Details for: ORC4

Gene ID: 5000

Symbol: ORC4

Ensembl ID: ENSG00000115947

Description: origin recognition complex subunit 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 295.6053
    Cell Significance Index: -45.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 188.5718
    Cell Significance Index: -47.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 132.5775
    Cell Significance Index: -54.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 111.3058
    Cell Significance Index: -52.5500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 101.6105
    Cell Significance Index: -41.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 93.3250
    Cell Significance Index: -48.0100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 43.3834
    Cell Significance Index: -41.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 41.4127
    Cell Significance Index: -51.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.7049
    Cell Significance Index: -44.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5864
    Cell Significance Index: -41.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.2728
    Cell Significance Index: -52.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8818
    Cell Significance Index: -17.2500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6076
    Cell Significance Index: 20.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1341
    Cell Significance Index: 248.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.1329
    Cell Significance Index: 26.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0755
    Cell Significance Index: 416.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9727
    Cell Significance Index: 121.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9590
    Cell Significance Index: 109.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9464
    Cell Significance Index: 192.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9018
    Cell Significance Index: 377.4300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.7125
    Cell Significance Index: 41.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3807
    Cell Significance Index: 495.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1620
    Cell Significance Index: 126.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0604
    Cell Significance Index: 63.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0472
    Cell Significance Index: 170.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9979
    Cell Significance Index: 690.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7828
    Cell Significance Index: 52.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6923
    Cell Significance Index: 124.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6814
    Cell Significance Index: 52.2900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6689
    Cell Significance Index: 42.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6640
    Cell Significance Index: 81.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6602
    Cell Significance Index: 18.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6267
    Cell Significance Index: 16.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5511
    Cell Significance Index: 20.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5495
    Cell Significance Index: 300.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5453
    Cell Significance Index: 492.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.5383
    Cell Significance Index: 23.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5043
    Cell Significance Index: 6.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4601
    Cell Significance Index: 15.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4448
    Cell Significance Index: 12.8200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4438
    Cell Significance Index: 7.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3988
    Cell Significance Index: 8.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3668
    Cell Significance Index: 162.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3358
    Cell Significance Index: 15.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1832
    Cell Significance Index: 25.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1695
    Cell Significance Index: 2.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1652
    Cell Significance Index: 311.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1586
    Cell Significance Index: 20.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1194
    Cell Significance Index: 8.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1147
    Cell Significance Index: 5.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1018
    Cell Significance Index: 64.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0912
    Cell Significance Index: 4.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0880
    Cell Significance Index: 135.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0860
    Cell Significance Index: 158.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0743
    Cell Significance Index: 3.8600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0584
    Cell Significance Index: 9.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0418
    Cell Significance Index: 56.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0300
    Cell Significance Index: 5.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0280
    Cell Significance Index: 12.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0163
    Cell Significance Index: 0.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0117
    Cell Significance Index: 0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0064
    Cell Significance Index: 0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0162
    Cell Significance Index: -12.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0255
    Cell Significance Index: -18.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0288
    Cell Significance Index: -2.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0352
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0398
    Cell Significance Index: -24.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0541
    Cell Significance Index: -40.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0572
    Cell Significance Index: -32.2600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0909
    Cell Significance Index: -2.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0914
    Cell Significance Index: -10.7800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1011
    Cell Significance Index: -2.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1204
    Cell Significance Index: -12.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1254
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1340
    Cell Significance Index: -28.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1529
    Cell Significance Index: -43.9800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1596
    Cell Significance Index: -20.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1688
    Cell Significance Index: -24.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2008
    Cell Significance Index: -23.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2533
    Cell Significance Index: -6.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2703
    Cell Significance Index: -17.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2933
    Cell Significance Index: -33.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3044
    Cell Significance Index: -22.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3176
    Cell Significance Index: -5.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4023
    Cell Significance Index: -41.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4188
    Cell Significance Index: -11.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5052
    Cell Significance Index: -40.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5729
    Cell Significance Index: -12.1600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.5892
    Cell Significance Index: -11.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6170
    Cell Significance Index: -19.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6673
    Cell Significance Index: -40.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7065
    Cell Significance Index: -13.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7142
    Cell Significance Index: -14.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7254
    Cell Significance Index: -23.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7498
    Cell Significance Index: -23.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7600
    Cell Significance Index: -11.2200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7626
    Cell Significance Index: -9.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7845
    Cell Significance Index: -15.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8186
    Cell Significance Index: -24.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8518
    Cell Significance Index: -22.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ORC4 is a subunit of the ORC complex, which consists of six subunits: ORC1, ORC2, ORC3, ORC4, ORC5, and ORC6. ORC4 is a conserved protein, with high sequence similarity across species, and is predominantly expressed in cells with high proliferative potential, such as germ cells, neurons, and kidney cells. The ORC complex is composed of four subunits (ORC1-4) with one of the subunits (ORC5) being the smallest and least conserved. ORC4 is a relatively large subunit, with a molecular weight of approximately 120 kDa. **Pathways and Functions:** ORC4 is involved in several critical pathways, including: 1. **Assembly of the ORC complex at the origin of replication**: ORC4 plays a key role in recognizing and binding to the origin of replication, a process essential for initiating DNA replication. 2. **Activation of the pre-replicative complex**: ORC4 is involved in the assembly of the pre-replicative complex, a multi-protein complex that is necessary for DNA replication. 3. **DNA replication initiation**: ORC4 is required for the initiation of DNA replication, ensuring accurate and efficient replication of the genome. 4. **Cell cycle regulation**: ORC4 is involved in the regulation of the cell cycle, particularly in the G1/S transition, where it plays a crucial role in the progression from the G1 phase to the S phase. **Clinical Significance:** Dysregulation of the ORC complex, including ORC4, has been implicated in various diseases, including: 1. **Cancer**: Alterations in the ORC complex, including ORC4, have been observed in several types of cancer, suggesting a role in tumorigenesis. 2. **Neurological disorders**: Mutations in the ORC4 gene have been associated with neurological disorders, such as epilepsy and cognitive impairment. 3. **Cellular aging**: Dysregulation of the ORC complex, including ORC4, has been linked to cellular aging and senescence. In conclusion, ORC4 is a critical component of the ORC complex, essential for initiating DNA replication and regulating the cell cycle. Dysregulation of ORC4 has been implicated in various diseases, highlighting the importance of this protein in maintaining genome stability and promoting cellular homeostasis. Further research is necessary to fully understand the role of ORC4 in human disease and to develop therapeutic strategies to target this protein in the treatment of related disorders.

Genular Protein ID: 3857950599

Symbol: ORC4_HUMAN

Name: Origin recognition complex subunit 4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9353276

Title: Identification of HsORC4, a member of the human origin of replication recognition complex.

PubMed ID: 9353276

DOI: 10.1074/jbc.272.45.28247

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12909626

Title: The ORC1 cycle in human cells: II. Dynamic changes in the human ORC complex during the cell cycle.

PubMed ID: 12909626

DOI: 10.1074/jbc.m307535200

PubMed ID: 17716973

Title: ATP-dependent assembly of the human origin recognition complex.

PubMed ID: 17716973

DOI: 10.1074/jbc.m705905200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22427655

Title: Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.

PubMed ID: 22427655

DOI: 10.1074/jbc.m111.337980

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 24989122

Title: A role for DNA polymerase theta in the timing of DNA replication.

PubMed ID: 24989122

DOI: 10.1038/ncomms5285

PubMed ID: 21358632

Title: Mutations in the pre-replication complex cause Meier-Gorlin syndrome.

PubMed ID: 21358632

DOI: 10.1038/ng.775

PubMed ID: 21358631

Title: Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.

PubMed ID: 21358631

DOI: 10.1038/ng.777

Sequence Information:

  • Length: 436
  • Mass: 50377
  • Checksum: A7020B6690E30B4E
  • Sequence:
  • MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL LKRTALHGES 
    NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL 
    ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS 
    QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF 
    PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV 
    DLMEASQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK 
    AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN 
    CPTDVRQWAT SSLSWL

Genular Protein ID: 2898103770

Symbol: Q96B14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 356
  • Mass: 41354
  • Checksum: 0360A0E1A18C4644
  • Sequence:
  • LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL ENVVGDKVFG SFAENLSFLL 
    EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS QSAQTPIAVI GLTCRLDILE 
    LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF PDKVFAEKWN ENVQYLSEDR 
    SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV DLMEASQLCS MDSKANIVHG 
    LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK AHSVYNFEKP VVMKAFEHLQ 
    QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN CPTDVRQWAT SSLSWL

Genular Protein ID: 2098111564

Symbol: A8K7H4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 436
  • Mass: 50393
  • Checksum: B35204368BE30B4E
  • Sequence:
  • MSSRKSKSNS LIHTECLSQV QRILRERFCR QSPHSNLFGV QVQYKHLSEL LKRTALHGES 
    NSVLIIGPRG SGKTMLINHA LKELMEIEEV SENVLQVHLN GLLQINDKIA LKEITRQLNL 
    ENVVGDKVFG SFAENLSFLL EALKKGDRTS SCPVIFILDE FDLFAHHKNQ TLLYNLFDIS 
    QSAQTPIAVI GLTCRLDILE LLEKRVKSRF SHRQIHLMNS FGFPQYVKIF KEQLSLPAEF 
    PDKVFAEKWN ENVQYLSEDR SVQEVLQKHF NISKNLRSLH MLLMLALNRV TASHPFMTAV 
    DLMEACQLCS MDSKANIVHG LSVLEICLII AMKHLNDIYE EEPFNFQMVY NEFQKFVQRK 
    AHSVYNFEKP VVMKAFEHLQ QLELIKPMER TSGNSQREYQ LMKLLLDNTQ IMNALQKYPN 
    CPTDVRQWAT SSLSWL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.