Details for: TVP23B

Gene ID: 51030

Symbol: TVP23B

Ensembl ID: ENSG00000171928

Description: trans-golgi network vesicle protein 23 homolog B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 117.9078
    Cell Significance Index: -18.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 74.6718
    Cell Significance Index: -18.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.1271
    Cell Significance Index: -18.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 41.2181
    Cell Significance Index: -19.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 15.8319
    Cell Significance Index: -19.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5723
    Cell Significance Index: -14.9300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.0126
    Cell Significance Index: -19.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.4637
    Cell Significance Index: -13.7100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1534
    Cell Significance Index: -9.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.1859
    Cell Significance Index: 254.7400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.7764
    Cell Significance Index: 28.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3941
    Cell Significance Index: 19.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3542
    Cell Significance Index: 220.2400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1019
    Cell Significance Index: 8.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8867
    Cell Significance Index: 53.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7467
    Cell Significance Index: 20.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7132
    Cell Significance Index: 389.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6811
    Cell Significance Index: 42.9300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6242
    Cell Significance Index: 123.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5721
    Cell Significance Index: 29.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5610
    Cell Significance Index: 14.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4761
    Cell Significance Index: 47.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4670
    Cell Significance Index: 32.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4510
    Cell Significance Index: 13.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4409
    Cell Significance Index: 126.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4308
    Cell Significance Index: 77.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4085
    Cell Significance Index: 8.8500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3374
    Cell Significance Index: 15.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3306
    Cell Significance Index: 20.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3034
    Cell Significance Index: 8.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2749
    Cell Significance Index: 7.8800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2716
    Cell Significance Index: 5.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2649
    Cell Significance Index: 36.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2445
    Cell Significance Index: 30.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2428
    Cell Significance Index: 48.7000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2378
    Cell Significance Index: 148.4900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2316
    Cell Significance Index: 17.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2303
    Cell Significance Index: 6.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2057
    Cell Significance Index: 9.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1855
    Cell Significance Index: 8.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1796
    Cell Significance Index: 10.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1689
    Cell Significance Index: 21.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1440
    Cell Significance Index: 51.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1320
    Cell Significance Index: 3.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1173
    Cell Significance Index: 9.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1106
    Cell Significance Index: 3.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1080
    Cell Significance Index: 47.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0853
    Cell Significance Index: 10.0700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0652
    Cell Significance Index: 11.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0289
    Cell Significance Index: 3.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0270
    Cell Significance Index: 50.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0134
    Cell Significance Index: 24.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0132
    Cell Significance Index: 8.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0098
    Cell Significance Index: 15.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0062
    Cell Significance Index: 0.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0004
    Cell Significance Index: 0.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0012
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0056
    Cell Significance Index: -0.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0164
    Cell Significance Index: -0.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0180
    Cell Significance Index: -13.2200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.0193
    Cell Significance Index: -0.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0205
    Cell Significance Index: -11.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0225
    Cell Significance Index: -0.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0315
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0436
    Cell Significance Index: -9.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0467
    Cell Significance Index: -3.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0486
    Cell Significance Index: -7.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0665
    Cell Significance Index: -1.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0671
    Cell Significance Index: -7.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1201
    Cell Significance Index: -2.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1202
    Cell Significance Index: -3.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1213
    Cell Significance Index: -2.0400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1412
    Cell Significance Index: -16.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1712
    Cell Significance Index: -17.8300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1833
    Cell Significance Index: -5.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1883
    Cell Significance Index: -12.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1912
    Cell Significance Index: -10.0400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1999
    Cell Significance Index: -7.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2019
    Cell Significance Index: -8.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2193
    Cell Significance Index: -4.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2293
    Cell Significance Index: -18.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2358
    Cell Significance Index: -8.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2745
    Cell Significance Index: -16.8300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3013
    Cell Significance Index: -5.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3043
    Cell Significance Index: -7.0300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3114
    Cell Significance Index: -2.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3152
    Cell Significance Index: -4.7500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3201
    Cell Significance Index: -1.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3462
    Cell Significance Index: -7.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3490
    Cell Significance Index: -4.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3520
    Cell Significance Index: -8.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3584
    Cell Significance Index: -4.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3637
    Cell Significance Index: -12.6400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.3817
    Cell Significance Index: -6.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4033
    Cell Significance Index: -11.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4066
    Cell Significance Index: -14.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4105
    Cell Significance Index: -6.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Function:** TVP23B is localized to the Golgi apparatus membrane, where it plays a crucial role in protein binding, secretion, and vesicle-mediated transport. 2. **Cellular Expression:** TVP23B is expressed in various cell types, including polychromatophilic erythroblasts, hematopoietic oligopotent progenitor cells, embryonic stem cells, smooth muscle fibers of the ileum, and immune cells such as CD8-alpha-beta-positive, alpha-beta intraepithelial T cells, and regulatory T cells. 3. **Protein Homology:** TVP23B is homologous to the Golgi apparatus membrane protein TVP23, highlighting its conserved function across species. **Pathways and Functions:** 1. **Golgi Membrane Function:** TVP23B is involved in regulating protein secretion and binding in the Golgi apparatus, ensuring proper protein processing and transport to the cell surface. 2. **Vesicle-Mediated Transport:** TVP23B is also involved in the formation and regulation of vesicles, facilitating the transport of proteins and lipids between compartments within the cell. 3. **Immune Regulation:** TVP23B is expressed in immune cells, suggesting its involvement in immune regulation and response. Its expression in CD8-positive, alpha-beta regulatory T cells may play a role in modulating immune responses. **Clinical Significance:** 1. **Disease Association:** The expression of TVP23B in hematopoietic cells and immune cells suggests its potential involvement in hematological disorders, such as leukemia and lymphoma. 2. **Immune-Related Disorders:** TVP23B's expression in immune cells may also be relevant to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer Research:** Further studies on TVP23B's role in cancer may reveal its potential as a biomarker or therapeutic target. In conclusion, TVP23B is a multifunctional protein involved in various cellular processes, including protein binding, secretion, and vesicle-mediated transport. Its expression in immune cells and hematopoietic cells highlights its potential significance in immune regulation and disease. Further research on TVP23B's role in human disease may reveal new insights into the mechanisms underlying immune-related disorders and cancer.

Genular Protein ID: 3217696730

Symbol: TV23B_HUMAN

Name: Golgi apparatus membrane protein TVP23 homolog B

UniProtKB Accession Codes:

Q9NYZ1 A8K448 Q96HK5 Q9Y3E6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 7 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

Sequence Information:

  • Length: 205
  • Mass: 23576
  • Checksum: E221C320822187FC
  • Sequence:
    • MLQQDSNDDT EDVSLFDAEE ETTNRPRKAK IRHPVASFFH LFFRVSAIIV YLLCGLLSSS 
FITCMVTIIL LLSCDFWAVK NVTGRLMVGL RWWNHIDEDG KSHWVFESRK ESSQENKTVS 
EAESRIFWLG LIACPVLWVI FAFSALFSFR VKWLAVVIMG VVLQGANLYG YIRCKVRSRK 
HLTSMATSYF GKQFLRQNTG DDQTS

Genular Protein ID: 2127867750

Symbol: J3QL63_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QL63

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 1 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 RefSeq 3 RuleBase 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 141
  • Mass: 16270
  • Checksum: 6E2750BA7C7E5DF9
  • Sequence:
    • MVTIILLLSC DFWAVKNVTG RLMVGLRWWN HIDEDGKSHW VFESRKESSQ ENKTVSEAES 
RIFWLGLIAC PVLWVIFAFS ALFSFRVKWL AVVIMGVVLQ GANLYGYIRC KVRSRKHLTS 
MATSYFGKQF LRQNTGDDQT S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.