Details for: PCDHGC3

Gene ID: 5098

Symbol: PCDHGC3

Ensembl ID: ENSG00000240184

Description: protocadherin gamma subfamily C, 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.4969
    Cell Significance Index: -11.5400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.6249
    Cell Significance Index: 34.8000
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 4.1788
    Cell Significance Index: 67.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9105
    Cell Significance Index: -11.4900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5694
    Cell Significance Index: 38.0200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7419
    Cell Significance Index: 11.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3874
    Cell Significance Index: 73.7300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1961
    Cell Significance Index: 19.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1631
    Cell Significance Index: 147.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1028
    Cell Significance Index: 16.7200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.1026
    Cell Significance Index: 1.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0876
    Cell Significance Index: 9.5300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0720
    Cell Significance Index: 4.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0671
    Cell Significance Index: 3.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0562
    Cell Significance Index: 1.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0518
    Cell Significance Index: 1.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0476
    Cell Significance Index: 0.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0454
    Cell Significance Index: 5.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0228
    Cell Significance Index: 1.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0214
    Cell Significance Index: 1.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0132
    Cell Significance Index: 4.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0080
    Cell Significance Index: 3.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0077
    Cell Significance Index: 0.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0057
    Cell Significance Index: 0.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0036
    Cell Significance Index: 0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0033
    Cell Significance Index: -0.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0064
    Cell Significance Index: -0.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0135
    Cell Significance Index: -7.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0136
    Cell Significance Index: -2.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0139
    Cell Significance Index: -0.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0149
    Cell Significance Index: -11.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.3100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0168
    Cell Significance Index: -0.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0183
    Cell Significance Index: -3.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0183
    Cell Significance Index: -0.4000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0185
    Cell Significance Index: -0.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0196
    Cell Significance Index: -5.6500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0207
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0277
    Cell Significance Index: -20.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0284
    Cell Significance Index: -17.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0333
    Cell Significance Index: -18.7900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0405
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0442
    Cell Significance Index: -5.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0516
    Cell Significance Index: -6.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0621
    Cell Significance Index: -1.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0630
    Cell Significance Index: -0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0646
    Cell Significance Index: -29.3100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0697
    Cell Significance Index: -2.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0714
    Cell Significance Index: -5.0500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0778
    Cell Significance Index: -0.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0812
    Cell Significance Index: -8.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0863
    Cell Significance Index: -11.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0899
    Cell Significance Index: -1.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0944
    Cell Significance Index: -5.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0978
    Cell Significance Index: -20.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0995
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0998
    Cell Significance Index: -17.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1008
    Cell Significance Index: -2.0900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1245
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1343
    Cell Significance Index: -15.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1396
    Cell Significance Index: -7.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1503
    Cell Significance Index: -11.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1510
    Cell Significance Index: -3.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1522
    Cell Significance Index: -2.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1617
    Cell Significance Index: -10.1900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1691
    Cell Significance Index: -9.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1981
    Cell Significance Index: -10.4000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2047
    Cell Significance Index: -9.6200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2221
    Cell Significance Index: -3.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2294
    Cell Significance Index: -6.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2406
    Cell Significance Index: -6.0000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2430
    Cell Significance Index: -5.3200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2493
    Cell Significance Index: -2.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2652
    Cell Significance Index: -6.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2670
    Cell Significance Index: -7.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2944
    Cell Significance Index: -10.2300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3101
    Cell Significance Index: -4.3500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3113
    Cell Significance Index: -5.2100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3244
    Cell Significance Index: -4.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3359
    Cell Significance Index: -8.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3487
    Cell Significance Index: -10.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3518
    Cell Significance Index: -9.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3518
    Cell Significance Index: -9.2500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.3592
    Cell Significance Index: -3.2600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3629
    Cell Significance Index: -3.4400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3753
    Cell Significance Index: -5.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3799
    Cell Significance Index: -4.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3872
    Cell Significance Index: -13.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3926
    Cell Significance Index: -12.8600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.3927
    Cell Significance Index: -3.5700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3933
    Cell Significance Index: -7.6900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4066
    Cell Significance Index: -3.9200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.4092
    Cell Significance Index: -5.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4108
    Cell Significance Index: -15.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4119
    Cell Significance Index: -13.1200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4180
    Cell Significance Index: -11.2000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4403
    Cell Significance Index: -8.9600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4504
    Cell Significance Index: -9.4000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4697
    Cell Significance Index: -12.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** PCDHGC3 is a protocadherin that belongs to the gamma subfamily of protocadherins. It is characterized by its small size (approximately 38 kDa) and its ability to form homophilic cell-cell adhesions through its extracellular domain. PCDHGC3 is also known to interact with other protocadherins and cell surface molecules, such as cadherins and selectins, to regulate cell-cell adhesion and signaling. The protein is highly expressed in the nervous system, where it plays a crucial role in the development and organization of synapses. **Pathways and Functions** PCDHGC3 is involved in several key pathways, including: 1. **Calcium-dependent cell-cell adhesion**: PCDHGC3 forms homophilic cell-cell adhesions through its extracellular domain, which is mediated by calcium ions. This process is essential for the maintenance of tissue structure and function. 2. **Nervous system development**: PCDHGC3 is highly expressed in the nervous system, where it plays a crucial role in the development and organization of synapses. It is also involved in the regulation of neuronal apoptosis and the maintenance of the blood-brain barrier. 3. **Synapse organization**: PCDHGC3 is involved in the organization of synapses, including the formation of synaptic terminals and the regulation of neurotransmitter release. 4. **Negative regulation of neuron apoptotic process**: PCDHGC3 has been shown to inhibit neuronal apoptosis, suggesting its role in the maintenance of neuronal health and function. **Clinical Significance** Dysregulation of PCDHGC3 has been implicated in several pathological conditions, including: 1. **Neurological disorders**: PCDHGC3 has been associated with neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Cancer**: PCDHGC3 has been found to be overexpressed in several types of cancer, including breast cancer, lung cancer, and colon cancer. 3. **Neurodevelopmental disorders**: PCDHGC3 has been implicated in neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, PCDHGC3 is a critical component of the protocadherin family, playing a key role in cell-cell adhesion, signaling, and nervous system development. Its dysregulation has been implicated in several pathological conditions, highlighting the importance of further research into the functions and mechanisms of PCDHGC3.

Genular Protein ID: 3982300798

Symbol: PCDGK_HUMAN

Name: Protocadherin gamma-C3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8508762

Title: Protocadherins: a large family of cadherin-related molecules in central nervous system.

PubMed ID: 8508762

DOI: 10.1002/j.1460-2075.1993.tb05878.x

PubMed ID: 9360932

Title: Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.

PubMed ID: 9360932

DOI: 10.1126/science.278.5341.1315

PubMed ID: 10380929

Title: A striking organization of a large family of human neural cadherin-like cell adhesion genes.

PubMed ID: 10380929

DOI: 10.1016/s0092-8674(00)80789-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 934
  • Mass: 101077
  • Checksum: 1C8E1EADD485AB10
  • Sequence:
  • MVPEAWRSGL VSTGRVVGVL LLLGALNKAS TVIHYEIPEE REKGFAVGNV VANLGLDLGS 
    LSARRFRVVS GASRRFFEVN RETGEMFVND RLDREELCGT LPSCTVTLEL VVENPLELFS 
    VEVVIQDIND NNPAFPTQEM KLEISEAVAP GTRFPLESAH DPDVGSNSLQ TYELSRNEYF 
    ALRVQTREDS TKYAELVLER ALDREREPSL QLVLTALDGG TPALSASLPI HIKVLDANDN 
    APVFNQSLYR ARVLEDAPSG TRVVQVLATD LDEGPNGEII YSFGSHNRAG VRQLFALDLV 
    TGMLTIKGRL DFEDTKLHEI YIQAKDKGAN PEGAHCKVLV EVVDVNDNAP EITVTSVYSP 
    VPEDAPLGTV IALLSVTDLD AGENGLVTCE VPPGLPFSLT SSLKNYFTLK TSADLDRETV 
    PEYNLSITAR DAGTPSLSAL TIVRVQVSDI NDNPPQSSQS SYDVYIEENN LPGAPILNLS 
    VWDPDAPQNA RLSFFLLEQG AETGLVGRYF TINRDNGIVS SLVPLDYEDR REFELTAHIS 
    DGGTPVLATN ISVNIFVTDR NDNAPQVLYP RPGGSSVEML PRGTSAGHLV SRVVGWDADA 
    GHNAWLSYSL LGSPNQSLFA IGLHTGQIST ARPVQDTDSP RQTLTVLIKD NGEPSLSTTA 
    TLTVSVTEDS PEARAEFPSG SAPREQKKNL TFYLLLSLIL VSVGFVVTVF GVIIFKVYKW 
    KQSRDLYRAP VSSLYRTPGP SLHADAVRGG LMSPHLYHQV YLTTDSRRSD PLLKKPGAAS 
    PLASRQNTLR SCDPVFYRQV LGAESAPPGQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW 
    PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP 
    GSNATLTNAA GKRDGKAPAG GNGNKKKSGK KEKK

Genular Protein ID: 2922955207

Symbol: Q9BR81_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 134
  • Mass: 14071
  • Checksum: 968E142D201C1114
  • Sequence:
  • MVPEAWRSGL QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW PNNQFDTEML QAMILASASE 
    AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP GSNATLTNAA GKRDGKAPAG 
    GNGNKKKSGK KEKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.