Details for: PAFAH1B2
Gene ID: 5049
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PAFAH1B2
Ensembl ID: ENSG00000168092
Description: platelet activating factor acetylhydrolase 1b catalytic subunit 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 19.03rCSI 25.93%PRS 29.05
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CSI 12.77rCSI 15.8%PRS 30.15
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CSI 11.51rCSI 20.29%PRS 41.91
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CSI 10.5rCSI 7.89%PRS 36.27
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CSI 8.57rCSI 12.66%PRS 49.68
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CSI 8.04rCSI 18.02%PRS 22.03
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CSI 5.99rCSI 10.58%PRS 20.71
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CSI 5.62rCSI 9.11%PRS 33.05
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CSI 5.01rCSI 19.37%PRS 54.21
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CSI 4.66rCSI 5.81%PRS 44.57
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CSI 4.56rCSI 7.35%PRS 44.36
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CSI 4.13rCSI 7.06%PRS 59.84
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CSI 4.12rCSI 3.61%PRS 42.87
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CSI 4.04rCSI 6.46%PRS 36.64
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CSI 4.02rCSI 14.54%PRS 51.83
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CSI 3.92rCSI 3.57%PRS 48.07
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CSI 3.8rCSI 7.38%PRS 35.08
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CSI 3.77rCSI 16.77%PRS 32.46
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CSI 3.61rCSI 5.55%PRS 39.13
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CSI 3.61rCSI 17.29%PRS 31.7
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CSI 3.56rCSI 4.89%PRS 54.47
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CSI 3.54rCSI 5.42%PRS 42.03
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CSI 3.49rCSI 3.59%PRS 50.32
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CSI 3.47rCSI 2.78%PRS 54.24
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CSI 3.37rCSI 11.3%PRS 25.34
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CSI 3.27rCSI 1.93%PRS 46.36
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CSI 3.21rCSI 4.54%PRS 43.54
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CSI 3.2rCSI 2.22%PRS 40.51
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CSI 2.99rCSI 7.89%PRS 39.84
-
CSI 2.95rCSI 6.07%PRS 31.11
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CSI 2.85rCSI 3.58%PRS 46.79
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CSI 2.73rCSI 3.16%PRS 29.54
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CSI 2.7rCSI 3.96%PRS 35.29
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CSI 2.63rCSI 3.28%PRS 36.03
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CSI 2.62rCSI 14.11%PRS 50.21
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CSI 2.62rCSI 3.76%PRS 26.98
-
CSI 2.56rCSI 4.94%PRS 63.79
-
CSI 2.5rCSI 5.58%PRS 39.16
-
CSI 2.45rCSI 2.15%PRS 38.28
-
CSI 2.42rCSI 2.03%PRS 38.49
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CSI 2.32rCSI 1.92%PRS 34.29
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CSI 2.29rCSI 1.86%PRS 34.62
-
CSI 2.29rCSI 3.3%PRS 47.52
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CSI 2.26rCSI 3.25%PRS 43.45
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CSI 2.24rCSI 1.97%PRS 25.08
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CSI 2.21rCSI 1.49%PRS 41.92
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CSI 2.21rCSI 4.22%PRS 49.85
-
CSI 2.11rCSI 3.69%PRS 27.33
-
CSI 2.09rCSI 15.35%PRS 23.88
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CSI 2.04rCSI 1.87%PRS 39.7
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CSI 2.03rCSI 1.58%PRS 48.37
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CSI 1.99rCSI 3.03%PRS 34.02
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CSI 1.96rCSI 3.11%PRS 28.56
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CSI 1.94rCSI 5.76%PRS 44.38
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CSI 1.93rCSI 2.84%PRS 31.36
-
CSI 1.93rCSI 1.38%PRS 44.88
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CSI 1.91rCSI 2.47%PRS 22.16
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CSI 1.9rCSI 2.81%PRS 38.02
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CSI 1.86rCSI 4.24%PRS 33.24
-
CSI 1.84rCSI 2.24%PRS 40.71
-
CSI 1.83rCSI 2.5%PRS 37.67
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CSI 1.81rCSI 3.13%PRS 26.29
-
CSI 1.8rCSI 1.97%PRS 37.31
-
CSI 1.78rCSI 2.73%PRS 49.96
-
CSI 1.77rCSI 1.38%PRS 33.34
-
CSI 1.77rCSI 5.22%PRS 38.3
-
CSI 1.75rCSI 4.32%PRS 32.02
-
CSI 1.74rCSI 3.9%PRS 55.48
-
CSI 1.69rCSI 1.59%PRS 34.86
-
CSI 1.68rCSI 2.33%PRS 33.92
-
CSI 1.67rCSI 2.15%PRS 38.19
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CSI 1.67rCSI 6.49%PRS 52.7
-
CSI 1.66rCSI 3.29%PRS 34.03
-
CSI 1.64rCSI 6.14%PRS 28.72
-
CSI 1.63rCSI 1.42%PRS 41.67
-
CSI 1.61rCSI 2.9%PRS 28.5
-
CSI 1.6rCSI 1.54%PRS 34.6
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CSI 1.58rCSI 4.17%PRS 56.85
-
CSI 1.57rCSI 1.67%PRS 49.59
-
CSI 1.56rCSI 1.46%PRS 33.53
-
CSI 1.56rCSI 4.87%PRS 24.27
-
CSI 1.55rCSI 2.26%PRS 35.95
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CSI 1.53rCSI 3.26%PRS 48.55
-
CSI 1.52rCSI 3.06%PRS 25.64
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CSI 1.52rCSI 1.59%PRS 35.68
-
CSI 1.51rCSI 4.37%PRS 55.07
-
CSI 1.5rCSI 4.82%PRS 34.23
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CSI 1.49rCSI 2%PRS 41.28
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CSI 1.49rCSI 1.38%PRS 34.88
-
CSI 1.49rCSI 1.47%PRS 35.86
-
CSI 1.49rCSI 1.04%PRS 35.39
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CSI 1.49rCSI 3.87%PRS 32.92
-
CSI 1.48rCSI 1.17%PRS 23.85
-
CSI 1.47rCSI 2.76%PRS 25.66
-
CSI 1.47rCSI 4.06%PRS 31.68
-
CSI 1.47rCSI 2%PRS 36.38
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CSI 1.46rCSI 1.41%PRS 26
-
CSI 1.46rCSI 1.26%PRS 37.18
-
CSI 1.46rCSI 3.39%PRS 61.53
-
CSI 1.45rCSI 1.45%PRS 29.02
-
CSI 0.2rCSI 4.4%PRS 59.0%
-
CSI 0.2rCSI 4.4%PRS 21.7%
-
CSI 0.2rCSI 4.7%PRS 20.9%
-
CSI 0.2rCSI 2.4%PRS 51.0%
-
CSI 0.2rCSI 0.9%PRS 47.9%
-
CSI 0.3rCSI 1.5%PRS 60.4%
-
CSI 0.3rCSI 1.6%PRS 27.9%
-
CSI 0.3rCSI 1.6%PRS 22.6%
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CSI 0.3rCSI 0.7%PRS 25.5%
-
CSI 0.3rCSI 2.2%PRS 53.1%
-
CSI 0.3rCSI 0.8%PRS 49.6%
-
CSI 0.3rCSI 0.7%PRS 31.3%
-
CSI 0.3rCSI 1.7%PRS 43.9%
-
CSI 0.3rCSI 1.5%PRS 50.3%
-
CSI 0.3rCSI 2.0%PRS 45.1%
-
CSI 0.4rCSI 2.0%PRS 44.8%
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CSI 0.4rCSI 1.8%PRS 57.1%
-
CSI 0.4rCSI 1.3%PRS 42.4%
-
CSI 0.4rCSI 1.0%PRS 46.1%
-
CSI 0.4rCSI 2.5%PRS 44.9%
-
CSI 0.4rCSI 1.6%PRS 20.4%
-
CSI 0.5rCSI 1.3%PRS 31.6%
-
CSI 0.5rCSI 1.5%PRS 36.6%
-
CSI 0.5rCSI 2.7%PRS 57.2%
-
CSI 0.5rCSI 0.5%PRS 31.0%
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CSI 0.5rCSI 2.0%PRS 22.3%
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CSI 0.6rCSI 1.9%PRS 22.4%
-
CSI 0.6rCSI 1.5%PRS 39.4%
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CSI 0.6rCSI 0.9%PRS 41.6%
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CSI 0.7rCSI 1.4%PRS 41.4%
-
CSI 0.7rCSI 1.9%PRS 52.4%
-
CSI 0.7rCSI 3.2%PRS 37.3%
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CSI 0.7rCSI 1.1%PRS 26.5%
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CSI 0.7rCSI 4.9%PRS 63.7%
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CSI 0.7rCSI 2.3%PRS 45.3%
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CSI 0.7rCSI 1.0%PRS 32.2%
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CSI 0.7rCSI 2.3%PRS 68.1%
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CSI 0.7rCSI 1.6%PRS 24.7%
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CSI 0.7rCSI 1.1%PRS 37.9%
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CSI 0.7rCSI 3.2%PRS 29.3%
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CSI 0.7rCSI 2.0%PRS 42.3%
-
CSI 0.8rCSI 2.6%PRS 50.1%
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CSI 0.8rCSI 1.8%PRS 50.1%
-
CSI 0.8rCSI 1.2%PRS 26.4%
-
CSI 0.8rCSI 1.7%PRS 26.5%
-
CSI 0.8rCSI 1.2%PRS 34.9%
-
CSI 0.8rCSI 8.8%PRS 55.1%
-
CSI 0.8rCSI 0.7%PRS 34.0%
-
CSI 0.8rCSI 1.3%PRS 23.3%
-
CSI 0.8rCSI 0.6%PRS 38.1%
-
CSI 0.9rCSI 1.5%PRS 21.4%
-
CSI 0.9rCSI 1.2%PRS 46.3%
-
CSI 0.9rCSI 1.1%PRS 38.3%
-
CSI 0.9rCSI 1.5%PRS 42.8%
-
CSI 0.9rCSI 1.7%PRS 69.4%
-
CSI 0.9rCSI 1.4%PRS 28.9%
-
CSI 0.9rCSI 1.2%PRS 35.6%
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CSI 0.9rCSI 3.7%PRS 49.7%
-
CSI 0.9rCSI 1.8%PRS 42.3%
-
CSI 0.9rCSI 1.0%PRS 31.6%
-
CSI 1.0rCSI 2.3%PRS 20.8%
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CSI 1.0rCSI 0.7%PRS 32.1%
-
CSI 1.0rCSI 2.4%PRS 31.6%
-
CSI 1.0rCSI 1.4%PRS 48.5%
-
CSI 1.0rCSI 3.9%PRS 43.5%
-
CSI 1.0rCSI 3.3%PRS 37.1%
-
CSI 1.0rCSI 1.5%PRS 43.3%
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CSI 1.0rCSI 2.4%PRS 36.9%
-
CSI 1.0rCSI 1.3%PRS 21.3%
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CSI 1.1rCSI 2.4%PRS 27.9%
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CSI 1.1rCSI 2.7%PRS 26.4%
-
CSI 1.1rCSI 1.6%PRS 39.6%
-
CSI 1.1rCSI 1.7%PRS 38.6%
-
CSI 1.1rCSI 1.9%PRS 32.0%
-
CSI 1.1rCSI 2.4%PRS 43.1%
-
CSI 1.1rCSI 1.6%PRS 36.3%
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CSI 1.1rCSI 6.2%PRS 22.7%
-
CSI 1.1rCSI 3.2%PRS 51.8%
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CSI 1.1rCSI 2.4%PRS 47.8%
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CSI 1.1rCSI 1.8%PRS 34.4%
-
CSI 1.2rCSI 2.6%PRS 37.5%
-
CSI 1.2rCSI 1.5%PRS 42.3%
-
CSI 1.2rCSI 1.8%PRS 31.3%
-
CSI 1.2rCSI 1.6%PRS 37.2%
-
CSI 1.2rCSI 3.4%PRS 27.2%
-
CSI 1.2rCSI 1.5%PRS 32.3%
-
CSI 1.2rCSI 4.8%PRS 33.3%
-
CSI 1.2rCSI 1.3%PRS 31.5%
-
CSI 1.2rCSI 3.2%PRS 47.0%
-
CSI 1.2rCSI 2.2%PRS 49.7%
-
CSI 1.2rCSI 1.3%PRS 39.1%
-
CSI 1.2rCSI 2.3%PRS 57.7%
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CSI 1.2rCSI 1.4%PRS 25.7%
-
CSI 1.2rCSI 1.5%PRS 40.1%
-
CSI 1.2rCSI 2.2%PRS 48.9%
-
CSI 1.2rCSI 5.0%PRS 32.7%
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CSI 1.2rCSI 3.2%PRS 31.0%
-
CSI 1.3rCSI 2.8%PRS 40.1%
-
CSI 1.3rCSI 1.5%PRS 32.4%
-
CSI 1.3rCSI 1.1%PRS 32.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3549328308
Symbol: PA1B2_HUMAN
Name: PAF acetylhydrolase 30 kDa subunit
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9144386
Title: Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I).
PubMed ID: 9144386
PubMed ID: 18155631
Title: Novel isoforms of intracellular platelet activating factor acetylhydrolase (PAFAH1b2) in human testis; encoded by alternatively spliced mRNAs.
PubMed ID: 18155631
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 15572112
Title: Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
PubMed ID: 15572112
Sequence Information:
- Length: 229
- Mass: 25569
- Checksum: 14CF5D48621AA504
- Sequence:
MSQGDSNPAA IPHAAEDIQG DDRWMSQHNR FVLDCKDKEP DVLFVGDSMV QLMQQYEIWR ELFSPLHALN FGIGGDTTRH VLWRLKNGEL ENIKPKVIVV WVGTNNHENT AEEVAGGIEA IVQLINTRQP QAKIIVLGLL PRGEKPNPLR QKNAKVNQLL KVSLPKLANV QLLDTDGGFV HSDGAISCHD MFDFLHLTGG GYAKICKPLH ELIMQLLEET PEEKQTTIA