Details for: ABCC1

Gene ID: 4363

Symbol: ABCC1

Ensembl ID: ENSG00000103222

Description: ATP binding cassette subfamily C member 1 (ABCC1 blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.3977
    Cell Significance Index: -28.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.5205
    Cell Significance Index: -25.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.5685
    Cell Significance Index: -29.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.3313
    Cell Significance Index: -24.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 25.7609
    Cell Significance Index: -24.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.8475
    Cell Significance Index: -28.1700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.6089
    Cell Significance Index: -21.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1768
    Cell Significance Index: -28.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.0032
    Cell Significance Index: -21.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.2304
    Cell Significance Index: 108.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.9628
    Cell Significance Index: 79.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.6157
    Cell Significance Index: 73.1000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.9078
    Cell Significance Index: 46.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5979
    Cell Significance Index: 573.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5976
    Cell Significance Index: 31.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3311
    Cell Significance Index: 102.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2640
    Cell Significance Index: 253.5600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.2516
    Cell Significance Index: 11.1100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.0949
    Cell Significance Index: 16.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0919
    Cell Significance Index: 108.0200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9285
    Cell Significance Index: 642.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8438
    Cell Significance Index: 761.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6763
    Cell Significance Index: 134.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5344
    Cell Significance Index: 86.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5116
    Cell Significance Index: 6.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4951
    Cell Significance Index: 25.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4659
    Cell Significance Index: 50.6800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.4270
    Cell Significance Index: 6.8900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.4247
    Cell Significance Index: 2.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3000
    Cell Significance Index: 16.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2703
    Cell Significance Index: 147.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2448
    Cell Significance Index: 9.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2437
    Cell Significance Index: 10.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2357
    Cell Significance Index: 14.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2155
    Cell Significance Index: 405.7200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2138
    Cell Significance Index: 6.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1856
    Cell Significance Index: 84.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1688
    Cell Significance Index: 11.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1535
    Cell Significance Index: 67.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1315
    Cell Significance Index: 23.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1283
    Cell Significance Index: 24.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1169
    Cell Significance Index: 12.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1019
    Cell Significance Index: 2.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0951
    Cell Significance Index: 11.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0905
    Cell Significance Index: 123.0800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0849
    Cell Significance Index: 1.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0777
    Cell Significance Index: 119.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0633
    Cell Significance Index: 116.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0579
    Cell Significance Index: 0.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0378
    Cell Significance Index: 0.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0280
    Cell Significance Index: 17.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0220
    Cell Significance Index: 3.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0108
    Cell Significance Index: -0.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0109
    Cell Significance Index: -1.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0152
    Cell Significance Index: -0.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0196
    Cell Significance Index: -2.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0225
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0282
    Cell Significance Index: -20.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0322
    Cell Significance Index: -23.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0366
    Cell Significance Index: -27.7400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0452
    Cell Significance Index: -25.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0495
    Cell Significance Index: -30.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0661
    Cell Significance Index: -8.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0820
    Cell Significance Index: -23.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0942
    Cell Significance Index: -6.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1004
    Cell Significance Index: -4.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1097
    Cell Significance Index: -12.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1141
    Cell Significance Index: -19.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1157
    Cell Significance Index: -11.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1443
    Cell Significance Index: -30.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1544
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1765
    Cell Significance Index: -20.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1908
    Cell Significance Index: -24.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2076
    Cell Significance Index: -5.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2107
    Cell Significance Index: -14.9000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2114
    Cell Significance Index: -5.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2243
    Cell Significance Index: -10.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2350
    Cell Significance Index: -14.8100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2374
    Cell Significance Index: -5.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2454
    Cell Significance Index: -12.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2555
    Cell Significance Index: -19.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2622
    Cell Significance Index: -5.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2660
    Cell Significance Index: -3.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3069
    Cell Significance Index: -6.5600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3120
    Cell Significance Index: -3.8900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3302
    Cell Significance Index: -6.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3318
    Cell Significance Index: -9.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3328
    Cell Significance Index: -10.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3381
    Cell Significance Index: -26.7800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3416
    Cell Significance Index: -7.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3556
    Cell Significance Index: -11.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3723
    Cell Significance Index: -12.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3854
    Cell Significance Index: -23.6300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3954
    Cell Significance Index: -4.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3967
    Cell Significance Index: -8.5700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4577
    Cell Significance Index: -6.4200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4582
    Cell Significance Index: -9.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4719
    Cell Significance Index: -16.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ABCC1 is a member of the ATP-binding cassette (ABC) transporter family, characterized by its ability to pump substrates across cell membranes using ATP hydrolysis. It exhibits broad substrate specificity, transporting a wide range of compounds, including xenobiotics, vitamins (B12), lipids, and amino acids. ABCC1 is also involved in various cellular processes, including: 1. **Xenobiotic transport:** ABCC1 is a major efflux transporter for xenobiotics, including drugs and environmental toxins, contributing to their elimination from the body. 2. **Vitamin B12 transport:** ABCC1 plays a crucial role in the transport of vitamin B12 across cell membranes, essential for its metabolism and function in the body. 3. **Lipid transport:** ABCC1 is involved in the transport of lipids, including fatty acids and phospholipids, across cell membranes. 4. **Cellular stress response:** ABCC1 is activated in response to cellular stress, contributing to the elimination of toxic substances and maintaining cellular homeostasis. **Pathways and Functions:** ABCC1 is involved in various cellular pathways, including: 1. **Apical plasma membrane transport:** ABCC1 is expressed on the apical surface of epithelial cells, where it facilitates the transport of substrates across the plasma membrane. 2. **Basolateral plasma membrane transport:** ABCC1 is also expressed on the basolateral surface of epithelial cells, where it contributes to the transport of substrates from the lumen to the cytoplasm. 3. **Cellular responses to stimuli:** ABCC1 is activated in response to various cellular stimuli, including oxidative stress, heat shock, and inflammatory responses. 4. **Keap1-Nfe2L2 pathway:** ABCC1 interacts with the Keap1-Nfe2L2 pathway, a key regulator of cellular antioxidant response. **Clinical Significance:** ABCC1 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of ABCC1 has been observed in various cancers, including breast, lung, and colon cancer, contributing to chemotherapy resistance. 2. **Neurological disorders:** ABCC1 has been linked to neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Metabolic conditions:** ABCC1 has been implicated in metabolic conditions, including diabetes and obesity, contributing to the development of insulin resistance and metabolic dysregulation. 4. **Pharmacokinetics:** ABCC1 plays a crucial role in the pharmacokinetics of various drugs, influencing their absorption, distribution, and elimination. In conclusion, the ABCC1 gene is a multifaceted transporter involved in various cellular processes, including xenobiotic transport, vitamin B12 transport, lipid transport, and cellular stress response. Its widespread expression and involvement in various diseases make it an important target for therapeutic interventions and a valuable tool for understanding the complex biology of cellular transport.

Genular Protein ID: 3367801994

Symbol: MRP1_HUMAN

Name: ATP-binding cassette sub-family C member 1

UniProtKB Accession Codes:

P33527 A3RJX2 C9JPJ4 O14819 O43333 P78419 Q59GI9 Q9UQ97 Q9UQ99 Q9UQA0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CTD 1 ChEBI 46 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 70 DrugCentral 1 EC 2 EMBL 100 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 8 RefSeq 1 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1360704

Title: Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.

PubMed ID: 1360704

DOI: 10.1126/science.1360704

PubMed ID: 8098549

Title: Multidrug resistance-associated protein: sequence correction.

PubMed ID: 8098549

DOI: 10.1126/science.8098549

PubMed ID: 9344662

Title: Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA.

PubMed ID: 9344662

DOI: 10.1006/geno.1997.4950

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 7961706

Title: The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

PubMed ID: 7961706

DOI: 10.1016/s0021-9258(18)46856-1

PubMed ID: 9295302

Title: Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

PubMed ID: 9295302

DOI: 10.1074/jbc.272.38.23623

PubMed ID: 9334225

Title: Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence.

PubMed ID: 9334225

DOI: 10.1074/jbc.272.42.26479

PubMed ID: 9281595

Title: Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells.

PubMed ID: 9281595

DOI: 10.1124/mol.52.3.344

PubMed ID: 9485377

Title: Epitope insertion favors a six transmembrane domain model for the carboxy-terminal portion of the multidrug resistance-associated protein.

PubMed ID: 9485377

DOI: 10.1021/bi972332v

PubMed ID: 10064732

Title: Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1.

PubMed ID: 10064732

PubMed ID: 11114332

Title: The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes.

PubMed ID: 11114332

DOI: 10.1016/s0092-8674(00)00179-3

PubMed ID: 11469806

Title: Mutations of the Walker B motif in the first nucleotide binding domain of multidrug resistance protein MRP1 prevent conformational maturation.

PubMed ID: 11469806

DOI: 10.1006/abbi.2001.2441

PubMed ID: 11278867

Title: Mutation of a single conserved tryptophan in multidrug resistance protein 1 (MRP1/ABCC1) results in loss of drug resistance and selective loss of organic anion transport.

PubMed ID: 11278867

DOI: 10.1074/jbc.m011246200

PubMed ID: 11278596

Title: Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines.

PubMed ID: 11278596

DOI: 10.1074/jbc.m010008200

PubMed ID: 15208328

Title: Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transporter.

PubMed ID: 15208328

DOI: 10.1074/jbc.m403832200

PubMed ID: 15260484

Title: Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1.

PubMed ID: 15260484

DOI: 10.1021/bi0495230

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16230346

Title: Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1).

PubMed ID: 16230346

DOI: 10.1074/jbc.m510143200

PubMed ID: 17050692

Title: Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.

PubMed ID: 17050692

DOI: 10.1073/pnas.0603734103

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23580527

Title: Latency-associated degradation of the MRP1 drug transporter during latent human cytomegalovirus infection.

PubMed ID: 23580527

DOI: 10.1126/science.1235047

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 36070769

Title: ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP.

PubMed ID: 36070769

DOI: 10.1016/j.immuni.2022.08.006

PubMed ID: 16697012

Title: Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site.

PubMed ID: 16697012

DOI: 10.1016/j.jmb.2006.04.005

PubMed ID: 10835642

Title: Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum.

PubMed ID: 10835642

DOI: 10.1038/76102

PubMed ID: 10811882

Title: Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter.

PubMed ID: 10811882

DOI: 10.1073/pnas.100041297

PubMed ID: 11721885

Title: Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.

PubMed ID: 11721885

DOI: 10.1007/s100380170017

PubMed ID: 11139250

Title: Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum.

PubMed ID: 11139250

DOI: 10.1002/1098-1004(2001)17:1<74::aid-humu14>3.0.co;2-f

PubMed ID: 11266082

Title: Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects.

PubMed ID: 11266082

DOI: 10.1097/00008571-200103000-00008

PubMed ID: 18987736

Title: DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.

PubMed ID: 18987736

DOI: 10.1038/nature07485

PubMed ID: 31273342

Title: Extrusion pump ABCC1 was first linked with nonsyndromic hearing loss in humans by stepwise genetic analysis.

PubMed ID: 31273342

DOI: 10.1038/s41436-019-0594-y

Sequence Information:

  • Length: 1531
  • Mass: 171591
  • Checksum: 46A7CB643B9478C4
  • Sequence:
    • MALRGFCSAD GSDPLWDWNV TWNTSNPDFT KCFQNTVLVW VPCFYLWACF PFYFLYLSRH 
DRGYIQMTPL NKTKTALGFL LWIVCWADLF YSFWERSRGI FLAPVFLVSP TLLGITMLLA 
TFLIQLERRK GVQSSGIMLT FWLVALVCAL AILRSKIMTA LKEDAQVDLF RDITFYVYFS 
LLLIQLVLSC FSDRSPLFSE TIHDPNPCPE SSASFLSRIT FWWITGLIVR GYRQPLEGSD 
LWSLNKEDTS EQVVPVLVKN WKKECAKTRK QPVKVVYSSK DPAQPKESSK VDANEEVEAL 
IVKSPQKEWN PSLFKVLYKT FGPYFLMSFF FKAIHDLMMF SGPQILKLLI KFVNDTKAPD 
WQGYFYTVLL FVTACLQTLV LHQYFHICFV SGMRIKTAVI GAVYRKALVI TNSARKSSTV 
GEIVNLMSVD AQRFMDLATY INMIWSAPLQ VILALYLLWL NLGPSVLAGV AVMVLMVPVN 
AVMAMKTKTY QVAHMKSKDN RIKLMNEILN GIKVLKLYAW ELAFKDKVLA IRQEELKVLK 
KSAYLSAVGT FTWVCTPFLV ALCTFAVYVT IDENNILDAQ TAFVSLALFN ILRFPLNILP 
MVISSIVQAS VSLKRLRIFL SHEELEPDSI ERRPVKDGGG TNSITVRNAT FTWARSDPPT 
LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG HVAIKGSVAY VPQQAWIQND 
SLRENILFGC QLEEPYYRSV IQACALLPDL EILPSGDRTE IGEKGVNLSG GQKQRVSLAR 
AVYSNADIYL FDDPLSAVDA HVGKHIFENV IGPKGMLKNK TRILVTHSMS YLPQVDVIIV 
MSGGKISEMG SYQELLARDG AFAEFLRTYA STEQEQDAEE NGVTGVSGPG KEAKQMENGM 
LVTDSAGKQL QRQLSSSSSY SGDISRHHNS TAELQKAEAK KEETWKLMEA DKAQTGQVKL 
SVYWDYMKAI GLFISFLSIF LFMCNHVSAL ASNYWLSLWT DDPIVNGTQE HTKVRLSVYG 
ALGISQGIAV FGYSMAVSIG GILASRCLHV DLLHSILRSP MSFFERTPSG NLVNRFSKEL 
DTVDSMIPEV IKMFMGSLFN VIGACIVILL ATPIAAIIIP PLGLIYFFVQ RFYVASSRQL 
KRLESVSRSP VYSHFNETLL GVSVIRAFEE QERFIHQSDL KVDENQKAYY PSIVANRWLA 
VRLECVGNCI VLFAALFAVI SRHSLSAGLV GLSVSYSLQV TTYLNWLVRM SSEMETNIVA 
VERLKEYSET EKEAPWQIQE TAPPSSWPQV GRVEFRNYCL RYREDLDFVL RHINVTINGG 
EKVGIVGRTG AGKSSLTLGL FRINESAEGE IIIDGINIAK IGLHDLRFKI TIIPQDPVLF 
SGSLRMNLDP FSQYSDEEVW TSLELAHLKD FVSALPDKLD HECAEGGENL SVGQRQLVCL 
ARALLRKTKI LVLDEATAAV DLETDDLIQS TIRTQFEDCT VLTIAHRLNT IMDYTRVIVL 
DKGEIQEYGA PSDLLQQRGL FYSMAKDAGL V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.