OXA1L | ENSG00000155463 | NCBI 5018

Details for: OXA1L

Gene ID: 5018

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: OXA1L

Ensembl ID: ENSG00000155463

Description: OXA1L mitochondrial inner membrane protein

Cell Significance Landscape

Display Count:

Associated with

Aerobic respiration and respiratory electron transport
(R-HSA-1428517)
Complex i biogenesis
(R-HSA-6799198)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial translation elongation
(R-HSA-5389840)
Mitochondrial translation initiation
(R-HSA-5368286)
Mitochondrial translation termination
(R-HSA-5419276)
Respiratory electron transport
(R-HSA-611105)
Translation
(R-HSA-72766)
Aerobic respiration
(GO:0009060)
Membrane insertase activity
(GO:0032977)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial membrane
(GO:0031966)
Mitochondrial protein quality control
(GO:0141164)
Mitochondrial proton-transporting atp synthase complex assembly
(GO:0033615)
Mitochondrial respiratory chain complex i assembly
(GO:0032981)
Mitochondrial ribosome binding
(GO:0097177)
Mitochondrial translation
(GO:0032543)
Mitochondrion
(GO:0005739)
Negative regulation of atp-dependent activity
(GO:0032780)
Negative regulation of oxidoreductase activity
(GO:0051354)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein insertion into mitochondrial inner membrane from matrix
(GO:0032979)
Protein tetramerization
(GO:0051262)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

common myeloid progenitor CL0000049

CSI 28.73

rCSI 23.23%

PRS 51.12
intestinal epithelial cell CL0002563

CSI 25.67

rCSI 26.83%

PRS 49.2
hematopoietic stem cell CL0000037

CSI 25.64

rCSI 17.04%

PRS 54
megakaryocyte-erythroid progenitor cell CL0000050

CSI 25.38

rCSI 22.92%

PRS 47.04
pancreatic acinar cell CL0002064

CSI 21.57

rCSI 28.67%

PRS 55.56
CD14-low, CD16-positive monocyte CL0002396

CSI 20.94

rCSI 16.13%

PRS 49.49
granulocyte monocyte progenitor cell CL0000557

CSI 18.69

rCSI 16.19%

PRS 54.55
Langerhans cell CL0000453

CSI 17.44

rCSI 26.63%

PRS 67.36
early lymphoid progenitor CL0000936

CSI 14.39

rCSI 12.64%

PRS 55.59
stem cell CL0000034

CSI 13.35

rCSI 12.87%

PRS 40.83
promonocyte CL0000559

CSI 13.33

rCSI 22.83%

PRS 59.75
plasmablast CL0000980

CSI 12.78

rCSI 10.06%

PRS 56.84
Hofbauer cell CL3000001

CSI 12.52

rCSI 23.63%

PRS 60.71
tracheobronchial smooth muscle cell CL0019019

CSI 12.39

rCSI 21.84%

PRS 58.56
ciliated epithelial cell CL0000067

CSI 12.11

rCSI 10.65%

PRS 38.98
dendritic cell, human CL0001056

CSI 10.9

rCSI 16.74%

PRS 58.04
large pre-B-II cell CL0000957

CSI 10.7

rCSI 30.56%

PRS 64.22
alpha-beta T cell CL0000789

CSI 10.34

rCSI 12.11%

PRS 66.41
lung secretory cell CL1000272

CSI 10.15

rCSI 25.11%

PRS 48.14
vascular associated smooth muscle cell CL0000359

CSI 10.01

rCSI 32.48%

PRS 52.49
naive thymus-derived CD4-positive, alpha-beta T cell CL0000895

CSI 9.99

rCSI 12.56%

PRS 83.09
promyelocyte CL0000836

CSI 9.99

rCSI 14.4%

PRS 60.21
mesodermal cell CL0000222

CSI 9.51

rCSI 11.42%

PRS 48.15
pulmonary alveolar type 2 cell CL0002063

CSI 9.5

rCSI 14.74%

PRS 59.14
centrilobular region hepatocyte CL0019029

CSI 9.4

rCSI 24.53%

PRS 57.13
common dendritic progenitor CL0001029

CSI 9.29

rCSI 11.66%

PRS 60.34
mature alpha-beta T cell CL0000791

CSI 8.51

rCSI 30.8%

PRS 70.13
neural progenitor cell CL0011020

CSI 7.88

rCSI 34.69%

PRS 42.76
enteric smooth muscle cell CL0002504

CSI 7.61

rCSI 10.86%

PRS 52.74
double negative thymocyte CL0002489

CSI 7.56

rCSI 5.26%

PRS 60.09
activated CD4-positive, alpha-beta T cell CL0000896

CSI 7.28

rCSI 6.73%

PRS 70.82
hepatocyte CL0000182

CSI 6.76

rCSI 12.09%

PRS 48.78
ciliated columnar cell of tracheobronchial tree CL0002145

CSI 6.72

rCSI 15.32%

PRS 48.09
cardiac muscle cell CL0000746

CSI 6.72

rCSI 9.65%

PRS 40.8
ionocyte CL0005006

CSI 6.71

rCSI 7.19%

PRS 48.48
alveolar adventitial fibroblast CL4028006

CSI 6.66

rCSI 10.51%

PRS 51.51
activated type II NK T cell CL0000931

CSI 6.62

rCSI 7.45%

PRS 67.06
intestine goblet cell CL0019031

CSI 6.56

rCSI 5.83%

PRS 48.77
OFF-bipolar cell CL0000750

CSI 6.53

rCSI 8.93%

PRS 59.67
conventional dendritic cell CL0000990

CSI 6.42

rCSI 5.36%

PRS 67.83
ciliated cell CL0000064

CSI 6.39

rCSI 10.35%

PRS 48.17
mononuclear phagocyte CL0000113

CSI 6.34

rCSI 13.96%

PRS 54.36
CD14-positive monocyte CL0001054

CSI 6.28

rCSI 7.83%

PRS 61.54
fraction A pre-pro B cell CL0002045

CSI 6.08

rCSI 6.96%

PRS 72.27
kidney connecting tubule epithelial cell CL1000768

CSI 5.69

rCSI 14.44%

PRS 40.2
effector CD4-positive, alpha-beta T cell CL0001044

CSI 5.61

rCSI 16.09%

PRS 69.19
enteroendocrine cell CL0000164

CSI 5.28

rCSI 7.22%

PRS 52.69
respiratory epithelial cell CL0002368

CSI 5.19

rCSI 32.04%

PRS 83.21
eosinophil CL0000771

CSI 5.17

rCSI 33.92%

PRS 80.14
myeloid leukocyte CL0000766

CSI 4.79

rCSI 4.42%

PRS 51.22
basophil mast progenitor cell CL0002028

CSI 4.79

rCSI 25.53%

PRS 85.22
CD8-positive, alpha-beta thymocyte CL0000811

CSI 4.74

rCSI 7.39%

PRS 77.03
effector CD8-positive, alpha-beta T cell CL0001050

CSI 4.74

rCSI 3.61%

PRS 62.49
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 4.65

rCSI 2.75%

PRS 66.67
pancreatic ductal cell CL0002079

CSI 4.48

rCSI 8.71%

PRS 52.49
perivascular cell CL4033054

CSI 4.37

rCSI 5.98%

PRS 55.49
rod bipolar cell CL0000751

CSI 4.35

rCSI 7.82%

PRS 43.53
keratinocyte CL0000312

CSI 4.2

rCSI 3.52%

PRS 55.29
enterocyte CL0000584

CSI 4.1

rCSI 6.62%

PRS 57.44
erythroid progenitor cell CL0000038

CSI 4.1

rCSI 23.51%

PRS 60.98
interstitial cell of Cajal CL0002088

CSI 4.07

rCSI 5.18%

PRS 55.98
myofibroblast cell CL0000186

CSI 4.03

rCSI 5.59%

PRS 53.95
enteroendocrine cell of colon CL0009042

CSI 4.01

rCSI 18.79%

PRS 73.36
naive T cell CL0000898

CSI 3.98

rCSI 2.77%

PRS 64.11
respiratory basal cell CL0002633

CSI 3.9

rCSI 4.04%

PRS 56.22
secretory cell CL0000151

CSI 3.9

rCSI 4.07%

PRS 50.76
memory B cell CL0000787

CSI 3.85

rCSI 3.8%

PRS 80.07
pvalb GABAergic cortical interneuron CL4023018

CSI 3.81

rCSI 4.74%

PRS 31.93
hematopoietic precursor cell CL0008001

CSI 3.78

rCSI 3.89%

PRS 68.4
non-classical monocyte CL0000875

CSI 3.75

rCSI 6.01%

PRS 76.83
alternatively activated macrophage CL0000890

CSI 3.68

rCSI 4.62%

PRS 63.7
lung pericyte CL0009089

CSI 3.67

rCSI 9.7%

PRS 58.49
immature B cell CL0000816

CSI 3.66

rCSI 2.72%

PRS 63.85
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 3.61

rCSI 3.29%

PRS 65.06
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 3.57

rCSI 4.33%

PRS 42.71
unswitched memory B cell CL0000970

CSI 3.57

rCSI 3%

PRS 67.88
colon epithelial cell CL0011108

CSI 3.56

rCSI 3.73%

PRS 47.16
colon macrophage CL0009038

CSI 3.47

rCSI 16.01%

PRS 71.83
naive thymus-derived CD8-positive, alpha-beta T cell CL0000900

CSI 3.45

rCSI 2.42%

PRS 70.75
pre-conventional dendritic cell CL0002010

CSI 3.42

rCSI 45.26%

PRS 81.77
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.4

rCSI 2.72%

PRS 72.01
pulmonary capillary endothelial cell CL4028001

CSI 3.37

rCSI 6.43%

PRS 66.93
goblet cell CL0000160

CSI 3.11

rCSI 2.94%

PRS 50.79
CD16-negative, CD56-bright natural killer cell, human CL0000938

CSI 3.07

rCSI 2.3%

PRS 81.05
common lymphoid progenitor CL0000051

CSI 3.03

rCSI 4.05%

PRS 72.99
placental villous trophoblast CL2000060

CSI 3.03

rCSI 4.68%

PRS 48.04
neuroblast (sensu Vertebrata) CL0000031

CSI 2.98

rCSI 3.82%

PRS 48.16
precursor B cell CL0000817

CSI 2.97

rCSI 2.6%

PRS 60.24
skin fibroblast CL0002620

CSI 2.94

rCSI 2.53%

PRS 57.71
B cell CL0000236

CSI 2.93

rCSI 3.92%

PRS 75.94
midzonal region hepatocyte CL0019028

CSI 2.9

rCSI 6.8%

PRS 57.66
interneuron CL0000099

CSI 2.88

rCSI 5.79%

PRS 39.78
neural crest cell CL0011012

CSI 2.88

rCSI 2.28%

PRS 37.6
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.81

rCSI 1.89%

PRS 61.98
epithelial cell CL0000066

CSI 2.78

rCSI 4.28%

PRS 50.13
fibroblast of lung CL0002553

CSI 2.78

rCSI 2.58%

PRS 49.98
dendritic cell CL0000451

CSI 2.76

rCSI 3.4%

PRS 70.85
transit amplifying cell of colon CL0009011

CSI 2.72

rCSI 3.2%

PRS 53.39
renal alpha-intercalated cell CL0005011

CSI 2.71

rCSI 3.62%

PRS 58.83
CD4-positive, alpha-beta memory T cell CL0000897

CSI 2.61

rCSI 1.87%

PRS 63.92

acinar cell of salivary gland CL0002623

CSI 0.1

rCSI 1.6%

PRS 72.4%
pluripotent stem cell CL0002248

CSI 0.2

rCSI 5.9%

PRS 73.2%
B-2 B cell CL0000822

CSI 0.2

rCSI 4.2%

PRS 85.8%
paneth cell of colon CL0009009

CSI 0.2

rCSI 2.3%

PRS 73.1%
mesenchymal lymphangioblast CL0005021

CSI 0.3

rCSI 7.9%

PRS 79.5%
CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074

CSI 0.3

rCSI 3.5%

PRS 82.1%
helper T cell CL0000912

CSI 0.4

rCSI 0.5%

PRS 58.0%
group 2 innate lymphoid cell CL0001069

CSI 0.4

rCSI 2.1%

PRS 83.3%
type B pancreatic cell CL0000169

CSI 0.4

rCSI 0.9%

PRS 47.8%
IgM plasma cell CL0000986

CSI 0.4

rCSI 2.0%

PRS 86.0%
basal cell of epithelium of trachea CL1000348

CSI 0.4

rCSI 3.1%

PRS 71.1%
type EC enteroendocrine cell CL0000577

CSI 0.6

rCSI 2.0%

PRS 62.1%
stromal cell of ovary CL0002132

CSI 0.6

rCSI 1.6%

PRS 65.4%
myelocyte CL0002193

CSI 0.6

rCSI 3.9%

PRS 80.9%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.6

rCSI 3.6%

PRS 73.3%
intestinal crypt stem cell of colon CL0009043

CSI 0.6

rCSI 4.5%

PRS 69.2%
podocyte CL0000653

CSI 0.6

rCSI 2.7%

PRS 49.2%
transit amplifying cell of small intestine CL0009012

CSI 0.7

rCSI 2.9%

PRS 67.9%
L6b glutamatergic cortical neuron CL4023038

CSI 0.7

rCSI 2.1%

PRS 35.0%
tracheobronchial serous cell CL0019001

CSI 0.7

rCSI 3.0%

PRS 65.9%
periportal region hepatocyte CL0019026

CSI 0.7

rCSI 2.7%

PRS 57.9%
myeloid dendritic cell, human CL0001057

CSI 0.7

rCSI 3.9%

PRS 79.4%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.7

rCSI 3.2%

PRS 82.8%
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 0.7

rCSI 1.0%

PRS 70.8%
intermediate monocyte CL0002393

CSI 0.7

rCSI 1.1%

PRS 53.0%
late pro-B cell CL0002048

CSI 0.7

rCSI 1.8%

PRS 79.0%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.7

rCSI 1.8%

PRS 68.9%
ventricular cardiac muscle cell CL2000046

CSI 0.8

rCSI 2.6%

PRS 79.3%
megakaryocyte progenitor cell CL0000553

CSI 0.8

rCSI 14.5%

PRS 83.1%
retinal cone cell CL0000573

CSI 0.8

rCSI 1.3%

PRS 40.5%
colon goblet cell CL0009039

CSI 0.8

rCSI 1.9%

PRS 61.5%
intestinal crypt stem cell of small intestine CL0009017

CSI 0.8

rCSI 2.2%

PRS 58.7%
retinal ganglion cell CL0000740

CSI 0.8

rCSI 1.8%

PRS 37.8%
retinal blood vessel endothelial cell CL0002585

CSI 0.9

rCSI 1.5%

PRS 54.3%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.9

rCSI 4.7%

PRS 62.0%
thymocyte CL0000893

CSI 1.0

rCSI 3.4%

PRS 84.2%
mammary gland epithelial cell CL0002327

CSI 1.0

rCSI 3.4%

PRS 64.9%
natural T-regulatory cell CL0000903

CSI 1.0

rCSI 1.9%

PRS 82.8%
paneth cell CL0000510

CSI 1.0

rCSI 1.5%

PRS 67.6%
pancreatic stellate cell CL0002410

CSI 1.0

rCSI 6.0%

PRS 60.8%
alveolar macrophage CL0000583

CSI 1.0

rCSI 1.7%

PRS 55.8%
sst GABAergic cortical interneuron CL4023017

CSI 1.0

rCSI 1.3%

PRS 34.6%
B-1 B cell CL0000819

CSI 1.0

rCSI 26.7%

PRS 86.4%
peptic cell CL0000155

CSI 1.0

rCSI 10.2%

PRS 74.7%
intestinal tuft cell CL0019032

CSI 1.1

rCSI 1.6%

PRS 54.9%
tracheal goblet cell CL1000329

CSI 1.1

rCSI 2.4%

PRS 68.3%
bronchial goblet cell CL1000312

CSI 1.1

rCSI 4.4%

PRS 70.1%
nasal mucosa goblet cell CL0002480

CSI 1.1

rCSI 1.3%

PRS 59.9%
peripheral nervous system neuron CL2000032

CSI 1.1

rCSI 1.5%

PRS 43.1%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 1.2

rCSI 1.6%

PRS 77.4%
enteric neuron CL0007011

CSI 1.2

rCSI 17.3%

PRS 70.5%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.2

rCSI 2.0%

PRS 33.6%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.2

rCSI 2.4%

PRS 68.7%
alveolar type 1 fibroblast cell CL4028004

CSI 1.2

rCSI 1.3%

PRS 54.0%
forebrain radial glial cell CL0013000

CSI 1.2

rCSI 3.9%

PRS 57.3%
elicited macrophage CL0000861

CSI 1.3

rCSI 1.2%

PRS 58.5%
T-helper 1 cell CL0000545

CSI 1.3

rCSI 2.3%

PRS 75.4%
mucous neck cell CL0000651

CSI 1.3

rCSI 1.8%

PRS 63.2%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.3

rCSI 2.3%

PRS 32.7%
respiratory suprabasal cell CL4033048

CSI 1.3

rCSI 1.7%

PRS 55.1%
germinal center B cell CL0000844

CSI 1.3

rCSI 4.0%

PRS 71.4%
erythroid lineage cell CL0000764

CSI 1.3

rCSI 8.6%

PRS 71.4%
class switched memory B cell CL0000972

CSI 1.4

rCSI 1.0%

PRS 68.3%
foveolar cell of stomach CL0002179

CSI 1.4

rCSI 3.0%

PRS 64.3%
choroid plexus epithelial cell CL0000706

CSI 1.4

rCSI 2.3%

PRS 40.3%
myoepithelial cell CL0000185

CSI 1.4

rCSI 3.6%

PRS 58.6%
erythroblast CL0000765

CSI 1.4

rCSI 3.8%

PRS 63.5%
kidney epithelial cell CL0002518

CSI 1.4

rCSI 2.7%

PRS 72.7%
retina horizontal cell CL0000745

CSI 1.4

rCSI 2.2%

PRS 46.7%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 1.5

rCSI 3.5%

PRS 32.5%
pulmonary ionocyte CL0017000

CSI 1.5

rCSI 1.8%

PRS 58.1%
IgG plasma cell CL0000985

CSI 1.5

rCSI 1.8%

PRS 69.1%
granulocyte CL0000094

CSI 1.5

rCSI 2.3%

PRS 59.7%
microcirculation associated smooth muscle cell CL0008035

CSI 1.5

rCSI 4.4%

PRS 52.4%
retinal pigment epithelial cell CL0002586

CSI 1.6

rCSI 3.1%

PRS 48.8%
lung macrophage CL1001603

CSI 1.6

rCSI 3.5%

PRS 57.3%
M cell of gut CL0000682

CSI 1.6

rCSI 1.7%

PRS 63.9%
multi-ciliated epithelial cell CL0005012

CSI 1.6

rCSI 1.6%

PRS 44.2%
inflammatory macrophage CL0000863

CSI 1.6

rCSI 2.7%

PRS 76.1%
small pre-B-II cell CL0000954

CSI 1.6

rCSI 1.5%

PRS 74.1%
erythrocyte CL0000232

CSI 1.6

rCSI 3.6%

PRS 55.5%
myeloid lineage restricted progenitor cell CL0000839

CSI 1.6

rCSI 8.3%

PRS 73.9%
mature B cell CL0000785

CSI 1.6

rCSI 1.4%

PRS 60.5%
conjunctival epithelial cell CL1000432

CSI 1.6

rCSI 2.5%

PRS 51.0%
bronchus fibroblast of lung CL2000093

CSI 1.6

rCSI 1.3%

PRS 50.8%
colonocyte CL1000347

CSI 1.6

rCSI 2.4%

PRS 56.5%
pancreatic A cell CL0000171

CSI 1.7

rCSI 1.8%

PRS 53.6%
Kupffer cell CL0000091

CSI 1.7

rCSI 3.8%

PRS 49.6%
transit amplifying cell CL0009010

CSI 1.7

rCSI 2.6%

PRS 66.1%
CD1c-positive myeloid dendritic cell CL0002399

CSI 1.7

rCSI 2.1%

PRS 58.4%
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 1.7

rCSI 2.1%

PRS 70.9%
T-helper 17 cell CL0000899

CSI 1.7

rCSI 1.4%

PRS 72.9%
double-positive, alpha-beta thymocyte CL0000809

CSI 1.8

rCSI 1.8%

PRS 63.9%
paneth cell of epithelium of small intestine CL1000343

CSI 1.8

rCSI 4.9%

PRS 64.1%
CD4-positive helper T cell CL0000492

CSI 1.8

rCSI 1.4%

PRS 63.6%
duct epithelial cell CL0000068

CSI 1.8

rCSI 2.7%

PRS 53.6%
glioblast CL0000030

CSI 1.8

rCSI 2.9%

PRS 43.8%
club cell CL0000158

CSI 1.8

rCSI 2.7%

PRS 48.6%
IgA plasma cell CL0000987

CSI 1.8

rCSI 1.9%

PRS 67.7%
mature T cell CL0002419

CSI 1.9

rCSI 1.5%

PRS 68.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Node Color (Target Cell CSI, relative to current network):
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- High
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- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [OXA1L](/details-gene/5018) is a protein-coding gene located on chromosome 14q11.2 that encodes the OXA1L mitochondrial inner membrane protein. This protein is a crucial component of the mitochondrial protein synthesis and insertion machinery, functioning as a membrane insertase that facilitates the integration of both mitochondrially and nuclear-encoded proteins into the mitochondrial inner membrane. Its function is essential for the assembly and maintenance of respiratory chain complexes, particularly complex I and ATP synthase, and it plays a key role in mitochondrial protein quality control. Reflecting its fundamental role in cellular energy metabolism, **Overall** expression data shows [OXA1L](/details-gene/5018) is highly significant in metabolically active cells and progenitor populations, including [common myeloid progenitor](/details-cell/CL0000049) and [intestinal epithelial cell](/details-cell/CL0002563). Mutations in [OXA1L](/details-gene/5018) are associated with severe mitochondrial encephalopathy and combined oxidative phosphorylation defects ([OMIM [601066](https://omim.org/entry/601066)]), underscoring its indispensable role in mitochondrial function ([Link](https://doi.org/10.15252/emmm.201809060)). ## Cellular Roles and Expression Landscape The expression profile of [OXA1L](/details-gene/5018) highlights its importance in cells characterized by high energy demands, rapid proliferation, or complex biosynthetic activities. **Overall**, the gene shows the highest significance in hematopoietic progenitor cells, such as [common myeloid progenitor](/details-cell/CL0000049) (CSI: 28.73), [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 25.64), and [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 25.38). This pattern suggests that robust mitochondrial biogenesis, mediated by [OXA1L](/details-gene/5018), is essential to support the energetic requirements of hematopoietic differentiation and lineage commitment. Beyond the hematopoietic system, [OXA1L](/details-gene/5018) is also a significant gene in highly active epithelial and secretory cells. Its high CSI in [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 25.67) and [pancreatic acinar cell](/details-cell/CL0002064) (CSI: 21.57) is consistent with the substantial metabolic activity required for nutrient absorption and the synthesis of digestive enzymes, respectively. Furthermore, its notable expression in various immune cells, including [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 20.94) and [Langerhans cell](/details-cell/CL0000453) (CSI: 17.44), indicates a critical role in maintaining mitochondrial function during immune surveillance and response. The widespread significance of [OXA1L](/details-gene/5018) across diverse, high-activity cell types underscores its fundamental housekeeping role in cellular bioenergetics. ## Pathways and Molecular Function [OXA1L](/details-gene/5018) is centrally involved in core mitochondrial processes, as detailed by its functional annotations. Its primary molecular function is [membrane insertase activity](/details-go/GO:0032977), where it acts as a translocase in the [mitochondrial inner membrane](/details-go/GO:0005743) to insert newly synthesized proteins from the [mitochondrial matrix](/details-go/GO:0005759). This function is integral to [mitochondrial translation](/details-go/GO:0032543) ([R-HSA-5368287](https://reactome.org/content/detail/R-HSA-5368287)), as [OXA1L](/details-gene/5018) interacts with mitochondrial ribosomes to co-translationally insert nascent polypeptide chains ([Link](https://doi.org/10.1074/jbc.m110.148262)). This insertase activity is essential for the biogenesis of the oxidative phosphorylation system. Specifically, [OXA1L](/details-gene/5018) is required for the assembly of [mitochondrial respiratory chain complex I](/details-go/GO:0032981) ([R-HSA-6799198](https://reactome.org/content/detail/R-HSA-6799198)) and the [mitochondrial proton-transporting ATP synthase complex](/details-go/GO:0033615). Experimental evidence demonstrates that knockdown of [OXA1L](/details-gene/5018) impairs the biogenesis of these crucial complexes, directly impacting [aerobic respiration](/details-go/GO:0009060) ([R-HSA-1428517](https://reactome.org/content/detail/R-HSA-1428517)) ([Link](https://doi.org/10.1016/j.jmb.2007.09.044)). More recent studies also implicate [OXA1L](/details-gene/5018) in [mitochondrial protein quality control](/details-go/GO:0141164), where it interacts with TMEM126A to manage stalled ribosomes during translation, preventing the accumulation of aberrant mitochondrial proteins ([Link](https://doi.org/10.1016/j.molcel.2023.12.013)). ## Research Directions The widespread and essential role of [OXA1L](/details-gene/5018) in mitochondrial function makes it a critical gene to study in contexts of high metabolic stress, cellular differentiation, and disease. **Proposed Hypotheses:** 1. Given its high significance in hematopoietic precursors like [common myeloid progenitor](/details-cell/CL0000049) and [hematopoietic stem cell](/details-cell/CL0000037), haploinsufficiency or subtle dysregulation of [OXA1L](/details-gene/5018) may lead to lineage skewing or bone marrow failure syndromes by selectively impairing the differentiation of the most energetically demanding hematopoietic lineages. 2. In cancers that are highly reliant on oxidative phosphorylation (OXPHOS), cancer cells may upregulate [OXA1L](/details-gene/5018) as a compensatory mechanism to meet increased demands for mitochondrial biogenesis. This dependency could represent a specific vulnerability in these tumors. **Experimental Approach:** To test the first hypothesis regarding hematopoietic differentiation, a suitable approach would be to generate a conditional knockout mouse model where *Oxa1l* is deleted specifically in the hematopoietic compartment (e.g., using a Vav1-Cre driver). The phenotype could be assessed by performing bone marrow transplants into irradiated recipients followed by serial complete blood counts and flow cytometric analysis of hematopoietic stem and progenitor cell populations. *In vitro* colony-forming unit assays using isolated progenitors would further reveal cell-autonomous defects in proliferation and differentiation into specific lineages. Single-cell RNA sequencing of the bone marrow from these mice could precisely map the differentiation blocks and metabolic reprogramming caused by the loss of *Oxa1l*. **Therapeutic Potential:** As a fundamental component of mitochondrial biogenesis, [OXA1L](/details-gene/5018) is unlikely to be a suitable target for therapeutic inhibition due to the high probability of severe, on-target toxicity in healthy tissues. Its clinical relevance is primarily in the context of loss-of-function mutations causing severe mitochondrial disease. Therefore, therapeutic strategies would likely focus on activation or restoration of function. For patients with [OXA1L](/details-gene/5018)-deficiency syndromes, gene replacement therapy using AAV vectors to deliver a functional copy of the gene to affected tissues could represent a potential long-term treatment strategy.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 968346786

Symbol: OXA1L_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q15070 A0A087X0L7 B4DPA2

Database IDs:

Citations:

PubMed ID: 7991568

Title: Cloning of a human gene involved in cytochrome oxidase assembly by functional complementation of an oxa1- mutation in Saccharomyces cerevisiae.

PubMed ID: 7991568

DOI: 10.1073/pnas.91.25.11978

PubMed ID: 9247084

Title: Sequence and structure of the human OXA1L gene and its upstream elements.

PubMed ID: 9247084

DOI: 10.1016/s0925-4439(97)00031-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17936786

Title: Knockdown of human Oxa1l impairs the biogenesis of F1Fo-ATP synthase and NADH:ubiquinone oxidoreductase.

PubMed ID: 17936786

DOI: 10.1016/j.jmb.2007.09.044

PubMed ID: 20601428

Title: Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes.

PubMed ID: 20601428

DOI: 10.1074/jbc.m110.148262

PubMed ID: 20739282

Title: Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L.

PubMed ID: 20739282

DOI: 10.1074/jbc.m110.163808

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30201738

Title: OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect.

PubMed ID: 30201738

DOI: 10.15252/emmm.201809060

PubMed ID: 38199007

Title: Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria.

PubMed ID: 38199007

DOI: 10.1016/j.molcel.2023.12.013

PubMed ID: 33243891

Title: Elongational stalling activates mitoribosome-associated quality control.

PubMed ID: 33243891

DOI: 10.1126/science.abc7782

PubMed ID: 33602856

Title: Mechanism of membrane-tethered mitochondrial protein synthesis.

PubMed ID: 33602856

DOI: 10.1126/science.abe0763

Sequence Information:

Length: 435
Mass: 48520
Checksum: B346B35346ACA675
Sequence:

MAMGLMCGRR ELLRLLQSGR RVHSVAGPSQ WLGKPLTTRL LFPAAPCCCR PHYLFLAASG 
PRSLSTSAIS FAEVQVQAPP VVAATPSPTA VPEVASGETA DVVQTAAEQS FAELGLGSYT 
PVGLIQNLLE FMHVDLGLPW WGAIAACTVF ARCLIFPLIV TGQREAARIH NHLPEIQKFS 
SRIREAKLAG DHIEYYKASS EMALYQKKHG IKLYKPLILP VTQAPIFISF FIALREMANL 
PVPSLQTGGL WWFQDLTVSD PIYILPLAVT ATMWAVLELG AETGVQSSDL QWMRNVIRMM 
PLITLPITMH FPTAVFMYWL SSNLFSLVQV SCLRIPAVRT VLKIPQRVVH DLDKLPPREG 
FLESFKKGWK NAEMTRQLRE REQRMRNQLE LAARGPLRQT FTHNPLLQPG KDNPPNIPSS 
SSKPKSKYPW HDTLG

Genular Protein ID: 1584135688

Symbol: J3KNA0_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KNA0

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

Length: 495
Mass: 55270
Checksum: 90D4CDD582F750B1
Sequence:

MVTWLYRFLP TSNMAAKLRS LLPPDLRLQF WLHARLQKCF LSRGCGSYCA GAKASPLPGK 
MAMGLMCGRR ELLRLLQSGR RVHSVAGPSQ WLGKPLTTRL LFPAAPCCCR PHYLFLAASG 
PRSLSTSAIS FAEVQVQAPP VVAATPSPTA VPEVASGETA DVVQTAAEQS FAELGLGSYT 
PVGLIQNLLE FMHVDLGLPW WGAIAACTVF ARCLIFPLIV TGQREAARIH NHLPEIQKFS 
SRIREAKLAG DHIEYYKASS EMALYQKKHG IKLYKPLILP VTQAPIFISF FIALREMANL 
PVPSLQTGGL WWFQDLTVSD PIYILPLAVT ATMWAVLELG AETGVQSSDL QWMRNVIRMM 
PLITLPITMH FPTAVFMYWL SSNLFSLVQV SCLRIPAVRT VLKIPQRVVH DLDKLPPREG 
FLESFKKGWK NAEMTRQLRE REQRMRNQLE LAARGPLRQT FTHNPLLQPG KDNPPNIPSS 
SSKPKSKYPW HDTLG

Genular Protein ID: 3665949509

Symbol: Q2M1J6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q2M1J6

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 496
Mass: 55385
Checksum: 8C46271F2083728A
Sequence:

MVTWLYRFLP TSNMAAKLRS LLPPDLRLQF WLHARLQKCF LSRGCGSYCA GAKASPLPGK 
MAMGLMCGRR ELLRLLQSGR RVHSVAGPSQ WLGKPLTTRL LFPVAPCCCR PHYLFLAASG 
PRSLSTSAIS FAEVQVQAPP VVAATPSPTA VPEVASGETA DVVQTAAEQS FAELGLGSYT 
PVGLIQNLLE FMHVDLGLPW WGAIAACTVF ARCLIFPLIV TGQREAARIH NHLPEIQKFS 
SRIREAKLAG DHIEYYKASS EMALYQKKHG IKLYKPLILP VTQAPIFISF FIALREMANL 
PVPSLQTGGL WWFQDLTVSD PIYILPLAVT ATMWAVLELG AETGVQSSDL QWMRNVIRMM 
PLITLPITMH FPTAVFMYWL SSNLFSLVQV SCLRIPAVRT VLKIPQRVVH DLDKLPPREG 
FLESFKKGWK NAEMTRQLRE REQRMRNQLE LAARGPLRQT FTHNPLLQPG KDNPPNIPSS 
SSSKPKSKYP WHDTLG

Details for: OXA1L

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Cloning of a human gene involved in cytochrome oxidase assembly by functional complementation of an oxa1- mutation in Saccharomyces cerevisiae. PubMed ID: 7991568

Sequence and structure of the human OXA1L gene and its upstream elements. PubMed ID: 9247084

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Knockdown of human Oxa1l impairs the biogenesis of F1Fo-ATP synthase and NADH:ubiquinone oxidoreductase. PubMed ID: 17936786

Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. PubMed ID: 20601428

Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L. PubMed ID: 20739282

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. PubMed ID: 30201738

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria. PubMed ID: 38199007

Elongational stalling activates mitoribosome-associated quality control. PubMed ID: 33243891

Mechanism of membrane-tethered mitochondrial protein synthesis. PubMed ID: 33602856

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and analysis of human chromosome 14. PubMed ID: 12508121

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

PubMed ID: 7991568

PubMed ID: 9247084

PubMed ID: 14702039

PubMed ID: 12508121

PubMed ID: 15489334

PubMed ID: 17936786

PubMed ID: 20601428

PubMed ID: 20739282

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 25944712

PubMed ID: 30201738

PubMed ID: 38199007

PubMed ID: 33243891

PubMed ID: 33602856

PubMed ID: 11237011

PubMed ID: 12508121

PubMed ID: 15496913

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 25944712

PubMed ID: 15489334