Details for: TAS2R4

Gene ID: 50832

Symbol: TAS2R4

Ensembl ID: ENSG00000127364

Description: taste 2 receptor member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.8948
    Cell Significance Index: -4.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.1357
    Cell Significance Index: -4.6000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 9.8460
    Cell Significance Index: -4.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.8201
    Cell Significance Index: -4.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.2012
    Cell Significance Index: -4.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3128
    Cell Significance Index: 18.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2787
    Cell Significance Index: 27.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2384
    Cell Significance Index: 215.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2291
    Cell Significance Index: 11.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2147
    Cell Significance Index: 23.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1800
    Cell Significance Index: 5.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1738
    Cell Significance Index: 7.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1467
    Cell Significance Index: 23.8600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1336
    Cell Significance Index: 1.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1197
    Cell Significance Index: 42.9500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1142
    Cell Significance Index: 7.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1038
    Cell Significance Index: 7.1800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0951
    Cell Significance Index: 1.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0795
    Cell Significance Index: 9.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0794
    Cell Significance Index: 15.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0692
    Cell Significance Index: 1.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0626
    Cell Significance Index: 2.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0469
    Cell Significance Index: 2.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0384
    Cell Significance Index: 26.5300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0315
    Cell Significance Index: 0.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0314
    Cell Significance Index: 3.6000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0196
    Cell Significance Index: 0.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0151
    Cell Significance Index: 0.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0141
    Cell Significance Index: 7.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0141
    Cell Significance Index: 1.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0138
    Cell Significance Index: 0.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0047
    Cell Significance Index: 0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0046
    Cell Significance Index: 0.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0043
    Cell Significance Index: 1.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0009
    Cell Significance Index: -0.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0019
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0026
    Cell Significance Index: -0.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0028
    Cell Significance Index: -0.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0030
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0050
    Cell Significance Index: -3.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0055
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0059
    Cell Significance Index: -4.5000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0067
    Cell Significance Index: -0.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0078
    Cell Significance Index: -2.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0080
    Cell Significance Index: -1.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0142
    Cell Significance Index: -1.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0161
    Cell Significance Index: -1.6400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0166
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0214
    Cell Significance Index: -4.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0230
    Cell Significance Index: -1.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0248
    Cell Significance Index: -3.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0287
    Cell Significance Index: -2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0327
    Cell Significance Index: -1.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0362
    Cell Significance Index: -0.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0375
    Cell Significance Index: -1.0000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0407
    Cell Significance Index: -0.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0410
    Cell Significance Index: -4.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0422
    Cell Significance Index: -3.1500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0454
    Cell Significance Index: -0.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0476
    Cell Significance Index: -3.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0596
    Cell Significance Index: -3.1300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0624
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0682
    Cell Significance Index: -0.5800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0702
    Cell Significance Index: -1.0500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0754
    Cell Significance Index: -3.9300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0764
    Cell Significance Index: -1.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0826
    Cell Significance Index: -2.8700
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0826
    Cell Significance Index: -1.0800
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0834
    Cell Significance Index: -0.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0919
    Cell Significance Index: -2.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1041
    Cell Significance Index: -2.4100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1085
    Cell Significance Index: -1.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1097
    Cell Significance Index: -3.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1187
    Cell Significance Index: -4.1600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1216
    Cell Significance Index: -1.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1221
    Cell Significance Index: -3.8900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1249
    Cell Significance Index: -3.6800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1305
    Cell Significance Index: -4.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1308
    Cell Significance Index: -5.3600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1361
    Cell Significance Index: -3.6500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1419
    Cell Significance Index: -1.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1424
    Cell Significance Index: -3.7500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1432
    Cell Significance Index: -2.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1458
    Cell Significance Index: -3.7300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1484
    Cell Significance Index: -2.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1503
    Cell Significance Index: -3.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1536
    Cell Significance Index: -4.1100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1564
    Cell Significance Index: -2.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1583
    Cell Significance Index: -3.3600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1583
    Cell Significance Index: -3.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1585
    Cell Significance Index: -3.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1608
    Cell Significance Index: -4.6100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1612
    Cell Significance Index: -2.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1654
    Cell Significance Index: -3.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1671
    Cell Significance Index: -3.3600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1672
    Cell Significance Index: -4.9100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1672
    Cell Significance Index: -2.3800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1717
    Cell Significance Index: -2.1300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1730
    Cell Significance Index: -4.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Bitter Taste Receptor:** TAS2R4 is a member of the TAS2R family of bitter taste receptors, which are responsible for detecting bitter compounds in food and drinks. 2. **High Expression:** The TAS2R4 gene is highly expressed in various tissues, including the gut, colon, and bladder, suggesting a wide range of functions beyond taste perception. 3. **Cellular Distribution:** TAS2R4 is found in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, mucosal type mast cell, and intestinal crypt stem cell of colon. **Pathways and Functions:** 1. **Bitter Taste Receptor Activity:** TAS2R4 is a bitter taste receptor that detects bitter compounds in food and drinks, playing a crucial role in the perception of bitterness. 2. **G-Protein Coupled Receptor Signaling:** TAS2R4 is a G-protein coupled receptor (GPCR) that activates Gα(i) signaling events, leading to various downstream effects, including changes in ion channel activity and gene expression. 3. **Sensory Perception:** TAS2R4 is involved in the sensory perception of bitter taste, as well as other sensory perceptions, such as sweet, umami, and glutamate taste. 4. **Respiratory Function:** TAS2R4 is also expressed in the respiratory system, where it may play a role in the detection of gaseous exchange and the regulation of respiratory function. **Clinical Significance:** 1. **Bitter Taste Disorder:** Mutations in the TAS2R4 gene have been associated with bitter taste disorder, a condition characterized by impaired bitter taste perception. 2. **Gastrointestinal Disorders:** TAS2R4 may play a role in gastrointestinal disorders, such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), where altered bitter taste perception may contribute to symptom development. 3. **Cancer Research:** TAS2R4 is highly expressed in cancer cells, suggesting its potential role in cancer development and progression. 4. **Neurological Disorders:** TAS2R4 may also be involved in neurological disorders, such as Parkinson's disease, where altered bitter taste perception may contribute to disease progression. In conclusion, the TAS2R4 gene is a crucial component in bitter taste perception and beyond, with implications for various diseases and disorders. Further research is needed to fully elucidate the functions and clinical significance of this gene.

Genular Protein ID: 3389660025

Symbol: TA2R4_HUMAN

Name: Taste receptor type 2 member 4

UniProtKB Accession Codes:

Q9NYW5 Q645W5 Q75MV8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 3 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10761934

Title: A novel family of mammalian taste receptors.

PubMed ID: 10761934

DOI: 10.1016/s0092-8674(00)80705-9

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 10761935

Title: T2Rs function as bitter taste receptors.

PubMed ID: 10761935

DOI: 10.1016/s0092-8674(00)80706-0

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

PubMed ID: 19628819

Title: Motile cilia of human airway epithelia are chemosensory.

PubMed ID: 19628819

DOI: 10.1126/science.1173869

Sequence Information:

  • Length: 299
  • Mass: 33841
  • Checksum: 8265610092B19945
  • Sequence:
    • MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS LGITRFLMLG 
LFLVNTIYFV SSNTERSVYL SAFFVLCFMF LDSSSVWFVT LLNILYCVKI TNFQHSVFLL 
LKRNISPKIP RLLLACVLIS AFTTCLYITL SQASPFPELV TTRNNTSFNI SEGILSLVVS 
LVLSSSLQFI INVTSASLLI HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI 
PYSVATLVQY LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.