Details for: NEUROD2

Gene ID: 4761

Symbol: NEUROD2

Ensembl ID: ENSG00000171532

Description: neuronal differentiation 2

Associated with

  • Associative learning
    (GO:0008306)
  • Axon development
    (GO:0061564)
  • Behavioral fear response
    (GO:0001662)
  • Cellular response to calcium ion
    (GO:0071277)
  • Cellular response to electrical stimulus
    (GO:0071257)
  • Cerebellar cortex development
    (GO:0021695)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • E-box binding
    (GO:0070888)
  • Negative regulation of synapse maturation
    (GO:2000297)
  • Nervous system development
    (GO:0007399)
  • Nucleus
    (GO:0005634)
  • Positive regulation of calcium-mediated signaling
    (GO:0050850)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of synapse maturation
    (GO:0090129)
  • Positive regulation of synaptic plasticity
    (GO:0031915)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein ubiquitination
    (GO:0016567)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Sensory organ development
    (GO:0007423)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 91.7418
    Cell Significance Index: -14.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.4322
    Cell Significance Index: -14.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5738
    Cell Significance Index: -14.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1585
    Cell Significance Index: -11.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7102
    Cell Significance Index: 194.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 3.4055
    Cell Significance Index: 58.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5201
    Cell Significance Index: 43.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8957
    Cell Significance Index: 60.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7945
    Cell Significance Index: 159.3800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5711
    Cell Significance Index: 56.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5149
    Cell Significance Index: 464.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3811
    Cell Significance Index: 24.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2943
    Cell Significance Index: 56.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2890
    Cell Significance Index: 47.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.2878
    Cell Significance Index: 4.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2142
    Cell Significance Index: 9.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1934
    Cell Significance Index: 21.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0989
    Cell Significance Index: 6.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0897
    Cell Significance Index: 2.5900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.0085
    Cell Significance Index: 0.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0022
    Cell Significance Index: 0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0066
    Cell Significance Index: -4.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0078
    Cell Significance Index: -0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0113
    Cell Significance Index: -17.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0116
    Cell Significance Index: -8.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0135
    Cell Significance Index: -5.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0171
    Cell Significance Index: -0.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0209
    Cell Significance Index: -15.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0217
    Cell Significance Index: -1.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0250
    Cell Significance Index: -13.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0254
    Cell Significance Index: -14.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0287
    Cell Significance Index: -13.0300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0402
    Cell Significance Index: -11.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0486
    Cell Significance Index: -8.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0559
    Cell Significance Index: -6.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0596
    Cell Significance Index: -8.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0603
    Cell Significance Index: -1.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0609
    Cell Significance Index: -1.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0629
    Cell Significance Index: -12.4900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0672
    Cell Significance Index: -2.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0711
    Cell Significance Index: -8.7400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0739
    Cell Significance Index: -4.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0748
    Cell Significance Index: -15.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0907
    Cell Significance Index: -15.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0968
    Cell Significance Index: -2.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0994
    Cell Significance Index: -10.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1032
    Cell Significance Index: -5.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1051
    Cell Significance Index: -6.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1057
    Cell Significance Index: -14.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1247
    Cell Significance Index: -14.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1265
    Cell Significance Index: -16.3400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1292
    Cell Significance Index: -5.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1302
    Cell Significance Index: -3.6400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1386
    Cell Significance Index: -1.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1415
    Cell Significance Index: -14.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1512
    Cell Significance Index: -17.8300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.1800
    Cell Significance Index: -2.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1832
    Cell Significance Index: -11.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1908
    Cell Significance Index: -6.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1937
    Cell Significance Index: -10.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2147
    Cell Significance Index: -4.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2167
    Cell Significance Index: -16.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2178
    Cell Significance Index: -7.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2227
    Cell Significance Index: -16.6000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.2231
    Cell Significance Index: -2.5400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2331
    Cell Significance Index: -2.2100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2446
    Cell Significance Index: -4.5200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2470
    Cell Significance Index: -2.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2526
    Cell Significance Index: -6.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2647
    Cell Significance Index: -5.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2654
    Cell Significance Index: -6.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2657
    Cell Significance Index: -6.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2701
    Cell Significance Index: -9.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2717
    Cell Significance Index: -3.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2729
    Cell Significance Index: -12.8300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2791
    Cell Significance Index: -6.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2874
    Cell Significance Index: -16.1300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3016
    Cell Significance Index: -4.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3044
    Cell Significance Index: -13.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3099
    Cell Significance Index: -4.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3179
    Cell Significance Index: -6.9600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3268
    Cell Significance Index: -4.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3296
    Cell Significance Index: -6.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3570
    Cell Significance Index: -13.5200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3583
    Cell Significance Index: -8.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3644
    Cell Significance Index: -7.7900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3661
    Cell Significance Index: -4.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3727
    Cell Significance Index: -5.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3745
    Cell Significance Index: -11.0300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3981
    Cell Significance Index: -4.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4165
    Cell Significance Index: -11.1200
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.4236
    Cell Significance Index: -4.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.4310
    Cell Significance Index: -2.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4549
    Cell Significance Index: -11.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** NEUROD2 acts as a transcriptional regulator, influencing the expression of genes involved in neuronal differentiation, synaptic plasticity, and calcium-mediated signaling. 2. **Cell-Specific Expression:** NEUROD2 is significantly expressed in various neuronal populations, including blood vessel endothelial cells, glycinergic neurons, and intestinal crypt stem cells. 3. **Dimerization and Ubiquitination:** NEUROD2 interacts with other transcription factors and undergoes ubiquitination, which regulates its activity and localization. 4. **Involvement in Neural Development:** NEUROD2 is essential for the development of the nervous system, including axon development, cerebellar cortex development, and sensory organ development. **Pathways and Functions:** 1. **Neuronal Differentiation:** NEUROD2 regulates the expression of genes involved in neuronal differentiation, including those involved in axon development and synapse maturation. 2. **Synaptic Plasticity:** NEUROD2 modulates the expression of genes involved in synaptic transmission and plasticity, including those involved in calcium-mediated signaling. 3. **Calcium-Mediated Signaling:** NEUROD2 regulates the activity of calcium channels and kinases, which are essential for neuronal signaling and synaptic plasticity. 4. **Transcriptional Regulation:** NEUROD2 interacts with other transcription factors and RNA polymerase II to regulate the expression of genes involved in neuronal development and function. **Clinical Significance:** 1. **Neurodevelopmental Disorders:** Alterations in NEUROD2 expression have been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Neurodegenerative Diseases:** NEUROD2 dysregulation has been linked to neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 3. **Synaptic Plasticity Disorders:** NEUROD2 modulates synaptic plasticity, and dysregulation of this gene has been implicated in synaptic plasticity disorders, such as epilepsy and learning disorders. 4. **Cancer:** NEUROD2 has been identified as a potential oncogene in certain cancers, including glioblastoma and colon cancer. In conclusion, the NEUROD2 gene plays a critical role in regulating neuronal differentiation, synaptic plasticity, and overall nervous system development. Further research is needed to fully understand the mechanisms by which NEUROD2 regulates gene expression and its clinical significance in various diseases.

Genular Protein ID: 2790038091

Symbol: NDF2_HUMAN

Name: Neurogenic differentiation factor 2

UniProtKB Accession Codes:

Q15784 Q8TBI7 Q9UQC6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8816493

Title: NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.

PubMed ID: 8816493

DOI: 10.1128/mcb.16.10.5792

PubMed ID: 10209266

Title: Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF).

PubMed ID: 10209266

DOI: 10.1016/s0167-4781(99)00038-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 30323019

Title: De novo pathogenic variants in neuronal differentiation factor 2 (NEUROD2) cause a form of early infantile epileptic encephalopathy.

PubMed ID: 30323019

DOI: 10.1136/jmedgenet-2018-105322

Sequence Information:

  • Length: 382
  • Mass: 41361
  • Checksum: E33AA5C0BE371B47
  • Sequence:
    • MLTRLFSEPG LLSDVPKFAS WGDGEDDEPR SDKGDAPPPP PPAPGPGAPG PARAAKPVPL 
RGEEGTEATL AEVKEEGELG GEEEEEEEEE EGLDEAEGER PKKRGPKKRK MTKARLERSK 
LRRQKANARE RNRMHDLNAA LDNLRKVVPC YSKTQKLSKI ETLRLAKNYI WALSEILRSG 
KRPDLVSYVQ TLCKGLSQPT TNLVAGCLQL NSRNFLTEQG ADGAGRFHGS GGPFAMHPYP 
YPCSRLAGAQ CQAAGGLGGG AAHALRTHGY CAAYETLYAA AGGGGASPDY NSSEYEGPLS 
PPLCLNGNFS LKQDSSPDHE KSYHYSMHYS ALPGSRPTGH GLVFGSSAVR GGVHSENLLS 
YDMHLHHDRG PMYEELNAFF HN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.