Details for: NEK3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 110.8038
Cell Significance Index: -17.2400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 60.8729
Cell Significance Index: -15.4400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 37.4147
Cell Significance Index: -15.2000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 37.3844
Cell Significance Index: -17.6500 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 15.9624
Cell Significance Index: -15.2400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 14.0597
Cell Significance Index: -17.3400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 4.4095
Cell Significance Index: -17.4000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.2402
Cell Significance Index: -9.2800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0343
Cell Significance Index: 112.5000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0311
Cell Significance Index: 61.9000 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9041
Cell Significance Index: 147.0400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8214
Cell Significance Index: 23.6700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8095
Cell Significance Index: 36.6900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5793
Cell Significance Index: 12.5500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5529
Cell Significance Index: 38.2400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5144
Cell Significance Index: 50.8900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4471
Cell Significance Index: 88.7400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.3982
Cell Significance Index: 46.4100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.3788
Cell Significance Index: 8.3000 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2818
Cell Significance Index: 5.5000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2688
Cell Significance Index: 14.0000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.2449
Cell Significance Index: 3.6700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2424
Cell Significance Index: 13.6000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2228
Cell Significance Index: 154.1000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.2085
Cell Significance Index: 1.7000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.2005
Cell Significance Index: 4.1600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1836
Cell Significance Index: 3.9100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1462
Cell Significance Index: 20.0800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1409
Cell Significance Index: 4.9500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.1328
Cell Significance Index: 1.9100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1213
Cell Significance Index: 23.0900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1085
Cell Significance Index: 6.6700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0895
Cell Significance Index: 39.5700 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0893
Cell Significance Index: 4.5100 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.0855
Cell Significance Index: 1.0600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0730
Cell Significance Index: 13.1700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0496
Cell Significance Index: 3.8100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0447
Cell Significance Index: 0.2700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0375
Cell Significance Index: 4.8100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0298
Cell Significance Index: 10.6900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0235
Cell Significance Index: 12.8100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0206
Cell Significance Index: 0.3500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0197
Cell Significance Index: 26.8300 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0147
Cell Significance Index: 0.2000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0113
Cell Significance Index: 17.4000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0097
Cell Significance Index: 18.2200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0095
Cell Significance Index: 17.5300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0010
Cell Significance Index: -0.4500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0013
Cell Significance Index: -0.2700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0018
Cell Significance Index: -1.1300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0019
Cell Significance Index: -1.7400 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0096
Cell Significance Index: -0.2000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0131
Cell Significance Index: -9.6100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0188
Cell Significance Index: -3.2100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0215
Cell Significance Index: -16.3100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0216
Cell Significance Index: -15.9800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0249
Cell Significance Index: -1.5700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0277
Cell Significance Index: -4.0300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0292
Cell Significance Index: -3.5900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0313
Cell Significance Index: -17.6400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0321
Cell Significance Index: -20.0700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0382
Cell Significance Index: -1.7800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0485
Cell Significance Index: -3.4300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0510
Cell Significance Index: -14.6600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0531
Cell Significance Index: -1.7000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0698
Cell Significance Index: -7.1300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0760
Cell Significance Index: -1.9000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0954
Cell Significance Index: -20.0900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0996
Cell Significance Index: -12.8700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0999
Cell Significance Index: -5.1900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1085
Cell Significance Index: -12.8000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1127
Cell Significance Index: -12.9100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1263
Cell Significance Index: -9.4100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1273
Cell Significance Index: -3.4000 - Cell Name: germ cell (CL0000586)
Fold Change: -0.1351
Cell Significance Index: -1.0200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1362
Cell Significance Index: -6.4000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1462
Cell Significance Index: -15.2200 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1630
Cell Significance Index: -2.3400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1693
Cell Significance Index: -4.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1719
Cell Significance Index: -11.5600 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1826
Cell Significance Index: -1.8900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1927
Cell Significance Index: -6.7000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1963
Cell Significance Index: -5.2500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2011
Cell Significance Index: -15.9300 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2021
Cell Significance Index: -13.0400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2375
Cell Significance Index: -6.2500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2588
Cell Significance Index: -15.8700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2790
Cell Significance Index: -7.6000 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3040
Cell Significance Index: -15.9600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3044
Cell Significance Index: -7.3000 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.3092
Cell Significance Index: -9.0800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3167
Cell Significance Index: -8.1400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.3434
Cell Significance Index: -15.1900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3436
Cell Significance Index: -7.3500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3915
Cell Significance Index: -10.4900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4056
Cell Significance Index: -15.3600 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.4216
Cell Significance Index: -4.5200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4290
Cell Significance Index: -10.9600 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.4397
Cell Significance Index: -12.9500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4402
Cell Significance Index: -16.1600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 291469016
Symbol: NEK3_HUMAN
Name: Serine/threonine-protein kinase Nek3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12063396
Title: Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3).
PubMed ID: 12063396
DOI: 10.1159/000059342
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7522034
Title: Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.
PubMed ID: 7522034
PubMed ID: 8274451
Title: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.
PubMed ID: 8274451
PubMed ID: 15618286
Title: Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.
PubMed ID: 15618286
DOI: 10.1210/me.2004-0443
PubMed ID: 17297458
Title: Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.
PubMed ID: 17297458
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 506
- Mass: 57705
- Checksum: 4437EB4A41A44777
- Sequence:
MDDYMVLRMI GEGSFGRALL VQHESSNQMF AMKEIRLPKS FSNTQNSRKE AVLLAKMKHP NIVAFKESFE AEGHLYIVME YCDGGDLMQK IKQQKGKLFP EDMILNWFTQ MCLGVNHIHK KRVLHRDIKS KNIFLTQNGK VKLGDFGSAR LLSNPMAFAC TYVGTPYYVP PEIWENLPYN NKSDIWSLGC ILYELCTLKH PFQANSWKNL ILKVCQGCIS PLPSHYSYEL QFLVKQMFKR NPSHRPSATT LLSRGIVARL VQKCLPPEII MEYGEEVLEE IKNSKHNTPR KKTNPSRIRI ALGNEASTVQ EEEQDRKGSH TDLESINENL VESALRRVNR EEKGNKSVHL RKASSPNLHR RQWEKNVPNT ALTALENASI LTSSLTAEDD RGGSVIKYSK NTTRKQWLKE TPDTLLNILK NADLSLAFQT YTIYRPGSEG FLKGPLSEET EASDSVDGGH DSVILDPERL EPGLDEEDTD FEEEDDNPDW VSELKKRAGW QGLCDR
Genular Protein ID: 3727989115
Symbol: Q6ZN64_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
Sequence Information:
- Length: 510
- Mass: 58030
- Checksum: B7E3328C7B740FA4
- Sequence:
MQFGRAHGDC VSGAQLCGCP SMDDYMVLRM IGEGSFGRAL LVQHESSNQM FAMKEIRLPK SFSNTQNSRK EAVLLAKMKH PNIVAFKESF EAEGHLYIVM EYCDGGDLMQ KIKQQKGKLF PEDMILNWFT QMCLGVNHIH KKRVLHRDIK SKNIFLTQNG KVKLGDFGSA RLLSNPMAFA CTYVGTPYYV PPEIWENLPY NNKSDIWSLG CILYELCTLK HPFQANSWKN LILKVCQGCI SPLPSHYSYE LQFLVKQMFK RNPSHRPSAT TLLSRGIVAR LVQKCLPPEI IMEYGEEVLE EIKNSKHNTP RKKQEEEQDR KGSHTDLESI NENLVESALR RVNREEKGNK SVHLRKASSP NLHRRQWEKN VPNTALTALE NASILTSSLT AEDDRGGSVI KYSKNTTRKQ WLKETPDTLL NILKNADLSL AFQTYTIYRP GSEGFLKGPL SEETEASDSV DGGHDSVILD PERLEPGLDE EDTDFEEEDD NPDWVSELKK RAGWQGLCDR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.