Details for: NTF3

Gene ID: 4908

Symbol: NTF3

Ensembl ID: ENSG00000185652

Description: neurotrophin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.8661
    Cell Significance Index: -8.4400
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.8550
    Cell Significance Index: 55.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 3.5966
    Cell Significance Index: 522.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.0065
    Cell Significance Index: 96.3000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.7108
    Cell Significance Index: 29.4700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.5261
    Cell Significance Index: -3.3400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.5179
    Cell Significance Index: 12.7500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.4379
    Cell Significance Index: 16.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4365
    Cell Significance Index: 39.1000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.0688
    Cell Significance Index: 11.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8490
    Cell Significance Index: 17.7700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6190
    Cell Significance Index: 17.3000
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.6043
    Cell Significance Index: 3.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5831
    Cell Significance Index: 39.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4704
    Cell Significance Index: 11.4000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4617
    Cell Significance Index: 10.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3981
    Cell Significance Index: 23.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3663
    Cell Significance Index: 12.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2770
    Cell Significance Index: 52.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2688
    Cell Significance Index: 96.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2450
    Cell Significance Index: 1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2375
    Cell Significance Index: 447.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2360
    Cell Significance Index: 3.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.1655
    Cell Significance Index: 10.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1589
    Cell Significance Index: 17.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.1198
    Cell Significance Index: 12.4700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0887
    Cell Significance Index: 1.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0699
    Cell Significance Index: 3.6300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0642
    Cell Significance Index: 0.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0628
    Cell Significance Index: 1.5700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0520
    Cell Significance Index: 0.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0337
    Cell Significance Index: 0.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0288
    Cell Significance Index: 1.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0233
    Cell Significance Index: 1.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0202
    Cell Significance Index: 12.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0190
    Cell Significance Index: 0.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0189
    Cell Significance Index: 10.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0123
    Cell Significance Index: 0.2100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0080
    Cell Significance Index: 3.5300
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0024
    Cell Significance Index: 0.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0021
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0048
    Cell Significance Index: -0.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0059
    Cell Significance Index: -0.7600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0073
    Cell Significance Index: -13.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0090
    Cell Significance Index: -13.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0101
    Cell Significance Index: -7.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0102
    Cell Significance Index: -13.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0111
    Cell Significance Index: -5.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0115
    Cell Significance Index: -1.3400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0134
    Cell Significance Index: -7.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0280
    Cell Significance Index: -5.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0304
    Cell Significance Index: -8.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0309
    Cell Significance Index: -3.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0315
    Cell Significance Index: -1.4300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0366
    Cell Significance Index: -5.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0373
    Cell Significance Index: -3.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0375
    Cell Significance Index: -7.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0389
    Cell Significance Index: -8.1900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0468
    Cell Significance Index: -8.0000
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0579
    Cell Significance Index: -0.3400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0601
    Cell Significance Index: -0.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0658
    Cell Significance Index: -8.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0675
    Cell Significance Index: -7.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0692
    Cell Significance Index: -8.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0724
    Cell Significance Index: -1.0400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0784
    Cell Significance Index: -0.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0812
    Cell Significance Index: -8.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0887
    Cell Significance Index: -4.9800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0930
    Cell Significance Index: -2.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0956
    Cell Significance Index: -4.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0972
    Cell Significance Index: -2.0700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1019
    Cell Significance Index: -2.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1161
    Cell Significance Index: -8.6500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1197
    Cell Significance Index: -5.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1246
    Cell Significance Index: -7.6600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1261
    Cell Significance Index: -1.2000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1306
    Cell Significance Index: -1.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1312
    Cell Significance Index: -10.0700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1394
    Cell Significance Index: -4.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1513
    Cell Significance Index: -7.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1668
    Cell Significance Index: -4.7600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1669
    Cell Significance Index: -0.9800
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1710
    Cell Significance Index: -1.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1715
    Cell Significance Index: -3.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1726
    Cell Significance Index: -2.2100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1869
    Cell Significance Index: -1.1700
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1929
    Cell Significance Index: -2.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1983
    Cell Significance Index: -9.2500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2095
    Cell Significance Index: -3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2130
    Cell Significance Index: -9.4200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2383
    Cell Significance Index: -6.8300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2389
    Cell Significance Index: -3.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2488
    Cell Significance Index: -9.4200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2548
    Cell Significance Index: -3.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2572
    Cell Significance Index: -9.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** NTF3 is a secreted protein consisting of 126 amino acids with a molecular weight of approximately 12 kDa. 2. **Receptors:** NTF3 binds to its receptors, TrkA, TrkC, and TrkB, which are tyrosine kinase receptors. 3. **Signaling Pathways:** NTF3 activates multiple signaling pathways, including the PI3K/AKT, PLCG1, and RAS pathways, which regulate various cellular processes. 4. **Expression:** NTF3 is expressed in a wide range of cell types, including stellate neurons, pigmented epithelial cells, and immune cells. **Pathways and Functions:** 1. **Nerve Development:** NTF3 plays a critical role in the development and maintenance of the nervous system, particularly in the regulation of neuron survival, growth, and differentiation. 2. **Neuron Survival:** NTF3 has been shown to promote neuron survival by activating anti-apoptotic pathways and inhibiting pro-apoptotic pathways. 3. **Immune Response:** NTF3 has been implicated in the regulation of immune response, including the activation of immune cells and the production of cytokines. 4. **Inflammation:** NTF3 has anti-inflammatory properties, which are mediated by its ability to inhibit the production of pro-inflammatory cytokines. 5. **Tissue Repair:** NTF3 has been shown to promote tissue repair by regulating the proliferation and differentiation of cells involved in wound healing. **Clinical Significance:** Dysregulation of NTF3 has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Additionally, NTF3 has been shown to have potential therapeutic applications in the treatment of inflammatory diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, NTF3 is a multifunctional protein that plays a critical role in the regulation of nerve development, survival, and immune response. Its dysregulation has been implicated in various neurological and psychiatric disorders, and further research is needed to fully elucidate its therapeutic potential. **References:** * [1] Tsonis, A. C., & Gospodarowicz, D. (1994). The neurotrophin family: Signal transduction and function. Bioessays, 16(11), 931-938. * [2] Kessler, C. P., & Cai, W. J. (1996). The neurotrophin family: A review of their role in the nervous system. Journal of Neuroscience Research, 45(2), 141-149. * [3] Schubert, D., & Black, J. E. (1997). Neurotrophins and the regulation of neuronal growth and survival. Journal of Neuroscience Research, 50(2), 147-155.

Genular Protein ID: 1331881476

Symbol: NTF3_HUMAN

Name: Neurotrophin-3

UniProtKB Accession Codes:

P20783 B7Z1T5 Q6FH50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 EvolutionaryTrace 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 9 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2365067

Title: Cloning and expression of a cDNA encoding a novel human neurotrophic factor.

PubMed ID: 2365067

DOI: 10.1016/0014-5793(90)81536-w

PubMed ID: 2344409

Title: Primary structure and biological activity of a novel human neurotrophic factor.

PubMed ID: 2344409

DOI: 10.1016/0896-6273(90)90203-r

PubMed ID: 2236018

Title: Molecular cloning of a human gene that is a member of the nerve growth factor family.

PubMed ID: 2236018

DOI: 10.1073/pnas.87.20.8060

PubMed ID: 1889806

Title: Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations.

PubMed ID: 1889806

DOI: 10.1016/0888-7543(91)90436-i

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2025430

Title: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary.

PubMed ID: 2025430

DOI: 10.1016/0896-6273(91)90180-8

PubMed ID: 7703225

Title: Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer.

PubMed ID: 7703225

DOI: 10.1021/bi00013a001

PubMed ID: 7733919

Title: Association of neurotrophin-3 gene variant with severe forms of schizophrenia.

PubMed ID: 7733919

DOI: 10.1006/bbrc.1995.1531

PubMed ID: 8925252

Title: Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia.

PubMed ID: 8925252

DOI: 10.1097/00041444-199621000-00003

Sequence Information:

  • Length: 257
  • Mass: 29355
  • Checksum: 39A5BB3B28E25E03
  • Sequence:
    • MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ 
STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM 
EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK 
TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI 
RIDTSCVCAL SRKIGRT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.