Details for: ACP6

Gene ID: 51205

Symbol: ACP6

Ensembl ID: ENSG00000162836

Description: acid phosphatase 6, lysophosphatidic

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 90.9060
    Cell Significance Index: -14.1400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.2567
    Cell Significance Index: -12.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.7102
    Cell Significance Index: -12.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.7783
    Cell Significance Index: -12.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.5414
    Cell Significance Index: -14.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.2186
    Cell Significance Index: -13.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.6518
    Cell Significance Index: -14.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.6400
    Cell Significance Index: -11.1800
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 2.7129
    Cell Significance Index: 3.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.6273
    Cell Significance Index: -5.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.0752
    Cell Significance Index: 14.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0223
    Cell Significance Index: 923.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9327
    Cell Significance Index: 48.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8749
    Cell Significance Index: 173.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8595
    Cell Significance Index: 51.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8330
    Cell Significance Index: 90.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6897
    Cell Significance Index: 112.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4233
    Cell Significance Index: 151.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4160
    Cell Significance Index: 83.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4128
    Cell Significance Index: 74.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4058
    Cell Significance Index: 28.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3806
    Cell Significance Index: 263.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3525
    Cell Significance Index: 9.8500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3311
    Cell Significance Index: 4.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3245
    Cell Significance Index: 7.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3160
    Cell Significance Index: 24.2500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3103
    Cell Significance Index: 7.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2916
    Cell Significance Index: 2.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2617
    Cell Significance Index: 7.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2441
    Cell Significance Index: 13.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2260
    Cell Significance Index: 27.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1744
    Cell Significance Index: 95.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1674
    Cell Significance Index: 4.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1662
    Cell Significance Index: 7.5400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1633
    Cell Significance Index: 31.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1199
    Cell Significance Index: 4.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1190
    Cell Significance Index: 5.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1030
    Cell Significance Index: 6.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1007
    Cell Significance Index: 44.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0810
    Cell Significance Index: 2.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0800
    Cell Significance Index: 7.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0798
    Cell Significance Index: 3.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0683
    Cell Significance Index: 4.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0629
    Cell Significance Index: 118.3700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0590
    Cell Significance Index: 1.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0493
    Cell Significance Index: 31.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0484
    Cell Significance Index: 21.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0356
    Cell Significance Index: 54.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0296
    Cell Significance Index: 54.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0279
    Cell Significance Index: 3.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0166
    Cell Significance Index: 0.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0143
    Cell Significance Index: 0.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0054
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0046
    Cell Significance Index: 0.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0021
    Cell Significance Index: 0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0003
    Cell Significance Index: 0.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0027
    Cell Significance Index: -1.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0065
    Cell Significance Index: -0.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0071
    Cell Significance Index: -1.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0097
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0140
    Cell Significance Index: -10.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0193
    Cell Significance Index: -10.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0246
    Cell Significance Index: -15.3600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0371
    Cell Significance Index: -3.7900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0437
    Cell Significance Index: -0.9300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0447
    Cell Significance Index: -0.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0448
    Cell Significance Index: -0.9300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0452
    Cell Significance Index: -0.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0482
    Cell Significance Index: -6.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0506
    Cell Significance Index: -14.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0590
    Cell Significance Index: -6.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0706
    Cell Significance Index: -14.8800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0742
    Cell Significance Index: -1.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0806
    Cell Significance Index: -3.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0842
    Cell Significance Index: -8.7700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0862
    Cell Significance Index: -1.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0887
    Cell Significance Index: -10.4600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0957
    Cell Significance Index: -2.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1002
    Cell Significance Index: -7.4700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1068
    Cell Significance Index: -1.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1204
    Cell Significance Index: -7.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1340
    Cell Significance Index: -2.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1349
    Cell Significance Index: -8.2700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1359
    Cell Significance Index: -3.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1437
    Cell Significance Index: -4.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1529
    Cell Significance Index: -4.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1604
    Cell Significance Index: -12.7000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1922
    Cell Significance Index: -1.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2001
    Cell Significance Index: -12.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2031
    Cell Significance Index: -4.3100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2099
    Cell Significance Index: -4.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2147
    Cell Significance Index: -7.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2182
    Cell Significance Index: -6.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2217
    Cell Significance Index: -5.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2331
    Cell Significance Index: -12.2400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2341
    Cell Significance Index: -4.7000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2398
    Cell Significance Index: -2.9900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2401
    Cell Significance Index: -7.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ACP6 gene exhibits a wide range of cellular and tissue-specific expression patterns, with significant expression in hematopoietic progenitor cells, mast cells, and epithelial cells. These cells are essential for immune function, tissue homeostasis, and the maintenance of epithelial barriers. The ACP6 gene has been implicated in various cellular processes, including: 1. **Hematopoiesis**: ACP6 expression is essential for the regulation of hematopoietic progenitor cell differentiation and proliferation. 2. **Lipid metabolism**: ACP6 plays a critical role in the degradation of LPA, which is involved in lipid metabolism and signaling pathways. 3. **Immune cell function**: ACP6 expression is required for the proper functioning of immune cells, including T cells, mast cells, and epithelial cells. **Pathways and Functions** The ACP6 gene is involved in several signaling pathways, including: 1. **Acid phosphatase activity**: ACP6 catalyzes the degradation of phosphatidic acid, a key intermediate in lipid metabolism. 2. **Lysobisphosphatidic acid metabolic process**: ACP6 regulates the degradation of lysobisphosphatidic acid (LBP), a signaling molecule involved in cell proliferation and differentiation. 3. **Hematopoietic progenitor cell differentiation**: ACP6 expression is essential for the regulation of hematopoietic progenitor cell differentiation and proliferation. **Clinical Significance** Dysregulation of the ACP6 gene has been implicated in various diseases, including: 1. **Immunodeficiency disorders**: ACP6 expression is essential for the proper functioning of immune cells, and dysregulation of this gene can lead to immunodeficiency disorders. 2. **Cancer**: ACP6 expression is altered in various types of cancer, including leukemia, lymphoma, and solid tumors. 3. **Metabolic disorders**: ACP6 plays a critical role in lipid metabolism, and dysregulation of this gene can contribute to metabolic disorders, including obesity and type 2 diabetes. In conclusion, the ACP6 gene plays a critical role in regulating immune cell function, lipid metabolism, and cellular signaling pathways. Further research is needed to fully elucidate the functions of this gene and its implications in human disease.

Genular Protein ID: 3173815787

Symbol: PPA6_HUMAN

Name: Lysophosphatidic acid phosphatase type 6

UniProtKB Accession Codes:

Q9NPH0 Q59G61 Q5T490 Q6IAQ3 Q7LG81 Q9UIG6 X5D289

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10506173

Title: Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis.

PubMed ID: 10506173

DOI: 10.1074/jbc.274.41.29172

PubMed ID: 12010880

Title: Novel human and mouse genes encoding an acid phosphatase family member and its downregulation in W/W(V) mouse jejunum.

PubMed ID: 12010880

DOI: 10.1136/gut.50.6.790

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

DOI: 10.1038/ncomms4650

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 23807634

Title: Crystal structures and biochemical studies of human lysophosphatidic acid phosphatase type 6.

PubMed ID: 23807634

DOI: 10.1007/s13238-013-3031-z

Sequence Information:

  • Length: 428
  • Mass: 48886
  • Checksum: 3CA08CFD1BB44BFA
  • Sequence:
    • MITGVFSMRL WTPVGVLTSL AYCLHQRRVA LAELQEADGQ CPVDRSLLKL KMVQVVFRHG 
ARSPLKPLPL EEQVEWNPQL LEVPPQTQFD YTVTNLAGGP KPYSPYDSQY HETTLKGGMF 
AGQLTKVGMQ QMFALGERLR KNYVEDIPFL SPTFNPQEVF IRSTNIFRNL ESTRCLLAGL 
FQCQKEGPII IHTDEADSEV LYPNYQSCWS LRQRTRGRRQ TASLQPGISE DLKKVKDRMG 
IDSSDKVDFF ILLDNVAAEQ AHNLPSCPML KRFARMIEQR AVDTSLYILP KEDRESLQMA 
VGPFLHILES NLLKAMDSAT APDKIRKLYL YAAHDVTFIP LLMTLGIFDH KWPPFAVDLT 
MELYQHLESK EWFVQLYYHG KEQVPRGCPD GLCPLDMFLN AMSVYTLSPE KYHALCSQTQ 
VMEVGNEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.