Details for: NEK2

Gene ID: 4751

Symbol: NEK2

Ensembl ID: ENSG00000117650

Description: NIMA related kinase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.9526
    Cell Significance Index: -7.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 5.8864
    Cell Significance Index: -5.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4179
    Cell Significance Index: -6.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8154
    Cell Significance Index: 132.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6856
    Cell Significance Index: 130.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6158
    Cell Significance Index: 66.9900
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.5822
    Cell Significance Index: 7.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5796
    Cell Significance Index: 14.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5376
    Cell Significance Index: 18.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4620
    Cell Significance Index: 417.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3828
    Cell Significance Index: 12.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3727
    Cell Significance Index: 43.4300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3689
    Cell Significance Index: 4.0100
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.3607
    Cell Significance Index: 2.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3578
    Cell Significance Index: 10.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3269
    Cell Significance Index: 22.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2802
    Cell Significance Index: 2.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2485
    Cell Significance Index: 12.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2341
    Cell Significance Index: 23.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2265
    Cell Significance Index: 7.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2214
    Cell Significance Index: 26.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2180
    Cell Significance Index: 119.0500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2047
    Cell Significance Index: 2.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1853
    Cell Significance Index: 36.7800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1500
    Cell Significance Index: 4.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1290
    Cell Significance Index: 2.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1062
    Cell Significance Index: 5.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0873
    Cell Significance Index: 1.8600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0827
    Cell Significance Index: 3.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0760
    Cell Significance Index: 1.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0626
    Cell Significance Index: 39.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0568
    Cell Significance Index: 1.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0496
    Cell Significance Index: 1.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0343
    Cell Significance Index: 2.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0161
    Cell Significance Index: 0.2700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0139
    Cell Significance Index: 0.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0116
    Cell Significance Index: 0.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0113
    Cell Significance Index: 4.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0017
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0040
    Cell Significance Index: -2.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -8.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0073
    Cell Significance Index: -11.2200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0088
    Cell Significance Index: -6.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0097
    Cell Significance Index: -0.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0133
    Cell Significance Index: -2.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0141
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0173
    Cell Significance Index: -7.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0174
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0210
    Cell Significance Index: -3.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0230
    Cell Significance Index: -1.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0256
    Cell Significance Index: -7.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0286
    Cell Significance Index: -3.2600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0295
    Cell Significance Index: -0.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0301
    Cell Significance Index: -3.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0311
    Cell Significance Index: -5.6100
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0330
    Cell Significance Index: -0.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0333
    Cell Significance Index: -3.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0354
    Cell Significance Index: -4.8700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0363
    Cell Significance Index: -0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0429
    Cell Significance Index: -6.2300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0469
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0564
    Cell Significance Index: -6.4600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: -0.0643
    Cell Significance Index: 0.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0768
    Cell Significance Index: -9.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0783
    Cell Significance Index: -2.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0819
    Cell Significance Index: -5.5100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0870
    Cell Significance Index: -5.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0915
    Cell Significance Index: -5.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0957
    Cell Significance Index: -6.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0960
    Cell Significance Index: -5.0000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1003
    Cell Significance Index: -0.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1047
    Cell Significance Index: -1.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1091
    Cell Significance Index: -8.3700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.1304
    Cell Significance Index: -1.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1322
    Cell Significance Index: -9.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1367
    Cell Significance Index: -7.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1484
    Cell Significance Index: -6.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1586
    Cell Significance Index: -2.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1692
    Cell Significance Index: -4.3500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1740
    Cell Significance Index: -1.9700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1797
    Cell Significance Index: -6.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1811
    Cell Significance Index: -8.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1850
    Cell Significance Index: -5.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1937
    Cell Significance Index: -7.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2031
    Cell Significance Index: -9.4700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2043
    Cell Significance Index: -6.0000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.2053
    Cell Significance Index: -1.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2075
    Cell Significance Index: -4.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2123
    Cell Significance Index: -8.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2123
    Cell Significance Index: -8.7000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2179
    Cell Significance Index: -3.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2206
    Cell Significance Index: -5.8000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2208
    Cell Significance Index: -7.2300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.2236
    Cell Significance Index: -2.7100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2237
    Cell Significance Index: -7.1300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2287
    Cell Significance Index: -3.3200
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2628
    Cell Significance Index: -3.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NEK2 is a member of the NIMA-related kinase family, which is characterized by its ability to regulate cell cycle progression and centrosome function. The kinase is serine/threonine-specific and has been shown to phosphorylate and activate various substrates, including the APC/C and CDC20 complexes. NEK2 is also involved in the regulation of spindle assembly and the separation of centrosomes during mitosis. **Pathways and Functions** NEK2 is involved in several key signaling pathways, including: 1. **Activation of APC/C and APC/C:CDC20 complexes**: NEK2 phosphorylates and activates the APC/C and APC/C:CDC20 complexes, which regulate the degradation of mitotic proteins and the proper progression of the cell cycle. 2. **Anchoring of the basal body to the plasma membrane**: NEK2 regulates the anchoring of the basal body to the plasma membrane, which is essential for the proper formation of cilia and flagella. 3. **Degradation of mitotic proteins**: NEK2 regulates the degradation of mitotic proteins, including the APC/C and CDC20 complexes, which is essential for the proper progression of the cell cycle. 4. **Regulation of spindle assembly**: NEK2 regulates the assembly of the spindle microtubules and the separation of centrosomes during mitosis. 5. **Regulation of centrosome maturation and separation**: NEK2 regulates the maturation and separation of centrosomes during mitosis. **Clinical Significance** Dysregulation of NEK2 has been implicated in various diseases, including: 1. **Cancer**: NEK2 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurological disorders**: NEK2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 3. **Reproductive disorders**: NEK2 has been shown to play a role in the regulation of cell cycle progression and centrosome function in germ cells, and dysregulation of NEK2 has been implicated in reproductive disorders, including infertility and miscarriage. In conclusion, NEK2 is a critical regulator of cellular processes, including cell cycle progression, centrosome maturation and separation, and spindle assembly. Dysregulation of NEK2 has been implicated in various diseases, and further research is needed to fully understand the role of NEK2 in human health and disease.

Genular Protein ID: 2045205005

Symbol: NEK2_HUMAN

Name: Serine/threonine-protein kinase Nek2

UniProtKB Accession Codes:

P51955 Q53FD6 Q5I1Z9 Q5VXZ1 Q6NZX8 Q7Z634 Q86XH2 Q96QN9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 4 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 3 EMBL 12 EMDB 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 30 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 8 RefSeq 4 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7522034

Title: Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.

PubMed ID: 7522034

PubMed ID: 11742531

Title: Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis.

PubMed ID: 11742531

DOI: 10.1042/0264-6021:3610077

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8274451

Title: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

PubMed ID: 8274451

PubMed ID: 15659832

Title: Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception.

PubMed ID: 15659832

DOI: 10.1196/annals.1329.059

PubMed ID: 14978040

Title: NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling.

PubMed ID: 14978040

DOI: 10.1074/jbc.m314205200

PubMed ID: 12857871

Title: Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.

PubMed ID: 12857871

DOI: 10.1091/mbc.e03-02-0108

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15358203

Title: Nek2A specifies the centrosomal localization of Erk2.

PubMed ID: 15358203

DOI: 10.1016/j.bbrc.2004.06.171

PubMed ID: 15388344

Title: Nek2A kinase regulates the localization of numatrin to centrosome in mitosis.

PubMed ID: 15388344

DOI: 10.1016/j.febslet.2004.08.047

PubMed ID: 15161910

Title: Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.

PubMed ID: 15161910

DOI: 10.1074/jbc.m404104200

PubMed ID: 17283141

Title: Protein phosphatase-1alpha regulates centrosome splitting through Nek2.

PubMed ID: 17283141

DOI: 10.1158/0008-5472.can-06-3071

PubMed ID: 17621308

Title: Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis.

PubMed ID: 17621308

DOI: 10.1038/cr.2007.55

PubMed ID: 17626005

Title: Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.

PubMed ID: 17626005

DOI: 10.1074/jbc.m704969200

PubMed ID: 18086858

Title: beta-Catenin is a Nek2 substrate involved in centrosome separation.

PubMed ID: 18086858

DOI: 10.1101/gad.1596308

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18297113

Title: The mitotic checkpoint kinase NEK2A regulates kinetochore microtubule attachment stability.

PubMed ID: 18297113

DOI: 10.1038/onc.2008.34

PubMed ID: 19941817

Title: An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.

PubMed ID: 19941817

DOI: 10.1016/j.molcel.2009.09.038

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20599736

Title: Involvement of a centrosomal protein kendrin in the maintenance of centrosome cohesion by modulating Nek2A kinase activity.

PubMed ID: 20599736

DOI: 10.1016/j.bbrc.2010.06.063

PubMed ID: 20034488

Title: Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.

PubMed ID: 20034488

DOI: 10.1016/j.yexmp.2009.12.004

PubMed ID: 21076410

Title: Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction.

PubMed ID: 21076410

DOI: 10.1038/ncb2120

PubMed ID: 21669869

Title: An undecided coiled-coil: the leucine zipper of NEK2 kinase exhibits atypical conformational exchange dynamics.

PubMed ID: 21669869

DOI: 10.1074/jbc.m110.196972

PubMed ID: 16280549

Title: Caught Nek-ing: cilia and centrioles.

PubMed ID: 16280549

DOI: 10.1242/jcs.02681

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24043777

Title: Whole genome sequencing in patients with retinitis pigmentosa reveals pathogenic DNA structural changes and NEK2 as a new disease gene.

PubMed ID: 24043777

DOI: 10.1073/pnas.1308243110

PubMed ID: 24554434

Title: Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.

PubMed ID: 24554434

DOI: 10.1242/jcs.139451

PubMed ID: 25704143

Title: Cep68 can be regulated by Nek2 and SCF complex.

PubMed ID: 25704143

DOI: 10.1016/j.ejcb.2015.01.004

PubMed ID: 26220856

Title: Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction.

PubMed ID: 26220856

DOI: 10.1242/jcs.171637

PubMed ID: 26471995

Title:

PubMed ID: 26471995

DOI: 10.1242/jcs.180463

PubMed ID: 30404835

Title: CCDC102B functions in centrosome linker assembly and centrosome cohesion.

PubMed ID: 30404835

DOI: 10.1242/jcs.222901

PubMed ID: 17197699

Title: Structure and regulation of the human Nek2 centrosomal kinase.

PubMed ID: 17197699

DOI: 10.1074/jbc.m609721200

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 445
  • Mass: 51763
  • Checksum: D33A37778ABB6D9E
  • Sequence:
    • MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 
ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 
TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 
YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 
SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 
PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 
RKFLSLASNP ELLNLPSSVI KKKVHFSGES KENIMRSENS ESQLTSKSKC KDLKKRLHAA 
QLRAQALSDI EKNYQLKSRQ ILGMR

Genular Protein ID: 876142129

Symbol: F6U4U2_HUMAN

Name: N/A

UniProtKB Accession Codes:

F6U4U2

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 388
  • Mass: 45217
  • Checksum: E9E0A632E7180241
  • Sequence:
    • MPSRAEDYEV LYTIGTGSYG RCQKIRRKSD GKILVWKELD YGSMTEAEKQ MLVSEVNLLR 
ELKHPNIVRY YDRIIDRTNT TLYIVMEYCE GGDLASVITK GTKERQYLDE EFVLRVMTQL 
TLALKECHRR SDGGHTVLHR DLKPANVFLD GKQNVKLGDF GLARILNHDT SFAKTFVGTP 
YYMSPEQMNR MSYNEKSDIW SLGCLLYELC ALMPPFTAFS QKELAGKIRE GKFRRIPYRY 
SDELNEIITR MLNLKDYHRP SVEEILENPL IADLVADEQR RNLERRGRQL GEPEKSQDSS 
PVLSELKLKE IQLQERERAL KAREERLEQK EQELCVRERL AEDKLARAEN LLKNYSLLKE 
RKFLSLASNP ESHFVAQAGM QWCDHSSM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.