Details for: MTCP1

Gene ID: 4515

Symbol: MTCP1

Ensembl ID: ENSG00000214827

Description: mature T cell proliferation 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 55.1608
    Cell Significance Index: -8.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 34.0241
    Cell Significance Index: -8.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 16.4674
    Cell Significance Index: -6.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.0595
    Cell Significance Index: -6.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.9670
    Cell Significance Index: -8.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.9739
    Cell Significance Index: -4.3200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9613
    Cell Significance Index: 21.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.8934
    Cell Significance Index: 15.3100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7456
    Cell Significance Index: 4.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4737
    Cell Significance Index: 90.1600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4698
    Cell Significance Index: 4.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4643
    Cell Significance Index: 92.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4399
    Cell Significance Index: 19.4600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4279
    Cell Significance Index: 16.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3999
    Cell Significance Index: 7.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3462
    Cell Significance Index: 5.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3419
    Cell Significance Index: 68.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3191
    Cell Significance Index: 31.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2671
    Cell Significance Index: 241.1900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2639
    Cell Significance Index: 3.6000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.2539
    Cell Significance Index: 8.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2335
    Cell Significance Index: 13.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2111
    Cell Significance Index: 16.2000
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1876
    Cell Significance Index: 2.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1724
    Cell Significance Index: 28.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1656
    Cell Significance Index: 5.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1579
    Cell Significance Index: 56.6500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1402
    Cell Significance Index: 1.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1327
    Cell Significance Index: 14.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1195
    Cell Significance Index: 2.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1029
    Cell Significance Index: 6.9200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1009
    Cell Significance Index: 1.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0941
    Cell Significance Index: 13.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0794
    Cell Significance Index: 2.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0722
    Cell Significance Index: 98.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0672
    Cell Significance Index: 1.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0659
    Cell Significance Index: 101.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0536
    Cell Significance Index: 0.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0534
    Cell Significance Index: 3.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0506
    Cell Significance Index: 3.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0493
    Cell Significance Index: 2.5600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0489
    Cell Significance Index: 0.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0481
    Cell Significance Index: 88.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0322
    Cell Significance Index: 1.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0258
    Cell Significance Index: 0.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0253
    Cell Significance Index: 47.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0183
    Cell Significance Index: 2.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0182
    Cell Significance Index: 1.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0177
    Cell Significance Index: 2.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0108
    Cell Significance Index: 1.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0044
    Cell Significance Index: 2.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0035
    Cell Significance Index: 2.2300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0011
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0003
    Cell Significance Index: -0.1200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0044
    Cell Significance Index: -0.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0083
    Cell Significance Index: -6.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0098
    Cell Significance Index: -7.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0098
    Cell Significance Index: -5.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0106
    Cell Significance Index: -8.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0135
    Cell Significance Index: -7.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0168
    Cell Significance Index: -2.1600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0190
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0247
    Cell Significance Index: -4.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0295
    Cell Significance Index: -8.5000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0372
    Cell Significance Index: -0.5600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0372
    Cell Significance Index: -0.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0390
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0401
    Cell Significance Index: -8.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0452
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0484
    Cell Significance Index: -5.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0486
    Cell Significance Index: -1.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0498
    Cell Significance Index: -5.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0522
    Cell Significance Index: -0.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0552
    Cell Significance Index: -1.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0554
    Cell Significance Index: -7.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0590
    Cell Significance Index: -6.1400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0610
    Cell Significance Index: -0.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0611
    Cell Significance Index: -7.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0656
    Cell Significance Index: -7.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0685
    Cell Significance Index: -1.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0734
    Cell Significance Index: -1.9600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0766
    Cell Significance Index: -1.5900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0773
    Cell Significance Index: -1.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0796
    Cell Significance Index: -1.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1012
    Cell Significance Index: -4.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1067
    Cell Significance Index: -7.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1080
    Cell Significance Index: -6.9700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1154
    Cell Significance Index: -1.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1193
    Cell Significance Index: -7.3300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1226
    Cell Significance Index: -2.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1315
    Cell Significance Index: -2.2200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1325
    Cell Significance Index: -3.7800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1333
    Cell Significance Index: -1.8700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1414
    Cell Significance Index: -4.6300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1422
    Cell Significance Index: -2.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1572
    Cell Significance Index: -8.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MTCP1 is a gene that codes for a protein, p13 MTCP-1, which plays a crucial role in the regulation of intracellular signaling pathways. The protein exhibits kinase activity, specifically activating protein serine/threonine kinases, and is involved in the positive regulation of peptidyl-serine phosphorylation. MTCP1 is expressed in various cell types, including retinal bipolar neurons, cardiac muscle cells, and intestinal crypt stem cells, highlighting its broad tissue distribution. **Pathways and Functions:** MTCP1 is intricately involved in several key signaling pathways, including: 1. **Intracellular signal transduction**: MTCP1 acts as a protein kinase activator, influencing the activity of serine/threonine kinases, which are essential for cellular responses to external stimuli. 2. **Positive regulation of peptidyl-serine phosphorylation**: MTCP1 facilitates the phosphorylation of serine residues on proteins, modulating their activity and function. 3. **Protein kinase binding**: MTCP1 interacts with various protein kinases, influencing their activity and localization. These pathways suggest that MTCP1 plays a pivotal role in regulating cellular responses to environmental cues, influencing cell growth, differentiation, and survival. **Clinical Significance:** The expression of MTCP1 in various tissues and cell types implies its potential involvement in several diseases and disorders. Some potential clinical implications of MTCP1 dysregulation include: 1. **Immunological disorders**: Alterations in MTCP1 expression may contribute to immune system dysregulation, leading to conditions such as autoimmune diseases or immunodeficiency disorders. 2. **Cardiovascular diseases**: The expression of MTCP1 in cardiac muscle cells suggests its potential role in the development of cardiovascular diseases, such as heart failure or arrhythmias. 3. **Cancer**: MTCP1's involvement in cell proliferation and differentiation pathways may contribute to cancer development and progression, particularly in tissues with high MTCP1 expression, such as the intestinal crypt. In conclusion, MTCP1 is a complex gene that plays a multifaceted role in regulating intracellular signaling pathways. Further research is necessary to fully elucidate the functions and clinical significance of MTCP1, but its involvement in various cellular processes and tissue distributions suggests its potential as a therapeutic target for diseases related to immune regulation and cellular proliferation.

Genular Protein ID: 888170386

Symbol: MTCP1_HUMAN

Name: Protein p13 MTCP-1

UniProtKB Accession Codes:

P56278 Q5HYP2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 8361760

Title: MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations.

PubMed ID: 8361760

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 10983986

Title: The protooncogene TCL1 is an Akt kinase coactivator.

PubMed ID: 10983986

DOI: 10.1016/s1097-2765(00)00039-3

PubMed ID: 11707444

Title: Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.

PubMed ID: 11707444

DOI: 10.1074/jbc.m107069200

PubMed ID: 9520380

Title: Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies.

PubMed ID: 9520380

DOI: 10.1073/pnas.95.7.3413

PubMed ID: 10959629

Title: Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data.

PubMed ID: 10959629

DOI: 10.1023/a:1008386110930

Sequence Information:

  • Length: 107
  • Mass: 12600
  • Checksum: C00967E1AECDDDCA
  • Sequence:
    • MAGEDVGAPP DHLWVHQEGI YRDEYQRTWV AVVEEETSFL RARVQQIQVP LGDAARPSHL 
LTSQLPLMWQ LYPEERYMDN NSRLWQIQHH LMVRGVQELL LKLLPDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.