Details for: LACTB2

Gene ID: 51110

Symbol: LACTB2

Ensembl ID: ENSG00000147592

Description: lactamase beta 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.0978
    Cell Significance Index: -19.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.1933
    Cell Significance Index: -18.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 49.7117
    Cell Significance Index: -23.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.6299
    Cell Significance Index: -19.3500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 35.0212
    Cell Significance Index: -23.5000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.2777
    Cell Significance Index: -19.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.5513
    Cell Significance Index: -21.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.5405
    Cell Significance Index: -20.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5194
    Cell Significance Index: -21.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.9102
    Cell Significance Index: -12.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.1070
    Cell Significance Index: -6.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0660
    Cell Significance Index: 124.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3476
    Cell Significance Index: 219.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8627
    Cell Significance Index: 11.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7773
    Cell Significance Index: 16.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7238
    Cell Significance Index: 50.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5809
    Cell Significance Index: 115.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4699
    Cell Significance Index: 57.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4640
    Cell Significance Index: 45.9000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4584
    Cell Significance Index: 23.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4576
    Cell Significance Index: 82.5000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4112
    Cell Significance Index: 18.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3813
    Cell Significance Index: 24.0300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3404
    Cell Significance Index: 9.1200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3388
    Cell Significance Index: 3.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3149
    Cell Significance Index: 5.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3119
    Cell Significance Index: 137.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2904
    Cell Significance Index: 158.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2472
    Cell Significance Index: 17.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2228
    Cell Significance Index: 28.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2003
    Cell Significance Index: 40.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1777
    Cell Significance Index: 30.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1684
    Cell Significance Index: 32.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1662
    Cell Significance Index: 19.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1622
    Cell Significance Index: 5.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1340
    Cell Significance Index: 6.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1330
    Cell Significance Index: 4.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1141
    Cell Significance Index: 15.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1032
    Cell Significance Index: 2.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1008
    Cell Significance Index: 36.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1005
    Cell Significance Index: 1.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0927
    Cell Significance Index: 64.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0661
    Cell Significance Index: 1.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0643
    Cell Significance Index: 1.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0569
    Cell Significance Index: 43.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0547
    Cell Significance Index: 6.2700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0333
    Cell Significance Index: 0.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0271
    Cell Significance Index: 36.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0167
    Cell Significance Index: 0.5800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0159
    Cell Significance Index: 29.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0086
    Cell Significance Index: 6.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0049
    Cell Significance Index: 9.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0035
    Cell Significance Index: 5.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0045
    Cell Significance Index: -2.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0054
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0072
    Cell Significance Index: -4.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0150
    Cell Significance Index: -1.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0179
    Cell Significance Index: -0.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0198
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0217
    Cell Significance Index: -12.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0249
    Cell Significance Index: -3.2200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0258
    Cell Significance Index: -0.2100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0290
    Cell Significance Index: -13.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0464
    Cell Significance Index: -6.7400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0480
    Cell Significance Index: -10.1200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0548
    Cell Significance Index: -15.7600
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0560
    Cell Significance Index: -0.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0593
    Cell Significance Index: -3.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0689
    Cell Significance Index: -5.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0723
    Cell Significance Index: -8.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0993
    Cell Significance Index: -2.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1146
    Cell Significance Index: -8.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1177
    Cell Significance Index: -1.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1322
    Cell Significance Index: -6.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1382
    Cell Significance Index: -15.7800
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1413
    Cell Significance Index: -1.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1415
    Cell Significance Index: -3.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1426
    Cell Significance Index: -11.3000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1591
    Cell Significance Index: -1.2700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1743
    Cell Significance Index: -5.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2006
    Cell Significance Index: -20.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2012
    Cell Significance Index: -5.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2163
    Cell Significance Index: -12.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2266
    Cell Significance Index: -5.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2410
    Cell Significance Index: -16.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2418
    Cell Significance Index: -15.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2439
    Cell Significance Index: -3.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2443
    Cell Significance Index: -3.6600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2593
    Cell Significance Index: -6.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2636
    Cell Significance Index: -13.7300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2777
    Cell Significance Index: -2.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2942
    Cell Significance Index: -4.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3087
    Cell Significance Index: -13.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3158
    Cell Significance Index: -19.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3366
    Cell Significance Index: -20.6900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3440
    Cell Significance Index: -9.8600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3503
    Cell Significance Index: -11.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3595
    Cell Significance Index: -13.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3636
    Cell Significance Index: -7.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Beta-lactamase-like activity**: The LACTB2 protein possesses a unique enzymatic activity, characterized by its ability to hydrolyze beta-lactam substrates. This activity is distinct from traditional beta-lactamases, which are primarily involved in antibiotic resistance. 2. **Multifaceted expression patterns**: LACTB2 is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. This broad expression pattern suggests a diverse range of functional roles. 3. **Zinc ion binding**: The LACTB2 protein exhibits a high affinity for zinc ions, which is essential for its enzymatic activity and may also play a role in its cellular localization. 4. **RNA endonuclease activity**: LACTB2 possesses RNA endonuclease activity, which can cleave single-stranded RNA molecules. This activity may contribute to its role in regulating RNA metabolism and gene expression. **Pathways and Functions:** 1. **Immune response**: LACTB2 is expressed in immune cells, including T cells and mast cells, where it may contribute to the regulation of immune responses and the modulation of inflammation. 2. **Cellular homeostasis**: The LACTB2 protein may play a role in maintaining cellular homeostasis by regulating RNA metabolism and gene expression in various cell types. 3. **Tissue repair**: LACTB2 is expressed in smooth muscle fibers and epithelial cells, where it may contribute to tissue repair and regeneration. 4. **Mitochondrial function**: The LACTB2 protein is localized to the mitochondrial matrix, where it may regulate mitochondrial function and biogenesis. **Clinical Significance:** 1. **Autoimmune diseases**: Alterations in LACTB2 expression or function may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: The LACTB2 protein may play a role in cancer development and progression, particularly in tissues with high expression levels, such as the gut and lungs. 3. **Infectious diseases**: LACTB2 may contribute to the development of antibiotic-resistant pathogens, highlighting the need for novel therapeutic strategies. 4. **Regenerative medicine**: The LACTB2 protein may be useful as a biomarker for tissue repair and regeneration, and its expression patterns may inform the development of novel therapeutic approaches. In conclusion, LACTB2 is a multifaceted gene that plays a crucial role in immune response, cellular homeostasis, and tissue repair. Its diverse expression patterns and functional characteristics highlight the complexity of its role in maintaining cellular and tissue homeostasis. Further research is needed to fully elucidate the clinical significance of LACTB2 and its potential applications in medicine.

Genular Protein ID: 1533456362

Symbol: LACB2_HUMAN

Name: Beta-lactamase-like protein 2

UniProtKB Accession Codes:

Q53H82 A8K2D6 Q9Y392

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10810093

Title: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.

PubMed ID: 10810093

DOI: 10.1101/gr.10.5.703

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26826708

Title: Identification of LACTB2, a metallo-beta-lactamase protein, as a human mitochondrial endoribonuclease.

PubMed ID: 26826708

DOI: 10.1093/nar/gkw050

Sequence Information:

  • Length: 288
  • Mass: 32806
  • Checksum: F569C7DFB070D52C
  • Sequence:
    • MAAVLQRVER LSNRVVRVLG CNPGPMTLQG TNTYLVGTGP RRILIDTGEP AIPEYISCLK 
QALTEFNTAI QEIVVTHWHR DHSGGIGDIC KSINNDTTYC IKKLPRNPQR EEIIGNGEQQ 
YVYLKDGDVI KTEGATLRVL YTPGHTDDHM ALLLEEENAI FSGDCILGEG TTVFEDLYDY 
MNSLKELLKI KADIIYPGHG PVIHNAEAKI QQYISHRNIR EQQILTLFRE NFEKSFTVME 
LVKIIYKNTP ENLHEMAKHN LLLHLKKLEK EGKIFSNTDP DKKWKAHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.