Details for: MEF2D

Gene ID: 4209

Symbol: MEF2D

Ensembl ID: ENSG00000116604

Description: myocyte enhancer factor 2D

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 205.7922
    Cell Significance Index: -32.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.3765
    Cell Significance Index: -31.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 84.0398
    Cell Significance Index: -34.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 70.5325
    Cell Significance Index: -33.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.3711
    Cell Significance Index: -27.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.3949
    Cell Significance Index: -32.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.8769
    Cell Significance Index: -27.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.0999
    Cell Significance Index: -32.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.4638
    Cell Significance Index: -30.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.2285
    Cell Significance Index: -32.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8823
    Cell Significance Index: -24.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.8766
    Cell Significance Index: -15.0500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.9036
    Cell Significance Index: 15.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4783
    Cell Significance Index: 20.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3914
    Cell Significance Index: 87.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3781
    Cell Significance Index: 276.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3589
    Cell Significance Index: 34.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3014
    Cell Significance Index: 58.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2947
    Cell Significance Index: 83.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1343
    Cell Significance Index: 1024.1500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1283
    Cell Significance Index: 27.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0472
    Cell Significance Index: 30.0200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.0037
    Cell Significance Index: 11.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9420
    Cell Significance Index: 72.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9228
    Cell Significance Index: 11.0000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.8926
    Cell Significance Index: 6.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7937
    Cell Significance Index: 78.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7487
    Cell Significance Index: 16.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6519
    Cell Significance Index: 70.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5427
    Cell Significance Index: 32.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5099
    Cell Significance Index: 82.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5048
    Cell Significance Index: 181.0600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5026
    Cell Significance Index: 14.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4133
    Cell Significance Index: 18.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3725
    Cell Significance Index: 5.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3498
    Cell Significance Index: 69.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3381
    Cell Significance Index: 23.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3137
    Cell Significance Index: 43.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2989
    Cell Significance Index: 8.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2839
    Cell Significance Index: 10.7500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2758
    Cell Significance Index: 4.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2610
    Cell Significance Index: 13.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2559
    Cell Significance Index: 176.9600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.2374
    Cell Significance Index: 3.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2302
    Cell Significance Index: 11.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2064
    Cell Significance Index: 5.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1908
    Cell Significance Index: 22.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1871
    Cell Significance Index: 23.0100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1760
    Cell Significance Index: 33.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1459
    Cell Significance Index: 24.9100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1406
    Cell Significance Index: 25.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1396
    Cell Significance Index: 61.7100
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1226
    Cell Significance Index: 1.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1057
    Cell Significance Index: 57.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0952
    Cell Significance Index: 179.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0798
    Cell Significance Index: 2.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0689
    Cell Significance Index: 3.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0652
    Cell Significance Index: 29.5700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.0347
    Cell Significance Index: 0.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0296
    Cell Significance Index: 45.6200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0207
    Cell Significance Index: 0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0168
    Cell Significance Index: 10.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0167
    Cell Significance Index: 30.8000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0100
    Cell Significance Index: 13.5800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0082
    Cell Significance Index: 0.3800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0035
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0193
    Cell Significance Index: -12.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0264
    Cell Significance Index: -3.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0288
    Cell Significance Index: -21.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0335
    Cell Significance Index: -25.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0344
    Cell Significance Index: -19.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0692
    Cell Significance Index: -3.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0698
    Cell Significance Index: -14.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0793
    Cell Significance Index: -8.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0921
    Cell Significance Index: -26.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0930
    Cell Significance Index: -10.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0997
    Cell Significance Index: -14.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1065
    Cell Significance Index: -2.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1194
    Cell Significance Index: -6.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1223
    Cell Significance Index: -2.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1288
    Cell Significance Index: -9.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1525
    Cell Significance Index: -19.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1775
    Cell Significance Index: -4.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1781
    Cell Significance Index: -18.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1822
    Cell Significance Index: -20.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1980
    Cell Significance Index: -22.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2168
    Cell Significance Index: -5.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2183
    Cell Significance Index: -4.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2244
    Cell Significance Index: -15.8700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2277
    Cell Significance Index: -2.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2488
    Cell Significance Index: -13.9600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2919
    Cell Significance Index: -2.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3341
    Cell Significance Index: -6.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3645
    Cell Significance Index: -28.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3802
    Cell Significance Index: -7.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4582
    Cell Significance Index: -28.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4983
    Cell Significance Index: -15.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5150
    Cell Significance Index: -16.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5611
    Cell Significance Index: -3.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MEF2D exhibits several key characteristics that enable it to regulate gene expression: 1. **DNA-binding specificity**: MEF2D binds to specific DNA sequences, known as MEF2D binding sites, which are typically located in the promoter regions of target genes. 2. **Transcriptional activation**: MEF2D acts as a transcriptional activator, increasing the transcription of target genes by interacting with RNA polymerase II and other transcriptional co-activators. 3. **Cell-type specificity**: MEF2D is expressed in various cell types, including cardiac muscle myoblasts, skeletal muscle satellite stem cells, and neuronal cells, suggesting its role in specific cellular processes. 4. **Regulation of gene expression**: MEF2D regulates the expression of target genes involved in muscle development, neuronal differentiation, and other cellular processes, including apoptosis, cell differentiation, and stress response. **Pathways and Functions** MEF2D is involved in several cellular pathways, including: 1. **Muscle development**: MEF2D regulates the expression of muscle-specific genes, such as myosin heavy chain and actin, during muscle development. 2. **Neuronal differentiation**: MEF2D is involved in the regulation of neuronal differentiation, including the expression of neuronal-specific genes, such as neurofilament and synaptophysin. 3. **Apoptotic process**: MEF2D regulates the expression of genes involved in apoptosis, including pro-apoptotic and anti-apoptotic genes. 4. **Cell differentiation**: MEF2D is involved in the regulation of cell differentiation, including the expression of genes involved in developmental processes, such as embryonic development and tissue repair. 5. **Stress response**: MEF2D regulates the expression of genes involved in stress response, including genes involved in the regulation of inflammation and oxidative stress. **Clinical Significance** MEF2D dysregulation has been implicated in several diseases, including: 1. **Muscle disorders**: MEF2D mutations have been associated with muscle disorders, such as muscular dystrophy and myopathy. 2. **Neurological disorders**: MEF2D dysregulation has been implicated in neurological disorders, such as epilepsy and schizophrenia. 3. **Cancer**: MEF2D has been shown to regulate the expression of genes involved in cancer, including genes involved in cell proliferation and apoptosis. 4. **Cardiovascular disease**: MEF2D dysregulation has been implicated in cardiovascular disease, including heart failure and arrhythmias. In conclusion, MEF2D is a transcription factor that plays a crucial role in various cellular processes, including cell differentiation, development, and survival. Its dysregulation has been implicated in several diseases, highlighting the importance of MEF2D in maintaining cellular homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which MEF2D regulates gene expression and its role in disease pathogenesis.

Genular Protein ID: 1171292330

Symbol: MEF2D_HUMAN

Name: Myocyte-specific enhancer factor 2D

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8269842

Title: A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage.

PubMed ID: 8269842

DOI: 10.1242/dev.118.4.1095

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9858528

Title: Regulation of the MEF2 family of transcription factors by p38.

PubMed ID: 9858528

DOI: 10.1128/mcb.19.1.21

PubMed ID: 10523670

Title: HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor.

PubMed ID: 10523670

DOI: 10.1128/mcb.19.11.7816

PubMed ID: 10849446

Title: Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.

PubMed ID: 10849446

DOI: 10.1074/jbc.m001573200

PubMed ID: 10617605

Title: Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.

PubMed ID: 10617605

DOI: 10.1074/jbc.275.1.197

PubMed ID: 11904443

Title: Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.

PubMed ID: 11904443

DOI: 10.1073/pnas.022036399

PubMed ID: 12691662

Title: Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.

PubMed ID: 12691662

DOI: 10.1016/s0896-6273(03)00191-0

PubMed ID: 15834131

Title: Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain.

PubMed ID: 15834131

DOI: 10.1074/jbc.m502491200

PubMed ID: 15888658

Title: Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.

PubMed ID: 15888658

DOI: 10.1523/jneurosci.1331-05.2005

PubMed ID: 15743823

Title: Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.

PubMed ID: 15743823

DOI: 10.1128/mcb.25.6.2273-2287.2005

PubMed ID: 16166628

Title: Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.

PubMed ID: 16166628

DOI: 10.1128/mcb.25.19.8456-8464.2005

PubMed ID: 15831463

Title: Myocyte enhancer factor 2 acetylation by p300 enhances its DNA binding activity, transcriptional activity, and myogenic differentiation.

PubMed ID: 15831463

DOI: 10.1128/mcb.25.9.3575-3582.2005

PubMed ID: 16356933

Title: Control of MEF2 transcriptional activity by coordinated phosphorylation and sumoylation.

PubMed ID: 16356933

DOI: 10.1074/jbc.m509471200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21030595

Title: HDAC3 is negatively regulated by the nuclear protein DBC1.

PubMed ID: 21030595

DOI: 10.1074/jbc.m110.153270

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 521
  • Mass: 55938
  • Checksum: 5C9790AD598619BA
  • Sequence:
  • MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH SNKLFQYAST 
    DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE PDGEDSLEQS PLLEDKYRRA 
    SEELDGLFRR YGSTVPAPNF AMPVTVPVSN QSSLQFSNPS GSLVTPSLVT SSLTDPRLLS 
    PQQPALQRNS VSPGLPQRPA SAGAMLGGDL NSANGACPSP VGNGYVSARA SPGLLPVANG 
    NSLNKVIPAK SPPPPTHSTQ LGAPSRKPDL RVITSQAGKG LMHHLTEDHL DLNNAQRLGV 
    SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF SSPGGLSLGN 
    VTAWQQPQQP QQPQQPQPPQ QQPPQPQQPQ PQQPQQPQQP PQQQSHLVPV SLSNLIPGSP 
    LPHVGAALTV TTHPHISIKS EPVSPSRERS PAPPPPAVFP AARPEPGDGL SSPAGGSYET 
    GDRDDGRGDF GPTLGLLRPA PEPEAEGSAV KRMRLDTWTL K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.