Details for: MYEF2

Gene ID: 50804

Symbol: MYEF2

Ensembl ID: ENSG00000104177

Description: myelin expression factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 250.2166
    Cell Significance Index: -38.9200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 149.0478
    Cell Significance Index: -37.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.2479
    Cell Significance Index: -30.5700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.0086
    Cell Significance Index: -30.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.6800
    Cell Significance Index: -39.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9097
    Cell Significance Index: -36.5800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.6240
    Cell Significance Index: -10.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.9842
    Cell Significance Index: 167.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.6590
    Cell Significance Index: 32.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9767
    Cell Significance Index: 396.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8664
    Cell Significance Index: 669.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.8060
    Cell Significance Index: 113.8300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.5724
    Cell Significance Index: 12.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1959
    Cell Significance Index: 45.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.1855
    Cell Significance Index: 52.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0928
    Cell Significance Index: 73.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8067
    Cell Significance Index: 131.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7969
    Cell Significance Index: 86.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6838
    Cell Significance Index: 373.4300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6476
    Cell Significance Index: 447.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4678
    Cell Significance Index: 13.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4348
    Cell Significance Index: 392.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4056
    Cell Significance Index: 11.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3974
    Cell Significance Index: 748.2200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3929
    Cell Significance Index: 74.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3330
    Cell Significance Index: 19.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2871
    Cell Significance Index: 19.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2760
    Cell Significance Index: 21.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2720
    Cell Significance Index: 14.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2367
    Cell Significance Index: 10.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2250
    Cell Significance Index: 44.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2111
    Cell Significance Index: 134.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2107
    Cell Significance Index: 3.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1447
    Cell Significance Index: 1.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1421
    Cell Significance Index: 24.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1396
    Cell Significance Index: 6.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1172
    Cell Significance Index: 13.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1130
    Cell Significance Index: 208.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1038
    Cell Significance Index: 159.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0905
    Cell Significance Index: 123.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0771
    Cell Significance Index: 2.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0605
    Cell Significance Index: 5.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0533
    Cell Significance Index: 24.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0427
    Cell Significance Index: 1.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0292
    Cell Significance Index: 0.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0124
    Cell Significance Index: 9.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0011
    Cell Significance Index: 0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0003
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0100
    Cell Significance Index: -6.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0118
    Cell Significance Index: -8.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0432
    Cell Significance Index: -32.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0457
    Cell Significance Index: -25.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0600
    Cell Significance Index: -26.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0733
    Cell Significance Index: -9.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0786
    Cell Significance Index: -16.5500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0824
    Cell Significance Index: -1.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0844
    Cell Significance Index: -10.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1119
    Cell Significance Index: -32.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1161
    Cell Significance Index: -11.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1235
    Cell Significance Index: -1.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1287
    Cell Significance Index: -9.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1407
    Cell Significance Index: -3.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1493
    Cell Significance Index: -9.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1655
    Cell Significance Index: -5.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1698
    Cell Significance Index: -20.8800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1704
    Cell Significance Index: -1.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1784
    Cell Significance Index: -4.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1820
    Cell Significance Index: -21.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2113
    Cell Significance Index: -4.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2145
    Cell Significance Index: -22.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2200
    Cell Significance Index: -25.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2204
    Cell Significance Index: -30.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2344
    Cell Significance Index: -26.7600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3130
    Cell Significance Index: -3.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3562
    Cell Significance Index: -7.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3691
    Cell Significance Index: -29.2300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3793
    Cell Significance Index: -7.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4081
    Cell Significance Index: -13.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4088
    Cell Significance Index: -13.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4226
    Cell Significance Index: -11.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4321
    Cell Significance Index: -30.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4640
    Cell Significance Index: -14.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4934
    Cell Significance Index: -25.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5051
    Cell Significance Index: -26.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5125
    Cell Significance Index: -31.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5221
    Cell Significance Index: -32.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5624
    Cell Significance Index: -11.2900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5968
    Cell Significance Index: -7.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5979
    Cell Significance Index: -16.0200
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7179
    Cell Significance Index: -10.0700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.7346
    Cell Significance Index: -8.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7350
    Cell Significance Index: -25.7500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.7360
    Cell Significance Index: -18.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7554
    Cell Significance Index: -22.2500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.8005
    Cell Significance Index: -5.8200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.8122
    Cell Significance Index: -12.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8325
    Cell Significance Index: -18.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.8378
    Cell Significance Index: -18.1000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8623
    Cell Significance Index: -14.9100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8798
    Cell Significance Index: -8.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYEF2 is a transcription factor that belongs to the MYF family, which is known for its role in regulating cell differentiation and survival. The gene is characterized by its ability to bind to DNA, RNA, and proteins, influencing various cellular processes. The expression of MYEF2 is widespread, with significant levels found in cells of the hematopoietic system, nervous system, and epithelial tissues. This gene's expression is tightly regulated, suggesting that its dysregulation may contribute to various diseases. **Pathways and Functions:** MYEF2 is involved in several key pathways, including: 1. **Myelination:** MYEF2 plays a crucial role in the regulation of myelination, a process essential for the formation of myelin sheaths around axons in the nervous system. Dysregulation of MYEF2 may contribute to demyelinating diseases, such as multiple sclerosis. 2. **Immune responses:** MYEF2 is expressed in immune cells, including regulatory T cells and mast cells, suggesting its involvement in immune regulation and tolerance. 3. **Cell differentiation:** MYEF2 regulates the differentiation of various cell types, including hematopoietic cells, neurons, and epithelial cells. 4. **RNA binding:** MYEF2 interacts with RNA molecules, influencing the regulation of gene expression and translation. **Clinical Significance:** Dysregulation of MYEF2 has been implicated in various diseases, including: 1. **Multiple sclerosis:** MYEF2 mutations have been associated with demyelinating diseases, such as multiple sclerosis. 2. **Immunodeficiency disorders:** MYEF2 deficiency has been linked to immunodeficiency disorders, highlighting its importance in immune regulation. 3. **Neurological disorders:** MYEF2 expression has been altered in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer:** MYEF2 expression has been studied in various cancers, including leukemia and lymphoma, suggesting its potential role in tumorigenesis. In conclusion, MYEF2 is a multifunctional gene that plays a crucial role in regulating cellular processes, including myelination, immune responses, and cell differentiation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying MYEF2 function.

Genular Protein ID: 790608520

Symbol: MYEF2_HUMAN

Name: Myelin expression factor 2

UniProtKB Accession Codes:

Q9P2K5 A7MCZ9 C9J921 C9K0J4 Q6NUM5 Q7L388 Q7Z4B7 Q9H922 Q9NUQ1

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 600
  • Mass: 64122
  • Checksum: C965138A61B62DC3
  • Sequence:
    • MADANKAEVP GATGGDSPHL QPAEPPGEPR REPHPAEAEK QQPQHSSSSN GVKMENDESA 
KEEKSDLKEK STGSKKANRF HPYSKDKNSG AGEKKGPNRN RVFISNIPYD MKWQAIKDLM 
REKVGEVTYV ELFKDAEGKS RGCGVVEFKD EEFVKKALET MNKYDLSGRP LNIKEDPDGE 
NARRALQRTG GSFPGGHVPD MGSGLMNLPP SILNNPNIPP EVISNLQAGR LGSTIFVANL 
DFKVGWKKLK EVFSIAGTVK RADIKEDKDG KSRGMGTVTF EQAIEAVQAI SMFNGQFLFD 
RPMHVKMDDK SVPHEEYRSH DGKTPQLPRG LGGIGMGLGP GGQPISASQL NIGGVMGNLG 
PGGMGMDGPG FGGMNRIGGG IGFGGLEAMN SMGGFGGVGR MGELYRGAMT SSMERDFGRG 
DIGINQGFGD SFGRLGSAMI GGFAGRIGSS NMGPVGSGIS GGMGSMNSVT GGMGMGLDRM 
SSSFDRMGPG IGAILERSID MDRGFLSGPM GSGMRERIGS KGNQIFVRNL PFDLTWQKLK 
EKFSQCGHVM FAEIKMENGK SKGCGTVRFD SPESAEKACR IMNGIKISGR EIDVRLDRNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.