Details for: RPS27L

Gene ID: 51065

Symbol: RPS27L

Ensembl ID: ENSG00000185088

Description: ribosomal protein S27 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 243.4533
    Cell Significance Index: -100.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 224.6361
    Cell Significance Index: -91.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 210.8986
    Cell Significance Index: -99.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 193.4542
    Cell Significance Index: -99.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 149.2201
    Cell Significance Index: -100.1300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 96.3558
    Cell Significance Index: -92.0000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.9061
    Cell Significance Index: -66.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 8.5095
    Cell Significance Index: 869.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 6.2503
    Cell Significance Index: 291.4200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.3783
    Cell Significance Index: 26.9500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.4497
    Cell Significance Index: 79.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.3132
    Cell Significance Index: 155.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.2776
    Cell Significance Index: 37.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.8803
    Cell Significance Index: 1573.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.8020
    Cell Significance Index: 384.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7464
    Cell Significance Index: 80.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.5256
    Cell Significance Index: 38.0600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3814
    Cell Significance Index: 177.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.3378
    Cell Significance Index: 299.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1835
    Cell Significance Index: 268.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.1404
    Cell Significance Index: 97.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1088
    Cell Significance Index: 208.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0985
    Cell Significance Index: 247.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.0942
    Cell Significance Index: 53.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.0687
    Cell Significance Index: 372.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9480
    Cell Significance Index: 861.2700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.9399
    Cell Significance Index: 51.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8053
    Cell Significance Index: 49.1400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7582
    Cell Significance Index: 124.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7245
    Cell Significance Index: 111.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4328
    Cell Significance Index: 185.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.3984
    Cell Significance Index: 29.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.3346
    Cell Significance Index: 227.8900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3036
    Cell Significance Index: 8.1000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1636
    Cell Significance Index: 10.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0253
    Cell Significance Index: 203.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0174
    Cell Significance Index: 15.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8930
    Cell Significance Index: 15.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8188
    Cell Significance Index: 133.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7694
    Cell Significance Index: 14.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5965
    Cell Significance Index: 17.1000
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.4958
    Cell Significance Index: 10.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4146
    Cell Significance Index: 21.6000
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3847
    Cell Significance Index: 2.2600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3616
    Cell Significance Index: 273.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3578
    Cell Significance Index: 68.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2975
    Cell Significance Index: 17.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2807
    Cell Significance Index: 56.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2338
    Cell Significance Index: 83.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1836
    Cell Significance Index: 9.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0670
    Cell Significance Index: 1.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0615
    Cell Significance Index: 45.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0509
    Cell Significance Index: 95.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0456
    Cell Significance Index: 70.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0392
    Cell Significance Index: 72.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0163
    Cell Significance Index: -12.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0514
    Cell Significance Index: -69.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0595
    Cell Significance Index: -33.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0679
    Cell Significance Index: -42.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0765
    Cell Significance Index: -48.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1212
    Cell Significance Index: -54.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1898
    Cell Significance Index: -54.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2111
    Cell Significance Index: -44.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2426
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3306
    Cell Significance Index: -37.8700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3948
    Cell Significance Index: -10.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4615
    Cell Significance Index: -67.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4645
    Cell Significance Index: -11.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4927
    Cell Significance Index: -17.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5115
    Cell Significance Index: -40.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5727
    Cell Significance Index: -3.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5933
    Cell Significance Index: -67.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6011
    Cell Significance Index: -46.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7625
    Cell Significance Index: -16.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8590
    Cell Significance Index: -54.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8778
    Cell Significance Index: -14.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8831
    Cell Significance Index: -91.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0717
    Cell Significance Index: -56.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1306
    Cell Significance Index: -76.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2266
    Cell Significance Index: -32.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2351
    Cell Significance Index: -69.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.2691
    Cell Significance Index: -10.6600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2959
    Cell Significance Index: -22.3400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3829
    Cell Significance Index: -26.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.4205
    Cell Significance Index: -71.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4215
    Cell Significance Index: -41.8700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5285
    Cell Significance Index: -93.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6293
    Cell Significance Index: -99.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9306
    Cell Significance Index: -26.3400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.9510
    Cell Significance Index: -21.2100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -2.0090
    Cell Significance Index: -16.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.1275
    Cell Significance Index: -78.1000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.1601
    Cell Significance Index: -25.7500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.1710
    Cell Significance Index: -96.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.2800
    Cell Significance Index: -65.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.3909
    Cell Significance Index: -50.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.4863
    Cell Significance Index: -63.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.5285
    Cell Significance Index: -26.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.5407
    Cell Significance Index: -96.2100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.5565
    Cell Significance Index: -89.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The RPS27L gene is a part of the ribosomal protein family, which is essential for protein synthesis and translation. The protein encoded by RPS27L is a 40S ribosomal protein that is involved in the initiation of translation, elongation, and termination of protein synthesis. The RPS27L protein is also involved in the regulation of apoptosis, particularly in response to DNA damage. Additionally, RPS27L has been shown to interact with other proteins and molecules, including the cap-binding complex, eIFs, and p53 class mediators, to regulate various cellular processes. **Pathways and Functions** The RPS27L gene is involved in several key cellular pathways, including: 1. **Translation initiation**: RPS27L plays a crucial role in the initiation of translation, particularly in the recognition of start codons and the assembly of the 40S ribosomal subunit. 2. **Apoptosis**: RPS27L is involved in the intrinsic apoptotic signaling pathway in response to DNA damage, particularly through interaction with p53 class mediators. 3. **Cap-dependent translation initiation**: RPS27L is involved in the regulation of cap-dependent translation initiation, which is a critical process in the translation of mRNA. 4. **Ribosomal small subunit assembly**: RPS27L is involved in the assembly of the 40S ribosomal subunit, which is essential for protein synthesis. 5. **Nonsense-mediated decay (NMD)**: RPS27L has been shown to interact with the exon junction complex (EJC) and regulate NMD, a process that involves the degradation of aberrant mRNAs. **Clinical Significance** Dysregulation of the RPS27L gene has been implicated in various diseases and viral infections, including: 1. **Cancer**: RPS27L has been shown to be overexpressed in certain types of cancer, including breast and lung cancer. 2. **Infectious diseases**: RPS27L has been shown to be involved in the translation of viral mRNAs, particularly in the context of influenza and SARS-CoV-2 infections. 3. **Autoimmune diseases**: RPS27L has been shown to be involved in the regulation of immune responses, particularly in the context of autoimmune diseases such as multiple sclerosis. 4. **Neurological disorders**: RPS27L has been shown to be involved in the regulation of neuronal function and development, particularly in the context of neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, the RPS27L gene plays a crucial role in various cellular processes, including translation initiation, apoptosis, and ribosomal small subunit assembly. Its dysregulation has been implicated in various diseases and viral infections, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully elucidate the functions and clinical significance of the RPS27L gene.

Genular Protein ID: 3237141024

Symbol: RS27L_HUMAN

Name: 40S ribosomal protein S27-like

UniProtKB Accession Codes:

Q71UM5 Q9BTJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 18 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 84
  • Mass: 9477
  • Checksum: 271CCACFBB269E38
  • Sequence:
    • MPLARDLLHP SLEEEKKKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA QTVVLCVGCS 
TVLCQPTGGK ARLTEGCSFR RKQH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.