Details for: FCF1

Gene ID: 51077

Symbol: FCF1

Ensembl ID: ENSG00000119616

Description: FCF1 rRNA-processing protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.1942
    Cell Significance Index: -19.9400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.8078
    Cell Significance Index: -20.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 48.5891
    Cell Significance Index: -22.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.9407
    Cell Significance Index: -19.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.9844
    Cell Significance Index: -19.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.7703
    Cell Significance Index: -21.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7272
    Cell Significance Index: -22.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9438
    Cell Significance Index: -10.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.5874
    Cell Significance Index: -14.0900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 4.4294
    Cell Significance Index: 72.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9300
    Cell Significance Index: 55.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7264
    Cell Significance Index: 209.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5047
    Cell Significance Index: 100.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4584
    Cell Significance Index: 31.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4432
    Cell Significance Index: 88.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4327
    Cell Significance Index: 78.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4236
    Cell Significance Index: 11.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4110
    Cell Significance Index: 371.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4016
    Cell Significance Index: 49.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2895
    Cell Significance Index: 8.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2834
    Cell Significance Index: 12.8500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2534
    Cell Significance Index: 5.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2356
    Cell Significance Index: 32.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2305
    Cell Significance Index: 82.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2299
    Cell Significance Index: 11.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2051
    Cell Significance Index: 90.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2020
    Cell Significance Index: 25.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1872
    Cell Significance Index: 35.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1678
    Cell Significance Index: 91.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1483
    Cell Significance Index: 102.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1267
    Cell Significance Index: 7.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1008
    Cell Significance Index: 4.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0960
    Cell Significance Index: 7.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0823
    Cell Significance Index: 9.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0780
    Cell Significance Index: 7.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0755
    Cell Significance Index: 2.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0673
    Cell Significance Index: 4.7600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0594
    Cell Significance Index: 1.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0333
    Cell Significance Index: 0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0224
    Cell Significance Index: 42.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0157
    Cell Significance Index: 0.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0096
    Cell Significance Index: 6.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0050
    Cell Significance Index: 2.2800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0027
    Cell Significance Index: 4.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0080
    Cell Significance Index: -10.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0145
    Cell Significance Index: -10.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0235
    Cell Significance Index: -4.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0237
    Cell Significance Index: -17.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0281
    Cell Significance Index: -4.0900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0323
    Cell Significance Index: -18.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0381
    Cell Significance Index: -2.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0381
    Cell Significance Index: -2.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0406
    Cell Significance Index: -25.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0432
    Cell Significance Index: -1.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0519
    Cell Significance Index: -6.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0569
    Cell Significance Index: -5.8200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0627
    Cell Significance Index: -4.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0706
    Cell Significance Index: -8.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0752
    Cell Significance Index: -8.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0887
    Cell Significance Index: -4.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0958
    Cell Significance Index: -1.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1022
    Cell Significance Index: -3.5900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1027
    Cell Significance Index: -1.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1155
    Cell Significance Index: -5.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1180
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1194
    Cell Significance Index: -25.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1240
    Cell Significance Index: -8.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1544
    Cell Significance Index: -4.0600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1635
    Cell Significance Index: -6.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2035
    Cell Significance Index: -21.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2245
    Cell Significance Index: -17.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2367
    Cell Significance Index: -14.5100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2675
    Cell Significance Index: -3.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2688
    Cell Significance Index: -6.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2837
    Cell Significance Index: -9.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2903
    Cell Significance Index: -15.1200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2996
    Cell Significance Index: -9.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2998
    Cell Significance Index: -15.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3060
    Cell Significance Index: -2.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3115
    Cell Significance Index: -6.5200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3141
    Cell Significance Index: -5.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3180
    Cell Significance Index: -9.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3340
    Cell Significance Index: -5.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3536
    Cell Significance Index: -5.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3782
    Cell Significance Index: -10.8400
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3983
    Cell Significance Index: -5.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4302
    Cell Significance Index: -10.9900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4308
    Cell Significance Index: -6.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4402
    Cell Significance Index: -14.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4570
    Cell Significance Index: -12.2300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4677
    Cell Significance Index: -10.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4707
    Cell Significance Index: -17.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4741
    Cell Significance Index: -16.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4795
    Cell Significance Index: -15.7000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5022
    Cell Significance Index: -10.7400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5309
    Cell Significance Index: -15.1500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5313
    Cell Significance Index: -7.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FCF1 is a rRNA-processing protein that is involved in the maturation of small ribosomal subunits. It is primarily expressed in cells undergoing rapid proliferation, such as hematopoietic and epithelial cells. The gene is associated with several cellular processes, including RNA binding, ribosomal biogenesis, and modification of rRNA in the nucleus and cytosol. **Pathways and Functions:** FCF1 is integral to the major pathway of rRNA processing in the nucleolus and cytosol. It interacts with other proteins to regulate the assembly and maturation of small ribosomal subunits. The protein is also involved in the regulation of RNA modification, including the phosphorylation and methylation of rRNA. Additionally, FCF1 is required for the proper functioning of the processome, a complex of proteins that coordinates rRNA processing and ribosomal biogenesis. **Clinical Significance:** The clinical significance of FCF1 lies in its involvement in immune responses and tissue homeostasis. Aberrant expression of FCF1 has been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions. For instance, alterations in FCF1 expression have been observed in hematological malignancies, such as leukemia and lymphoma. Furthermore, FCF1 has been implicated in the regulation of immune cell function, including the development and differentiation of T cells and B cells. **Implications for Immunological Function:** The role of FCF1 in immune cell function is multifaceted. It is involved in the regulation of RNA processing and modification, which is critical for the proper functioning of immune cells. Aberrant expression of FCF1 has been linked to immune dysregulation, including autoimmune disorders and cancer. Additionally, FCF1 has been shown to interact with other proteins that regulate immune cell function, including T cell receptor signaling and cytokine production. **Conclusion:** In conclusion, FCF1 is a critical gene involved in RNA processing and modification in both the nucleus and cytosol. Its expression is significantly linked to various cell types, including hematopoietic and epithelial cells. The clinical significance of FCF1 lies in its involvement in immune responses and tissue homeostasis, and aberrant expression has been linked to various diseases, including cancer and autoimmune disorders. Further research is needed to fully elucidate the role of FCF1 in immunological and cellular functions, and to explore its potential as a therapeutic target for the treatment of immune-related diseases.

Genular Protein ID: 1504173166

Symbol: FCF1_HUMAN

Name: rRNA-processing protein FCF1 homolog

UniProtKB Accession Codes:

Q9Y324 Q86TW8 Q8TBL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 3 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 34516797

Title: Nucleolar maturation of the human small subunit processome.

PubMed ID: 34516797

DOI: 10.1126/science.abj5338

Sequence Information:

  • Length: 198
  • Mass: 23370
  • Checksum: A0C98414C21F16AE
  • Sequence:
    • MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ HPSCLFFQYN 
TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP CITDCVMAEI EKLGQKYRVA 
LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT QHKCYIVATV DRDLKRRIRK IPGVPIMYIS 
NHRYNIERMP DDYGAPRF

Genular Protein ID: 28385150

Symbol: G3V1S4_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V1S4 A0A024R6D0

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 186
  • Mass: 21948
  • Checksum: F3F569196C06AC3B
  • Sequence:
    • MKRMLSLRDQ RLKEKDRLKP KKKEKKDPSA LKEREVPQHP SCLFFQYNTQ LGPPYHILVD 
TNFINFSIKA KLDLVQSMMD CLYAKCIPCI TDCVMAEIEK LGQKYRVALR IAKDPRFERL 
PCTHKGTYAD DCLVQRVTQH KCYIVATVDR DLKRRIRKIP GVPIMYISNH RYNIERMPDD 
YGAPRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.