Details for: MTF1

Gene ID: 4520

Symbol: MTF1

Ensembl ID: ENSG00000188786

Description: metal regulatory transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.1790
    Cell Significance Index: -17.7600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.6003
    Cell Significance Index: -17.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.2560
    Cell Significance Index: -19.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.9839
    Cell Significance Index: -16.6500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 36.4513
    Cell Significance Index: -18.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.5230
    Cell Significance Index: -16.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.0695
    Cell Significance Index: -18.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.0814
    Cell Significance Index: -18.9700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2711
    Cell Significance Index: -16.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7833
    Cell Significance Index: -18.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1716
    Cell Significance Index: -9.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1295
    Cell Significance Index: 15.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.8879
    Cell Significance Index: 103.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6900
    Cell Significance Index: 112.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6779
    Cell Significance Index: 135.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6730
    Cell Significance Index: 66.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6320
    Cell Significance Index: 570.6600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6047
    Cell Significance Index: 36.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4926
    Cell Significance Index: 53.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4263
    Cell Significance Index: 7.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4114
    Cell Significance Index: 284.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3522
    Cell Significance Index: 43.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3434
    Cell Significance Index: 61.9100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3248
    Cell Significance Index: 116.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2704
    Cell Significance Index: 53.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2652
    Cell Significance Index: 7.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2641
    Cell Significance Index: 13.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2371
    Cell Significance Index: 16.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2208
    Cell Significance Index: 6.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2023
    Cell Significance Index: 110.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1929
    Cell Significance Index: 5.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1916
    Cell Significance Index: 4.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1722
    Cell Significance Index: 32.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1681
    Cell Significance Index: 23.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1345
    Cell Significance Index: 3.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1335
    Cell Significance Index: 59.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1295
    Cell Significance Index: 8.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0933
    Cell Significance Index: 2.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0874
    Cell Significance Index: 3.9600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0705
    Cell Significance Index: 5.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0700
    Cell Significance Index: 0.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0672
    Cell Significance Index: 1.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0651
    Cell Significance Index: 8.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0522
    Cell Significance Index: 2.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0499
    Cell Significance Index: 8.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0434
    Cell Significance Index: 2.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0418
    Cell Significance Index: 2.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0399
    Cell Significance Index: 4.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0398
    Cell Significance Index: 1.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0253
    Cell Significance Index: 0.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0226
    Cell Significance Index: 1.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0142
    Cell Significance Index: 1.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0063
    Cell Significance Index: 0.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0050
    Cell Significance Index: -7.7700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0159
    Cell Significance Index: -8.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0164
    Cell Significance Index: -7.4600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0174
    Cell Significance Index: -13.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0325
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0351
    Cell Significance Index: -7.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0359
    Cell Significance Index: -1.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0423
    Cell Significance Index: -1.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0431
    Cell Significance Index: -2.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0452
    Cell Significance Index: -6.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0511
    Cell Significance Index: -5.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0567
    Cell Significance Index: -16.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0766
    Cell Significance Index: -8.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0944
    Cell Significance Index: -2.0100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0974
    Cell Significance Index: -1.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1057
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1084
    Cell Significance Index: -12.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1352
    Cell Significance Index: -7.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1468
    Cell Significance Index: -2.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1679
    Cell Significance Index: -4.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1781
    Cell Significance Index: -18.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1783
    Cell Significance Index: -5.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1889
    Cell Significance Index: -1.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1896
    Cell Significance Index: -6.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1914
    Cell Significance Index: -4.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2076
    Cell Significance Index: -16.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2344
    Cell Significance Index: -5.0100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2451
    Cell Significance Index: -6.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2537
    Cell Significance Index: -7.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2664
    Cell Significance Index: -16.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2867
    Cell Significance Index: -5.6000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.2983
    Cell Significance Index: -1.9800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3175
    Cell Significance Index: -4.5200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3393
    Cell Significance Index: -7.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3738
    Cell Significance Index: -9.8300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3746
    Cell Significance Index: -8.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3805
    Cell Significance Index: -9.7200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4075
    Cell Significance Index: -14.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4141
    Cell Significance Index: -11.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MTF1 is a DNA-binding transcription activator that regulates the expression of target genes involved in lipid metabolism, cholesterol biosynthesis, and the response to metal ions and oxidative stress. This gene exhibits sequence-specific DNA binding activity, enabling it to bind to specific DNA sequences and activate or repress gene expression. MTF1 is also capable of interacting with other transcription factors, such as SREBF and PPARα, to modulate gene expression. Notably, MTF1 is highly expressed in cells that are sensitive to metal ions and oxidative stress, suggesting its critical role in protecting these cells from damage. **Pathways and Functions:** MTF1 is involved in several key pathways, including: 1. **Activation of gene expression by SREBF and PPARα**: MTF1 interacts with SREBF and PPARα to regulate the expression of genes involved in lipid metabolism and cholesterol biosynthesis. 2. **Response to metal ions and oxidative stress**: MTF1 acts as a master regulator in the cellular response to metal ions, cadmium, and oxidative stress, activating genes involved in detoxification and protection against damage. 3. **Central nervous system development**: MTF1 is expressed in the central nervous system, where it regulates the expression of genes involved in neuronal development and function. 4. **Regulation of cholesterol biosynthesis**: MTF1 modulates the expression of genes involved in cholesterol biosynthesis, highlighting its role in lipid metabolism. **Clinical Significance:** The dysregulation of MTF1 has been implicated in various diseases, including: 1. **Metal toxicity**: MTF1 deficiency has been linked to increased susceptibility to metal toxicity, highlighting its critical role in protecting cells from metal ion damage. 2. **Oxidative stress**: MTF1 plays a key role in regulating the expression of genes involved in oxidative stress response, suggesting its potential as a therapeutic target for diseases related to oxidative stress. 3. **Neurodegenerative diseases**: MTF1 expression has been altered in neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlighting its potential role in the pathogenesis of these diseases. 4. **Cancer**: MTF1 has been implicated in cancer, where it regulates the expression of genes involved in cell growth and survival. In conclusion, MTF1 is a critical gene that plays a pivotal role in regulating gene expression in response to metal ions and oxidative stress. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target for the treatment of metal toxicity, oxidative stress, and neurodegenerative diseases.

Genular Protein ID: 4236473647

Symbol: MTF1_HUMAN

Name: Metal regulatory transcription factor 1

UniProtKB Accession Codes:

Q14872 B2RAK6 Q96CB1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 5 Ensembl 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8065932

Title: Cloning, chromosomal mapping and characterization of the human metal-regulatory transcription factor MTF-1.

PubMed ID: 8065932

DOI: 10.1093/nar/22.15.3167

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 753
  • Mass: 80957
  • Checksum: CC96518824170E98
  • Sequence:
    • MGEHSPDNNI IYFEAEEDEL TPDDKMLRFV DKNGLVPSSS GTVYDRTTVL IEQDPGTLED 
EDDDGQCGEH LPFLVGGEEG FHLIDHEAMS QGYVQHIISP DQIHLTINPG STPMPRNIEG 
ATLTLQSECP ETKRKEVKRY QCTFEGCPRT YSTAGNLRTH QKTHRGEYTF VCNQEGCGKA 
FLTSYSLRIH VRVHTKEKPF ECDVQGCEKA FNTLYRLKAH QRLHTGKTFN CESEGCSKYF 
TTLSDLRKHI RTHTGEKPFR CDHDGCGKAF AASHHLKTHV RTHTGERPFF CPSNGCEKTF 
STQYSLKSHM KGHDNKGHSY NALPQHNGSE DTNHSLCLSD LSLLSTDSEL RENSSTTQGQ 
DLSTISPAII FESMFQNSDD TAIQEDPQQT ASLTESFNGD AESVSDVPPS TGNSASLSLP 
LVLQPGLSEP PQPLLPASAP SAPPPAPSLG PGSQQAAFGN PPALLQPPEV PVPHSTQFAA 
NHQEFLPHPQ APQPIVPGLS VVAGASASAA AVASAVAAPA PPQSTTEPLP AMVQTLPLGA 
NSVLTNNPTI TITPTPNTAI LQSSLVMGEQ NLQWILNGAT SSPQNQEQIQ QASKVEKVFF 
TTAVPVASSP GSSVQQIGLS VPVIIIKQEE ACQCQCACRD SAKERASSRR KGCSSPPPPE 
PSPQAPDGPS LQLPAQTFSS APVPGSSSST LPSSCEQSRQ AETPSDPQTE TLSAMDVSEF 
LSLQSLDTPS NLIPIEALLQ GEEEMGLTSS FSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.