Details for: IER3IP1
Gene ID: 51124
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IER3IP1
Ensembl ID: ENSG00000134049
Description: immediate early response 3 interacting protein 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 44.23rCSI 43.51%PRS 45.26
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CSI 34.38rCSI 36.02%PRS 45.64
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CSI 24.35rCSI 25.45%PRS 42.69
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CSI 21.59rCSI 26.71%PRS 39.11
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CSI 20.51rCSI 45.41%PRS 40.46
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CSI 19.41rCSI 24.17%PRS 54.4
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CSI 16.36rCSI 19.21%PRS 46.77
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CSI 15.61rCSI 30.36%PRS 45.03
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CSI 14.4rCSI 8.51%PRS 57.85
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CSI 13.06rCSI 10.28%PRS 49.44
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CSI 12.32rCSI 24.42%PRS 66.54
-
CSI 12.32rCSI 16.37%PRS 47.63
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CSI 12.14rCSI 22.95%PRS 66.54
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CSI 10.94rCSI 14.91%PRS 36.94
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CSI 10.8rCSI 16.75%PRS 53.07
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CSI 10.11rCSI 9.13%PRS 39.85
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CSI 10.06rCSI 9.23%PRS 50.31
-
CSI 9.66rCSI 8.8%PRS 58.09
-
CSI 9.14rCSI 36.39%PRS 58.33
-
CSI 8.68rCSI 8.08%PRS 43.02
-
CSI 8.65rCSI 7.25%PRS 48.14
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CSI 8.65rCSI 16.66%PRS 73.04
-
CSI 8.19rCSI 17%PRS 41.14
-
CSI 8.17rCSI 10.4%PRS 48.23
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CSI 8.17rCSI 47.51%PRS 53.98
-
CSI 8rCSI 22.93%PRS 60.36
-
CSI 7.4rCSI 11.37%PRS 49.9
-
CSI 6.66rCSI 10.71%PRS 34.36
-
CSI 6.4rCSI 5.52%PRS 51.86
-
CSI 6.09rCSI 15.44%PRS 34.14
-
CSI 6.09rCSI 8.32%PRS 47.8
-
CSI 5.77rCSI 5.07%PRS 48.01
-
CSI 5.73rCSI 4.82%PRS 60.28
-
CSI 5.51rCSI 8.92%PRS 41.75
-
CSI 5.49rCSI 17.82%PRS 46.11
-
CSI 5.4rCSI 4.98%PRS 44.03
-
CSI 5.36rCSI 5.17%PRS 34.2
-
CSI 5.12rCSI 10.17%PRS 42.65
-
CSI 5.04rCSI 9.62%PRS 59.87
-
CSI 4.92rCSI 5.14%PRS 43.78
-
CSI 4.83rCSI 6.72%PRS 42.63
-
CSI 4.7rCSI 4.83%PRS 60.62
-
CSI 4.45rCSI 3.56%PRS 64.43
-
CSI 4.43rCSI 6.03%PRS 55.92
-
CSI 4.33rCSI 15.21%PRS 58.54
-
CSI 4.25rCSI 6.07%PRS 45.8
-
CSI 4.17rCSI 3%PRS 55.71
-
CSI 3.65rCSI 5.64%PRS 41.06
-
CSI 3.61rCSI 5.18%PRS 34.96
-
CSI 3.57rCSI 3.82%PRS 41.05
-
CSI 3.54rCSI 5.8%PRS 34.29
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CSI 3.52rCSI 9.29%PRS 50.43
-
CSI 3.5rCSI 2.65%PRS 55.13
-
CSI 3.45rCSI 6.09%PRS 51.61
-
CSI 3.45rCSI 2.66%PRS 41.81
-
CSI 3.41rCSI 2.66%PRS 59.77
-
CSI 3.41rCSI 5.2%PRS 40.01
-
CSI 3.36rCSI 6.11%PRS 59.43
-
CSI 3.35rCSI 5.92%PRS 27.35
-
CSI 3.33rCSI 2.47%PRS 37.13
-
CSI 3.21rCSI 4.84%PRS 44.97
-
CSI 3.17rCSI 3%PRS 44.04
-
CSI 3.16rCSI 34.4%PRS 63.71
-
CSI 3.15rCSI 4.62%PRS 54.03
-
CSI 3.15rCSI 4.3%PRS 45.6
-
CSI 3.14rCSI 5.99%PRS 66.22
-
CSI 3.12rCSI 4.32%PRS 48.13
-
CSI 3.11rCSI 3.75%PRS 50.67
-
CSI 3.07rCSI 4.68%PRS 51.99
-
CSI 3.05rCSI 2.41%PRS 31.48
-
CSI 3.02rCSI 15.51%PRS 78.53
-
CSI 3.01rCSI 2.29%PRS 54.27
-
CSI 2.99rCSI 4.59%PRS 45.38
-
CSI 2.9rCSI 1.93%PRS 68.83
-
CSI 2.85rCSI 13.3%PRS 66.1
-
CSI 2.85rCSI 2.13%PRS 57.65
-
CSI 2.8rCSI 2.22%PRS 65.08
-
CSI 2.79rCSI 2.31%PRS 44.05
-
CSI 2.78rCSI 2.68%PRS 43.63
-
CSI 2.74rCSI 2.73%PRS 37.61
-
CSI 2.73rCSI 4.34%PRS 53.4
-
CSI 2.73rCSI 2.52%PRS 63.31
-
CSI 2.71rCSI 2.25%PRS 41.63
-
CSI 2.67rCSI 3.1%PRS 53.95
-
CSI 2.65rCSI 6.84%PRS 39.45
-
CSI 2.65rCSI 11.61%PRS 62.37
-
CSI 2.56rCSI 1.72%PRS 53.1
-
CSI 2.54rCSI 3.72%PRS 45.92
-
CSI 2.53rCSI 2.59%PRS 61.63
-
CSI 2.53rCSI 3.63%PRS 50.37
-
CSI 2.52rCSI 2.75%PRS 46.94
-
CSI 2.51rCSI 3.73%PRS 45.84
-
CSI 2.48rCSI 5.9%PRS 55.36
-
CSI 2.48rCSI 3.32%PRS 51.33
-
CSI 2.46rCSI 2%PRS 43.92
-
CSI 2.45rCSI 3.95%PRS 51.91
-
CSI 2.42rCSI 1.82%PRS 46.36
-
CSI 2.4rCSI 4.82%PRS 33.56
-
CSI 2.39rCSI 1.79%PRS 61.5
-
CSI 2.38rCSI 11.92%PRS 53.86
-
CSI 0.2rCSI 1.0%PRS 55.3%
-
CSI 0.2rCSI 4.7%PRS 69.9%
-
CSI 0.3rCSI 2.7%PRS 68.6%
-
CSI 0.3rCSI 0.8%PRS 58.5%
-
CSI 0.4rCSI 6.5%PRS 68.9%
-
CSI 0.5rCSI 2.6%PRS 67.0%
-
CSI 0.6rCSI 3.0%PRS 57.9%
-
CSI 0.6rCSI 3.1%PRS 65.7%
-
CSI 0.6rCSI 2.1%PRS 56.1%
-
CSI 0.6rCSI 15.8%PRS 69.1%
-
CSI 0.7rCSI 1.3%PRS 77.1%
-
CSI 0.7rCSI 2.3%PRS 29.4%
-
CSI 0.8rCSI 5.5%PRS 61.5%
-
CSI 0.9rCSI 1.2%PRS 52.1%
-
CSI 0.9rCSI 4.0%PRS 84.6%
-
CSI 0.9rCSI 1.9%PRS 38.1%
-
CSI 1.0rCSI 2.7%PRS 57.8%
-
CSI 1.0rCSI 4.7%PRS 54.7%
-
CSI 1.0rCSI 1.3%PRS 70.9%
-
CSI 1.0rCSI 1.2%PRS 62.3%
-
CSI 1.0rCSI 2.4%PRS 41.8%
-
CSI 1.1rCSI 3.1%PRS 61.0%
-
CSI 1.1rCSI 3.7%PRS 52.8%
-
CSI 1.1rCSI 1.7%PRS 60.3%
-
CSI 1.2rCSI 1.6%PRS 64.0%
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CSI 1.2rCSI 2.6%PRS 47.0%
-
CSI 1.2rCSI 1.8%PRS 59.4%
-
CSI 1.2rCSI 1.9%PRS 30.3%
-
CSI 1.2rCSI 5.9%PRS 83.4%
-
CSI 1.2rCSI 2.1%PRS 52.3%
-
CSI 1.2rCSI 7.8%PRS 65.4%
-
CSI 1.3rCSI 3.0%PRS 45.4%
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CSI 1.3rCSI 6.8%PRS 58.5%
-
CSI 1.3rCSI 2.4%PRS 62.9%
-
CSI 1.3rCSI 1.7%PRS 56.4%
-
CSI 1.4rCSI 3.4%PRS 39.4%
-
CSI 1.4rCSI 2.2%PRS 46.8%
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CSI 1.4rCSI 6.5%PRS 68.8%
-
CSI 1.4rCSI 3.4%PRS 60.8%
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CSI 1.4rCSI 5.6%PRS 64.6%
-
CSI 1.4rCSI 4.2%PRS 45.7%
-
CSI 1.5rCSI 3.1%PRS 58.0%
-
CSI 1.5rCSI 4.2%PRS 60.9%
-
CSI 1.5rCSI 1.8%PRS 41.3%
-
CSI 1.5rCSI 6.6%PRS 41.7%
-
CSI 1.5rCSI 2.9%PRS 53.1%
-
CSI 1.6rCSI 2.8%PRS 41.6%
-
CSI 1.6rCSI 2.1%PRS 41.2%
-
CSI 1.7rCSI 4.6%PRS 57.5%
-
CSI 1.7rCSI 2.5%PRS 53.1%
-
CSI 1.7rCSI 1.8%PRS 40.5%
-
CSI 1.7rCSI 3.5%PRS 60.9%
-
CSI 1.7rCSI 2.8%PRS 44.1%
-
CSI 1.8rCSI 6.4%PRS 62.2%
-
CSI 1.8rCSI 2.0%PRS 65.9%
-
CSI 1.8rCSI 4.5%PRS 39.4%
-
CSI 1.9rCSI 2.8%PRS 43.7%
-
CSI 1.9rCSI 1.7%PRS 42.2%
-
CSI 1.9rCSI 3.4%PRS 58.7%
-
CSI 1.9rCSI 1.7%PRS 32.8%
-
CSI 2.0rCSI 2.2%PRS 59.2%
-
CSI 2.0rCSI 2.7%PRS 53.2%
-
CSI 2.0rCSI 2.8%PRS 40.2%
-
CSI 2.0rCSI 5.7%PRS 43.2%
-
CSI 2.0rCSI 4.5%PRS 53.0%
-
CSI 2.0rCSI 3.8%PRS 33.5%
-
CSI 2.1rCSI 5.5%PRS 65.7%
-
CSI 2.1rCSI 1.6%PRS 56.1%
-
CSI 2.1rCSI 2.7%PRS 47.8%
-
CSI 2.1rCSI 2.8%PRS 44.6%
-
CSI 2.1rCSI 9.1%PRS 59.6%
-
CSI 2.1rCSI 2.3%PRS 58.1%
-
CSI 2.2rCSI 3.4%PRS 36.7%
-
CSI 2.2rCSI 3.1%PRS 56.7%
-
CSI 2.2rCSI 3.2%PRS 42.8%
-
CSI 2.2rCSI 3.8%PRS 34.3%
-
CSI 2.2rCSI 2.8%PRS 52.6%
-
CSI 2.3rCSI 3.7%PRS 48.5%
-
CSI 2.3rCSI 5.0%PRS 49.4%
-
CSI 2.3rCSI 3.5%PRS 70.2%
-
CSI 2.3rCSI 22.3%PRS 70.2%
-
CSI 2.3rCSI 2.7%PRS 33.7%
-
CSI 2.3rCSI 1.8%PRS 43.5%
-
CSI 2.3rCSI 4.8%PRS 49.8%
-
CSI 2.3rCSI 5.8%PRS 41.2%
-
CSI 2.4rCSI 2.4%PRS 48.9%
-
CSI 2.4rCSI 4.2%PRS 36.8%
-
CSI 2.4rCSI 3.5%PRS 47.9%
-
CSI 2.4rCSI 11.9%PRS 53.9%
-
CSI 2.4rCSI 1.8%PRS 61.5%
-
CSI 2.4rCSI 4.8%PRS 33.6%
-
CSI 2.4rCSI 1.8%PRS 46.4%
-
CSI 2.5rCSI 4.0%PRS 51.9%
-
CSI 2.5rCSI 2.0%PRS 43.9%
-
CSI 2.5rCSI 3.3%PRS 51.3%
-
CSI 2.5rCSI 5.9%PRS 55.4%
-
CSI 2.5rCSI 3.7%PRS 45.8%
-
CSI 2.5rCSI 2.8%PRS 46.9%
-
CSI 2.5rCSI 3.6%PRS 50.4%
-
CSI 2.5rCSI 2.6%PRS 61.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3473738547
Symbol: IR3IP_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15276200
Title: Cloning and characterization of a novel endoplasmic reticulum localized G-patch domain protein, IER3IP1.
PubMed ID: 15276200
PubMed ID: 11042152
Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.
PubMed ID: 11042152
DOI: 10.1101/gr.140200
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 33122427
Title: A human tissue screen identifies a regulator of ER secretion as a brain-size determinant.
PubMed ID: 33122427
PubMed ID: 21835305
Title: Microcephaly with simplified gyration, epilepsy, and infantile diabetes linked to inappropriate apoptosis of neural progenitors.
PubMed ID: 21835305
PubMed ID: 22991235
Title: A homozygous IER3IP1 mutation causes microcephaly with simplified gyral pattern, epilepsy, and permanent neonatal diabetes syndrome (MEDS).
PubMed ID: 22991235
DOI: 10.1002/ajmg.a.35583
PubMed ID: 24138066
Title: Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder.
PubMed ID: 24138066
DOI: 10.1111/pedi.12086
Sequence Information:
- Length: 82
- Mass: 8969
- Checksum: 2015B211F0AFF580
- Sequence:
MAFTLYSLLQ AALLCVNAIA VLHEERFLKN IGWGTDQGIG GFGEEPGIKS QLMNLIRSVR TVMRVPLIIV NSIAIVLLLL FG