Details for: MELTF

Gene ID: 4241

Symbol: MELTF

Ensembl ID: ENSG00000163975

Description: melanotransferrin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 9.6969
    Cell Significance Index: 6.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 5.4811
    Cell Significance Index: 56.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4306
    Cell Significance Index: -9.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8063
    Cell Significance Index: 343.7600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7694
    Cell Significance Index: 17.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.4464
    Cell Significance Index: 143.0900
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 1.4188
    Cell Significance Index: 29.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2439
    Cell Significance Index: 35.8400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1696
    Cell Significance Index: 18.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0339
    Cell Significance Index: 168.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7150
    Cell Significance Index: 77.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6653
    Cell Significance Index: 31.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.5747
    Cell Significance Index: 9.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5734
    Cell Significance Index: 26.9500
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 0.5354
    Cell Significance Index: 2.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4847
    Cell Significance Index: 29.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3996
    Cell Significance Index: 80.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3548
    Cell Significance Index: 18.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3513
    Cell Significance Index: 7.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2791
    Cell Significance Index: 12.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2718
    Cell Significance Index: 35.1200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2160
    Cell Significance Index: 4.4800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2098
    Cell Significance Index: 2.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1879
    Cell Significance Index: 3.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1732
    Cell Significance Index: 6.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1629
    Cell Significance Index: 18.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1613
    Cell Significance Index: 32.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1584
    Cell Significance Index: 19.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1510
    Cell Significance Index: 17.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1394
    Cell Significance Index: 3.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1272
    Cell Significance Index: 2.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1261
    Cell Significance Index: 1.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1098
    Cell Significance Index: 59.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1059
    Cell Significance Index: 2.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0796
    Cell Significance Index: 4.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0677
    Cell Significance Index: 4.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0608
    Cell Significance Index: 7.7900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.0556
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0555
    Cell Significance Index: 0.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0550
    Cell Significance Index: 7.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0483
    Cell Significance Index: 3.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0419
    Cell Significance Index: 18.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0399
    Cell Significance Index: 7.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0388
    Cell Significance Index: 35.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0148
    Cell Significance Index: 0.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0107
    Cell Significance Index: 3.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0107
    Cell Significance Index: 19.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0088
    Cell Significance Index: 1.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0087
    Cell Significance Index: 0.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0073
    Cell Significance Index: 11.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0025
    Cell Significance Index: 4.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0013
    Cell Significance Index: 0.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0064
    Cell Significance Index: -4.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0085
    Cell Significance Index: -0.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0111
    Cell Significance Index: -8.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0113
    Cell Significance Index: -3.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0129
    Cell Significance Index: -0.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0132
    Cell Significance Index: -7.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0242
    Cell Significance Index: -3.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0290
    Cell Significance Index: -1.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0328
    Cell Significance Index: -0.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0351
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0459
    Cell Significance Index: -9.6700
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.0485
    Cell Significance Index: -0.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0488
    Cell Significance Index: -0.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0501
    Cell Significance Index: -3.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0697
    Cell Significance Index: -4.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0785
    Cell Significance Index: -4.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0801
    Cell Significance Index: -8.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0848
    Cell Significance Index: -3.4700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0852
    Cell Significance Index: -3.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0892
    Cell Significance Index: -2.8400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0982
    Cell Significance Index: -1.5200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0989
    Cell Significance Index: -0.6700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1014
    Cell Significance Index: -3.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1053
    Cell Significance Index: -8.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1084
    Cell Significance Index: -5.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1092
    Cell Significance Index: -6.1300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1144
    Cell Significance Index: -1.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1242
    Cell Significance Index: -1.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1267
    Cell Significance Index: -7.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1331
    Cell Significance Index: -3.5600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1434
    Cell Significance Index: -2.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1439
    Cell Significance Index: -4.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1446
    Cell Significance Index: -7.5300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1483
    Cell Significance Index: -1.4300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1485
    Cell Significance Index: -3.1000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1525
    Cell Significance Index: -3.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1526
    Cell Significance Index: -4.3800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1531
    Cell Significance Index: -3.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1671
    Cell Significance Index: -3.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1720
    Cell Significance Index: -4.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1778
    Cell Significance Index: -2.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1784
    Cell Significance Index: -6.2500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1915
    Cell Significance Index: -7.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Melanotransferrin, also known as melanoma-associated antigen p97, exhibits a unique combination of characteristics that set it apart from other proteins. These include: 1. **Iron binding and transport**: Melanotransferrin possesses an iron-binding domain, which enables it to regulate iron ion transport and metabolism within cells. 2. **Cell surface and extracellular presence**: The protein is localized to both the plasma membrane and extracellular space, where it interacts with various extracellular ligands and receptors. 3. **Glycosylation and anchoring**: Melanotransferrin is glycosylated and anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor. 4. **Regulatory functions**: The protein plays a role in regulating cell growth, proliferation, and differentiation, as well as modulating the extracellular matrix and plasminogen activation. **Pathways and Functions:** Melanotransferrin is involved in a wide range of cellular processes, including: 1. **Iron metabolism**: Melanotransferrin regulates iron ion transport and metabolism, which is essential for various cellular functions, including energy production and DNA synthesis. 2. **Cell adhesion and migration**: The protein modulates substrate adhesion-dependent cell spreading and regulates cell growth and proliferation. 3. **Extracellular matrix remodeling**: Melanotransferrin influences the disassembly of the extracellular matrix, which is crucial for tissue remodeling and repair. 4. **Insulin-like growth factor (IGF) transport**: The protein regulates the transport and uptake of IGFs by IGFBPs, which is essential for growth and development. 5. **GABAergic signaling**: Melanotransferrin is expressed in GABAergic interneurons and plays a role in regulating GABAergic signaling, which is involved in neuronal development and function. **Clinical Significance:** The study of melanotransferrin has significant implications for the understanding and treatment of various immunological disorders, including: 1. **Cancer**: Melanotransferrin is overexpressed in certain types of cancer, including melanoma, and has been implicated in tumor progression and metastasis. 2. **Neurological disorders**: The protein's role in GABAergic signaling and neuronal development makes it a potential target for the treatment of neurological disorders, such as epilepsy and Parkinson's disease. 3. **Intestinal disorders**: Melanotransferrin's involvement in intestinal epithelial cell function and regulation of the extracellular matrix makes it a potential target for the treatment of intestinal disorders, such as inflammatory bowel disease. In conclusion, melanotransferrin is a multifaceted protein that plays a critical role in various cellular processes, including iron metabolism, cell adhesion, and extracellular matrix remodeling. Further studies on this gene are necessary to fully elucidate its functions and clinical significance, which may lead to the development of novel therapeutic strategies for immunological disorders.

Genular Protein ID: 659646473

Symbol: TRFM_HUMAN

Name: Melanoma-associated antigen p97

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2419904

Title: Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

PubMed ID: 2419904

DOI: 10.1073/pnas.83.5.1261

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2463331

Title: A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97.

PubMed ID: 2463331

DOI: 10.1084/jem.169.2.585

PubMed ID: 8300636

Title: Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.

PubMed ID: 8300636

DOI: 10.1016/s0021-9258(17)42043-6

PubMed ID: 7556058

Title: A novel iron uptake mechanism mediated by GPI-anchored human p97.

PubMed ID: 7556058

DOI: 10.1002/j.1460-2075.1995.tb00091.x

PubMed ID: 1544447

Title: Human melanotransferrin (p97) has only one functional iron-binding site.

PubMed ID: 1544447

DOI: 10.1016/0014-5793(92)80060-t

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 1633859

Title: A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function.

PubMed ID: 1633859

DOI: 10.1016/0014-5793(92)80654-y

Sequence Information:

  • Length: 738
  • Mass: 80215
  • Checksum: B0F08B708D2A0A0F
  • Sequence:
  • MRGPSGALWL LLALRTVLGG MEVRWCATSD PEQHKCGNMS EAFREAGIQP SLLCVRGTSA 
    DHCVQLIAAQ EADAITLDGG AIYEAGKEHG LKPVVGEVYD QEVGTSYYAV AVVRRSSHVT 
    IDTLKGVKSC HTGINRTVGW NVPVGYLVES GRLSVMGCDV LKAVSDYFGG SCVPGAGETS 
    YSESLCRLCR GDSSGEGVCD KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDGKT 
    LPSWGQALLS QDFELLCRDG SRADVTEWRQ CHLARVPAHA VVVRADTDGG LIFRLLNEGQ 
    RLFSHEGSSF QMFSSEAYGQ KDLLFKDSTS ELVPIATQTY EAWLGHEYLH AMKGLLCDPN 
    RLPPYLRWCV LSTPEIQKCG DMAVAFRRQR LKPEIQCVSA KSPQHCMERI QAEQVDAVTL 
    SGEDIYTAGK TYGLVPAAGE HYAPEDSSNS YYVVAVVRRD SSHAFTLDEL RGKRSCHAGF 
    GSPAGWDVPV GALIQRGFIR PKDCDVLTAV SEFFNASCVP VNNPKNYPSS LCALCVGDEQ 
    GRNKCVGNSQ ERYYGYRGAF RCLVENAGDV AFVRHTTVFD NTNGHNSEPW AAELRSEDYE 
    LLCPNGARAE VSQFAACNLA QIPPHAVMVR PDTNIFTVYG LLDKAQDLFG DDHNKNGFKM 
    FDSSNYHGQD LLFKDATVRA VPVGEKTTYR GWLGLDYVAA LEGMSSQQCS GAAAPAPGAP 
    LLPLLLPALA ARLLPPAL

Genular Protein ID: 4178761254

Symbol: Q53XS6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 302
  • Mass: 32723
  • Checksum: 0D51C8347D9EBD8F
  • Sequence:
  • MRGPSGALWL LLALRTVLGG MEVRWCATSD PEQHKCGNMS EAFREAGIQP SLLCVRGTSA 
    DHCVQLIAAQ EADAITLDGG AIYEAGKEHG LKPVVGEVYD QEVGTSYYAV AVVRRSSHVT 
    IDTLKGVKSC HTGINRTVGW NVPVGYLVES GRLSVMGCDV LKAVSDYFGG SCVPGAGETS 
    YSESLCRLCR GDSSGEGVCD KSPLERYYDY SGAFRCLAEG AGDVAFVKHS TVLENTDESP 
    SRRQTWTRSE EEEGECPAHE EARRTMRSSA GQAWKWAPVH RPQDESDKGE FGKRAKSRDM 
    LG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.