Details for: CDON

Gene ID: 50937

Symbol: CDON

Ensembl ID: ENSG00000064309

Description: cell adhesion associated, oncogene regulated

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.7082
    Cell Significance Index: -23.5900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.0232
    Cell Significance Index: -31.6600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1906
    Cell Significance Index: -11.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.1488
    Cell Significance Index: 100.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.8271
    Cell Significance Index: 102.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6756
    Cell Significance Index: 336.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1187
    Cell Significance Index: 222.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0001
    Cell Significance Index: 37.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9773
    Cell Significance Index: 59.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.9054
    Cell Significance Index: 60.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9018
    Cell Significance Index: 39.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8864
    Cell Significance Index: 19.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6804
    Cell Significance Index: 244.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5616
    Cell Significance Index: 15.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5425
    Cell Significance Index: 11.6000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5261
    Cell Significance Index: 16.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4113
    Cell Significance Index: 284.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4032
    Cell Significance Index: 6.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3707
    Cell Significance Index: 7.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3685
    Cell Significance Index: 4.5700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3671
    Cell Significance Index: 10.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3411
    Cell Significance Index: 216.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2664
    Cell Significance Index: 50.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1823
    Cell Significance Index: 164.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1509
    Cell Significance Index: 14.9300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1260
    Cell Significance Index: 232.3300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1077
    Cell Significance Index: 1.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0893
    Cell Significance Index: 5.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0617
    Cell Significance Index: 116.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0516
    Cell Significance Index: 8.4000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0511
    Cell Significance Index: 22.6100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0473
    Cell Significance Index: 0.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0117
    Cell Significance Index: -5.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0228
    Cell Significance Index: -30.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0287
    Cell Significance Index: -15.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0354
    Cell Significance Index: -26.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0373
    Cell Significance Index: -1.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0376
    Cell Significance Index: -27.5500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0401
    Cell Significance Index: -30.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0448
    Cell Significance Index: -8.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0491
    Cell Significance Index: -7.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0587
    Cell Significance Index: -36.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0589
    Cell Significance Index: -33.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0680
    Cell Significance Index: -7.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0806
    Cell Significance Index: -2.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0865
    Cell Significance Index: -3.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0882
    Cell Significance Index: -10.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0885
    Cell Significance Index: -25.4600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.1230
    Cell Significance Index: -0.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1313
    Cell Significance Index: -6.6400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1555
    Cell Significance Index: -1.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1598
    Cell Significance Index: -21.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1645
    Cell Significance Index: -21.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1725
    Cell Significance Index: -36.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1814
    Cell Significance Index: -3.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1884
    Cell Significance Index: -21.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2061
    Cell Significance Index: -35.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2062
    Cell Significance Index: -15.8300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2094
    Cell Significance Index: -14.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2236
    Cell Significance Index: -3.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2266
    Cell Significance Index: -29.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2318
    Cell Significance Index: -23.6800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2360
    Cell Significance Index: -5.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2424
    Cell Significance Index: -15.2800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2437
    Cell Significance Index: -7.7600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2446
    Cell Significance Index: -3.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2448
    Cell Significance Index: -28.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2607
    Cell Significance Index: -15.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2648
    Cell Significance Index: -31.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2744
    Cell Significance Index: -28.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2764
    Cell Significance Index: -19.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3097
    Cell Significance Index: -10.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3136
    Cell Significance Index: -23.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3516
    Cell Significance Index: -27.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3536
    Cell Significance Index: -7.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3548
    Cell Significance Index: -7.3600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.3569
    Cell Significance Index: -2.6000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3732
    Cell Significance Index: -7.3800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3984
    Cell Significance Index: -20.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3992
    Cell Significance Index: -10.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4154
    Cell Significance Index: -8.3400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4236
    Cell Significance Index: -6.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4384
    Cell Significance Index: -5.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4473
    Cell Significance Index: -23.4900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4524
    Cell Significance Index: -5.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4614
    Cell Significance Index: -23.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4735
    Cell Significance Index: -30.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5049
    Cell Significance Index: -23.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5312
    Cell Significance Index: -8.0100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5492
    Cell Significance Index: -19.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5645
    Cell Significance Index: -14.0800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5677
    Cell Significance Index: -8.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6038
    Cell Significance Index: -15.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6093
    Cell Significance Index: -28.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6551
    Cell Significance Index: -9.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6673
    Cell Significance Index: -7.2700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6832
    Cell Significance Index: -23.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDON is a cell surface protein that belongs to the immunoglobulin superfamily, characterized by its ability to facilitate cell-cell adhesion, particularly in epithelial and neural tissues. Its expression is widespread, with significantly elevated levels detected in various cell types, including ciliated cells of the bronchus, stromal cells of bone marrow, and neurons. Notably, CDON's expression is often down-regulated in neoplastic cells, suggesting its potential as a tumor suppressor. **Pathways and Functions:** CDON's involvement in multiple signaling pathways underscores its versatility and complexity. Key pathways include: 1. **Smoothened signaling pathway:** CDON's interaction with Smoothened (Smo) suggests a role in Hedgehog signaling, which regulates embryonic development, cell fate specification, and tissue homeostasis. 2. **Cell-cell adhesion:** CDON's ability to mediate adhesion between cells facilitates tissue organization and maintains tissue architecture. 3. **Cell fate specification:** CDON's involvement in anterior/posterior pattern specification and lens development in the camera-type eye underscores its role in regulating cell fate decisions. 4. **Neurogenesis and neuron differentiation:** CDON's expression in neurons and its interaction with signaling pathways involved in neurogenesis and neuron differentiation highlight its potential role in neural development and maintenance. **Clinical Significance:** CDON's dysregulation has been implicated in various cancers, including lung, breast, and colon carcinomas. Its down-regulation in neoplastic cells suggests that CDON may act as a tumor suppressor, preventing the uncontrolled proliferation and tumor formation characteristic of cancer. Furthermore, CDON's involvement in Hedgehog signaling pathways, which are frequently dysregulated in cancer, underscores its potential as a therapeutic target. In conclusion, CDON's complex role in cellular biology and disease highlights the need for further research into its mechanisms of action and its potential as a therapeutic target. As an oncogene, CDON's dysregulation has significant implications for cancer development and progression, and its involvement in various signaling pathways underscores its potential as a multifaceted therapeutic target.

Genular Protein ID: 2683834753

Symbol: CDON_HUMAN

Name: Cell adhesion molecule-related/down-regulated by oncogenes

UniProtKB Accession Codes:

Q4KMG0 O14631

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 22 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 7 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 8 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9214393

Title: CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family.

PubMed ID: 9214393

DOI: 10.1083/jcb.138.1.203

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18794898

Title: The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla.

PubMed ID: 18794898

DOI: 10.1038/nature07358

PubMed ID: 20519495

Title: All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.

PubMed ID: 20519495

DOI: 10.1074/jbc.m110.131680

PubMed ID: 21802063

Title: Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors.

PubMed ID: 21802063

DOI: 10.1016/j.ajhg.2011.07.001

Sequence Information:

  • Length: 1287
  • Mass: 139147
  • Checksum: B7870C66F5224BBE
  • Sequence:
    • MHPDLGPLCT LLYVTLTILC SSVSSDLAPY FTSEPLSAVQ KLGGPVVLHC SAQPVTTRIS 
WLHNGKTLDG NLEHVKIHQG TLTILSLNSS LLGYYQCLAN NSIGAIVSGP ATVSVAVLGD 
FGSSTKHVIT AEEKSAGFIG CRVPESNPKA EVRYKIRGKW LEHSTENYLI LPSGNLQILN 
VSLEDKGSYK CAAYNPVTHQ LKVEPIGRKL LVSRPSSDDV HILHPTHSQA LAVLSRSPVT 
LECVVSGVPA PQVYWLKDGQ DIAPGSNWRR LYSHLATDSV DPADSGNYSC MAGNKSGDVK 
YVTYMVNVLE HASISKGLQD QIVSLGATVH FTCDVHGNPA PNCTWFHNAQ PIHPSARHLT 
AGNGLKISGV TVEDVGMYQC VADNGIGFMH STGRLEIEND GGFKPVIITA PVSAKVADGD 
FVTLSCNASG LPVPVIRWYD SHGLITSHPS QVLRSKSRKS QLSRPEGLNL EPVYFVLSQA 
GASSLHIQAV TQEHAGKYIC EAANEHGTTQ AEASLMVVPF ETNTKAETVT LPDAAQNDDR 
SKRDGSETGL LSSFPVKVHP SAVESAPEKN ASGISVPDAP IILSPPQTHT PDTYNLVWRA 
GKDGGLPINA YFVKYRKLDD GVGMLGSWHT VRVPGSENEL HLAELEPSSL YEVLMVARSA 
AGEGQPAMLT FRTSKEKTAS SKNTQASSPP VGIPKYPVVS EAANNNFGVV LTDSSRHSGV 
PEAPDRPTIS TASETSVYVT WIPRANGGSP ITAFKVEYKR MRTSNWLVAA EDIPPSKLSV 
EVRSLEPGST YKFRVIAINH YGESFRSSAS RPYQVVGFPN RFSSRPITGP HIAYTEAVSD 
TQIMLKWTYI PSSNNNTPIQ GFYIYYRPTD SDNDSDYKRD VVEGSKQWHM IGHLQPETSY 
DIKMQCFNEG GESEFSNVMI CETKVKRVPG ASEYPVKDLS TPPNSLGSGG NVGPATSPAR 
SSDMLYLIVG CVLGVMVLIL MVFIAMCLWK NRQQNTIQKY DPPGYLYQGS DMNGQMVDYT 
TLSGASQING NVHGGFLTNG GLSSGYSHLH HKVPNAVNGI VNGSLNGGLY SGHSNSLTRT 
HVDFEHPHHL VNGGGMYTAV PQIDPLECVN CRNCRNNNRC FTKTNSTFSS SPPPVVPVVA 
PYPQDGLEMK PLSHVKVPVC LTSAVPDCGQ LPEESVKDNV EPVPTQRTCC QDIVNDVSSD 
GSEDPAEFSR GQEGMINLRI PDHLQLAKSC VWEGDSCAHS ETEINIVSWN ALILPPVPEG 
CAEKTMWSPP GIPLDSPTEV LQQPRET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.