Details for: IMPG2

Gene ID: 50939

Symbol: IMPG2

Ensembl ID: ENSG00000081148

Description: interphotoreceptor matrix proteoglycan 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 51.4963
    Cell Significance Index: -8.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.5403
    Cell Significance Index: -8.0000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 12.4895
    Cell Significance Index: 175.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 12.0954
    Cell Significance Index: 144.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 10.7392
    Cell Significance Index: 676.8600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.3213
    Cell Significance Index: -6.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.5047
    Cell Significance Index: -8.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.4067
    Cell Significance Index: 32.5000
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.9703
    Cell Significance Index: 12.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4146
    Cell Significance Index: 6.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2738
    Cell Significance Index: 54.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2440
    Cell Significance Index: 87.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1987
    Cell Significance Index: 4.3500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1651
    Cell Significance Index: 2.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1449
    Cell Significance Index: 100.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1421
    Cell Significance Index: 4.5500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1398
    Cell Significance Index: 1.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0958
    Cell Significance Index: 6.4400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0921
    Cell Significance Index: 0.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0893
    Cell Significance Index: 14.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0789
    Cell Significance Index: 4.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0732
    Cell Significance Index: 5.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0589
    Cell Significance Index: 4.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0530
    Cell Significance Index: 1.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0511
    Cell Significance Index: 3.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0462
    Cell Significance Index: 8.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0336
    Cell Significance Index: 0.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0292
    Cell Significance Index: 4.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0228
    Cell Significance Index: 4.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0050
    Cell Significance Index: 9.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0011
    Cell Significance Index: 0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0003
    Cell Significance Index: 0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0001
    Cell Significance Index: -0.1600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0028
    Cell Significance Index: -3.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0098
    Cell Significance Index: -5.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0106
    Cell Significance Index: -4.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0108
    Cell Significance Index: -3.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0115
    Cell Significance Index: -8.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0127
    Cell Significance Index: -7.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0224
    Cell Significance Index: -0.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0291
    Cell Significance Index: -0.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0342
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0389
    Cell Significance Index: -8.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0415
    Cell Significance Index: -5.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0432
    Cell Significance Index: -7.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0468
    Cell Significance Index: -0.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0481
    Cell Significance Index: -6.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0492
    Cell Significance Index: -0.7800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0545
    Cell Significance Index: -0.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0560
    Cell Significance Index: -2.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0594
    Cell Significance Index: -1.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0600
    Cell Significance Index: -1.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0610
    Cell Significance Index: -7.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0656
    Cell Significance Index: -7.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0694
    Cell Significance Index: -8.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0713
    Cell Significance Index: -7.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0729
    Cell Significance Index: -1.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0730
    Cell Significance Index: -5.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0741
    Cell Significance Index: -7.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0743
    Cell Significance Index: -7.5900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0912
    Cell Significance Index: -2.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0931
    Cell Significance Index: -1.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0977
    Cell Significance Index: -7.7400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0982
    Cell Significance Index: -1.4800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0994
    Cell Significance Index: -5.2200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1017
    Cell Significance Index: -3.3300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1029
    Cell Significance Index: -2.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1219
    Cell Significance Index: -5.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1229
    Cell Significance Index: -7.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1257
    Cell Significance Index: -5.8600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1278
    Cell Significance Index: -4.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1297
    Cell Significance Index: -2.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1300
    Cell Significance Index: -2.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1310
    Cell Significance Index: -4.8100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1317
    Cell Significance Index: -6.8600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1355
    Cell Significance Index: -1.6900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1424
    Cell Significance Index: -1.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1425
    Cell Significance Index: -7.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1443
    Cell Significance Index: -1.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1444
    Cell Significance Index: -5.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1463
    Cell Significance Index: -3.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1466
    Cell Significance Index: -2.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1550
    Cell Significance Index: -7.8300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1577
    Cell Significance Index: -3.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1577
    Cell Significance Index: -5.5400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1604
    Cell Significance Index: -4.0000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1648
    Cell Significance Index: -2.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1787
    Cell Significance Index: -3.8100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1811
    Cell Significance Index: -3.7800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1959
    Cell Significance Index: -2.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2031
    Cell Significance Index: -3.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2078
    Cell Significance Index: -5.0700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2169
    Cell Significance Index: -2.5300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2237
    Cell Significance Index: -2.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2283
    Cell Significance Index: -4.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Proteoglycan structure**: IMPG2 is a proteoglycan, consisting of a core protein and a long chain of covalently attached glycosaminoglycans (GAGs). This structure enables it to interact with other extracellular matrix components and facilitate cell-cell and cell-matrix interactions. 2. **Expression in photoreceptor cells**: IMPG2 is specifically expressed in photoreceptor cells, which are responsible for converting light into electrical signals that are transmitted to the brain, enabling vision. 3. **Significant expression in hematopoietic cells**: IMPG2 is also expressed in hematopoietic oligopotent progenitor cells, suggesting a potential role in the development and function of the hematopoietic system. 4. **Hyaluronic acid and heparin binding**: IMPG2 binds to hyaluronic acid and heparin, two key components of the extracellular matrix, facilitating its interaction with surrounding cells and matrix components. **Pathways and Functions** 1. **Extracellular matrix organization**: IMPG2 plays a crucial role in organizing the interphotoreceptor matrix, which is essential for maintaining the structural integrity of photoreceptor cells and facilitating cell-cell interactions. 2. **Protein localization**: IMPG2 influences the localization of proteins within the cell, including photoreceptor-specific proteins, which is critical for maintaining photoreceptor function and overall retinal health. 3. **Receptor complex formation**: IMPG2 interacts with other extracellular matrix components to form receptor complexes, which are essential for cell-cell interactions and signaling. 4. **Retina morphogenesis in camera-type eye**: IMPG2 is involved in the development and morphogenesis of the retina in camera-type eyes, highlighting its importance in retinal development and function. **Clinical Significance** 1. **Retinal degeneration**: Impaired IMPG2 expression has been linked to retinal degeneration, a condition characterized by progressive loss of photoreceptor cells and vision loss. 2. **Eye diseases**: Abnormalities in IMPG2 expression have been associated with various eye diseases, including age-related macular degeneration and retinitis pigmentosa. 3. **Hematopoietic disorders**: IMPG2 expression in hematopoietic cells suggests that abnormalities in this gene may contribute to hematopoietic disorders, such as anemia or leukemia. 4. **Therapeutic potential**: Understanding the role of IMPG2 in retinal and hematopoietic function may lead to the development of novel therapeutic strategies for treating retinal degeneration and other eye diseases. In conclusion, IMPG2 is a critical component of the interphotoreceptor matrix, playing a pivotal role in maintaining photoreceptor function and overall retinal health. Its involvement in various cellular processes and its significant expression in photoreceptor cells and hematopoietic cells highlight its importance in both retinal and hematopoietic function. Further research is needed to fully elucidate the role of IMPG2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1779747446

Symbol: IMPG2_HUMAN

Name: Interphotoreceptor matrix proteoglycan 2

UniProtKB Accession Codes:

Q9BZV3 A8MWT5 Q9UKD4 Q9UKK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 20 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10542133

Title: Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans.

PubMed ID: 10542133

DOI: 10.1006/mcbr.1999.0161

PubMed ID: 10702256

Title: SPACRCAN, a novel human interphotoreceptor matrix hyaluronan-binding proteoglycan synthesized by photoreceptors and pinealocytes.

PubMed ID: 10702256

DOI: 10.1074/jbc.275.10.6945

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 29777959

Title: Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

PubMed ID: 29777959

DOI: 10.1016/j.actbio.2018.05.023

PubMed ID: 11726612

Title: Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders.

PubMed ID: 11726612

PubMed ID: 20673862

Title: Mutations in IMPG2, encoding interphotoreceptor matrix proteoglycan 2, cause autosomal-recessive retinitis pigmentosa.

PubMed ID: 20673862

DOI: 10.1016/j.ajhg.2010.07.004

PubMed ID: 24876279

Title: IMPG2-associated retinitis pigmentosa displays relatively early macular involvement.

PubMed ID: 24876279

DOI: 10.1167/iovs.14-14129

PubMed ID: 25085631

Title: Frequency and clinical pattern of vitelliform macular dystrophy caused by mutations of interphotoreceptor matrix IMPG1 and IMPG2 genes.

PubMed ID: 25085631

DOI: 10.1016/j.ophtha.2014.06.028

PubMed ID: 28644393

Title: Mutations in the Genes for Interphotoreceptor Matrix Proteoglycans, IMPG1 and IMPG2, in Patients with Vitelliform Macular Lesions.

PubMed ID: 28644393

DOI: 10.3390/genes8070170

Sequence Information:

  • Length: 1241
  • Mass: 138621
  • Checksum: E72D7BFB84824078
  • Sequence:
    • MIMFPLFGKI SLGILIFVLI EGDFPSLTAQ TYLSIEEIQE PKSAVSFLLP EESTDLSLAT 
KKKQPLDRRE TERQWLIRRR RSILFPNGVK ICPDESVAEA VANHVKYFKV RVCQEAVWEA 
FRTFWDRLPG REEYHYWMNL CEDGVTSIFE MGTNFSESVE HRSLIMKKLT YAKETVSSSE 
LSSPVPVGDT STLGDTTLSV PHPEVDAYEG ASESSLERPE ESISNEIENV IEEATKPAGE 
QIAEFSIHLL GKQYREELQD SSSFHHQHLE EEFISEVENA FTGLPGYKEI RVLEFRSPKE 
NDSGVDVYYA VTFNGEAISN TTWDLISLHS NKVENHGLVE LDDKPTVVYT ISNFRDYIAE 
TLQQNFLLGN SSLNPDPDSL QLINVRGVLR HQTEDLVWNT QSSSLQATPS SILDNTFQAA 
WPSADESITS SIPPLDFSSG PPSATGRELW SESPLGDLVS THKLAFPSKM GLSSSPEVLE 
VSSLTLHSVT PAVLQTGLPV ASEERTSGSH LVEDGLANVE ESEDFLSIDS LPSSSFTQPV 
PKETIPSMED SDVSLTSSPY LTSSIPFGLD SLTSKVKDQL KVSPFLPDAS MEKELIFDGG 
LGSGSGQKVD LITWPWSETS SEKSAEPLSK PWLEDDDSLL PAEIEDKKLV LVDKMDSTDQ 
ISKHSKYEHD DRSTHFPEEE PLSGPAVPIF ADTAAESASL TLPKHISEVP GVDDYSVTKA 
PLILTSVAIS ASTDKSDQAD AILREDMEQI TESSNYEWFD SEVSMVKPDM QTLWTILPES 
ERVWTRTSSL EKLSRDILAS TPQSADRLWL SVTQSTKLPP TTISTLLEDE VIMGVQDISL 
ELDRIGTDYY QPEQVQEQNG KVGSYVEMST SVHSTEMVSV AWPTEGGDDL SYTQTSGALV 
VFFSLRVTNM MFSEDLFNKN SLEYKALEQR FLELLVPYLQ SNLTGFQNLE ILNFRNGSIV 
VNSRMKFANS VPPNVNNAVY MILEDFCTTA YNTMNLAIDK YSLDVESGDE ANPCKFQACN 
EFSECLVNPW SGEAKCRCFP GYLSVEERPC QSLCDLQPDF CLNDGKCDIM PGHGAICRCR 
VGENWWYRGK HCEEFVSEPV IIGITIASVV GLLVIFSAII YFFIRTLQAH HDRSERESPF 
SGSSRQPDSL SSIENAVKYN PVYESHRAGC EKYEGPYPQH PFYSSASGDV IGGLSREEIR 
QMYESSELSR EEIQERMRVL ELYANDPEFA AFVREQQVEE V

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.