Details for: CUTC

Gene ID: 51076

Symbol: CUTC

Ensembl ID: ENSG00000119929

Description: cutC copper transporter

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 131.1194
    Cell Significance Index: -20.4000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 62.7850
    Cell Significance Index: -15.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 52.5499
    Cell Significance Index: -24.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.1086
    Cell Significance Index: -23.5600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8910
    Cell Significance Index: -18.4600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1771
    Cell Significance Index: -24.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.8211
    Cell Significance Index: -12.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.2679
    Cell Significance Index: -16.1800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 4.1481
    Cell Significance Index: 66.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 3.9546
    Cell Significance Index: 96.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.3738
    Cell Significance Index: 234.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 2.1923
    Cell Significance Index: 46.6900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.9275
    Cell Significance Index: 13.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6028
    Cell Significance Index: 110.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.5308
    Cell Significance Index: 39.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2974
    Cell Significance Index: 34.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0944
    Cell Significance Index: 21.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0573
    Cell Significance Index: 954.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8548
    Cell Significance Index: 51.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8284
    Cell Significance Index: 52.2100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8271
    Cell Significance Index: 89.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7944
    Cell Significance Index: 157.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7251
    Cell Significance Index: 117.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6208
    Cell Significance Index: 17.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6005
    Cell Significance Index: 69.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5270
    Cell Significance Index: 40.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4984
    Cell Significance Index: 32.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4595
    Cell Significance Index: 12.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4341
    Cell Significance Index: 87.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.3137
    Cell Significance Index: 3.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2571
    Cell Significance Index: 46.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2372
    Cell Significance Index: 27.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2326
    Cell Significance Index: 44.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2309
    Cell Significance Index: 6.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2278
    Cell Significance Index: 28.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2017
    Cell Significance Index: 27.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1796
    Cell Significance Index: 23.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1776
    Cell Significance Index: 96.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1466
    Cell Significance Index: 7.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1463
    Cell Significance Index: 6.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1435
    Cell Significance Index: 63.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1377
    Cell Significance Index: 7.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1350
    Cell Significance Index: 48.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0991
    Cell Significance Index: 3.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0955
    Cell Significance Index: 1.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0938
    Cell Significance Index: 64.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0814
    Cell Significance Index: 3.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0507
    Cell Significance Index: 95.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0467
    Cell Significance Index: 21.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0459
    Cell Significance Index: 84.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0436
    Cell Significance Index: 67.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0406
    Cell Significance Index: 2.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0270
    Cell Significance Index: 36.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0251
    Cell Significance Index: 15.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0198
    Cell Significance Index: 0.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0040
    Cell Significance Index: 0.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0163
    Cell Significance Index: -2.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0201
    Cell Significance Index: -15.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0222
    Cell Significance Index: -16.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0255
    Cell Significance Index: -3.7100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0303
    Cell Significance Index: -0.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0366
    Cell Significance Index: -1.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0378
    Cell Significance Index: -21.2900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0393
    Cell Significance Index: -1.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0402
    Cell Significance Index: -4.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0436
    Cell Significance Index: -27.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0446
    Cell Significance Index: -1.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0461
    Cell Significance Index: -1.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0481
    Cell Significance Index: -13.8400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0580
    Cell Significance Index: -0.9200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0929
    Cell Significance Index: -1.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1162
    Cell Significance Index: -8.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1181
    Cell Significance Index: -1.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1252
    Cell Significance Index: -26.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1288
    Cell Significance Index: -2.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1382
    Cell Significance Index: -6.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1493
    Cell Significance Index: -10.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1556
    Cell Significance Index: -17.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1616
    Cell Significance Index: -2.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1689
    Cell Significance Index: -10.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1775
    Cell Significance Index: -18.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1806
    Cell Significance Index: -4.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1902
    Cell Significance Index: -6.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2267
    Cell Significance Index: -6.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2283
    Cell Significance Index: -2.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2412
    Cell Significance Index: -6.0300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2565
    Cell Significance Index: -1.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2703
    Cell Significance Index: -21.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2927
    Cell Significance Index: -3.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3397
    Cell Significance Index: -10.8800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3496
    Cell Significance Index: -5.1600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3554
    Cell Significance Index: -7.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3740
    Cell Significance Index: -10.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4033
    Cell Significance Index: -11.5100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4127
    Cell Significance Index: -25.3000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4129
    Cell Significance Index: -5.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Copper Transporter:** The CUTC gene encodes a protein that facilitates the transport of copper ions across cellular membranes, thereby regulating copper homeostasis. 2. **Highly Expressed Cells:** CUTC is significantly expressed in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, smooth muscle fibers, and other cell types, indicating its widespread importance in cellular function. 3. **Cellular Localization:** The CUTC protein is likely localized to the plasma membrane, where it can interact with copper ions and facilitate their transport into or out of cells. **Pathways and Functions:** 1. **Copper Ion Binding:** CUTC binds copper ions, which are essential for various cellular processes, including enzyme function, antioxidant defenses, and cell signaling. 2. **Copper Ion Homeostasis:** The CUTC gene helps regulate copper ion homeostasis by controlling the influx and efflux of copper ions into and out of cells. 3. **Ion Channel Transport:** CUTC may participate in ion channel transport by interacting with other proteins and facilitating the movement of ions across cellular membranes. 4. **Protein Binding:** The CUTC protein interacts with other proteins, potentially modulating their activity and function. **Clinical Significance:** 1. **Copper Deficiency:** Mutations in the CUTC gene could lead to copper deficiency, which can result in impaired immune function, anemia, and other health issues. 2. **Copper Toxicity:** Excessive copper levels can also be toxic, leading to conditions such as Wilson's disease, a genetic disorder characterized by copper accumulation in the liver and brain. 3. **Hematological Disorders:** The CUTC gene's role in hematopoietic cells makes it an important target for understanding the pathogenesis of anemia and other blood disorders. 4. **Muscle Function:** The CUTC gene's expression in muscle cells suggests its potential involvement in muscle function and disorders, such as muscular dystrophy. In conclusion, the CUTC gene plays a critical role in maintaining copper homeostasis within cells, and its dysregulation can lead to various health issues. Further research is necessary to fully elucidate the mechanisms by which the CUTC gene functions and its clinical significance in different diseases.

Genular Protein ID: 154457139

Symbol: CUTC_HUMAN

Name: Copper homeostasis protein cutC homolog

UniProtKB Accession Codes:

Q9NTM9 Q5TCZ8 Q9Y321

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16182249

Title: Identification and characterization of a novel Cut family cDNA that encodes human copper transporter protein CutC.

PubMed ID: 16182249

DOI: 10.1016/j.bbrc.2005.09.029

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 19878721

Title: Crystal structure of human copper homeostasis protein CutC reveals a potential copper-binding site.

PubMed ID: 19878721

DOI: 10.1016/j.jsb.2009.10.012

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 273
  • Mass: 29341
  • Checksum: 63C007AAB05C5492
  • Sequence:
    • MKRQGASSER KRARIPSGKA GAANGFLMEV CVDSVESAVN AERGGADRIE LCSGLSEGGT 
TPSMGVLQVV KQSVQIPVFV MIRPRGGDFL YSDREIEVMK ADIRLAKLYG ADGLVFGALT 
EDGHIDKELC MSLMAICRPL PVTFHRAFDM VHDPMAALET LLTLGFERVL TSGCDSSALE 
GLPLIKRLIE QAKGRIVVMP GGGITDRNLQ RILEGSGATE FHCSARSTRD SGMKFRNSSV 
AMGASLSCSE YSLKVTDVTK VRTLNAIAKN ILV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.