Details for: GLTP

Gene ID: 51228

Symbol: GLTP

Ensembl ID: ENSG00000139433

Description: glycolipid transfer protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 219.1646
    Cell Significance Index: -34.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 121.0361
    Cell Significance Index: -30.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.6461
    Cell Significance Index: -34.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.7958
    Cell Significance Index: -33.3300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.9208
    Cell Significance Index: -34.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.8518
    Cell Significance Index: -34.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6389
    Cell Significance Index: -28.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.2883
    Cell Significance Index: -31.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7607
    Cell Significance Index: -34.5700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.7708
    Cell Significance Index: -12.6300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 4.2631
    Cell Significance Index: 68.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.0603
    Cell Significance Index: 37.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8452
    Cell Significance Index: 77.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3411
    Cell Significance Index: 422.0300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.2414
    Cell Significance Index: 19.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.9401
    Cell Significance Index: 238.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.8777
    Cell Significance Index: 97.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3795
    Cell Significance Index: 82.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3361
    Cell Significance Index: 37.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1509
    Cell Significance Index: 125.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0805
    Cell Significance Index: 50.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9697
    Cell Significance Index: 428.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9280
    Cell Significance Index: 24.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7569
    Cell Significance Index: 123.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7524
    Cell Significance Index: 35.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6617
    Cell Significance Index: 46.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6393
    Cell Significance Index: 87.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5984
    Cell Significance Index: 41.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5404
    Cell Significance Index: 295.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5227
    Cell Significance Index: 9.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5171
    Cell Significance Index: 13.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4678
    Cell Significance Index: 93.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4314
    Cell Significance Index: 55.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3990
    Cell Significance Index: 29.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3330
    Cell Significance Index: 63.3700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2809
    Cell Significance Index: 18.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2317
    Cell Significance Index: 83.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2200
    Cell Significance Index: 43.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2182
    Cell Significance Index: 37.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2073
    Cell Significance Index: 3.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2064
    Cell Significance Index: 5.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1923
    Cell Significance Index: 24.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1828
    Cell Significance Index: 3.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1348
    Cell Significance Index: 15.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1020
    Cell Significance Index: 10.0900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0833
    Cell Significance Index: 2.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0680
    Cell Significance Index: 8.0200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0545
    Cell Significance Index: 0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0496
    Cell Significance Index: 36.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0467
    Cell Significance Index: 0.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0389
    Cell Significance Index: 26.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0188
    Cell Significance Index: 14.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -11.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0107
    Cell Significance Index: -6.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0114
    Cell Significance Index: -0.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0147
    Cell Significance Index: -22.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0158
    Cell Significance Index: -29.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0188
    Cell Significance Index: -25.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0247
    Cell Significance Index: -0.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0354
    Cell Significance Index: -22.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0365
    Cell Significance Index: -3.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0378
    Cell Significance Index: -21.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0446
    Cell Significance Index: -2.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0492
    Cell Significance Index: -22.3100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0618
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0830
    Cell Significance Index: -17.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0967
    Cell Significance Index: -1.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0974
    Cell Significance Index: -28.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1015
    Cell Significance Index: -2.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1081
    Cell Significance Index: -12.6000
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1375
    Cell Significance Index: -0.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1666
    Cell Significance Index: -4.8000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1670
    Cell Significance Index: -19.0600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1715
    Cell Significance Index: -3.5900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1733
    Cell Significance Index: -10.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1790
    Cell Significance Index: -26.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1791
    Cell Significance Index: -11.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2466
    Cell Significance Index: -18.9300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2534
    Cell Significance Index: -20.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2615
    Cell Significance Index: -7.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2759
    Cell Significance Index: -7.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2853
    Cell Significance Index: -16.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3227
    Cell Significance Index: -33.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3556
    Cell Significance Index: -23.9100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3789
    Cell Significance Index: -8.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4177
    Cell Significance Index: -21.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4178
    Cell Significance Index: -13.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4388
    Cell Significance Index: -26.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4522
    Cell Significance Index: -20.0000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -0.5511
    Cell Significance Index: -2.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5591
    Cell Significance Index: -28.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5733
    Cell Significance Index: -5.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5757
    Cell Significance Index: -21.8000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6392
    Cell Significance Index: -16.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6570
    Cell Significance Index: -11.6100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6643
    Cell Significance Index: -27.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6892
    Cell Significance Index: -20.3000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6974
    Cell Significance Index: -25.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7595
    Cell Significance Index: -11.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GLTP is a glycoprotein that exhibits a unique structure, comprising two extracellular domains and one intracellular domain. Its extracellular domains are characterized by a conserved sequence of 12 amino acids, which mediates its interaction with glycolipids. The protein's intracellular domain contains a C-terminal transmembrane domain, allowing it to cross the plasma membrane and interact with intracellular signaling pathways. GLTP's small size (approximately 20 kDa) and high expression levels in hematopoietic cells make it an attractive candidate for studying cell signaling and lipid metabolism. **Pathways and Functions:** GLTP's primary function is to facilitate the transfer of glycolipids between cells, playing a crucial role in maintaining cellular homeostasis and immune response. The protein's interactions with glycolipids are mediated by its extracellular domains, which bind to specific lipid molecules. This binding event triggers a conformational change in the protein, allowing it to interact with intracellular signaling pathways. GLTP's involvement in various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, highlights its role in regulating cell survival, proliferation, and differentiation. GLTP's functions can be categorized into three main areas: 1. **Glycolipid transfer:** GLTP's primary function is to transfer glycolipids between cells, facilitating the exchange of lipid molecules and maintaining cellular homeostasis. 2. **Cell signaling:** GLTP's interactions with glycolipids trigger a conformational change, allowing it to interact with intracellular signaling pathways and regulate cell survival, proliferation, and differentiation. 3. **Immune response:** GLTP's expression in hematopoietic cells and its involvement in immune response pathways highlight its role in regulating immune cell function and modulating immune responses. **Clinical Significance:** GLTP's dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders:** GLTP's involvement in immune response pathways makes it a potential target for the treatment of autoimmune disorders, such as rheumatoid arthritis and lupus. 2. **Cancer:** GLTP's expression in cancer cells highlights its potential role in cancer progression and metastasis. 3. **Neurological disorders:** GLTP's involvement in lipid metabolism and signaling pathways makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, GLTP is a multifunctional protein that plays a crucial role in various cellular processes, including lipid metabolism, immune response, and cell signaling. Further research into GLTP's functions and dysregulation is necessary to fully understand its clinical significance and potential therapeutic applications.

Genular Protein ID: 3682796810

Symbol: GLTP_HUMAN

Name: Glycolipid transfer protein

UniProtKB Accession Codes:

Q9NZD2 Q53Z13 Q96J68

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15287756

Title: Human glycolipid transfer protein: probing conformation using fluorescence spectroscopy.

PubMed ID: 15287756

DOI: 10.1021/bi0495432

PubMed ID: 18261224

Title: Human glycolipid transfer protein (GLTP) genes: organization, transcriptional status and evolution.

PubMed ID: 18261224

DOI: 10.1186/1471-2164-9-72

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15504043

Title: Glycolipid transfer protein mediated transfer of glycosphingolipids between membranes: a model for action based on kinetic and thermodynamic analyses.

PubMed ID: 15504043

DOI: 10.1021/bi0492197

PubMed ID: 17980653

Title: Human glycolipid transfer protein -- intracellular localization and effects on the sphingolipid synthesis.

PubMed ID: 17980653

DOI: 10.1016/j.bbalip.2007.09.001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 15329726

Title: Structural basis for glycosphingolipid transfer specificity.

PubMed ID: 15329726

DOI: 10.1038/nature02856

PubMed ID: 29164996

Title: CPTP: A sphingolipid transfer protein that regulates autophagy and inflammasome activation.

PubMed ID: 29164996

DOI: 10.1080/15548627.2017.1393129

PubMed ID: 17105344

Title: The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.

PubMed ID: 17105344

DOI: 10.1371/journal.pbio.0040362

Sequence Information:

  • Length: 209
  • Mass: 23850
  • Checksum: F3DD96D702AE22CF
  • Sequence:
    • MALLAEHLLK PLPADKQIET GPFLEAVSHL PPFFDCLGSP VFTPIKADIS GNITKIKAVY 
DTNPAKFRTL QNILEVEKEM YGAEWPKVGA TLALMWLKRG LRFIQVFLQS ICDGERDENH 
PNLIRVNATK AYEMALKKYH GWIVQKIFQA ALYAAPYKSD FLKALSKGQN VTEEECLEKI 
RLFLVNYTAT IDVIYEMYTQ MNAELNYKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.