Details for: MYO15A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 32.2736
Cell Significance Index: -5.0200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 19.3579
Cell Significance Index: -4.9100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 9.7229
Cell Significance Index: -3.9500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 4.0796
Cell Significance Index: -5.0300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 1.2772
Cell Significance Index: -5.0400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.9692
Cell Significance Index: 13.8800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.8540
Cell Significance Index: 52.3600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.5025
Cell Significance Index: 16.1000 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.4177
Cell Significance Index: 3.5500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3531
Cell Significance Index: 70.8400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2838
Cell Significance Index: 14.9000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2789
Cell Significance Index: 12.6400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2660
Cell Significance Index: 50.6200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.2221
Cell Significance Index: 2.7600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2044
Cell Significance Index: 5.8900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2016
Cell Significance Index: 2.7500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1781
Cell Significance Index: 3.9000 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.1653
Cell Significance Index: 1.1200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1458
Cell Significance Index: 14.4200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1395
Cell Significance Index: 27.6800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1340
Cell Significance Index: 120.9500 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.0914
Cell Significance Index: 1.4500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0844
Cell Significance Index: 12.2700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0760
Cell Significance Index: 27.2700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0753
Cell Significance Index: 1.4700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0729
Cell Significance Index: 11.8600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0704
Cell Significance Index: 7.6600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0676
Cell Significance Index: 2.3800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.0613
Cell Significance Index: 0.8800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0575
Cell Significance Index: 3.4500 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.0545
Cell Significance Index: 0.4500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0516
Cell Significance Index: 9.3100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0500
Cell Significance Index: 1.3400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0493
Cell Significance Index: 92.8200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0390
Cell Significance Index: 0.8300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0334
Cell Significance Index: 51.4400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0281
Cell Significance Index: 3.2800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0257
Cell Significance Index: 47.4000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0233
Cell Significance Index: 2.9900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0210
Cell Significance Index: 0.3600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0208
Cell Significance Index: 0.9200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0185
Cell Significance Index: 1.2800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0098
Cell Significance Index: 6.2400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0097
Cell Significance Index: 1.1900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0085
Cell Significance Index: 11.5300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0076
Cell Significance Index: 0.2700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0069
Cell Significance Index: 3.7700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0054
Cell Significance Index: 2.3700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0037
Cell Significance Index: 0.1400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0008
Cell Significance Index: 0.0200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0014
Cell Significance Index: -0.0300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0025
Cell Significance Index: -0.1300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.0032
Cell Significance Index: -0.0400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0034
Cell Significance Index: -1.5600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0035
Cell Significance Index: -2.6100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0052
Cell Significance Index: -3.9700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0054
Cell Significance Index: -3.9700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0065
Cell Significance Index: -3.6600 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0092
Cell Significance Index: -0.1700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0092
Cell Significance Index: -1.2700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0107
Cell Significance Index: -0.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0122
Cell Significance Index: -3.5100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0131
Cell Significance Index: -2.2500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0132
Cell Significance Index: -0.8100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0148
Cell Significance Index: -1.7000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0161
Cell Significance Index: -1.1400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0224
Cell Significance Index: -4.7200 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.0275
Cell Significance Index: -0.1500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0283
Cell Significance Index: -1.3200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0284
Cell Significance Index: -1.9100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0285
Cell Significance Index: -0.4300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0291
Cell Significance Index: -3.7600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0305
Cell Significance Index: -3.1200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0347
Cell Significance Index: -0.9500 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0357
Cell Significance Index: -0.4500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0358
Cell Significance Index: -1.1400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0363
Cell Significance Index: -2.2900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0368
Cell Significance Index: -4.3400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0413
Cell Significance Index: -4.3000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0462
Cell Significance Index: -3.4400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0463
Cell Significance Index: -0.9600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0471
Cell Significance Index: -3.6200 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0493
Cell Significance Index: -0.8300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0512
Cell Significance Index: -1.4300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0544
Cell Significance Index: -4.3100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0555
Cell Significance Index: -3.5800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0555
Cell Significance Index: -2.6100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.0568
Cell Significance Index: -1.6200 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0583
Cell Significance Index: -0.9800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0617
Cell Significance Index: -1.2200 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.0624
Cell Significance Index: -0.6500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0654
Cell Significance Index: -2.1400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0675
Cell Significance Index: -1.1300 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.0678
Cell Significance Index: -1.6900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.0722
Cell Significance Index: -1.4500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0741
Cell Significance Index: -3.2200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0760
Cell Significance Index: -3.9600 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0768
Cell Significance Index: -2.6900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0829
Cell Significance Index: -1.7600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0938
Cell Significance Index: -1.3900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1301953256
Symbol: MYO15_HUMAN
Name: Unconventional myosin-XV
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9603736
Title: Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3.
PubMed ID: 9603736
PubMed ID: 10552926
Title: Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.
PubMed ID: 10552926
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 19807924
Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
PubMed ID: 19807924
PubMed ID: 11735029
Title: Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome.
PubMed ID: 11735029
PubMed ID: 24926664
Title: Whole exome sequencing identifies new causative mutations in Tunisian families with non-syndromic deafness.
PubMed ID: 24926664
Sequence Information:
- Length: 3530
- Mass: 395293
- Checksum: DCCFBAD37BEA6309
- Sequence:
MAKEEDEEKK AKKGKKGKKA PEPEKPKRSL KGTSRLFMGF RDRTPKISKK GQFRSASAFF WGLHTGPQKT KRKRKARTVL KSTSKLMTQM RMGKKKRAMK GKKPSFMVIR FPGRRGYGRL RPRARSLSKA STAINWLTKK FLLKKAEESG SEQATVDAWL QRSSSRMGSR KLPFPSGAEI LRPGGRLRRF PRSRSIYASG EPLGFLPFED EAPFHHSGSR KSLYGLEGFQ DLGEYYDYHR DGDDYYDRQS LHRYEEQEPY LAGLGPYSPA WPPYGDHYYG YPPEDPYDYY HPDYYGGPFD PGYTYGYGYD DYEPPYAPPS GYSSPYSYHD GYEGEAHPYG YYLDPYAPYD APYPPYDLPY HTPYDVPYFD PYGVHYTVPY AEGVYGGGDE AIYPPEVPYF YPEESASAFV YPWVPPPIPS PHNPYAHAMD DIAELEEPED AGVERQGTSF RLPSAAFFEQ QGMDKPARSK LSLIRKFRLF PRPQVKLFGK EKLEVPLPPS LDIPLPLGDA DEEEDEEELP PVSAVPYGHP FWGFLTPRQR NLQRALSAFG AHRGLGFGPE FGRPVPRPAT SLARFLKKTL SEKKPIARLR GSQKARAGGP AVREAAYKRF GYKLAGMDPE KPGTPIVLRR AQPRARSSND ARRPPAPQPA PRTLSHWSAL LSPPVPPRPP SSGPPPAPPL SPALSGLPRP ASPYGSLRRH PPPWAAPAHV PPAPQASWWA FVEPPAVSPE VPPDLLAFPG PRPSFRGSRR RGAAFGFPGA SPRASRRRAW SPLASPQPSL RSSPGLGYCS PLAPPSPQLS LRTGPFQPPF LPPARRPRSL QESPAPRRAA GRLGPPGSPL PGSPRPPSPP LGLCHSPRRS SLNLPSRLPH TWRRLSEPPT RAVKPQVRLP FHRPPRAGAW RAPLEHRESP REPEDSETPW TVPPLAPSWD VDMPPTQRPP SPWPGGAGSR RGFSRPPPVP ENPFLQLLGP VPSPTLQPED PAADMTRVFL GRHHEPGPGQ LTKSAGPTPE KPEEEATLGD PQLPAETKPP TPAPPKDVTP PKDITPPKDV LPEQKTLRPS LSYPLAACDQ TRATWPPWHR WGTLPQAAAP LAPIRAPEPL PKGGERRQAA PGRFAVVMPR VQKLSSFQRV GPATLKPQVQ PIQDPKPRAC SLRWSCLWLR ADAYGPWPRV HTHPQSCHLG PGAACLSLRG SWEEVGPPSW RNKMHSIRNL PSMRFREQHG EDGVEDMTQL EDLQETTVLS NLKIRFERNL IYTYIGSILV SVNPYQMFGI YGPEQVQQYN GRALGENPPH LFAVANLAFA KMLDAKQNQC IIISGESGSG KTEATKLILR YLAAMNQKRE VMQQIKILEA TPLLESFGNA KTVRNDNSSR FGKFVEIFLE GGVISGAITS QYLLEKSRIV FQAKNERNYH IFYELLAGLP AQLRQAFSLQ EAETYYYLNQ GGNCEIAGKS DADDFRRLLA AMEVLGFSSE DQDSIFRILA SILHLGNVYF EKYETDAQEV ASVVSAREIQ AVAELLQISP EGLQKAITFK VTETMREKIF TPLTVESAVD ARDAIAKVLY ALLFSWLITR VNALVSPRQD TLSIAILDIY GFEDLSFNSF EQLCINYANE NLQYLFNKIV FQEEQEEYIR EQIDWQEITF ADNQPCINLI SLKPYGILRI LDDQCCFPQA TDHTFLQKCH YHHGANPLYS KPKMPLPEFT IKHYAGKVTY QVHKFLDKNH DQVRQDVLDL FVRSRTRVVA HLFSSHAPQA APQRLGKSSS VTRLYKAHTV AAKFQQSLLD LVEKMERCNP LFMRCLKPNH KKEPGLFEPD VVMAQLRYSG VLETVRIRKE GFPVRLPFQG FIDRYCCLVA LKHDLPANGD MCVSVLSRLC KVMPNMYRVG VSKLFLKEHL YQLLESMREH VLNLAALTLQ RCLRGFFIKR RFRSLRHKII LLQSRARGYL ARQRYQQMRR SLVKFRSLVH AYVSRRRYLK LRAEWRCQVE GALLWEQEEL SKREVVAVGH LEVPAELAGL LQAVAGLGLA QVPQVAPVRT PRLQAEPRVT LPLDINNYPM AKFVQCHFKE PAFGMLTVPL RTPLTQLPAE HHAEAVSIFK LILRFMGDPH LHGARENIFG NYIVQKGLAV PELRDEILAQ LANQVWHNHN AHNAERGWLL LAACLSGFAP SPCFNKYLLK FVSDYGRNGF QAVCQHRLMQ AMGRAQQQGS GAARTLPPTQ LEWTATYEKA SMALDVGCFN GDQFSCPVHS WSTGEEVAGD ILRHRGLADG WRGWTVAMKN GVQWAELAGH DYVLDLVSDL ELLRDFPRQK SYFIVGTEGP AASRGGPKVV FGNSWDSDED MSTRPQPQEH MPKVLDSDGY SSHNQDGTNG ETEAQRGTAT HQESDSLGEP AVPHKGLDCY LDSLFDPVLS YGDADLEKPT AIAYRMKGGG QPGGGSSSGT EDTPRRPPEP KPIPGLDAST LALQQAFIHK QAVLLAREMT LQATALQQQP LSAALRSLPA EKPPAPEAQP TSVGTGPPAK PVLLRATPKP LAPAPLAKAP RLPIKPVAAP VLAQDQASPE TTSPSPELVR YSTLNSEHFP QPTQQIKNIV RQYQQPFRGG RPEALRKDGG KVFMKRPDPH EEALMILKGQ MTHLAAAPGT QVSREAVALV KPVTSAPRPS MAPTSALPSR SLEPPEELTQ TRLHRLINPN FYGYQDAPWK IFLRKEVFYP KDSYSHPVQL DLLFRQILHD TLSEACLRIS EDERLRMKAL FAQNQLDTQK PLVTESVKRA VVSTARDTWE VYFSRIFPAT GSVGTGVQLL AVSHVGIKLL RMVKGGQEAG GQLRVLRAYS FADILFVTMP SQNMLEFNLA SEKVILFSAR AHQVKTLVDD FILELKKDSD YVVAVRNFLP EDPALLAFHK GDIIHLQPLE PPRVGYSAGC VVRRKVVYLE ELRRRGPDFG WRFGTIHGRV GRFPSELVQP AAAPDFLQLP TEPGRGRAAA VAAAVASAAA AQEVGRRREG PPVRARSADH GEDALALPPY TMLEFAQKYF RDPQRRPQDG LRLKSKEPRE SRTLEDMLCF TKTPLQESLI ELSDSSLSKM ATDMFLAVMR FMGDAPLKGQ SDLDVLCNLL KLCGDHEVMR DECYCQVVKQ ITDNTSSKQD SCQRGWRLLY IVTAYHSCSE VLHPHLTRFL QDVSRTPGLP FQGIAKACEQ NLQKTLRFGG RLELPSSIEL RAMLAGRSSK RQLFLLPGGL ERHLKIKTCT VALDVVEEIC AEMALTRPEA FNEYVIFVVT NRGQHVCPLS RRAYILDVAS EMEQVDGGYM LWFRRVLWDQ PLKFENELYV TMHYNQVLPD YLKGLFSSVP ASRPSEQLLQ QVSKLASLQH RAKDHFYLPS VREVQEYIPA QLYRTTAGST WLNLVSQHRQ QTQALSPHQA RAQFLGLLSA LPMFGSSFFF IQSCSNIAVP APCILAINHN GLNFLSTETH ELMVKFPLKE IQSTRTQRPT ANSSYPYVEI ALGDVAAQRT LQLQLEQGLE LCRVVAVHVE NLLSAHEKRL TLPPSEITLL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.