Details for: PAFAH1B2

Gene ID: 5049

Symbol: PAFAH1B2

Ensembl ID: ENSG00000168092

Description: platelet activating factor acetylhydrolase 1b catalytic subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.5621
    Cell Significance Index: -45.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 182.1455
    Cell Significance Index: -46.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 107.8533
    Cell Significance Index: -50.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.6290
    Cell Significance Index: -42.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 92.2849
    Cell Significance Index: -47.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.3156
    Cell Significance Index: -42.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 40.5043
    Cell Significance Index: -49.9400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.9031
    Cell Significance Index: -47.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.0156
    Cell Significance Index: -51.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7692
    Cell Significance Index: -39.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.9790
    Cell Significance Index: -21.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3494
    Cell Significance Index: 36.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1999
    Cell Significance Index: 240.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0854
    Cell Significance Index: 133.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0634
    Cell Significance Index: 191.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0138
    Cell Significance Index: 27.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9311
    Cell Significance Index: 71.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7170
    Cell Significance Index: 98.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7129
    Cell Significance Index: 255.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6823
    Cell Significance Index: 35.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6798
    Cell Significance Index: 134.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6750
    Cell Significance Index: 50.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6743
    Cell Significance Index: 368.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6391
    Cell Significance Index: 33.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6387
    Cell Significance Index: 121.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6289
    Cell Significance Index: 21.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5925
    Cell Significance Index: 38.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5735
    Cell Significance Index: 253.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5299
    Cell Significance Index: 24.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5218
    Cell Significance Index: 15.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4936
    Cell Significance Index: 13.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3845
    Cell Significance Index: 18.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3303
    Cell Significance Index: 228.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3158
    Cell Significance Index: 40.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2835
    Cell Significance Index: 20.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2834
    Cell Significance Index: 7.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2281
    Cell Significance Index: 12.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2227
    Cell Significance Index: 15.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1960
    Cell Significance Index: 9.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1933
    Cell Significance Index: 19.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1890
    Cell Significance Index: 32.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1636
    Cell Significance Index: 147.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1396
    Cell Significance Index: 7.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1353
    Cell Significance Index: 17.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0339
    Cell Significance Index: 21.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0335
    Cell Significance Index: 63.0900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0304
    Cell Significance Index: 0.2800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0283
    Cell Significance Index: 0.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0182
    Cell Significance Index: 0.6400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0099
    Cell Significance Index: 15.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0092
    Cell Significance Index: 17.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0013
    Cell Significance Index: 1.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0162
    Cell Significance Index: -7.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0207
    Cell Significance Index: -15.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0321
    Cell Significance Index: -24.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0335
    Cell Significance Index: -2.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0460
    Cell Significance Index: -28.7600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0466
    Cell Significance Index: -5.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0535
    Cell Significance Index: -0.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0629
    Cell Significance Index: -35.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0797
    Cell Significance Index: -8.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1065
    Cell Significance Index: -7.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1185
    Cell Significance Index: -24.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1395
    Cell Significance Index: -2.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1424
    Cell Significance Index: -2.4400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1459
    Cell Significance Index: -17.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1505
    Cell Significance Index: -43.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1663
    Cell Significance Index: -10.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1882
    Cell Significance Index: -27.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2011
    Cell Significance Index: -22.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2286
    Cell Significance Index: -26.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2487
    Cell Significance Index: -6.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2547
    Cell Significance Index: -5.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3328
    Cell Significance Index: -4.5400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3555
    Cell Significance Index: -5.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3623
    Cell Significance Index: -7.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4147
    Cell Significance Index: -43.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4280
    Cell Significance Index: -7.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5065
    Cell Significance Index: -40.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5107
    Cell Significance Index: -7.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5547
    Cell Significance Index: -24.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5678
    Cell Significance Index: -4.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5785
    Cell Significance Index: -16.5100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6344
    Cell Significance Index: -13.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6899
    Cell Significance Index: -26.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7098
    Cell Significance Index: -43.5200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7603
    Cell Significance Index: -24.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7641
    Cell Significance Index: -16.7300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7699
    Cell Significance Index: -22.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8193
    Cell Significance Index: -4.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8267
    Cell Significance Index: -21.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8273
    Cell Significance Index: -19.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9463
    Cell Significance Index: -10.7500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9939
    Cell Significance Index: -25.3900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.0204
    Cell Significance Index: -6.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0362
    Cell Significance Index: -30.5200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0471
    Cell Significance Index: -38.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.0677
    Cell Significance Index: -22.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0880
    Cell Significance Index: -34.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PAFAH1B2 is a catalytic subunit of the platelet-activating factor acetylhydrolase (PAF-AH) complex, which is responsible for the hydrolysis of PAF. This enzyme is expressed in various cell types, including peripheral nervous system neurons, glandular epithelial cells, and immune cells. The PAFAH1B2 gene is highly conserved across species, suggesting its critical role in maintaining cellular homeostasis. Notably, PAFAH1B2 is also involved in the regulation of lipid metabolism, suggesting a broader functional scope beyond PAF degradation. **Pathways and Functions:** PAFAH1B2 is integrated into multiple signaling pathways that regulate immune responses, cellular trafficking, and lipid metabolism. The most notable pathways involve: 1. **Immune system regulation**: PAFAH1B2 modulates the activity of PAF, which in turn influences the recruitment of immune cells, including neutrophils and macrophages, to sites of inflammation. 2. **Lipid catabolic process**: PAFAH1B2 is involved in the degradation of PAF, which is a potent lipid mediator that regulates inflammation and immune responses. 3. **Membrane trafficking**: PAFAH1B2 is required for the proper functioning of the Golgi apparatus and the regulation of vesicle-mediated transport, which is essential for the secretion of immune-related molecules. 4. **Protein heterodimerization and homodimerization**: PAFAH1B2 interacts with other proteins to form heterodimers and homodimers, which regulate the activity of PAF and other signaling molecules. **Clinical Significance:** Dysregulation of PAFAH1B2 has been implicated in various human diseases, including: 1. **Inflammatory disorders**: Altered PAF levels and PAFAH1B2 activity have been linked to conditions such as asthma, rheumatoid arthritis, and multiple sclerosis. 2. **Neurological disorders**: PAFAH1B2 dysfunction has been associated with neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer**: PAFAH1B2 expression has been altered in various types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumorigenesis and metastasis. In conclusion, PAFAH1B2 is a multifunctional gene that plays a critical role in immune regulation, lipid metabolism, and membrane trafficking. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms underlying PAFAH1B2 function and its implications for human health and disease.

Genular Protein ID: 3549328308

Symbol: PA1B2_HUMAN

Name: PAF acetylhydrolase 30 kDa subunit

UniProtKB Accession Codes:

P68402 A8DPS5 A8DPS6 A8DPS7 E9PEJ5 E9PLP3 O00687 Q29459 Q6IBR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 14 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9144386

Title: Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I).

PubMed ID: 9144386

DOI: 10.1006/bbrc.1997.6383

PubMed ID: 18155631

Title: Novel isoforms of intracellular platelet activating factor acetylhydrolase (PAFAH1b2) in human testis; encoded by alternatively spliced mRNAs.

PubMed ID: 18155631

DOI: 10.1016/j.prostaglandins.2007.10.005

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15572112

Title: Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.

PubMed ID: 15572112

DOI: 10.1016/j.neuron.2004.11.019

Sequence Information:

  • Length: 229
  • Mass: 25569
  • Checksum: 14CF5D48621AA504
  • Sequence:
    • MSQGDSNPAA IPHAAEDIQG DDRWMSQHNR FVLDCKDKEP DVLFVGDSMV QLMQQYEIWR 
ELFSPLHALN FGIGGDTTRH VLWRLKNGEL ENIKPKVIVV WVGTNNHENT AEEVAGGIEA 
IVQLINTRQP QAKIIVLGLL PRGEKPNPLR QKNAKVNQLL KVSLPKLANV QLLDTDGGFV 
HSDGAISCHD MFDFLHLTGG GYAKICKPLH ELIMQLLEET PEEKQTTIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.