Details for: NTSR1

Gene ID: 4923

Symbol: NTSR1

Ensembl ID: ENSG00000101188

Description: neurotensin receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.7014
    Cell Significance Index: -3.2200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.7344
    Cell Significance Index: -3.2300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7151
    Cell Significance Index: 10.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.6617
    Cell Significance Index: 9.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.4900
    Cell Significance Index: -1.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4158
    Cell Significance Index: -0.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2464
    Cell Significance Index: 379.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2395
    Cell Significance Index: 4.0400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.2139
    Cell Significance Index: 3.1100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1919
    Cell Significance Index: 6.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1581
    Cell Significance Index: 56.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1569
    Cell Significance Index: 289.4100
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.1511
    Cell Significance Index: 1.7200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.1356
    Cell Significance Index: 1.5400
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.1276
    Cell Significance Index: 1.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1254
    Cell Significance Index: 18.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0989
    Cell Significance Index: 1.3500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0969
    Cell Significance Index: 1.6600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0829
    Cell Significance Index: 1.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0700
    Cell Significance Index: 0.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0611
    Cell Significance Index: 12.2600
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.0534
    Cell Significance Index: 0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0533
    Cell Significance Index: 10.5700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0516
    Cell Significance Index: 35.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0424
    Cell Significance Index: 26.9100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0311
    Cell Significance Index: 0.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0304
    Cell Significance Index: 57.2500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0209
    Cell Significance Index: 0.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0208
    Cell Significance Index: 28.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0114
    Cell Significance Index: 0.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0036
    Cell Significance Index: 0.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0011
    Cell Significance Index: -0.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0018
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0037
    Cell Significance Index: -1.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0039
    Cell Significance Index: -2.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0042
    Cell Significance Index: -0.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0045
    Cell Significance Index: -3.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0046
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0047
    Cell Significance Index: -3.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0056
    Cell Significance Index: -1.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0059
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0094
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0106
    Cell Significance Index: -1.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0119
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0140
    Cell Significance Index: -1.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0165
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0172
    Cell Significance Index: -3.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0192
    Cell Significance Index: -0.4600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0201
    Cell Significance Index: -2.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0214
    Cell Significance Index: -1.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0230
    Cell Significance Index: -2.8300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0270
    Cell Significance Index: -2.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0312
    Cell Significance Index: -1.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0314
    Cell Significance Index: -3.2100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0323
    Cell Significance Index: -0.3300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0336
    Cell Significance Index: -0.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0360
    Cell Significance Index: -2.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0384
    Cell Significance Index: -2.9500
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0410
    Cell Significance Index: -0.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0428
    Cell Significance Index: -0.8600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0479
    Cell Significance Index: -1.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0482
    Cell Significance Index: -1.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0507
    Cell Significance Index: -3.1100
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0535
    Cell Significance Index: -0.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0535
    Cell Significance Index: -2.7800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0579
    Cell Significance Index: -1.2500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0580
    Cell Significance Index: -0.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0581
    Cell Significance Index: -3.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0589
    Cell Significance Index: -3.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0607
    Cell Significance Index: -1.7500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0615
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0617
    Cell Significance Index: -2.9000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0636
    Cell Significance Index: -1.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0641
    Cell Significance Index: -1.3300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0642
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0669
    Cell Significance Index: -1.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0703
    Cell Significance Index: -1.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0711
    Cell Significance Index: -0.8300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0712
    Cell Significance Index: -1.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0714
    Cell Significance Index: -2.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0801
    Cell Significance Index: -1.9400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0802
    Cell Significance Index: -1.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0820
    Cell Significance Index: -1.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0850
    Cell Significance Index: -2.1200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0861
    Cell Significance Index: -1.6800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0875
    Cell Significance Index: -0.9100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0877
    Cell Significance Index: -1.1300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0882
    Cell Significance Index: -1.3200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0884
    Cell Significance Index: -1.2400
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0895
    Cell Significance Index: -1.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0927
    Cell Significance Index: -2.7300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0936
    Cell Significance Index: -0.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0938
    Cell Significance Index: -2.5100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0959
    Cell Significance Index: -1.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0981
    Cell Significance Index: -2.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0988
    Cell Significance Index: -1.9700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0990
    Cell Significance Index: -0.9800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1009
    Cell Significance Index: -1.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** NTSR1 is a G protein-coupled receptor with a rhodopsin-like structure, consisting of seven transmembrane domains. 2. **Expression:** This gene is widely expressed in various cell types, including the retina, brain, and peripheral nervous system. 3. **Ligand:** Neurotensin, a neuropeptide, is the primary ligand for NTSR1, although other ligands, such as D-aspartate and L-glutamate, can also bind to this receptor. 4. **Signaling Pathways:** NTSR1 is involved in regulating multiple signaling pathways, including those related to synaptic transmission, apoptosis, gene expression, and temperature homeostasis. **Pathways and Functions:** 1. **Synaptic Transmission:** NTSR1 plays a crucial role in regulating synaptic transmission, particularly in the central nervous system. The receptor is involved in modulating the release of neurotransmitters, such as glutamate and GABA, and regulating the strength of synaptic connections. 2. **Apoptosis:** NTSR1 is also involved in regulating apoptosis, a process of programmed cell death. The receptor can modulate the activity of pro-apoptotic and anti-apoptotic proteins, influencing cell survival and death. 3. **Gene Expression:** NTSR1 can regulate gene expression by modulating the activity of transcription factors and other signaling molecules. 4. **Temperature Homeostasis:** This gene is involved in regulating temperature homeostasis, particularly in the pain perception pathway. NTSR1 can modulate the activity of nociceptors, which are specialized neurons that detect painful stimuli. 5. **Learning and Memory:** NTSR1 is also involved in regulating learning and memory processes, particularly in the hippocampus and other regions of the brain. **Clinical Significance:** 1. **Pain Management:** Dysregulation of the NTSR1 signaling pathway has been implicated in various pain disorders, including chronic pain and neuropathic pain. Targeting this pathway may provide a novel therapeutic approach for pain management. 2. **Neurodegenerative Diseases:** NTSR1 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Understanding the role of this gene in these diseases may provide insights into the development of new therapeutic strategies. 3. **Cancer:** NTSR1 has been found to be overexpressed in certain types of cancer, including breast cancer and lung cancer. The receptor may play a role in promoting tumor growth and metastasis. 4. **Neurological Disorders:** NTSR1 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). Targeting this pathway may provide a novel therapeutic approach for these conditions. In conclusion, the neurotensin receptor 1 gene plays a multifaceted role in regulating various physiological processes, including pain perception, learning, and temperature homeostasis. Understanding the mechanisms by which this gene regulates these processes may provide insights into the development of novel therapeutic strategies for various diseases and disorders.

Genular Protein ID: 2753204110

Symbol: NTR1_HUMAN

Name: Neurotensin receptor type 1

UniProtKB Accession Codes:

P30989 Q9H4H1 Q9H4T5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 8 Ensembl 1 EvolutionaryTrace 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8381365

Title: Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor.

PubMed ID: 8381365

DOI: 10.1016/0014-5793(93)81509-x

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 20048080

Title: Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.

PubMed ID: 20048080

DOI: 10.1158/0008-5472.can-09-1252

PubMed ID: 21725197

Title: Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains.

PubMed ID: 21725197

DOI: 10.4161/cbt.12.5.15984

PubMed ID: 23140271

Title: Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor.

PubMed ID: 23140271

DOI: 10.1080/07391102.2012.736776

Sequence Information:

  • Length: 418
  • Mass: 46259
  • Checksum: 471AD1C49D29C2C8
  • Sequence:
    • MRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP SSELDVNTDI 
YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLTLLLAM 
PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM 
SRSRTKKFIS AIWLASALLA VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN 
TFMSFIFPMV VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH 
GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN ALFYVSSTIN 
PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD SVSSNHTLSS NATRETLY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.