Details for: DDX47

Gene ID: 51202

Symbol: DDX47

Ensembl ID: ENSG00000213782

Description: DEAD-box helicase 47

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.8674
    Cell Significance Index: -7.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.2537
    Cell Significance Index: -7.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.9167
    Cell Significance Index: -6.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.5253
    Cell Significance Index: -6.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9937
    Cell Significance Index: -7.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7530
    Cell Significance Index: -7.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8905
    Cell Significance Index: -7.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5383
    Cell Significance Index: 28.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4012
    Cell Significance Index: 362.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3979
    Cell Significance Index: 20.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3148
    Cell Significance Index: 9.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2823
    Cell Significance Index: 30.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2762
    Cell Significance Index: 7.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2740
    Cell Significance Index: 44.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.2559
    Cell Significance Index: -0.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2357
    Cell Significance Index: 14.1500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2301
    Cell Significance Index: 2.6500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2189
    Cell Significance Index: 21.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2008
    Cell Significance Index: 12.3400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1478
    Cell Significance Index: 102.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1476
    Cell Significance Index: 6.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1372
    Cell Significance Index: 3.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1250
    Cell Significance Index: 14.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1235
    Cell Significance Index: 2.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1179
    Cell Significance Index: 8.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1108
    Cell Significance Index: 2.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0698
    Cell Significance Index: 13.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0688
    Cell Significance Index: 1.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0530
    Cell Significance Index: 1.5200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0341
    Cell Significance Index: 0.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0297
    Cell Significance Index: 1.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0292
    Cell Significance Index: 5.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0291
    Cell Significance Index: 3.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0265
    Cell Significance Index: 0.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0260
    Cell Significance Index: 3.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0251
    Cell Significance Index: 5.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0219
    Cell Significance Index: 9.6800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0195
    Cell Significance Index: 0.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0164
    Cell Significance Index: 2.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.0106
    Cell Significance Index: 0.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0067
    Cell Significance Index: 3.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0052
    Cell Significance Index: 0.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0048
    Cell Significance Index: 0.2400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0025
    Cell Significance Index: 0.0200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0018
    Cell Significance Index: 0.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0014
    Cell Significance Index: 0.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0005
    Cell Significance Index: -0.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0037
    Cell Significance Index: -7.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0047
    Cell Significance Index: -0.1000
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0050
    Cell Significance Index: -1.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0053
    Cell Significance Index: -9.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0064
    Cell Significance Index: -0.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0089
    Cell Significance Index: -1.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0096
    Cell Significance Index: -0.6800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0097
    Cell Significance Index: -0.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0102
    Cell Significance Index: -7.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0108
    Cell Significance Index: -6.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0111
    Cell Significance Index: -8.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0145
    Cell Significance Index: -8.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0151
    Cell Significance Index: -9.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0163
    Cell Significance Index: -7.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0221
    Cell Significance Index: -0.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0243
    Cell Significance Index: -6.9800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0257
    Cell Significance Index: -1.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0261
    Cell Significance Index: -1.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0295
    Cell Significance Index: -1.9100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0325
    Cell Significance Index: -0.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0371
    Cell Significance Index: -3.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0378
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0394
    Cell Significance Index: -4.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0394
    Cell Significance Index: -6.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0407
    Cell Significance Index: -8.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0422
    Cell Significance Index: -8.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0466
    Cell Significance Index: -6.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0497
    Cell Significance Index: -1.0300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0547
    Cell Significance Index: -0.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0555
    Cell Significance Index: -0.6300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0579
    Cell Significance Index: -0.8800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0653
    Cell Significance Index: -3.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0722
    Cell Significance Index: -7.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0732
    Cell Significance Index: -5.6200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0748
    Cell Significance Index: -0.6800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0768
    Cell Significance Index: -2.4600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0797
    Cell Significance Index: -0.5400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0880
    Cell Significance Index: -1.4100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0893
    Cell Significance Index: -7.0800
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0984
    Cell Significance Index: -0.6400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1004
    Cell Significance Index: -1.6800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1016
    Cell Significance Index: -1.5200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1044
    Cell Significance Index: -1.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1048
    Cell Significance Index: -5.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1061
    Cell Significance Index: -3.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1093
    Cell Significance Index: -2.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1194
    Cell Significance Index: -2.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1227
    Cell Significance Index: -8.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **RNA Processing:** DDX47 is involved in the major pathway of RNA processing in the nucleolus and cytosol, playing a crucial role in the maturation and regulation of RNA molecules. 2. **Apoptosis:** DDX47 is implicated in the extrinsic apoptotic signaling pathway via death domain receptors, suggesting its role in regulating programmed cell death. 3. **Protein Binding:** DDX47 exhibits high affinity for proteins, indicating its potential involvement in protein-protein interactions and regulation. 4. **Cellular Localization:** DDX47 is found in both the nucleus and cytosol, suggesting its involvement in processes that require both nuclear and cytoplasmic localization. **Pathways and Functions:** DDX47 is involved in several key pathways, including: 1. **RNA Processing:** DDX47 is a critical component of the RNA processing machinery, responsible for unwinding and unwinding RNA secondary structures, facilitating the maturation of RNA molecules. 2. **Apoptosis:** DDX47's involvement in the extrinsic apoptotic signaling pathway via death domain receptors suggests its role in regulating programmed cell death. 3. **Metabolism of RNA:** DDX47 is also involved in the metabolism of RNA, including RNA degradation and degradation of RNA secondary structures. 4. **Protein Binding:** DDX47's high affinity for proteins suggests its potential involvement in protein-protein interactions and regulation. **Clinical Significance:** 1. **Immune System Dysregulation:** DDX47's involvement in hematopoietic cell development and function suggests its potential role in immune system dysregulation, such as autoimmune diseases or cancer. 2. **Apoptosis Disorders:** DDX47's role in the extrinsic apoptotic signaling pathway via death domain receptors suggests its potential involvement in apoptosis disorders, such as cancer or neurodegenerative diseases. 3. **RNA-Related Disorders:** DDX47's involvement in RNA processing and metabolism suggests its potential role in RNA-related disorders, such as RNA-binding protein disorders or RNA processing disorders. In conclusion, DDX47 is a multifaceted gene with a wide range of functions, from RNA processing and apoptosis to protein binding and cellular localization. Its involvement in various cellular processes highlights the importance of its regulation in maintaining cellular homeostasis and responding to external stimuli. Further research is needed to fully elucidate the clinical significance of DDX47 and its potential role in human diseases.

Genular Protein ID: 3297853797

Symbol: DDX47_HUMAN

Name: Probable ATP-dependent RNA helicase DDX47

UniProtKB Accession Codes:

Q9H0S4 B3KXP4 G5E955 Q96GM0 Q96NV8 Q9UI98

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12429849

Title: Functional proteomic analysis of human nucleolus.

PubMed ID: 12429849

DOI: 10.1091/mbc.e02-05-0271

PubMed ID: 15977068

Title: GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).

PubMed ID: 15977068

DOI: 10.1007/s10529-005-3628-2

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16963496

Title: NOP132 is required for proper nucleolus localization of DEAD-box RNA helicase DDX47.

PubMed ID: 16963496

DOI: 10.1093/nar/gkl603

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

PubMed ID: 31256877

Title: Paralog studies augment gene discovery: DDX and DHX genes.

PubMed ID: 31256877

DOI: 10.1016/j.ajhg.2019.06.001

Sequence Information:

  • Length: 455
  • Mass: 50647
  • Checksum: 5F64F26AD2C11286
  • Sequence:
    • MAAPEEHDSP TEASQPIVEE EETKTFKDLG VTDVLCEACD QLGWTKPTKI QIEAIPLALQ 
GRDIIGLAET GSGKTGAFAL PILNALLETP QRLFALVLTP TRELAFQISE QFEALGSSIG 
VQSAVIVGGI DSMSQSLALA KKPHIIIATP GRLIDHLENT KGFNLRALKY LVMDEADRIL 
NMDFETEVDK ILKVIPRDRK TFLFSATMTK KVQKLQRAAL KNPVKCAVSS KYQTVEKLQQ 
YYIFIPSKFK DTYLVYILNE LAGNSFMIFC STCNNTQRTA LLLRNLGFTA IPLHGQMSQS 
KRLGSLNKFK AKARSILLAT DVASRGLDIP HVDVVVNFDI PTHSKDYIHR VGRTARAGRS 
GKAITFVTQY DVELFQRIEH LIGKKLPGFP TQDDEVMMLT ERVAEAQRFA RMELREHGEK 
KKRSREDAGD NDDTEGAIGV RNKVAGGKMK KRKGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.