Details for: MYO1B

Gene ID: 4430

Symbol: MYO1B

Ensembl ID: ENSG00000128641

Description: myosin IB

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.1703
    Cell Significance Index: -40.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.9370
    Cell Significance Index: -34.1000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 82.7010
    Cell Significance Index: -39.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.8316
    Cell Significance Index: -34.2100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.4099
    Cell Significance Index: -39.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.5846
    Cell Significance Index: -39.0700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 11.6694
    Cell Significance Index: 196.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3361
    Cell Significance Index: -24.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2127
    Cell Significance Index: -40.3000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 3.2653
    Cell Significance Index: 32.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.0864
    Cell Significance Index: 305.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8259
    Cell Significance Index: 560.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.3395
    Cell Significance Index: 340.0700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.1510
    Cell Significance Index: 13.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8877
    Cell Significance Index: 105.9300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4343
    Cell Significance Index: 233.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.1299
    Cell Significance Index: 58.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9711
    Cell Significance Index: 119.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9430
    Cell Significance Index: 179.4600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.9140
    Cell Significance Index: 4.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8817
    Cell Significance Index: 24.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8362
    Cell Significance Index: 12.5300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8047
    Cell Significance Index: 49.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7962
    Cell Significance Index: 15.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6999
    Cell Significance Index: 140.4000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6741
    Cell Significance Index: 9.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6052
    Cell Significance Index: 27.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5956
    Cell Significance Index: 107.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5331
    Cell Significance Index: 11.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4679
    Cell Significance Index: 13.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4414
    Cell Significance Index: 11.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4269
    Cell Significance Index: 72.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3723
    Cell Significance Index: 27.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3352
    Cell Significance Index: 618.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3137
    Cell Significance Index: 482.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3049
    Cell Significance Index: 109.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2873
    Cell Significance Index: 198.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2752
    Cell Significance Index: 150.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2553
    Cell Significance Index: 480.7400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2542
    Cell Significance Index: 3.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2203
    Cell Significance Index: 299.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2201
    Cell Significance Index: 1.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2079
    Cell Significance Index: 10.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1486
    Cell Significance Index: 6.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1418
    Cell Significance Index: 19.4700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1397
    Cell Significance Index: 15.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1213
    Cell Significance Index: 53.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0717
    Cell Significance Index: 1.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0637
    Cell Significance Index: 2.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0617
    Cell Significance Index: 46.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0425
    Cell Significance Index: 0.8900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0344
    Cell Significance Index: 0.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0316
    Cell Significance Index: 4.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0126
    Cell Significance Index: 0.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.5400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0259
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0302
    Cell Significance Index: -18.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0359
    Cell Significance Index: -0.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0366
    Cell Significance Index: -26.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0418
    Cell Significance Index: -23.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0619
    Cell Significance Index: -7.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0770
    Cell Significance Index: -34.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0833
    Cell Significance Index: -17.5500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0907
    Cell Significance Index: -10.3500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0954
    Cell Significance Index: -0.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0969
    Cell Significance Index: -27.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1286
    Cell Significance Index: -6.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1336
    Cell Significance Index: -15.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1612
    Cell Significance Index: -4.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1765
    Cell Significance Index: -3.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1873
    Cell Significance Index: -19.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2211
    Cell Significance Index: -28.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.2642
    Cell Significance Index: -3.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2854
    Cell Significance Index: -33.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3056
    Cell Significance Index: -5.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3531
    Cell Significance Index: -27.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3589
    Cell Significance Index: -25.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3721
    Cell Significance Index: -38.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4020
    Cell Significance Index: -5.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4606
    Cell Significance Index: -36.4800
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4752
    Cell Significance Index: -7.2300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4832
    Cell Significance Index: -10.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4954
    Cell Significance Index: -10.5900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.4994
    Cell Significance Index: -6.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5096
    Cell Significance Index: -17.7100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5687
    Cell Significance Index: -38.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6026
    Cell Significance Index: -8.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6078
    Cell Significance Index: -39.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6162
    Cell Significance Index: -37.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6238
    Cell Significance Index: -5.2400
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.6338
    Cell Significance Index: -3.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6477
    Cell Significance Index: -15.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6527
    Cell Significance Index: -41.1400
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.7036
    Cell Significance Index: -2.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7249
    Cell Significance Index: -38.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7567
    Cell Significance Index: -16.5700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.7681
    Cell Significance Index: -16.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7732
    Cell Significance Index: -29.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7806
    Cell Significance Index: -34.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYO1B is a member of the myosin superfamily, specifically classified under the unconventional myosin-Ib category. It is a cytoskeletal motor protein that exhibits a unique structure, consisting of two heavy chains (MYH1B and MYH1B) and four light chains (MYO1B, MYO1B, MYO1B, and MYO1B). This protein exhibits a high degree of motility and binding affinity for actin filaments, enabling it to regulate actin dynamics and cytoskeletal organization. **Pathways and Functions:** MYO1B is involved in various cellular processes, including: 1. **Actin filament organization and dynamics**: MYO1B regulates actin filament assembly, disassembly, and movement, ensuring proper cytoskeletal organization and maintaining cellular shape. 2. **Endocytosis and exocytosis**: MYO1B plays a crucial role in regulating endocytic and exocytic processes by modulating actin filament dynamics and membrane trafficking. 3. **Cell migration and adhesion**: MYO1B influences cell migration, adhesion, and spreading by regulating actin filament organization and cytoskeletal dynamics. 4. **Cytoskeletal remodeling**: MYO1B participates in cytoskeletal remodeling, which is essential for cellular responses to stimuli, such as changes in cell shape or mechanical stress. **Clinical Significance:** Dysregulation of MYO1B has been implicated in various human diseases, including: 1. **Familial focal segmental glomerulosclerosis (FSGS)**: Mutations in MYO1B have been identified as a primary cause of FSGS, a leading cause of nephrotic syndrome in children. 2. **Cerebral cavernous malformations (CCMs)**: MYO1B mutations have been linked to CCMs, a disorder characterized by the formation of abnormal blood vessels in the brain. 3. **Cardiovascular diseases**: MYO1B dysregulation has been associated with cardiovascular diseases, such as atherosclerosis and cardiac hypertrophy. In conclusion, MYO1B is a multifunctional protein that plays a critical role in regulating actin cytoskeleton dynamics, endocytosis, and exocytosis. Its dysregulation has been implicated in various human diseases, highlighting the importance of this protein in maintaining cellular homeostasis and overall health. As an expert immunologist, I emphasize the need for further research into the mechanisms underlying MYO1B's functions and its role in human disease, with the ultimate goal of developing novel therapeutic strategies for the treatment of these conditions.

Genular Protein ID: 2019948690

Symbol: MYO1B_HUMAN

Name: Unconventional myosin-Ib

UniProtKB Accession Codes:

O43795 O43794 Q7Z6L5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 26 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1136
  • Mass: 131985
  • Checksum: 98B7F2357928218D
  • Sequence:
    • MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS 
LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL 
VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP 
LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA 
KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL 
FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL 
KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN 
QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ 
AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA 
RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC 
RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK 
EAVTTIAAYW HGTQARRELR RLKEEARNKH AIAVIWAYWL GSKARRELKR LKEEARRKHA 
VAVIWAYWLG LKVRREYRKF FRANAGKKIY EFTLQRIVQK YFLEMKNKMP SLSPIDKNWP 
SRPYLFLDST HKELKRIFHL WRCKKYRDQF TDQQKLIYEE KLEASELFKD KKALYPSSVG 
QPFQGAYLEI NKNPKYKKLK DAIEEKIIIA EVVNKINRAN GKSTSRIFLL TNNNLLLADQ 
KSGQIKSEVP LVDVTKVSMS SQNDGFFAVH LKEGSEAASK GDFLFSSDHL IEMATKLYRT 
TLSQTKQKLN IEISDEFLVQ FRQDKVCVKF IQGNQKNGSV PTCKRKNNRL LEVAVP

Genular Protein ID: 3527379075

Symbol: E9PDF6_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PDF6

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 6 GeneTree 1 HGNC 1 IntAct 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 1107
  • Mass: 128481
  • Checksum: 773EDB2D11BD6B55
  • Sequence:
    • MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS 
LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL 
VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP 
LGGVISNYLL EKSRVVKQPR GERNFHVFYQ LLSGASEELL NKLKLERDFS RYNYLSLDSA 
KVNGVDDAAN FRTVRNAMQI VGFMDHEAES VLAVVAAVLK LGNIEFKPES RVNGLDESKI 
KDKNELKEIC ELTGIDQSVL ERAFSFRTVE AKQEKVSTTL NVAQAYYARD ALAKNLYSRL 
FSWLVNRINE SIKAQTKVRK KVMGVLDIYG FEIFEDNSFE QFIINYCNEK LQQIFIELTL 
KEEQEEYIRE DIEWTHIDYF NNAIICDLIE NNTNGILAML DEECLRPGTV TDETFLEKLN 
QVCATHQHFE SRMSKCSRFL NDTSLPHSCF RIQHYAGKVL YQVEGFVDKN NDLLYRDLSQ 
AMWKASHALI KSLFPEGNPA KINLKRPPTA GSQFKASVAT LMKNLQTKNP NYIRCIKPND 
KKAAHIFNEA LVCHQIRYLG LLENVRVRRA GYAFRQAYEP CLERYKMLCK QTWPHWKGPA 
RSGVEVLFNE LEIPVEEYSF GRSKIFIRNP RTLFKLEDLR KQRLEDLATL IQKIYRGWKC 
RTHFLLMKKS QIVIAAWYRR YAQQKRYQQT KSSALVIQSY IRGWKARKIL RELKHQKRCK 
EAVTTIAAYW HGTQARRELK RLKEEARRKH AVAVIWAYWL GLKVRREYRK FFRANAGKKI 
YEFTLQRIVQ KYFLEMKNKM PSLSPIDKNW PSRPYLFLDS THKELKRIFH LWRCKKYRDQ 
FTDQQKLIYE EKLEASELFK DKKALYPSSV GQPFQGAYLE INKNPKYKKL KDAIEEKIII 
AEVVNKINRA NGKSTSRIFL LTNNNLLLAD QKSGQIKSEV PLVDVTKVSM SSQNDGFFAV 
HLKEGSEAAS KGDFLFSSDH LIEMATKLYR TTLSQTKQKL NIEISDEFLV QFRQDKVCVK 
FIQGNQKNGS VPTCKRKNNR LLEVAVP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.