Details for: TAS2R14

Gene ID: 50840

Symbol: TAS2R14

Ensembl ID: ENSG00000212127

Description: taste 2 receptor member 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.0018
    Cell Significance Index: -4.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.0067
    Cell Significance Index: -4.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.5605
    Cell Significance Index: -4.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1252
    Cell Significance Index: -4.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9318
    Cell Significance Index: 177.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6123
    Cell Significance Index: 38.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5943
    Cell Significance Index: 58.7900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4788
    Cell Significance Index: 432.3400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.4176
    Cell Significance Index: 3.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3823
    Cell Significance Index: 22.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3706
    Cell Significance Index: 40.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3132
    Cell Significance Index: 50.9400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3076
    Cell Significance Index: 4.8800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3000
    Cell Significance Index: 4.2100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1935
    Cell Significance Index: 2.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1901
    Cell Significance Index: 13.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1734
    Cell Significance Index: 34.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1191
    Cell Significance Index: 5.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1066
    Cell Significance Index: 5.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0967
    Cell Significance Index: 34.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0954
    Cell Significance Index: 2.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0932
    Cell Significance Index: 10.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0914
    Cell Significance Index: 1.9800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0581
    Cell Significance Index: 1.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0564
    Cell Significance Index: 4.3300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0551
    Cell Significance Index: 0.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0542
    Cell Significance Index: 7.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0456
    Cell Significance Index: 24.9200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0452
    Cell Significance Index: 0.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0433
    Cell Significance Index: 2.4300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0429
    Cell Significance Index: 0.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0282
    Cell Significance Index: 1.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0279
    Cell Significance Index: 1.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0133
    Cell Significance Index: 0.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0128
    Cell Significance Index: 5.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0126
    Cell Significance Index: 2.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0100
    Cell Significance Index: 0.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0095
    Cell Significance Index: 0.5000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0075
    Cell Significance Index: 0.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0066
    Cell Significance Index: 0.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0037
    Cell Significance Index: 0.1300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0023
    Cell Significance Index: -0.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0028
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0034
    Cell Significance Index: -2.4600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0043
    Cell Significance Index: -2.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0044
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0084
    Cell Significance Index: -0.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0087
    Cell Significance Index: -1.0700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0126
    Cell Significance Index: -0.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0126
    Cell Significance Index: -0.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0132
    Cell Significance Index: -0.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0143
    Cell Significance Index: -2.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0155
    Cell Significance Index: -0.3300
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0164
    Cell Significance Index: -0.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0167
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0189
    Cell Significance Index: -3.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0201
    Cell Significance Index: -2.9200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0209
    Cell Significance Index: -1.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0238
    Cell Significance Index: -2.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0305
    Cell Significance Index: -0.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0308
    Cell Significance Index: -3.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0309
    Cell Significance Index: -3.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0345
    Cell Significance Index: -1.6200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0350
    Cell Significance Index: -0.2700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0466
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0479
    Cell Significance Index: -3.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0494
    Cell Significance Index: -1.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0502
    Cell Significance Index: -1.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0574
    Cell Significance Index: -4.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0593
    Cell Significance Index: -1.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0682
    Cell Significance Index: -2.0100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0707
    Cell Significance Index: -1.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0711
    Cell Significance Index: -1.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0722
    Cell Significance Index: -2.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0730
    Cell Significance Index: -1.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0735
    Cell Significance Index: -2.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0777
    Cell Significance Index: -2.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0794
    Cell Significance Index: -1.3600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0814
    Cell Significance Index: -1.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0824
    Cell Significance Index: -1.7800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0831
    Cell Significance Index: -1.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0836
    Cell Significance Index: -0.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0895
    Cell Significance Index: -1.1100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0962
    Cell Significance Index: -2.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0964
    Cell Significance Index: -1.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0981
    Cell Significance Index: -2.5800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1039
    Cell Significance Index: -1.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1047
    Cell Significance Index: -3.0000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1059
    Cell Significance Index: -0.9000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1069
    Cell Significance Index: -2.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1081
    Cell Significance Index: -3.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1127
    Cell Significance Index: -2.2000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1155
    Cell Significance Index: -2.3500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1207
    Cell Significance Index: -1.3900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1227
    Cell Significance Index: -1.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TAS2R14 is a member of the taste receptor family, specifically a bitter taste receptor. It belongs to the class C/3 (metabotropic glutamate/pheromone receptors) and is involved in the detection of chemical stimuli involved in sensory perception of bitter taste. The gene is significantly expressed in various cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, orthochromatic erythroblast, stromal cell of bone marrow, enteroendocrine cell of colon, eye photoreceptor cell, colon goblet cell, tuft cell of colon, endothelial cell of hepatic sinusoid, and gut absorptive cell. **Pathways and Functions:** TAS2R14 is activated by a range of bitter compounds, including glucosinolates, which are found in cruciferous vegetables. Upon activation, TAS2R14 triggers a signaling cascade that involves Gαi protein-coupled receptor activity, G protein-coupled receptor signaling pathway, and membrane-bound signaling events. The receptor's activation leads to an increase in intracellular calcium levels, which in turn modulates various cellular processes, including gene expression and cell proliferation. **Clinical Significance:** TAS2R14 plays a crucial role in our ability to perceive bitter taste, which is essential for maintaining a healthy diet and avoiding toxic substances. Variations in the TAS2R14 gene have been associated with differences in bitter taste perception, with some individuals being more sensitive to certain bitter compounds. Additionally, TAS2R14 has been implicated in various diseases, including cancer, where altered taste perception can contribute to the development and progression of the disease. Furthermore, research has shown that TAS2R14 may play a role in the development of certain neurological disorders, such as Parkinson's disease and Alzheimer's disease, where impaired taste perception is a common symptom. **Conclusion:** In conclusion, TAS2R14 is a vital gene that plays a crucial role in our ability to perceive bitter taste. Its activation triggers a signaling cascade that modulates various cellular processes, including gene expression and cell proliferation. Variations in the TAS2R14 gene have been associated with differences in bitter taste perception, and the receptor has been implicated in various diseases, including cancer and neurological disorders. Further research is needed to fully understand the role of TAS2R14 in human health and disease, but it is clear that this gene is an essential component of our taste perception machinery. **Future Directions:** Future research should focus on the following areas: 1. Elucidating the molecular mechanisms underlying TAS2R14-mediated bitter taste perception. 2. Investigating the role of TAS2R14 in various diseases, including cancer and neurological disorders. 3. Developing new therapeutic strategies that target TAS2R14 to improve bitter taste perception and prevent disease. 4. Exploring the potential of TAS2R14 as a biomarker for disease diagnosis and monitoring. By advancing our understanding of TAS2R14, we can gain insights into the complex mechanisms of taste perception and its relationship to human health and disease.

Genular Protein ID: 3971320798

Symbol: T2R14_HUMAN

Name: Taste receptor type 2 member 14

UniProtKB Accession Codes:

Q9NYV8 Q645X3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 6 EMDB 2 Ensembl 3 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10761934

Title: A novel family of mammalian taste receptors.

PubMed ID: 10761934

DOI: 10.1016/s0092-8674(00)80705-9

PubMed ID: 15496549

Title: Evolution of bitter taste receptors in humans and apes.

PubMed ID: 15496549

DOI: 10.1093/molbev/msi027

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10761935

Title: T2Rs function as bitter taste receptors.

PubMed ID: 10761935

DOI: 10.1016/s0092-8674(00)80706-0

PubMed ID: 12139982

Title: Receptors for bitter and sweet taste.

PubMed ID: 12139982

DOI: 10.1016/s0959-4388(02)00345-8

PubMed ID: 11696554

Title: Molecular mechanisms of bitter and sweet taste transduction.

PubMed ID: 11696554

DOI: 10.1074/jbc.r100054200

PubMed ID: 12581520

Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.

PubMed ID: 12581520

DOI: 10.1016/s0092-8674(03)00071-0

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16720576

Title: Members of RTP and REEP gene families influence functional bitter taste receptor expression.

PubMed ID: 16720576

DOI: 10.1074/jbc.m513637200

Sequence Information:

  • Length: 317
  • Mass: 36160
  • Checksum: C79184343D679BE5
  • Sequence:
    • MGGVIKSIFT FVLIVEFIIG NLGNSFIALV NCIDWVKGRK ISSVDRILTA LAISRISLVW 
LIFGSWCVSV FFPALFATEK MFRMLTNIWT VINHFSVWLA TGLGTFYFLK IANFSNSIFL 
YLKWRVKKVV LVLLLVTSVF LFLNIALINI HINASINGYR RNKTCSSDSS NFTRFSSLIV 
LTSTVFIFIP FTLSLAMFLL LIFSMWKHRK KMQHTVKISG DASTKAHRGV KSVITFFLLY 
AIFSLSFFIS VWTSERLEEN LIILSQVMGM AYPSCHSCVL ILGNKKLRQA SLSVLLWLRY 
MFKDGEPSGH KEFRESS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.