Details for: MEF2D
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 205.7922
Cell Significance Index: -32.0100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 122.3765
Cell Significance Index: -31.0400 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 84.0398
Cell Significance Index: -34.6200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 70.5325
Cell Significance Index: -33.3000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 67.3711
Cell Significance Index: -27.3700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 62.3949
Cell Significance Index: -32.1000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 28.8769
Cell Significance Index: -27.5700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 26.0999
Cell Significance Index: -32.1800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.4638
Cell Significance Index: -30.7100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.2285
Cell Significance Index: -32.4700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 7.8823
Cell Significance Index: -24.2100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 6.8766
Cell Significance Index: -15.0500 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.9036
Cell Significance Index: 15.9900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.4783
Cell Significance Index: 20.1700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.3914
Cell Significance Index: 87.7000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.3781
Cell Significance Index: 276.4500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.3589
Cell Significance Index: 34.9300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3014
Cell Significance Index: 58.9900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2947
Cell Significance Index: 83.5300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1343
Cell Significance Index: 1024.1500 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.1283
Cell Significance Index: 27.5300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.0472
Cell Significance Index: 30.0200 - Cell Name: myometrial cell (CL0002366)
Fold Change: 1.0037
Cell Significance Index: 11.5600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9420
Cell Significance Index: 72.2900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.9228
Cell Significance Index: 11.0000 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.8926
Cell Significance Index: 6.8800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7937
Cell Significance Index: 78.5100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.7487
Cell Significance Index: 16.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6519
Cell Significance Index: 70.9100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.5427
Cell Significance Index: 32.5800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5099
Cell Significance Index: 82.9400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5048
Cell Significance Index: 181.0600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5026
Cell Significance Index: 14.4800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.4133
Cell Significance Index: 18.2800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.3725
Cell Significance Index: 5.5000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.3498
Cell Significance Index: 69.4200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3381
Cell Significance Index: 23.3800 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3137
Cell Significance Index: 43.0800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.2989
Cell Significance Index: 8.0100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2839
Cell Significance Index: 10.7500 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.2758
Cell Significance Index: 4.5400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2610
Cell Significance Index: 13.1900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2559
Cell Significance Index: 176.9600 - Cell Name: type II muscle cell (CL0002212)
Fold Change: 0.2374
Cell Significance Index: 3.8300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2302
Cell Significance Index: 11.9600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2064
Cell Significance Index: 5.1600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.1908
Cell Significance Index: 22.5000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1871
Cell Significance Index: 23.0100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1760
Cell Significance Index: 33.5000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1459
Cell Significance Index: 24.9100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1406
Cell Significance Index: 25.3500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1396
Cell Significance Index: 61.7100 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.1226
Cell Significance Index: 1.2800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1057
Cell Significance Index: 57.7100 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0952
Cell Significance Index: 179.1700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0798
Cell Significance Index: 2.8100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0689
Cell Significance Index: 3.5900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0652
Cell Significance Index: 29.5700 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.0347
Cell Significance Index: 0.2300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0296
Cell Significance Index: 45.6200 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0207
Cell Significance Index: 0.2200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0168
Cell Significance Index: 10.6900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0167
Cell Significance Index: 30.8000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0100
Cell Significance Index: 13.5800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0082
Cell Significance Index: 0.3800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0035
Cell Significance Index: -0.0600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0091
Cell Significance Index: -6.7600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0193
Cell Significance Index: -12.0300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0264
Cell Significance Index: -3.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0288
Cell Significance Index: -21.1400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0335
Cell Significance Index: -25.3800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0344
Cell Significance Index: -19.3800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0692
Cell Significance Index: -3.2500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0698
Cell Significance Index: -14.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0793
Cell Significance Index: -8.1000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0921
Cell Significance Index: -26.5100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0930
Cell Significance Index: -10.8400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0997
Cell Significance Index: -14.4900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.1065
Cell Significance Index: -2.9000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1194
Cell Significance Index: -6.2700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1223
Cell Significance Index: -2.2600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1288
Cell Significance Index: -9.6000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1525
Cell Significance Index: -19.7000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1775
Cell Significance Index: -4.9600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1781
Cell Significance Index: -18.5400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1822
Cell Significance Index: -20.8700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1980
Cell Significance Index: -22.6100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2168
Cell Significance Index: -5.7900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2183
Cell Significance Index: -4.6500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2244
Cell Significance Index: -15.8700 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.2277
Cell Significance Index: -2.9200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2488
Cell Significance Index: -13.9600 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2919
Cell Significance Index: -2.3800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3341
Cell Significance Index: -6.9300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3645
Cell Significance Index: -28.8700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3802
Cell Significance Index: -7.4200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4582
Cell Significance Index: -28.1000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.4983
Cell Significance Index: -15.8700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.5150
Cell Significance Index: -16.8600 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5611
Cell Significance Index: -3.3900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1171292330
Symbol: MEF2D_HUMAN
Name: Myocyte-specific enhancer factor 2D
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8269842
Title: A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.
PubMed ID: 8269842
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9858528
Title: Regulation of the MEF2 family of transcription factors by p38.
PubMed ID: 9858528
DOI: 10.1128/mcb.19.1.21
PubMed ID: 10523670
Title: HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.
PubMed ID: 10523670
PubMed ID: 10849446
Title: Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.
PubMed ID: 10849446
PubMed ID: 10617605
Title: Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.
PubMed ID: 10617605
PubMed ID: 11904443
Title: Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.
PubMed ID: 11904443
PubMed ID: 12691662
Title: Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.
PubMed ID: 12691662
PubMed ID: 15834131
Title: Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain.
PubMed ID: 15834131
PubMed ID: 15888658
Title: Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.
PubMed ID: 15888658
PubMed ID: 15743823
Title: Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.
PubMed ID: 15743823
PubMed ID: 16166628
Title: Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.
PubMed ID: 16166628
PubMed ID: 15831463
Title: Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation.
PubMed ID: 15831463
PubMed ID: 16356933
Title: Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation.
PubMed ID: 16356933
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 21030595
Title: HDAC3 is negatively regulated by the nuclear protein DBC1.
PubMed ID: 21030595
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
Sequence Information:
- Length: 521
- Mass: 55938
- Checksum: 5C9790AD598619BA
- Sequence:
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.