Details for: MTIF2

Gene ID: 4528

Symbol: MTIF2

Ensembl ID: ENSG00000085760

Description: mitochondrial translational initiation factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 125.7512
    Cell Significance Index: -19.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.1773
    Cell Significance Index: -17.8000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.2551
    Cell Significance Index: -24.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.3654
    Cell Significance Index: -18.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.2596
    Cell Significance Index: -23.6600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 27.7024
    Cell Significance Index: 445.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.4293
    Cell Significance Index: -18.5500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.4540
    Cell Significance Index: -21.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.4103
    Cell Significance Index: -22.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5803
    Cell Significance Index: -22.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4702
    Cell Significance Index: -13.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.7685
    Cell Significance Index: 106.1700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3568
    Cell Significance Index: 1225.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2489
    Cell Significance Index: 17.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0144
    Cell Significance Index: 45.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9974
    Cell Significance Index: 162.2100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8224
    Cell Significance Index: 42.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7122
    Cell Significance Index: 141.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6571
    Cell Significance Index: 118.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6312
    Cell Significance Index: 18.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5562
    Cell Significance Index: 68.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5313
    Cell Significance Index: 11.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5141
    Cell Significance Index: 35.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4191
    Cell Significance Index: 41.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4011
    Cell Significance Index: 219.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3935
    Cell Significance Index: 78.9400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.3746
    Cell Significance Index: 5.6900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3451
    Cell Significance Index: 58.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.3429
    Cell Significance Index: 8.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3264
    Cell Significance Index: 25.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3198
    Cell Significance Index: 14.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3079
    Cell Significance Index: 8.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2914
    Cell Significance Index: 55.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2841
    Cell Significance Index: 17.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2729
    Cell Significance Index: 19.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2663
    Cell Significance Index: 36.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2628
    Cell Significance Index: 13.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2540
    Cell Significance Index: 5.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2306
    Cell Significance Index: 101.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2197
    Cell Significance Index: 14.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2017
    Cell Significance Index: 6.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1888
    Cell Significance Index: 5.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1674
    Cell Significance Index: 115.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1409
    Cell Significance Index: 50.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1397
    Cell Significance Index: 16.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1389
    Cell Significance Index: 3.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1330
    Cell Significance Index: 3.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1132
    Cell Significance Index: 12.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0766
    Cell Significance Index: 2.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0602
    Cell Significance Index: 7.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0568
    Cell Significance Index: 2.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0455
    Cell Significance Index: 1.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0426
    Cell Significance Index: 5.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0219
    Cell Significance Index: 16.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0207
    Cell Significance Index: 2.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0152
    Cell Significance Index: 28.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0053
    Cell Significance Index: 3.3700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0040
    Cell Significance Index: 7.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0011
    Cell Significance Index: 1.7300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0072
    Cell Significance Index: -9.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0072
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0117
    Cell Significance Index: -8.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0145
    Cell Significance Index: -6.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0220
    Cell Significance Index: -3.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0223
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0237
    Cell Significance Index: -13.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0244
    Cell Significance Index: -0.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0273
    Cell Significance Index: -2.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0289
    Cell Significance Index: -1.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0316
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0530
    Cell Significance Index: -11.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0598
    Cell Significance Index: -1.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0627
    Cell Significance Index: -18.0400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0679
    Cell Significance Index: -0.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1024
    Cell Significance Index: -2.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1094
    Cell Significance Index: -8.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1103
    Cell Significance Index: -12.8600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1106
    Cell Significance Index: -1.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1280
    Cell Significance Index: -1.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1447
    Cell Significance Index: -5.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1541
    Cell Significance Index: -3.9600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1619
    Cell Significance Index: -1.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1707
    Cell Significance Index: -11.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1865
    Cell Significance Index: -14.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1883
    Cell Significance Index: -8.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1987
    Cell Significance Index: -20.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1987
    Cell Significance Index: -10.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2318
    Cell Significance Index: -14.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2416
    Cell Significance Index: -9.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2882
    Cell Significance Index: -2.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2982
    Cell Significance Index: -18.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3039
    Cell Significance Index: -5.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3042
    Cell Significance Index: -8.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3780
    Cell Significance Index: -11.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4193
    Cell Significance Index: -11.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4233
    Cell Significance Index: -8.8600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4510
    Cell Significance Index: -9.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.4673
    Cell Significance Index: -5.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: MTIF2 is specifically localized to the mitochondria, where it regulates the translation of mitochondrial mRNAs. 2. **Ribosomal interaction**: MTIF2 interacts with ribosomal small subunits, facilitating the assembly of the mitochondrial ribosome. 3. **GTPase activity**: MTIF2 possesses GTPase activity, which is essential for its function in regulating mitochondrial translation. 4. **High expression in specific cell types**: MTIF2 is highly expressed in mural cells, osteoclasts, and GABAergic interneurons, highlighting its importance in these cell types. **Pathways and Functions:** 1. **Mitochondrial translation regulation**: MTIF2 plays a central role in regulating the translation of mitochondrial mRNAs, which is essential for maintaining mitochondrial function and biogenesis. 2. **Ribosomal assembly**: MTIF2 interacts with ribosomal small subunits, facilitating the assembly of the mitochondrial ribosome, which is necessary for protein synthesis in mitochondria. 3. **GTPase activity**: MTIF2's GTPase activity is essential for its function in regulating mitochondrial translation, as it allows for the hydrolysis of GTP and the activation of downstream signaling pathways. 4. **Metabolic regulation**: MTIF2 has been implicated in regulating metabolic processes, including energy metabolism and autophagy, which are critical for maintaining cellular homeostasis. **Clinical Significance:** 1. **Neurodegenerative disorders**: Dysregulation of MTIF2 has been implicated in neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, highlighting its importance in maintaining neuronal function and survival. 2. **Metabolic disorders**: MTIF2 has been implicated in metabolic disorders, including diabetes and obesity, where it regulates glucose and lipid metabolism. 3. **Cancer**: MTIF2 has been shown to be overexpressed in various types of cancer, including osteosarcoma and glioblastoma, suggesting its potential role in tumorigenesis. 4. **Mitochondrial dysfunction**: MTIF2's role in regulating mitochondrial translation makes it a potential therapeutic target for mitochondrial dysfunction-related diseases, including neurodegenerative disorders and metabolic disorders. In conclusion, MTIF2 is a critical regulator of mitochondrial translation, and its dysregulation has been implicated in various diseases. Further research is necessary to fully elucidate the role of MTIF2 in regulating mitochondrial translation and its potential therapeutic applications.

Genular Protein ID: 565536383

Symbol: IF2M_HUMAN

Name: Translation initiation factor IF-2, mitochondrial

UniProtKB Accession Codes:

P46199 D6W5D0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EMDB 5 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 11 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7829522

Title: Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA.

PubMed ID: 7829522

DOI: 10.1074/jbc.270.4.1859

PubMed ID: 12932832

Title: The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene.

PubMed ID: 12932832

DOI: 10.1016/s0167-4781(03)00144-1

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 727
  • Mass: 81317
  • Checksum: AD2951AF3A5EB9E6
  • Sequence:
    • MNQKLLKLEN LLRFHTIYRQ LHSLCQRRAL RQWRHGFSSA YPVWTAQLCA WPWPTDVLTG 
AALSQYRLLV TKKEEGPWKS QLSSTKSKKV VEVWIGMTIE ELARAMEKNT DYVYEALLNT 
DIDIDSLEAD SHLDEVWIKE VITKAGMKLK WSKLKQDKVR KNKDAVRRPQ ADPALLTPRS 
PVVTIMGHVD HGKTTLLDKF RKTQVAAVET GGITQHIGAF LVSLPSGEKI TFLDTPGHAA 
FSAMRARGAQ VTDIVVLVVA ADDGVMKQTV ESIQHAKDAQ VPIILAVNKC DKAEADPEKV 
KKELLAYDVV CEDYGGDVQA VPVSALTGDN LMALAEATVA LAEMLELKAD PNGPVEGTVI 
ESFTDKGRGL VTTAIIQRGT LRKGSVLVAG KCWAKVRLMF DENGKTIDEA YPSMPVGITG 
WRDLPSAGEE ILEVESEPRA REVVDWRKYE QEQEKGQEDL KIIEEKRKEH KEAHQKAREK 
YGHLLWKKRS ILRFLERKEQ IPLKPKEKRE RDSNVLSVII KGDVDGSVEA ILNIIDTYDA 
SHECELELVH FGVGDVSAND VNLAETFDGV IYGFNVNAGN VIQQSAAKKG VKIKLHKIIY 
RLVEDLQEEL SSRLPCAVEE HPVGEASILA TFSVTEGKKK VPVAGCRVQK GQLEKQKKFK 
LTRNGHVIWK GSLTSLKHHK DDISIVKTGM DCGLSLDEDN MEFQVGDRIV CYEEKQIQAK 
TSWDPGF

Genular Protein ID: 3575632733

Symbol: Q6P1N2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6P1N2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 IntAct 1 InterPro 7 KEGG 1 MINT 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 465
  • Mass: 51750
  • Checksum: ED989E989A358585
  • Sequence:
    • MNQKLLKLEN LLRFHTIYRQ LHSLCQRRAL RQWRHGFSSA YPVWTAQLCA WPWPTDVLTG 
AALSQYRLLV TKKEEGPWKS QLSSTKSKKV VEVWIGMTIE ELARAMEKNT DYVYEALLNT 
DIDIDSLEAD SHLDEVWIKE VITKAGMKLK WSKLKQDKVR KNKDAVRRPQ ADPALLTPRS 
PVVTIMGHVD HGKTTLLDKF RKTQVAAVET GGITQHIGAF LVSLPSGEKI TFLDTPGHAA 
FSAMRARGAQ VTDIVVLVVA ADDGVMKQTV ESIQHAKDAQ VPIILAVNKC DKAEADPEKV 
KKELLAYDVV CEDYGGDVQA VPVSALTGDN LMALAEATVA LAEMLELKAD PNGPVEGTVI 
ESFTDKGRGL VTTAIIQRGT LRKGSVLVAG KCWAKVRLMF DENGKTIDEA YPSMPVGITG 
WRDLPSAGEE ILEVESEPRA REVVDWRKYE QEQEKGQEDL KKKKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.