Details for: NPPA

Gene ID: 4878

Symbol: NPPA

Ensembl ID: ENSG00000175206

Description: natriuretic peptide A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 12.5515
    Cell Significance Index: 35.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.0405
    Cell Significance Index: 65.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.9557
    Cell Significance Index: 42.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6170
    Cell Significance Index: 27.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5949
    Cell Significance Index: 113.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2910
    Cell Significance Index: 17.4700
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.2541
    Cell Significance Index: 1.5000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2462
    Cell Significance Index: 3.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2456
    Cell Significance Index: 5.2300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2439
    Cell Significance Index: 24.1300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2238
    Cell Significance Index: 24.3400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2230
    Cell Significance Index: 201.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2033
    Cell Significance Index: 5.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1455
    Cell Significance Index: 23.6700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1025
    Cell Significance Index: 7.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0688
    Cell Significance Index: 5.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0590
    Cell Significance Index: 1.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0419
    Cell Significance Index: 0.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0377
    Cell Significance Index: 7.4800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0331
    Cell Significance Index: 0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0073
    Cell Significance Index: 11.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0063
    Cell Significance Index: 1.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0051
    Cell Significance Index: 9.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0020
    Cell Significance Index: 0.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0011
    Cell Significance Index: 0.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0008
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0035
    Cell Significance Index: -4.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0067
    Cell Significance Index: -4.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0091
    Cell Significance Index: -1.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0094
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0137
    Cell Significance Index: -7.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0142
    Cell Significance Index: -6.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0143
    Cell Significance Index: -7.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0226
    Cell Significance Index: -6.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0360
    Cell Significance Index: -7.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0420
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0425
    Cell Significance Index: -7.2500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0429
    Cell Significance Index: -0.3600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0499
    Cell Significance Index: -2.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0542
    Cell Significance Index: -7.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0584
    Cell Significance Index: -6.8900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0587
    Cell Significance Index: -6.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0644
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0675
    Cell Significance Index: -7.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0677
    Cell Significance Index: -4.1600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0678
    Cell Significance Index: -0.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0707
    Cell Significance Index: -1.3800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0802
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0817
    Cell Significance Index: -1.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0819
    Cell Significance Index: -8.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0847
    Cell Significance Index: -3.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0905
    Cell Significance Index: -5.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1001
    Cell Significance Index: -6.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1009
    Cell Significance Index: -6.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1023
    Cell Significance Index: -1.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1098
    Cell Significance Index: -5.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1116
    Cell Significance Index: -1.8800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1160
    Cell Significance Index: -2.8100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1216
    Cell Significance Index: -1.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1350
    Cell Significance Index: -7.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1384
    Cell Significance Index: -2.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1400
    Cell Significance Index: -3.7500
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.1411
    Cell Significance Index: -1.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1419
    Cell Significance Index: -6.6700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1543
    Cell Significance Index: -2.0800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1548
    Cell Significance Index: -2.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1555
    Cell Significance Index: -1.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1626
    Cell Significance Index: -7.1900
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1632
    Cell Significance Index: -1.8800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.1643
    Cell Significance Index: -1.1800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1794
    Cell Significance Index: -1.7400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1829
    Cell Significance Index: -2.7400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1846
    Cell Significance Index: -1.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1880
    Cell Significance Index: -7.1200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1881
    Cell Significance Index: -1.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1955
    Cell Significance Index: -6.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1967
    Cell Significance Index: -6.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1985
    Cell Significance Index: -8.6300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2030
    Cell Significance Index: -6.4200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2030
    Cell Significance Index: -2.1000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.2047
    Cell Significance Index: -2.6200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2058
    Cell Significance Index: -10.4000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2087
    Cell Significance Index: -3.1700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2121
    Cell Significance Index: -2.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2148
    Cell Significance Index: -6.8400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2165
    Cell Significance Index: -5.4000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2171
    Cell Significance Index: -1.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2172
    Cell Significance Index: -5.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2176
    Cell Significance Index: -6.4100
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.2253
    Cell Significance Index: -2.5200
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.2265
    Cell Significance Index: -1.7400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2305
    Cell Significance Index: -3.3600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2355
    Cell Significance Index: -6.7200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2359
    Cell Significance Index: -9.6700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2383
    Cell Significance Index: -7.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NPPA exhibits several distinctive characteristics that distinguish it from other peptides: 1. **Structure**: NPPA is a 28-amino acid peptide, consisting of two disulfide bonds, which contribute to its stability and function. 2. **Synthesis**: NPPA is synthesized as a precursor protein, which undergoes post-translational modifications, including cleavage and glycosylation, to produce the mature hormone. 3. **Release**: NPPA is released from the atrial myocytes in response to increased stretch or pressure, triggering a cascade of signaling events. 4. **Receptor binding**: NPPA binds to specific receptors, guanylyl cyclase receptors, which activate the cGMP signaling pathway. **Pathways and Functions** NPPA's signaling pathways and functions are multifaceted and far-reaching: 1. **Cardiac conduction and muscle contraction**: NPPA regulates cardiac muscle contraction and relaxation by modulating calcium ion transmembrane transport and high-voltage-gated calcium channel activity. 2. **Blood pressure regulation**: NPPA acts as a vasodilator, reducing systemic arterial blood pressure by stimulating guanylyl cyclase receptors, which increase cGMP levels and relax vascular smooth muscle. 3. **Electrolyte balance**: NPPA influences potassium ion export across the plasma membrane, contributing to the regulation of cardiac repolarization and sodium ion export. 4. **Neurotransmission and neuronal function**: NPPA has been implicated in neuronal signaling, modulating the activity of retinal bipolar and rod cells, and influencing the regulation of atrial cardiac muscle cell membrane repolarization. **Clinical Significance** NPPA's dysregulation has been implicated in various cardiovascular and neurological disorders: 1. **Hypertension**: Elevated NPPA levels are associated with hypertension, while reduced levels are linked to orthostatic hypotension. 2. **Cardiac arrhythmias**: Abnormal NPPA signaling has been implicated in the development of atrial fibrillation and other cardiac arrhythmias. 3. **Neurological disorders**: NPPA has been linked to Alzheimer's disease, Parkinson's disease, and other neurodegenerative conditions. 4. **Pregnancy and cardiovascular disease**: NPPA plays a crucial role in regulating blood pressure and cardiac function during pregnancy, and its dysregulation is associated with an increased risk of cardiovascular disease. In conclusion, NPPA is a vital hormone that plays a critical role in maintaining cardiovascular homeostasis and regulating blood pressure. Its dysregulation has significant clinical implications, highlighting the importance of further research into the molecular mechanisms underlying NPPA's functions and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 3129020889

Symbol: ANF_HUMAN

Name: N/A

UniProtKB Accession Codes:

P01160 Q13766 Q5JZE1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 CarbonylDB 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 34 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6203042

Title: Cloning and sequence analysis of cDNA encoding a precursor for human atrial natriuretic polypeptide.

PubMed ID: 6203042

DOI: 10.1038/309724a0

PubMed ID: 6547996

Title: mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria.

PubMed ID: 6547996

DOI: 10.1038/310699a0

PubMed ID: 6095118

Title: Gene structure of human cardiac hormone precursor, pronatriodilatin.

PubMed ID: 6095118

DOI: 10.1038/312654a0

PubMed ID: 6095119

Title: Nucleotide sequence of the gene encoding human atrial natriuretic factor precursor.

PubMed ID: 6095119

DOI: 10.1038/312656a0

PubMed ID: 6542248

Title: Nucleotide sequences of the human and mouse atrial natriuretic factor genes.

PubMed ID: 6542248

DOI: 10.1126/science.6542248

PubMed ID: 3158606

Title: Molecular studies of the atrial natriuretic factor gene.

PubMed ID: 3158606

DOI: 10.1161/01.hyp.7.3_pt_2.i31

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6097248

Title: Cloning of genomic DNA for human atrial natriuretic factor.

PubMed ID: 6097248

DOI: 10.1016/0006-291x(84)90609-0

PubMed ID: 6238331

Title: Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors.

PubMed ID: 6238331

DOI: 10.1073/pnas.81.20.6325

PubMed ID: 6230082

Title: Purification and complete amino acid sequence of alpha-human atrial natriuretic polypeptide (alpha-hANP).

PubMed ID: 6230082

DOI: 10.1016/0006-291x(84)91077-5

PubMed ID: 3838202

Title: Structural identification of beta- and gamma-human atrial natriuretic polypeptides.

PubMed ID: 3838202

DOI: 10.1038/313397a0

PubMed ID: 2972874

Title: Isolation and structural analysis of 'urodilatin', a new peptide of the cardiodilatin-(ANP)-family, extracted from human urine.

PubMed ID: 2972874

DOI: 10.1007/bf01726570

PubMed ID: 1826098

Title: Hydrolysis of intact and Cys-Phe-cleaved human atrial natriuretic peptide in vitro by human tissue kallikrein.

PubMed ID: 1826098

DOI: 10.1111/j.1432-1033.1991.tb15815.x

PubMed ID: 2825692

Title: Atrial natriuretic prohormone peptides 1-30, 31-67, and 79-98 vasodilate the aorta.

PubMed ID: 2825692

DOI: 10.1016/s0006-291x(87)80307-8

PubMed ID: 2972276

Title: Hydrolysis of alpha-human atrial natriuretic peptide in vitro by human kidney membranes and purified endopeptidase-24.11. Evidence for a novel cleavage site.

PubMed ID: 2972276

DOI: 10.1042/bj2540531

PubMed ID: 2532366

Title: Increased release of the N-terminal and C-terminal portions of the prohormone of atrial natriuretic factor during immersion-induced central hypervolemia in normal humans.

PubMed ID: 2532366

DOI: 10.3181/00379727-192-42990

PubMed ID: 2528951

Title: Phosphorylation and dephosphorylation of the natriuretic peptide urodilatin (CDD-/ANP-95-126) and the effect on biological activity.

PubMed ID: 2528951

DOI: 10.1016/0006-291x(89)92297-3

PubMed ID: 2162527

Title: Specific binding sites for prohormone atrial natriuretic peptides 1-30, 31-67 and 99-126.

PubMed ID: 2162527

DOI: 10.1016/0196-9781(90)90070-l

PubMed ID: 1660465

Title: Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera.

PubMed ID: 1660465

DOI: 10.1016/s0021-9258(18)54463-x

PubMed ID: 1672777

Title: Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP).

PubMed ID: 1672777

DOI: 10.1126/science.1672777

PubMed ID: 8384600

Title: Urodilatin binds to and activates renal receptors for atrial natriuretic peptide.

PubMed ID: 8384600

DOI: 10.1161/01.hyp.21.4.432

PubMed ID: 8351194

Title: Development and application of a urodilatin (CDD/ANP-95-126)-specific radioimmunoassay.

PubMed ID: 8351194

DOI: 10.1007/bf00374930

PubMed ID: 8087923

Title: Three peptides from the atrial natriuretic factor prohormone amino terminus lower blood pressure and produce diuresis, natriuresis, and/or kaliuresis in humans.

PubMed ID: 8087923

DOI: 10.1161/01.cir.90.3.1129

PubMed ID: 7955907

Title: N-terminal atrial natriuretic peptide and atrial natriuretic peptide in human plasma: investigation of plasma levels and molecular circulating form(s) using radioimmunoassays for pro-atrial natriuretic peptide (31-67), pro-atrial natriuretic peptide (1-30) and atrial natriuretic peptide (99-126).

PubMed ID: 7955907

DOI: 10.1042/cs0870311

PubMed ID: 7984506

Title: Molecular forms of circulating atrial natriuretic peptides in human plasma and their metabolites.

PubMed ID: 7984506

DOI: 10.1016/0196-9781(94)90043-4

PubMed ID: 7831500

Title: Lack of biologic activity or specific binding of amino-terminal pro-ANP segments in the rat.

PubMed ID: 7831500

DOI: 10.1016/0167-0115(94)90612-2

PubMed ID: 8653797

Title: Temporal (circadian) and functional relationship between atrial natriuretic peptides and blood pressure.

PubMed ID: 8653797

DOI: 10.3109/07420529509064506

PubMed ID: 7720651

Title: Kaliuretic peptide: the most potent inhibitor of Na(+)-K+ ATPase of the atrial natriuretic peptides.

PubMed ID: 7720651

DOI: 10.1210/endo.136.5.7720651

PubMed ID: 7595132

Title: Kaliuretic peptide and long acting natriuretic peptide as well as atrial natriuretic factor inhibit aldosterone secretion.

PubMed ID: 7595132

DOI: 10.1677/joe.0.1460373

PubMed ID: 8779891

Title: Postprandial natriuresis in humans: further evidence that urodilatin, not ANP, modulates sodium excretion.

PubMed ID: 8779891

DOI: 10.1152/ajprenal.1996.270.2.f301

PubMed ID: 8853410

Title: Urodilatin is involved in sodium homeostasis and exerts sodium-state-dependent natriuretic and diuretic effects.

PubMed ID: 8853410

DOI: 10.1152/ajprenal.1996.271.3.f489

PubMed ID: 9794555

Title: The renal natriuretic peptide urodilatin is present in human kidney.

PubMed ID: 9794555

DOI: 10.1093/ndt/13.10.2529

PubMed ID: 9893117

Title: Regulation of natriuretic peptide (urodilatin) release in a human kidney cell line.

PubMed ID: 9893117

DOI: 10.1046/j.1523-1755.1999.00242.x

PubMed ID: 11145122

Title: Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide enhance the urinary excretion rate of beta2-microglobulin.

PubMed ID: 11145122

DOI: 10.1053/meta.2000.18557

PubMed ID: 10880574

Title: Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.

PubMed ID: 10880574

DOI: 10.1073/pnas.150149097

PubMed ID: 14559895

Title: Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.

PubMed ID: 14559895

DOI: 10.1074/jbc.m309991200

PubMed ID: 15741263

Title: Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans.

PubMed ID: 15741263

DOI: 10.1210/jc.2004-1953

PubMed ID: 16254193

Title: Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form.

PubMed ID: 16254193

DOI: 10.1373/clinchem.2005.057638

PubMed ID: 16875975

Title: Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension.

PubMed ID: 16875975

DOI: 10.1016/j.jacc.2005.12.081

PubMed ID: 18835931

Title: Atrial natriuretic peptide induces postprandial lipid oxidation in humans.

PubMed ID: 18835931

DOI: 10.2337/db08-0649

PubMed ID: 21672517

Title: Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK.

PubMed ID: 21672517

DOI: 10.1016/j.bbrc.2011.05.143

PubMed ID: 22291141

Title: First identification of circulating prepro-A-type natriuretic peptide (preproANP) signal peptide fragments in humans: initial assessment as cardiovascular biomarkers.

PubMed ID: 22291141

DOI: 10.1373/clinchem.2011.176990

PubMed ID: 22307324

Title: Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.

PubMed ID: 22307324

DOI: 10.1172/jci59701

PubMed ID: 25401746

Title: The C2238/alphaANP variant is a negative modulator of both viability and function of coronary artery smooth muscle cells.

PubMed ID: 25401746

DOI: 10.1371/journal.pone.0113108

PubMed ID: 30534047

Title: Natriuretic Peptides in Post-mortem Brain Tissue and Cerebrospinal Fluid of Non-demented Humans and Alzheimer's Disease Patients.

PubMed ID: 30534047

DOI: 10.3389/fnins.2018.00864

PubMed ID: 8043577

Title: Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor.

PubMed ID: 8043577

DOI: 10.1021/bi00196a006

PubMed ID: 16870210

Title: Structural determinants of natriuretic peptide receptor specificity and degeneracy.

PubMed ID: 16870210

DOI: 10.1016/j.jmb.2006.06.060

PubMed ID: 21098034

Title: Insulin-degrading enzyme modulates the natriuretic peptide-mediated signaling response.

PubMed ID: 21098034

DOI: 10.1074/jbc.m110.173252

PubMed ID: 18614783

Title: Atrial natriuretic peptide frameshift mutation in familial atrial fibrillation.

PubMed ID: 18614783

DOI: 10.1056/nejmoa0706300

PubMed ID: 23275345

Title: Autosomal recessive atrial dilated cardiomyopathy with standstill evolution associated with mutation of natriuretic peptide precursor A.

PubMed ID: 23275345

DOI: 10.1161/circgenetics.112.963520

Sequence Information:

  • Length: 151
  • Mass: 16396
  • Checksum: F3AA066A73EC97EF
  • Sequence:
    • MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK MPLEDEVVPP 
QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG PWDSSDRSAL LKSKLRALLT 
APRSLRRSSC FGGRMDRIGA QSGLGCNSFR Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.