Details for: NEK3

Gene ID: 4752

Symbol: NEK3

Ensembl ID: ENSG00000136098

Description: NIMA related kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.8038
    Cell Significance Index: -17.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.8729
    Cell Significance Index: -15.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.4147
    Cell Significance Index: -15.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.3844
    Cell Significance Index: -17.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.9624
    Cell Significance Index: -15.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0597
    Cell Significance Index: -17.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4095
    Cell Significance Index: -17.4000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2402
    Cell Significance Index: -9.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0343
    Cell Significance Index: 112.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0311
    Cell Significance Index: 61.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9041
    Cell Significance Index: 147.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8214
    Cell Significance Index: 23.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8095
    Cell Significance Index: 36.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5793
    Cell Significance Index: 12.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5529
    Cell Significance Index: 38.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5144
    Cell Significance Index: 50.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4471
    Cell Significance Index: 88.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3982
    Cell Significance Index: 46.4100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3788
    Cell Significance Index: 8.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2818
    Cell Significance Index: 5.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2688
    Cell Significance Index: 14.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2449
    Cell Significance Index: 3.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2424
    Cell Significance Index: 13.6000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2228
    Cell Significance Index: 154.1000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2085
    Cell Significance Index: 1.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2005
    Cell Significance Index: 4.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1836
    Cell Significance Index: 3.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1462
    Cell Significance Index: 20.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1409
    Cell Significance Index: 4.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.1328
    Cell Significance Index: 1.9100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1213
    Cell Significance Index: 23.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1085
    Cell Significance Index: 6.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0895
    Cell Significance Index: 39.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0893
    Cell Significance Index: 4.5100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0855
    Cell Significance Index: 1.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0730
    Cell Significance Index: 13.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0496
    Cell Significance Index: 3.8100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0447
    Cell Significance Index: 0.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0375
    Cell Significance Index: 4.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0298
    Cell Significance Index: 10.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0235
    Cell Significance Index: 12.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0206
    Cell Significance Index: 0.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0197
    Cell Significance Index: 26.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0147
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0113
    Cell Significance Index: 17.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0097
    Cell Significance Index: 18.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0095
    Cell Significance Index: 17.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0013
    Cell Significance Index: -0.2700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0019
    Cell Significance Index: -1.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0096
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0188
    Cell Significance Index: -3.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0215
    Cell Significance Index: -16.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0216
    Cell Significance Index: -15.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0249
    Cell Significance Index: -1.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0277
    Cell Significance Index: -4.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0292
    Cell Significance Index: -3.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0313
    Cell Significance Index: -17.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0321
    Cell Significance Index: -20.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0382
    Cell Significance Index: -1.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0485
    Cell Significance Index: -3.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0510
    Cell Significance Index: -14.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0531
    Cell Significance Index: -1.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0698
    Cell Significance Index: -7.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0760
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0954
    Cell Significance Index: -20.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0996
    Cell Significance Index: -12.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0999
    Cell Significance Index: -5.1900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1085
    Cell Significance Index: -12.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1127
    Cell Significance Index: -12.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1263
    Cell Significance Index: -9.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1273
    Cell Significance Index: -3.4000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1351
    Cell Significance Index: -1.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1362
    Cell Significance Index: -6.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1462
    Cell Significance Index: -15.2200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1630
    Cell Significance Index: -2.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1693
    Cell Significance Index: -4.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1719
    Cell Significance Index: -11.5600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1826
    Cell Significance Index: -1.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1927
    Cell Significance Index: -6.7000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1963
    Cell Significance Index: -5.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2011
    Cell Significance Index: -15.9300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2021
    Cell Significance Index: -13.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2375
    Cell Significance Index: -6.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2588
    Cell Significance Index: -15.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2790
    Cell Significance Index: -7.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3040
    Cell Significance Index: -15.9600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3044
    Cell Significance Index: -7.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3092
    Cell Significance Index: -9.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3167
    Cell Significance Index: -8.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3434
    Cell Significance Index: -15.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3436
    Cell Significance Index: -7.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3915
    Cell Significance Index: -10.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4056
    Cell Significance Index: -15.3600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4216
    Cell Significance Index: -4.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4290
    Cell Significance Index: -10.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4397
    Cell Significance Index: -12.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4402
    Cell Significance Index: -16.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NEK3 is a 432-amino acid protein that belongs to the NEK family of serine/threonine kinases. It is highly expressed in various cell types, including primordial germ cells, male germ cells, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. NEK3 exhibits a unique kinase domain and is characterized by its ability to bind to microtubules and regulate the dynamics of the cytoskeleton. **Pathways and Functions:** NEK3 is involved in several key pathways that regulate cell division, polarity, and neurogenesis. These include: 1. **Mitotic Cell Cycle:** NEK3 phosphorylates and regulates the activity of key proteins involved in the mitotic cell cycle, including the mitotic spindle and centrosome complexes. 2. **Establishment of Cell Polarity:** NEK3 regulates the establishment of cell polarity by phosphorylating and interacting with proteins involved in the planar cell polarity (PCP) pathway. 3. **Neuron Projection Morphogenesis:** NEK3 is essential for the development and morphogenesis of neurons, particularly in the cerebral cortex. 4. **Regulation of Tubulin Deacetylation:** NEK3 regulates the activity of tubulin deacetylases, which are involved in the regulation of microtubule stability and dynamics. **Clinical Significance:** Dysregulation of NEK3 has been implicated in various diseases, including: 1. **Neurodevelopmental Disorders:** Mutations in NEK3 have been associated with neurodevelopmental disorders, such as cerebral cortex abnormalities and neuronal migration defects. 2. **Cancer:** NEK3 is overexpressed in various types of cancer, including colorectal cancer, and is associated with poor prognosis and metastasis. 3. **Neurodegenerative Diseases:** NEK3 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates the activity of proteins involved in neuroinflammation and oxidative stress. In conclusion, NEK3 is a critical serine/threonine kinase that regulates various cellular processes, including cell division, polarity, and neurogenesis. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the role of NEK3 in human health and disease.

Genular Protein ID: 291469016

Symbol: NEK3_HUMAN

Name: Serine/threonine-protein kinase Nek3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12063396

Title: Molecular cloning and characterization of the human NIMA-related protein kinase 3 gene (NEK3).

PubMed ID: 12063396

DOI: 10.1159/000059342

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7522034

Title: Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans.

PubMed ID: 7522034

PubMed ID: 8274451

Title: Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans.

PubMed ID: 8274451

PubMed ID: 15618286

Title: Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.

PubMed ID: 15618286

DOI: 10.1210/me.2004-0443

PubMed ID: 17297458

Title: Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells.

PubMed ID: 17297458

DOI: 10.1038/sj.onc.1210264

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 506
  • Mass: 57705
  • Checksum: 4437EB4A41A44777
  • Sequence:
  • MDDYMVLRMI GEGSFGRALL VQHESSNQMF AMKEIRLPKS FSNTQNSRKE AVLLAKMKHP 
    NIVAFKESFE AEGHLYIVME YCDGGDLMQK IKQQKGKLFP EDMILNWFTQ MCLGVNHIHK 
    KRVLHRDIKS KNIFLTQNGK VKLGDFGSAR LLSNPMAFAC TYVGTPYYVP PEIWENLPYN 
    NKSDIWSLGC ILYELCTLKH PFQANSWKNL ILKVCQGCIS PLPSHYSYEL QFLVKQMFKR 
    NPSHRPSATT LLSRGIVARL VQKCLPPEII MEYGEEVLEE IKNSKHNTPR KKTNPSRIRI 
    ALGNEASTVQ EEEQDRKGSH TDLESINENL VESALRRVNR EEKGNKSVHL RKASSPNLHR 
    RQWEKNVPNT ALTALENASI LTSSLTAEDD RGGSVIKYSK NTTRKQWLKE TPDTLLNILK 
    NADLSLAFQT YTIYRPGSEG FLKGPLSEET EASDSVDGGH DSVILDPERL EPGLDEEDTD 
    FEEEDDNPDW VSELKKRAGW QGLCDR

Genular Protein ID: 3727989115

Symbol: Q6ZN64_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 510
  • Mass: 58030
  • Checksum: B7E3328C7B740FA4
  • Sequence:
  • MQFGRAHGDC VSGAQLCGCP SMDDYMVLRM IGEGSFGRAL LVQHESSNQM FAMKEIRLPK 
    SFSNTQNSRK EAVLLAKMKH PNIVAFKESF EAEGHLYIVM EYCDGGDLMQ KIKQQKGKLF 
    PEDMILNWFT QMCLGVNHIH KKRVLHRDIK SKNIFLTQNG KVKLGDFGSA RLLSNPMAFA 
    CTYVGTPYYV PPEIWENLPY NNKSDIWSLG CILYELCTLK HPFQANSWKN LILKVCQGCI 
    SPLPSHYSYE LQFLVKQMFK RNPSHRPSAT TLLSRGIVAR LVQKCLPPEI IMEYGEEVLE 
    EIKNSKHNTP RKKQEEEQDR KGSHTDLESI NENLVESALR RVNREEKGNK SVHLRKASSP 
    NLHRRQWEKN VPNTALTALE NASILTSSLT AEDDRGGSVI KYSKNTTRKQ WLKETPDTLL 
    NILKNADLSL AFQTYTIYRP GSEGFLKGPL SEETEASDSV DGGHDSVILD PERLEPGLDE 
    EDTDFEEEDD NPDWVSELKK RAGWQGLCDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.