KEKFAHEHEE 
MKNLEAIVQE IKPTALIGVA AIGGAFSEQI LKDMAAFNER PIIFALSNPT SKAECSAEQC 
YKITKGRAIF ASGSPFDPVT LPNGQTLYPG QGNNSYVFPG VALGVVACGL RQITDNIFLT 
TAEVIAQQVS DKHLEEGRLY PPLNTIRDVS LKIAEKIVKD AYQEKTATVY PEPQNKEAFV 
RSQMYSTDYD QILPDCYSWP EEVQKIQTKV DQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.