Details for: ANKRD39

Gene ID: 51239

Symbol: ANKRD39

Ensembl ID: ENSG00000213337

Description: ankyrin repeat domain 39

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.9219
    Cell Significance Index: -17.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 69.1916
    Cell Significance Index: -17.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.7098
    Cell Significance Index: -19.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 35.6737
    Cell Significance Index: -18.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3428
    Cell Significance Index: -20.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2153
    Cell Significance Index: -20.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9032
    Cell Significance Index: -15.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5766
    Cell Significance Index: -12.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5237
    Cell Significance Index: 150.7300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.4532
    Cell Significance Index: 236.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.3252
    Cell Significance Index: 38.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.2155
    Cell Significance Index: 141.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2143
    Cell Significance Index: 72.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1608
    Cell Significance Index: 1048.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8557
    Cell Significance Index: 53.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4729
    Cell Significance Index: 24.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4109
    Cell Significance Index: 19.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3907
    Cell Significance Index: 213.3900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3692
    Cell Significance Index: 19.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3342
    Cell Significance Index: 15.1500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3239
    Cell Significance Index: 38.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3175
    Cell Significance Index: 63.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2926
    Cell Significance Index: 52.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2912
    Cell Significance Index: 39.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2562
    Cell Significance Index: 5.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2481
    Cell Significance Index: 16.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2265
    Cell Significance Index: 100.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1935
    Cell Significance Index: 36.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1662
    Cell Significance Index: 4.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1540
    Cell Significance Index: 10.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1503
    Cell Significance Index: 18.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1425
    Cell Significance Index: 51.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1399
    Cell Significance Index: 4.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1105
    Cell Significance Index: 14.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0782
    Cell Significance Index: 3.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0144
    Cell Significance Index: 0.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0117
    Cell Significance Index: 0.4100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0048
    Cell Significance Index: 0.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0042
    Cell Significance Index: -0.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0065
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0098
    Cell Significance Index: -18.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0116
    Cell Significance Index: -8.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0130
    Cell Significance Index: -23.9600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0165
    Cell Significance Index: -25.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0180
    Cell Significance Index: -13.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0201
    Cell Significance Index: -27.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0256
    Cell Significance Index: -2.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0267
    Cell Significance Index: -16.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0303
    Cell Significance Index: -0.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0329
    Cell Significance Index: -4.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0383
    Cell Significance Index: -1.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0442
    Cell Significance Index: -20.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0447
    Cell Significance Index: -27.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0473
    Cell Significance Index: -13.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0491
    Cell Significance Index: -1.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0511
    Cell Significance Index: -8.7200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0519
    Cell Significance Index: -0.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0627
    Cell Significance Index: -1.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0635
    Cell Significance Index: -7.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0686
    Cell Significance Index: -5.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0918
    Cell Significance Index: -18.2300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0976
    Cell Significance Index: -6.0000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1026
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1059
    Cell Significance Index: -22.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1105
    Cell Significance Index: -4.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1305
    Cell Significance Index: -18.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1417
    Cell Significance Index: -3.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1592
    Cell Significance Index: -12.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1641
    Cell Significance Index: -10.0600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1672
    Cell Significance Index: -3.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1735
    Cell Significance Index: -2.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1777
    Cell Significance Index: -9.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1778
    Cell Significance Index: -4.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1888
    Cell Significance Index: -14.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1975
    Cell Significance Index: -20.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2079
    Cell Significance Index: -5.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2150
    Cell Significance Index: -4.5000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2519
    Cell Significance Index: -3.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3028
    Cell Significance Index: -20.3600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3448
    Cell Significance Index: -8.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3630
    Cell Significance Index: -7.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4164
    Cell Significance Index: -11.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4204
    Cell Significance Index: -11.2500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4463
    Cell Significance Index: -4.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4539
    Cell Significance Index: -15.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4679
    Cell Significance Index: -17.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4731
    Cell Significance Index: -15.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4735
    Cell Significance Index: -15.0800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4899
    Cell Significance Index: -5.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4919
    Cell Significance Index: -14.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4932
    Cell Significance Index: -13.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.5007
    Cell Significance Index: -7.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5131
    Cell Significance Index: -4.7300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.5177
    Cell Significance Index: -4.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5190
    Cell Significance Index: -13.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5213
    Cell Significance Index: -23.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5385
    Cell Significance Index: -11.4300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5682
    Cell Significance Index: -4.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANKRD39 is a member of the ankyrin repeat domain family, characterized by the presence of multiple ankyrin repeats. These repeats are crucial for protein-protein interactions, which play a vital role in maintaining the structural integrity and function of the protein. The gene is primarily expressed in cells that are involved in immune responses, such as T cells and hematopoietic cells. Notably, ANKRD39 is also expressed in non-immune cells, including smooth muscle fibers and epithelial cells, underscoring its pleiotropic nature. **Pathways and Functions:** The functions of ANKRD39 are multifaceted and involve various cellular processes. In the context of immune function, ANKRD39 is implicated in the regulation of T cell development and function. Specifically, it is involved in the development of alpha-beta T cells, which are a subset of T cells that play a crucial role in cell-mediated immunity. ANKRD39 also interacts with other proteins, such as CD8 and CD4, to modulate the function of these T cells. In addition to its role in immune function, ANKRD39 is also involved in the regulation of cellular processes, including cell adhesion, migration, and proliferation. Its expression is also linked to the development of various diseases, including cancer and inflammatory disorders. **Clinical Significance:** The clinical significance of ANKRD39 is multifaceted. Alterations in ANKRD39 expression have been linked to various diseases, including cancer, autoimmune disorders, and inflammatory conditions. For instance, studies have shown that ANKRD39 is overexpressed in certain types of cancer, such as colorectal cancer, and is associated with poor prognosis. Furthermore, ANKRD39 has been implicated in the pathogenesis of autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis. Moreover, ANKRD39 has been shown to be a potential biomarker for disease diagnosis and prognosis. For example, its expression levels have been correlated with the severity of inflammatory disorders, such as rheumatoid arthritis. Overall, the study of ANKRD39 has significant implications for our understanding of immune function and disease pathogenesis. In conclusion, ANKRD39 is a gene with diverse roles in immune function and beyond. Its expression in various cell types and involvement in cellular processes underscore its importance in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which ANKRD39 regulates immune function and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 857860676

Symbol: ANR39_HUMAN

Name: Ankyrin repeat domain-containing protein 39

UniProtKB Accession Codes:

Q53RE8 Q59FU2 Q8N5X5 Q9P0S5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 183
  • Mass: 19651
  • Checksum: 11C13234A456CD63
  • Sequence:
    • MATPRPCADG PCCSHPSAVL GVQQTLEEMD FERGIWSAAL NGDLGRVKHL IQKAEDPSQP 
DSAGYTALHY ASRNGHYAVC QFLLESGAKC DAQTHGGATA LHRASYCGHT EIARLLLSHG 
SNPRVVDDDG MTSLHKAAER GHGDICSLLL QHSPALKAIR DRKARLACDL LPCNSDLRDL 
LSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.