Details for: HERC5

Gene ID: 51191

Symbol: HERC5

Ensembl ID: ENSG00000138646

Description: HECT and RLD domain containing E3 ubiquitin protein ligase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.9808
    Cell Significance Index: -13.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 50.3857
    Cell Significance Index: -12.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.6738
    Cell Significance Index: -13.0600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 11.3957
    Cell Significance Index: 86.0500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.2534
    Cell Significance Index: -13.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.6069
    Cell Significance Index: -15.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5301
    Cell Significance Index: -13.9300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8716
    Cell Significance Index: -8.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.5637
    Cell Significance Index: 82.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.2543
    Cell Significance Index: 31.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9836
    Cell Significance Index: 44.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.8921
    Cell Significance Index: 18.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7971
    Cell Significance Index: 151.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.6972
    Cell Significance Index: 18.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4229
    Cell Significance Index: 381.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4210
    Cell Significance Index: 11.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3566
    Cell Significance Index: 6.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3473
    Cell Significance Index: 44.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3284
    Cell Significance Index: 7.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3087
    Cell Significance Index: 8.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2704
    Cell Significance Index: 43.9800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2554
    Cell Significance Index: 27.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2200
    Cell Significance Index: 14.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2060
    Cell Significance Index: 12.3700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.2011
    Cell Significance Index: 1.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1853
    Cell Significance Index: 18.3300
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.1813
    Cell Significance Index: 1.8800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1535
    Cell Significance Index: 4.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1428
    Cell Significance Index: 2.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1232
    Cell Significance Index: 4.3300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1173
    Cell Significance Index: 8.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0762
    Cell Significance Index: 52.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0687
    Cell Significance Index: 3.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0611
    Cell Significance Index: 6.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0538
    Cell Significance Index: 9.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0387
    Cell Significance Index: 2.0200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0383
    Cell Significance Index: 0.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0216
    Cell Significance Index: 9.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0180
    Cell Significance Index: 0.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0145
    Cell Significance Index: 7.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0079
    Cell Significance Index: 0.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0015
    Cell Significance Index: 0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0054
    Cell Significance Index: -3.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0056
    Cell Significance Index: -3.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0095
    Cell Significance Index: -17.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0113
    Cell Significance Index: -17.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0135
    Cell Significance Index: -8.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0136
    Cell Significance Index: -18.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0203
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0214
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0243
    Cell Significance Index: -2.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0256
    Cell Significance Index: -3.7200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0282
    Cell Significance Index: -12.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0287
    Cell Significance Index: -10.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0292
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0361
    Cell Significance Index: -7.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0384
    Cell Significance Index: -7.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0420
    Cell Significance Index: -12.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0454
    Cell Significance Index: -1.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0533
    Cell Significance Index: -10.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0632
    Cell Significance Index: -7.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0678
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0691
    Cell Significance Index: -7.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0786
    Cell Significance Index: -6.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0822
    Cell Significance Index: -10.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0832
    Cell Significance Index: -9.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0948
    Cell Significance Index: -5.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0960
    Cell Significance Index: -4.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0971
    Cell Significance Index: -6.8700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1092
    Cell Significance Index: -1.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1183
    Cell Significance Index: -8.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1254
    Cell Significance Index: -13.0600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1256
    Cell Significance Index: -3.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1378
    Cell Significance Index: -3.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1534
    Cell Significance Index: -12.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1575
    Cell Significance Index: -6.4500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1646
    Cell Significance Index: -1.6500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1659
    Cell Significance Index: -4.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1677
    Cell Significance Index: -10.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1700
    Cell Significance Index: -2.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1878
    Cell Significance Index: -10.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2038
    Cell Significance Index: -10.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2164
    Cell Significance Index: -5.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2245
    Cell Significance Index: -15.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2383
    Cell Significance Index: -15.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2621
    Cell Significance Index: -13.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2782
    Cell Significance Index: -7.1500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3010
    Cell Significance Index: -4.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3030
    Cell Significance Index: -8.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3049
    Cell Significance Index: -13.4900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3430
    Cell Significance Index: -5.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3471
    Cell Significance Index: -8.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3589
    Cell Significance Index: -13.5900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3597
    Cell Significance Index: -5.4200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3799
    Cell Significance Index: -16.5200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3834
    Cell Significance Index: -13.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3839
    Cell Significance Index: -12.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HERC5 is an E3 ubiquitin protein ligase, which means it facilitates the transfer of ubiquitin molecules to specific target proteins. This process, known as ubiquitination, is a key mechanism for regulating protein activity, localization, and degradation. HERC5 contains a HECT domain, a RLD domain, and a ubiquitin ligase activity, which are essential for its function. The gene is also associated with several signaling pathways, including interferon signaling, cytokine signaling, and protein kinase signaling. **Pathways and Functions** HERC5 is involved in various immune-related pathways, including: 1. **Antiviral mechanism by interferon-stimulated genes**: HERC5 regulates the expression of interferon-stimulated genes, which are critical for the innate immune response against viral infections. 2. **Adaptive immune system**: HERC5 is involved in the processing and presentation of antigens to T cells, which is essential for the adaptive immune response. 3. **Cytokine signaling in the immune system**: HERC5 regulates the activity of cytokines, which are signaling molecules that coordinate the immune response. 4. **Regulation of cyclin-dependent protein serine/threonine kinase activity**: HERC5 modulates the activity of cyclin-dependent kinases, which are essential for cell cycle progression and cellular regulation. 5. **Defense response to virus**: HERC5 is involved in the regulation of defense responses against viral infections, including the induction of interferon-alpha/beta and the transfer of Isg15. **Clinical Significance** HERC5 dysfunction has been implicated in various diseases, including: 1. **Viral infections**: HERC5 plays a critical role in the innate immune response against viral infections, and its dysfunction may lead to increased susceptibility to viral infections. 2. **Autoimmune diseases**: HERC5 regulates the activity of cytokines and immune cells, and its dysfunction may contribute to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Cancer**: HERC5 is involved in the regulation of cell cycle progression and apoptosis, and its dysfunction may contribute to cancer development and progression. 4. **Immune system disorders**: HERC5 is essential for the development and function of immune cells, and its dysfunction may lead to immune system disorders, such as immunodeficiency diseases. In conclusion, HERC5 is a crucial component of the innate immune system, and its dysfunction may have significant implications for human health. Further research is needed to understand the mechanisms of HERC5 function and its role in disease.

Genular Protein ID: 3232317592

Symbol: HERC5_HUMAN

Name: E3 ISG15--protein ligase HERC5

UniProtKB Accession Codes:

Q9UII4 B2RTQ1 Q69G20

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10581175

Title: A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins.

PubMed ID: 10581175

DOI: 10.1006/bbrc.1999.1777

PubMed ID: 15331633

Title: HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells.

PubMed ID: 15331633

DOI: 10.1242/jcs.01338

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16884686

Title: Identification and Herc5-mediated ISGylation of novel target proteins.

PubMed ID: 16884686

DOI: 10.1016/j.bbrc.2006.07.076

PubMed ID: 16407192

Title: Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.

PubMed ID: 16407192

DOI: 10.1074/jbc.m512830200

PubMed ID: 16815975

Title: HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets.

PubMed ID: 16815975

DOI: 10.1073/pnas.0600397103

PubMed ID: 20385878

Title: Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein.

PubMed ID: 20385878

DOI: 10.4049/jimmunol.0903588

PubMed ID: 20308324

Title: Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification.

PubMed ID: 20308324

DOI: 10.1128/mcb.01466-09

PubMed ID: 20542004

Title: The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.

PubMed ID: 20542004

DOI: 10.1016/j.molcel.2010.05.002

PubMed ID: 20133869

Title: ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells.

PubMed ID: 20133869

DOI: 10.1073/pnas.0909144107

PubMed ID: 22093708

Title: Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag.

PubMed ID: 22093708

DOI: 10.1186/1742-4690-8-95

PubMed ID: 26355087

Title: Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway.

PubMed ID: 26355087

DOI: 10.1128/jvi.01482-15

PubMed ID: 27564865

Title: Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators.

PubMed ID: 27564865

DOI: 10.1371/journal.ppat.1005850

PubMed ID: 27534820

Title: Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin.

PubMed ID: 27534820

DOI: 10.1098/rsob.160193

PubMed ID: 34661519

Title: HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication.

PubMed ID: 34661519

DOI: 10.1099/jgv.0.001668

PubMed ID: 34572049

Title: Interferon-Induced HERC5 Inhibits Ebola Virus Particle Production and Is Antagonized by Ebola Glycoprotein.

PubMed ID: 34572049

DOI: 10.3390/cells10092399

PubMed ID: 37279284

Title: The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN.

PubMed ID: 37279284

DOI: 10.1126/scisignal.abm1756

Sequence Information:

  • Length: 1024
  • Mass: 116852
  • Checksum: 1449C51A58269A6C
  • Sequence:
    • MERRSRRKSR RNGRSTAGKA AATQPAKSPG AQLWLFPSAA GLHRALLRRV EVTRQLCCSP 
GRLAVLERGG AGVQVHQLLA GSGGARTPKC IKLGKNMKIH SVDQGAEHML ILSSDGKPFE 
YDNYSMKHLR FESILQEKKI IQITCGDYHS LALSKGGELF AWGQNLHGQL GVGRKFPSTT 
TPQIVEHLAG VPLAQISAGE AHSMALSMSG NIYSWGKNEC GQLGLGHTES KDDPSLIEGL 
DNQKVEFVAC GGSHSALLTQ DGLLFTFGAG KHGQLGHNST QNELRPCLVA ELVGYRVTQI 
ACGRWHTLAY VSDLGKVFSF GSGKDGQLGN GGTRDQLMPL PVKVSSSEEL KLESHTSEKE 
LIMIAGGNQS ILLWIKKENS YVNLKRTIPT LNEGTVKRWI ADVETKRWQS TKREIQEIFS 
SPACLTGSFL RKRRTTEMMP VYLDLNKARN IFKELTQKDW ITNMITTCLK DNLLKRLPFH 
SPPQEALEIF FLLPECPMMH ISNNWESLVV PFAKVVCKMS DQSSLVLEEY WATLQESTFS 
KLVQMFKTAV ICQLDYWDES AEENGNVQAL LEMLKKLHRV NQVKCQLPES IFQVDELLHR 
LNFFVEVCRR YLWKMTVDAS ENVQCCVIFS HFPFIFNNLS KIKLLHTDTL LKIESKKHKA 
YLRSAAIEEE RESEFALRPT FDLTVRRNHL IEDVLNQLSQ FENEDLRKEL WVSFSGEIGY 
DLGGVKKEFF YCLFAEMIQP EYGMFMYPEG ASCMWFPVKP KFEKKRYFFF GVLCGLSLFN 
CNVANLPFPL ALFKKLLDQM PSLEDLKELS PDLGKNLQTL LDDEGDNFEE VFYIHFNVHW 
DRNDTNLIPN GSSITVNQTN KRDYVSKYIN YIFNDSVKAV YEEFRRGFYK MCDEDIIKLF 
HPEELKDVIV GNTDYDWKTF EKNARYEPGY NSSHPTIVMF WKAFHKLTLE EKKKFLVFLT 
GTDRLQMKDL NNMKITFCCP ESWNERDPIR ALTCFSVLFL PKYSTMETVE EALQEAINNN 
RGFG

Genular Protein ID: 1802626429

Symbol: B4DXV3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DXV3

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 578
  • Mass: 67938
  • Checksum: 01505931F4F3D3EA
  • Sequence:
    • MIAGGNQSIL LWIKKENSYV NLKRTIPTLN EGTVKRWIAD VETKRWQSTK REIQEIFSSP 
ACLTGSFLRK RRTTEMMPVY LDLNKARNIF KELTQKDWIT NMITTCLKDN LLKRLPFHSP 
PQEALEIFFL LPECPMMHIS NNWESLVVPF AKVVCKMSDQ SSLVLEEYWA TLQESTFSKL 
VQMFKTAVIC QLDYWDESAE ENGNVQALLE MLKKLHRVNQ VKCQLPESIF QVDELLHRLN 
FFVEVCRRYL WKMTVDASEN VQCCVIFSHF PFIFNNLSKI KLLHTDTLLK IESKKHKAYL 
RSAAIEEERE SEFALRPTFD LTVRRNHLIE DVLNQLSQFE NEDLRKELWV SFSGEIGYDL 
GGVKKEFFYC LFAEMIQPEY GMFMYPEGAS CMWFPVKPKF EKKRYFFFGV LCGLSLFNCN 
VANLPFPLAL FKKLLDQMPS LEDLKELSPD LGKNLQTLLD DEGDNFEEVF YIHFNVHWDR 
NDTNLIPNGS SITVNQTNKR DYVSKYINYI FNDSVKAVYE EFRRGFYKMC DGDIIKLFHP 
EELKDVIVGN TDYDWKTFEK NARYEPGYNS SHPTIVMF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.