Details for: ORC4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 295.6053
Cell Significance Index: -45.9800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 188.5718
Cell Significance Index: -47.8300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 132.5775
Cell Significance Index: -54.6200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 111.3058
Cell Significance Index: -52.5500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 101.6105
Cell Significance Index: -41.2800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 93.3250
Cell Significance Index: -48.0100 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 43.3834
Cell Significance Index: -41.4200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.4127
Cell Significance Index: -51.0600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.7049
Cell Significance Index: -44.7500 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.5864
Cell Significance Index: -41.7300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.2728
Cell Significance Index: -52.3800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.8818
Cell Significance Index: -17.2500 - Cell Name: kidney cell (CL1000497)
Fold Change: 2.6076
Cell Significance Index: 20.8200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.1341
Cell Significance Index: 248.7000 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.1329
Cell Significance Index: 26.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0755
Cell Significance Index: 416.3400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.9727
Cell Significance Index: 121.2500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.9590
Cell Significance Index: 109.9300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.9464
Cell Significance Index: 192.5400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9018
Cell Significance Index: 377.4300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.7125
Cell Significance Index: 41.0700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3807
Cell Significance Index: 495.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1620
Cell Significance Index: 126.3900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0604
Cell Significance Index: 63.6600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0472
Cell Significance Index: 170.3100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9979
Cell Significance Index: 690.1700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7828
Cell Significance Index: 52.6400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.6923
Cell Significance Index: 124.8000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6814
Cell Significance Index: 52.2900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.6689
Cell Significance Index: 42.1600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6640
Cell Significance Index: 81.6400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6602
Cell Significance Index: 18.4500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.6267
Cell Significance Index: 16.1100 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5511
Cell Significance Index: 20.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5495
Cell Significance Index: 300.1000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5453
Cell Significance Index: 492.4000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.5383
Cell Significance Index: 23.8100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5043
Cell Significance Index: 6.8800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.4601
Cell Significance Index: 15.9900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4448
Cell Significance Index: 12.8200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.4438
Cell Significance Index: 7.6100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3988
Cell Significance Index: 8.6400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3668
Cell Significance Index: 162.1500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3358
Cell Significance Index: 15.2200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1832
Cell Significance Index: 25.1600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1695
Cell Significance Index: 2.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1652
Cell Significance Index: 311.1100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1586
Cell Significance Index: 20.3300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1194
Cell Significance Index: 8.2600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.1147
Cell Significance Index: 5.3500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1018
Cell Significance Index: 64.6800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0912
Cell Significance Index: 4.7900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0880
Cell Significance Index: 135.4600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0860
Cell Significance Index: 158.5700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0743
Cell Significance Index: 3.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0584
Cell Significance Index: 9.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0418
Cell Significance Index: 56.8100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0300
Cell Significance Index: 5.7200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0280
Cell Significance Index: 12.6900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0163
Cell Significance Index: 0.7700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0117
Cell Significance Index: 0.4100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0064
Cell Significance Index: 0.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0162
Cell Significance Index: -12.0300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0255
Cell Significance Index: -18.7100 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0288
Cell Significance Index: -2.0400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0352
Cell Significance Index: -0.7700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0398
Cell Significance Index: -24.8800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0541
Cell Significance Index: -40.9400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0572
Cell Significance Index: -32.2600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0909
Cell Significance Index: -2.6000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0914
Cell Significance Index: -10.7800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1011
Cell Significance Index: -2.1600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1204
Cell Significance Index: -12.3000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1254
Cell Significance Index: -6.5300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1340
Cell Significance Index: -28.2200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1529
Cell Significance Index: -43.9800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1596
Cell Significance Index: -20.6300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1688
Cell Significance Index: -24.5300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2008
Cell Significance Index: -23.0100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2533
Cell Significance Index: -6.6600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2703
Cell Significance Index: -17.4400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2933
Cell Significance Index: -33.4800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3044
Cell Significance Index: -22.6900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3176
Cell Significance Index: -5.3200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4023
Cell Significance Index: -41.8900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.4188
Cell Significance Index: -11.4000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5052
Cell Significance Index: -40.0100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.5729
Cell Significance Index: -12.1600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.5892
Cell Significance Index: -11.5000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6170
Cell Significance Index: -19.7600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6673
Cell Significance Index: -40.9100 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.7065
Cell Significance Index: -13.9700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.7142
Cell Significance Index: -14.9500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7254
Cell Significance Index: -23.7500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7498
Cell Significance Index: -23.8800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.7600
Cell Significance Index: -11.2200 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.7626
Cell Significance Index: -9.5100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.7845
Cell Significance Index: -15.7500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8186
Cell Significance Index: -24.1100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8518
Cell Significance Index: -22.8300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3857950599
Symbol: ORC4_HUMAN
Name: Origin recognition complex subunit 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9353276
Title: Identification of HsORC4, a member of the human origin of replication recognition complex.
PubMed ID: 9353276
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12909626
Title: The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle.
PubMed ID: 12909626
PubMed ID: 17716973
Title: ATP-dependent assembly of the human origin recognition complex.
PubMed ID: 17716973
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22427655
Title: Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.
PubMed ID: 22427655
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 24989122
Title: A role for DNA polymerase theta in the timing of DNA replication.
PubMed ID: 24989122
DOI: 10.1038/ncomms5285
PubMed ID: 21358632
Title: Mutations in the pre-replication complex cause Meier-Gorlin syndrome.
PubMed ID: 21358632
DOI: 10.1038/ng.775
PubMed ID: 21358631
Title: Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.
PubMed ID: 21358631
DOI: 10.1038/ng.777
Sequence Information:
- Length: 436
- Mass: 50377
- Checksum: A7020B6690E30B4E
- Sequence:
MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL LKRTALHGES NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL
Genular Protein ID: 2898103770
Symbol: Q96B14_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 356
- Mass: 41354
- Checksum: 0360A0E1A18C4644
- Sequence:
LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL
Genular Protein ID: 2098111564
Symbol: A8K7H4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 436
- Mass: 50393
- Checksum: B35204368BE30B4E
- Sequence:
MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL LKRTALHGES NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV DLMEACQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.