Details for: MYO5A

Gene ID: 4644

Symbol: MYO5A

Ensembl ID: ENSG00000197535

Description: myosin VA

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 406.1198
    Cell Significance Index: -63.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 246.1724
    Cell Significance Index: -62.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 115.8503
    Cell Significance Index: -47.0700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 108.6734
    Cell Significance Index: -55.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.2508
    Cell Significance Index: -63.1900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.5369
    Cell Significance Index: -47.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.5917
    Cell Significance Index: -60.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.0352
    Cell Significance Index: -67.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.9307
    Cell Significance Index: -43.6200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.0338
    Cell Significance Index: -63.2700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.1890
    Cell Significance Index: 185.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.9448
    Cell Significance Index: 149.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.7897
    Cell Significance Index: 47.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0017
    Cell Significance Index: 602.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.9195
    Cell Significance Index: 1047.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.3156
    Cell Significance Index: 66.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1858
    Cell Significance Index: 56.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.1341
    Cell Significance Index: 143.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8982
    Cell Significance Index: 1312.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5351
    Cell Significance Index: 117.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3538
    Cell Significance Index: 43.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.0767
    Cell Significance Index: 23.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.8941
    Cell Significance Index: 50.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6684
    Cell Significance Index: 1258.4400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5806
    Cell Significance Index: 9.9500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4442
    Cell Significance Index: 401.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2575
    Cell Significance Index: 350.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2544
    Cell Significance Index: 158.8400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1945
    Cell Significance Index: 2.6000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1512
    Cell Significance Index: 68.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1482
    Cell Significance Index: 273.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1330
    Cell Significance Index: 84.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1102
    Cell Significance Index: 13.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1021
    Cell Significance Index: 157.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0856
    Cell Significance Index: 1.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0810
    Cell Significance Index: 13.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0530
    Cell Significance Index: 10.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0225
    Cell Significance Index: 4.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0166
    Cell Significance Index: 7.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0043
    Cell Significance Index: -0.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0081
    Cell Significance Index: -0.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0354
    Cell Significance Index: -26.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0471
    Cell Significance Index: -25.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0524
    Cell Significance Index: -1.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0610
    Cell Significance Index: -44.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0744
    Cell Significance Index: -2.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0831
    Cell Significance Index: -46.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0890
    Cell Significance Index: -67.3900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0954
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1103
    Cell Significance Index: -18.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1241
    Cell Significance Index: -3.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1263
    Cell Significance Index: -25.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1524
    Cell Significance Index: -16.5800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1565
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1625
    Cell Significance Index: -34.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1723
    Cell Significance Index: -25.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1783
    Cell Significance Index: -51.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2039
    Cell Significance Index: -20.8300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2219
    Cell Significance Index: -11.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2617
    Cell Significance Index: -11.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2908
    Cell Significance Index: -39.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3008
    Cell Significance Index: -35.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3264
    Cell Significance Index: -20.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3416
    Cell Significance Index: -35.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3843
    Cell Significance Index: -7.5000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4056
    Cell Significance Index: -5.2600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.4077
    Cell Significance Index: -3.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4150
    Cell Significance Index: -53.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4392
    Cell Significance Index: -30.3700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4479
    Cell Significance Index: -4.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4528
    Cell Significance Index: -51.8700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4572
    Cell Significance Index: -5.7700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4608
    Cell Significance Index: -9.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4623
    Cell Significance Index: -29.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5185
    Cell Significance Index: -33.4500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5241
    Cell Significance Index: -61.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5498
    Cell Significance Index: -70.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5511
    Cell Significance Index: -62.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5684
    Cell Significance Index: -11.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5843
    Cell Significance Index: -18.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5886
    Cell Significance Index: -19.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6154
    Cell Significance Index: -36.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6196
    Cell Significance Index: -28.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6257
    Cell Significance Index: -13.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6578
    Cell Significance Index: -52.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6657
    Cell Significance Index: -31.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7062
    Cell Significance Index: -52.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7435
    Cell Significance Index: -45.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8018
    Cell Significance Index: -10.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8071
    Cell Significance Index: -42.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8158
    Cell Significance Index: -42.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8348
    Cell Significance Index: -16.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8889
    Cell Significance Index: -62.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.8900
    Cell Significance Index: -12.7500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.9795
    Cell Significance Index: -7.5500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1024
    Cell Significance Index: -27.5000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1158
    Cell Significance Index: -39.0900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1379
    Cell Significance Index: -16.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1401
    Cell Significance Index: -23.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.1726
    Cell Significance Index: -28.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Motor Protein:** MYO5A is a member of the myosin superfamily, which is characterized by its ability to bind to actin filaments and undergo ATP-dependent movement. 2. **Unconventional Myosin:** MYO5A is an unconventional myosin, meaning it lacks the typical myosin head domain and instead possesses a long tail domain. 3. **Phagocytosis:** MYO5A is involved in regulating actin dynamics for phagocytic cup formation, which is essential for the uptake of pathogens and debris by phagocytic cells. 4. **Membrane Trafficking:** MYO5A is also involved in regulating membrane trafficking, including the transport of vesicles along actin filaments and the regulation of golgi organization. **Pathways and Functions:** 1. **Actin Cytoskeleton:** MYO5A regulates actin dynamics, which is essential for maintaining the structure and function of the actin cytoskeleton. 2. **Phagocytosis:** MYO5A is involved in regulating actin dynamics for phagocytic cup formation, which is essential for the uptake of pathogens and debris by phagocytic cells. 3. **Membrane Trafficking:** MYO5A regulates membrane trafficking, including the transport of vesicles along actin filaments and the regulation of golgi organization. 4. **Innate Immune Response:** MYO5A is involved in regulating the innate immune response, including the uptake of pathogens and debris by phagocytic cells. 5. **Neurotransmitter Release:** MYO5A is involved in regulating neurotransmitter release, including the transport of glut4 vesicles to the plasma membrane. **Clinical Significance:** Dysregulation of MYO5A has been implicated in various diseases, including: 1. **Leishmaniasis:** MYO5A has been shown to play a crucial role in the regulation of phagocytosis and the clearance of Leishmania parasites. 2. **Autoimmune Diseases:** Dysregulation of MYO5A has been implicated in autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. 3. **Neurodegenerative Diseases:** MYO5A has been shown to play a role in regulating neurotransmitter release and the clearance of amyloid-β peptides, which is essential for the prevention of neurodegenerative diseases. 4. **Cancer:** MYO5A has been shown to play a role in regulating membrane trafficking and the transport of cancer cells. In conclusion, MYO5A is a critical gene that plays a crucial role in various cellular processes, including actin dynamics, membrane trafficking, and phagocytosis. Dysregulation of MYO5A has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 3901421394

Symbol: MYO5A_HUMAN

Name: Unconventional myosin-Va

UniProtKB Accession Codes:

Q9Y4I1 A8MZC5 O60653 Q07902 Q16249 Q9UE30 Q9UE31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 4 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9207796

Title: Griscelli disease maps to chromosome 15q21 and is associated with mutations in the myosin-Va gene.

PubMed ID: 9207796

DOI: 10.1038/ng0797-289

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 8188282

Title: Cloning, analysis, and chromosomal localization of myoxin (MYH12), the human homologue to the mouse dilute gene.

PubMed ID: 8188282

DOI: 10.1006/geno.1994.1088

PubMed ID: 7835087

Title: Cloning and regional assignment of the human myosin heavy chain 12 (MYH12) gene to chromosome band 15q21.

PubMed ID: 7835087

DOI: 10.1159/000133937

PubMed ID: 10448864

Title: Myosin-V is a processive actin-based motor.

PubMed ID: 10448864

DOI: 10.1038/23072

PubMed ID: 12062444

Title: Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions.

PubMed ID: 12062444

DOI: 10.1016/s0014-5793(02)02634-0

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22908308

Title: Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes.

PubMed ID: 22908308

DOI: 10.1083/jcb.201111091

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 10733681

Title: Arg-Cys substitution at codon 1246 of the human myosin Va gene is not associated with Griscelli syndrome.

PubMed ID: 10733681

DOI: 10.1046/j.1523-1747.2000.00933.x

PubMed ID: 10704277

Title: Two genes are responsible for Griscelli syndrome at the same 15q21 locus.

PubMed ID: 10704277

DOI: 10.1006/geno.1999.6081

PubMed ID: 12058346

Title: Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A.

PubMed ID: 12058346

DOI: 10.1086/341606

PubMed ID: 12897212

Title: Griscelli syndrome restricted to hypopigmentation results from a melanophilin defect (GS3) or a MYO5A F-exon deletion (GS1).

PubMed ID: 12897212

DOI: 10.1172/jci18264

Sequence Information:

  • Length: 1855
  • Mass: 215405
  • Checksum: 78FD3B1D08D90A0A
  • Sequence:
    • MAASELYTKF ARVWIPDPEE VWKSAELLKD YKPGDKVLLL HLEEGKDLEY HLDPKTKELP 
HLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFIDSKLIY TYCGIVLVAI NPYEQLPIYG 
EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRYF 
ATVSGSASEA NVEEKVLASN PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR 
TYLLEKSRVV FQAEEERNYH IFYQLCASAK LPEFKMLRLG NADNFNYTKQ GGSPVIEGVD 
DAKEMAHTRQ ACTLLGISES HQMGIFRILA GILHLGNVGF TSRDADSCTI PPKHEPLCIF 
CELMGVDYEE MCHWLCHRKL ATATETYIKP ISKLQATNAR DALAKHIYAK LFNWIVDNVN 
QALHSAVKQH SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNMHVF KLEQEEYMKE 
QIPWTLIDFY DNQPCINLIE SKLGILDLLD EECKMPKGTD DTWAQKLYNT HLNKCALFEK 
PRLSNKAFII QHFADKVEYQ CEGFLEKNKD TVFEEQIKVL KSSKFKMLPE LFQDDEKAIS 
PTSATSSGRT PLTRTPAKPT KGRPGQMAKE HKKTVGHQFR NSLHLLMETL NATTPHYVRC 
IKPNDFKFPF TFDEKRAVQQ LRACGVLETI RISAAGFPSR WTYQEFFSRY RVLMKQKDVL 
SDRKQTCKNV LEKLILDKDK YQFGKTKIFF RAGQVAYLEK LRADKLRAAC IRIQKTIRGW 
LLRKKYLRMR KAAITMQRYV RGYQARCYAK FLRRTKAATI IQKYWRMYVV RRRYKIRRAA 
TIVLQSYLRG FLARNRYRKI LREHKAVIIQ KRVRGWLART HYKRSMHAII YLQCCFRRMM 
AKRELKKLKI EARSVERYKK LHIGMENKIM QLQRKVDEQN KDYKCLVEKL TNLEGIYNSE 
TEKLRSDLER LQLSEEEAKV ATGRVLSLQE EIAKLRKDLE QTRSEKKCIE EHADRYKQET 
EQLVSNLKEE NTLLKQEKEA LNHRIVQQAK EMTETMEKKL VEETKQLELD LNDERLRYQN 
LLNEFSRLEE RYDDLKEEMT LMVHVPKPGH KRTDSTHSSN ESEYIFSSEI AEMEDIPSRT 
EEPSEKKVPL DMSLFLKLQK RVTELEQEKQ VMQDELDRKE EQVLRSKAKE EERPQIRGAE 
LEYESLKRQE LESENKKLKN ELNELRKALS EKSAPEVTAP GAPAYRVLME QLTSVSEELD 
VRKEEVLILR SQLVSQKEAI QPKDDKNTMT DSTILLEDVQ KMKDKGEIAQ AYIGLKETNR 
SSALDYHELN EDGELWLVYE GLKQANRLLE SQLQSQKRSH ENEAEALRGE IQSLKEENNR 
QQQLLAQNLQ LPPEARIEAS LQHEITRLTN ENLDLMEQLE KQDKTVRKLK KQLKVFAKKI 
GELEVGQMEN ISPGQIIDEP IRPVNIPRKE KDFQGMLEYK KEDEQKLVKN LILELKPRGV 
AVNLIPGLPA YILFMCVRHA DYLNDDQKVR SLLTSTINSI KKVLKKRGDD FETVSFWLSN 
TCRFLHCLKQ YSGEEGFMKH NTSRQNEHCL TNFDLAEYRQ VLSDLAIQIY QQLVRVLENI 
LQPMIVSGML EHETIQGVSG VKPTGLRKRT SSIADEGTYT LDSILRQLNS FHSVMCQHGM 
DPELIKQVVK QMFYIIGAIT LNNLLLRKDM CSWSKGMQIR YNVSQLEEWL RDKNLMNSGA 
KETLEPLIQA AQLLQVKKKT DDDAEAICSM CNALTTAQIV KVLNLYTPVN EFEERVSVSF 
IRTIQMRLRD RKDSPQLLMD AKHIFPVTFP FNPSSLALET IQIPASLGLG FISRV

Genular Protein ID: 3156995941

Symbol: Q9UES4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UES4

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 RefSeq 1 SAM 1 SMR 1

Citations:

PubMed ID: 9826529

Title: Human myosin V gene produces different transcripts in a cell type-specific manner.

PubMed ID: 9826529

DOI: 10.1006/bbrc.1998.9644

Sequence Information:

  • Length: 206
  • Mass: 23612
  • Checksum: 4E445C84828A95D9
  • Sequence:
    • RQELESENKK LKNELNELRK ALSEKSAPEV TAPGAPAYRV LMEQLTSVSE ELDVRKEEVL 
ILRSQLVSQK EAIQPKDDKN TMTDSTILLE DVQKMKDKGE IAQAYIGLKE TNRSSALDYH 
ELNEDGELWL VYEGLKQANR LLESQLQSQK RSHENEAEAL RGEIQSLKEE NNRQQQLLAQ 
NLQLPPEARI EASLQHEITR LTNENL

Genular Protein ID: 2385929146

Symbol: A8CDT9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8CDT9

Database IDs:

ARBA 6 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 6 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 2 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 1828
  • Mass: 212259
  • Checksum: F8ADE83570ED0B76
  • Sequence:
    • MAASELYTKF ARVWIPDPEE VWKSAELLKD YKPGDKVLLL HLEEGKDLEY HLDPKTKELP 
HLRNPDILVG ENDLTALSYL HEPAVLHNLR VRFIDSKLIY TYCGIVLVAI NPYEQLPIYG 
EDIINAYSGQ NMGDMDPHIF AVAEEAYKQM ARDERNQSII VSGESGAGKT VSAKYAMRYF 
ATVSGSASEA NVEEKVLASN PIMESIGNAK TTRNDNSSRF GKYIEIGFDK RYRIIGANMR 
TYLLEKSRVV FQAEEERNYH IFYQLCASAK LPEFKMLRLG NADNFNYTKQ GGSPVIEGVD 
DAKEMAHTRQ ACTLLGISES HQMGIFRILA GILHLGNVGF TSRDADSCTI PPKHEPLCIF 
CDLMGVDYEE MCHWLCHRKL ATATETYIKP ISKLQATNAR DALAKHIYAK LFNWIVDNVN 
QALHSAVKQH SFIGVLDIYG FETFEINSFE QFCINYANEK LQQQFNMHVF KLEQEEYMKE 
QIPWTLIDFY DNQPCINLIE SKLGILDLLD EECKMPKGTD DTWAQKLYNT HLNKCALFEK 
PRLSNKAFII QHFADKVEYQ CEGFLEKNKD TVFEEQIKVL KSSKFKMLPE LFQDDEKAIS 
PTSATSSGRT PLTRTPAKPT KGRPGQMAKE HKKTVGHQFR NSLHLLMETL NATTPHYVRC 
IKPNDFKFPF TFDEKRAVQQ LRACGVLETI RISAAGFPSR WTYQEFFSRY RVLMKQKDVL 
SDRKQTCKNV LEKLILDKDK YQFGKTKIFF RAGQVAYLEK LRADKLRAAC IRIQKTIRGW 
LLRKKYLRMR KAAITMQRYV RGYQARCYAK FLRRTKAATI IQKYWRMYVV RRRYKIRRAA 
TIVLQSYLRG FLARNRYRKI LREHKAVIIQ KRVRGWLART HYKRSMHAII YLQCCFRRMM 
AKRELKKLKI EARSVERYKK LHIGMENKIM QLQRKVDEQN KDYKCLVEKL TNLEGIYNSE 
TEKLRSDLER LQLSEEEAKV ATGRVLSLQE EIAKLRKDLE QTRSEKKCIE EHADRYKQET 
EQLVSNLKEE NTLLKQEKEA LNHRIVQQAK EMTETMEKKL VEETKQLELD LNDERLRYQN 
LLNEFSRLEE RYDDLKEEMT LMVHVPKPGH KRTDSTHSSN ESEYIFSSEI AEMEDIPSRT 
EEPSEKKVPL DMSLFLKLQK RVTELEQEKQ VMQDELDRKE EQVLRSKAKE EERPQIRGAE 
LEYESLKRQE LESENKKLKN ELNELRKALS EKSAPEVTAP GAPAYRVLME QLTSVSEELD 
VRKEEVLILR SQLVSQKEAI QPKDDKNTMT DSTILLEDVQ KMKDKGEIAQ AYIGLKETNR 
LLESQLQSQK RSHENEAEAL RGEIQSLKEE NNRQQQLLAQ NLQLPPEARI EASLQHEITR 
LTNENLDLME QLEKQDKTVR KLKKQLKVFA KKIGELEVGQ MENISPGQII DEPIRPVNIP 
RKEKDFQGML EYKKEDEQKL VKNLILELKP RGVAVNLIPG LPAYILFMCV RHADYLNDDQ 
KVRSLLTSTI NSIKKVLKKR GDDFETVSFW LSNTCRFLHC LKQYSGEEGF MKHNTSRQNE 
HCLTNFDLAE YRQVLSDLAI QIYQQLVRVL ENILQPMIVS GMLEHETIQG VSGVKPTGLR 
KRTSSIADEG TYTLDSILRQ LNSFHSVMCQ HGMDPELIKQ VVKQMFYIIG AITLNNLLLR 
KDMCSWSKGM QIRYNVSQLE EWLRDKNLMN SGAKETLEPL IQAAQLLQVK KKTDDDAEAI 
CSMCNALTTA QIVKVLNLYT PVNEFEERVS VSFIRTIQMR LRDRKDSPQL LMDAKHIFPV 
TFPFNPSSLA LETIQIPASL GLGFISRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.