Details for: CDKL3

Gene ID: 51265

Symbol: CDKL3

Ensembl ID: ENSG00000006837

Description: cyclin dependent kinase like 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.0002
    Cell Significance Index: -17.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.1165
    Cell Significance Index: -16.7700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.1302
    Cell Significance Index: -17.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.0475
    Cell Significance Index: -17.3200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3367
    Cell Significance Index: -16.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4399
    Cell Significance Index: -17.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.8244
    Cell Significance Index: -8.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3167
    Cell Significance Index: 264.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3065
    Cell Significance Index: 16.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3041
    Cell Significance Index: 248.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8767
    Cell Significance Index: 314.4500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.8205
    Cell Significance Index: 13.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6780
    Cell Significance Index: 14.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6713
    Cell Significance Index: 133.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6519
    Cell Significance Index: 36.5800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5906
    Cell Significance Index: 45.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5835
    Cell Significance Index: 57.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5700
    Cell Significance Index: 13.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5569
    Cell Significance Index: 34.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4722
    Cell Significance Index: 426.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4585
    Cell Significance Index: 12.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4533
    Cell Significance Index: 20.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4450
    Cell Significance Index: 16.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3132
    Cell Significance Index: 6.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3100
    Cell Significance Index: 50.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3070
    Cell Significance Index: 33.3900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2886
    Cell Significance Index: 8.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.2880
    Cell Significance Index: 8.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2875
    Cell Significance Index: 19.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2730
    Cell Significance Index: 6.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2625
    Cell Significance Index: 11.9000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2440
    Cell Significance Index: 14.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2432
    Cell Significance Index: 15.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2226
    Cell Significance Index: 25.9400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1944
    Cell Significance Index: 4.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1404
    Cell Significance Index: 25.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1007
    Cell Significance Index: 2.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0921
    Cell Significance Index: 50.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0893
    Cell Significance Index: 4.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0878
    Cell Significance Index: 25.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0877
    Cell Significance Index: 10.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0861
    Cell Significance Index: 5.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0861
    Cell Significance Index: 11.8300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0827
    Cell Significance Index: 1.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0751
    Cell Significance Index: 3.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0670
    Cell Significance Index: 3.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0554
    Cell Significance Index: 1.2000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0434
    Cell Significance Index: 0.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0268
    Cell Significance Index: 18.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0186
    Cell Significance Index: 8.2300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0143
    Cell Significance Index: 0.1700
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0063
    Cell Significance Index: -0.1000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0086
    Cell Significance Index: -0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0088
    Cell Significance Index: -16.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0092
    Cell Significance Index: -16.9400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0099
    Cell Significance Index: -0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0100
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0111
    Cell Significance Index: -17.0800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0133
    Cell Significance Index: -18.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0194
    Cell Significance Index: -14.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0228
    Cell Significance Index: -17.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0238
    Cell Significance Index: -15.1400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0257
    Cell Significance Index: -0.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0259
    Cell Significance Index: -14.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0271
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0312
    Cell Significance Index: -19.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0345
    Cell Significance Index: -15.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0385
    Cell Significance Index: -4.9300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0425
    Cell Significance Index: -0.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0531
    Cell Significance Index: -5.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0569
    Cell Significance Index: -9.7100
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0762
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0872
    Cell Significance Index: -18.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1005
    Cell Significance Index: -14.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1028
    Cell Significance Index: -12.1200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1057
    Cell Significance Index: -13.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1148
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1239
    Cell Significance Index: -14.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1292
    Cell Significance Index: -1.8500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1331
    Cell Significance Index: -1.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1337
    Cell Significance Index: -8.2000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1400
    Cell Significance Index: -2.8100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1405
    Cell Significance Index: -4.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1429
    Cell Significance Index: -3.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1552
    Cell Significance Index: -3.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1560
    Cell Significance Index: -7.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1685
    Cell Significance Index: -17.5500
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1724
    Cell Significance Index: -1.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1727
    Cell Significance Index: -12.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1747
    Cell Significance Index: -5.5700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1883
    Cell Significance Index: -14.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1883
    Cell Significance Index: -6.0300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1935
    Cell Significance Index: -4.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2031
    Cell Significance Index: -13.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2197
    Cell Significance Index: -15.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2230
    Cell Significance Index: -7.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2293
    Cell Significance Index: -6.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2308
    Cell Significance Index: -10.7600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/threonine kinase activity**: CDKL3 possesses intrinsic serine/threonine kinase activity, enabling it to phosphorylate and regulate various downstream targets. 2. **Cellular localization**: CDKL3 is primarily localized to the cytoplasm and nucleus, with specific expression in neurons, hematopoietic progenitor cells, and smooth muscle fibers. 3. **Expression patterns**: CDKL3 is significantly expressed in polychromatophilic erythroblast, hematopoietic oligopotent progenitor cell, smooth muscle fiber of ileum, orthochromatic erythroblast, CD8-alpha-beta-positive, alpha-beta intraepithelial T cell, stromal cell of bone marrow, epidermal Langerhans cell, L2/3-6 intratelencephalic projecting glutamatergic neuron, GABAergic amacrine cell, and enteroendocrine cell of colon. 4. **Regulatory functions**: CDKL3 modulates various cellular processes, including cell cycle regulation, protein phosphorylation, and protein modification, which are essential for neuronal development and function. **Pathways and Functions:** CDKL3's regulatory functions can be attributed to its involvement in several key pathways: 1. **Cyclin-dependent kinase activity**: CDKL3 regulates the cell cycle by phosphorylating and activating cyclin-dependent kinases (CDKs), which drive cell cycle progression. 2. **Protein phosphorylation**: CDKL3 phosphorylates and regulates various proteins, including transcription factors, kinases, and phosphatases, thereby modulating their activity and function. 3. **Protein modification process**: CDKL3 participates in protein modification processes, including ubiquitination and SUMOylation, which regulate protein stability, localization, and activity. 4. **Dendrite extension and axon morphogenesis**: CDKL3's phosphorylation of specific proteins regulates dendrite extension and axon morphogenesis, which are critical for neuronal development and function. **Clinical Significance:** CDKL3's dysregulation has been implicated in various neurological disorders, including: 1. **Epilepsy**: CDKL3 mutations have been associated with infantile spasms and other forms of epilepsy. 2. **Intellectual disability**: CDKL3 mutations have been linked to intellectual disability and autism spectrum disorder. 3. **Neurodevelopmental disorders**: CDKL3's dysregulation has been implicated in other neurodevelopmental disorders, including cerebral palsy and Rett syndrome. In conclusion, CDKL3 plays a critical role in regulating neuronal development, dendrite extension, and axon morphogenesis. Its dysregulation has significant implications for neurological disorders, highlighting the importance of further research into the molecular mechanisms underlying CDKL3's functions and its role in human disease.

Genular Protein ID: 368631590

Symbol: CDKL3_HUMAN

Name: Serine/threonine-protein kinase NKIAMRE

UniProtKB Accession Codes:

Q8IVW4 D3DQA0 D3DQA1 Q9P114

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 29420175

Title: CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.

PubMed ID: 29420175

DOI: 10.1016/j.celrep.2017.12.083

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 592
  • Mass: 67514
  • Checksum: 2B1AF08906EB7697
  • Sequence:
    • MEMYETLGKV GEGSYGTVMK CKHKNTGQIV AIKIFYERPE QSVNKIAMRE IKFLKQFHHE 
NLVNLIEVFR QKKKIHLVFE FIDHTVLDEL QHYCHGLESK RLRKYLFQIL RAIDYLHSNN 
IIHRDIKPEN ILVSQSGITK LCDFGFARTL AAPGDIYTDY VATRWYRAPE LVLKDTSYGK 
PVDIWALGCM IIEMATGNPY LPSSSDLDLL HKIVLKVGNL SPHLQNIFSK SPIFAGVVLP 
QVQHPKNARK KYPKLNGLLA DIVHACLQID PADRISSSDL LHHEYFTRDG FIEKFMPELK 
AKLLQEAKVN SLIKPKESSK ENELRKDERK TVYTNTLLSS SVLGKEIEKE KKPKEIKVRV 
IKVKGGRGDI SEPKKKEYEG GLGQQDANEN VHPMSPDTKL VTIEPPNPIN PSTNCNGLKE 
NPHCGGSVTM PPINLTNSNL MAANLSSNLF HPSVRLTERA KKRRTSSQSI GQVMPNSRQE 
DPGPIQSQME KGIFNERTGH SDQMANENKR KLNFSRSDRK EFHFPELPVT IQSKDTKGME 
VKQIKMLKRE SKKTESSKIP TLLNVDQNQE KQEGGDGHCE GKNLKRNRFF FW

Genular Protein ID: 2853214167

Symbol: B4DX41_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DX41

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 401
  • Mass: 45086
  • Checksum: AE8D28183A7863C2
  • Sequence:
    • MIIEMATGNP YLPSSSDLDL LHKIVLKVGN LSPHLQNIFS KSPIFAGVVL PQVQHPKNAR 
KKYPKLNGLL ADIVHACLQI DPADRISSSD LLHHEYFTRD GFIEKFMPEL KAKLLQEAKV 
NSLIKPKESS KENELRKDER KTVYTNTLLS SSVLGKEIEK EKKPKEIKVR VIKVKGGRGD 
ISEPKKKEYE GGLGQQDANE NVHPMSPDTK LVTIEPPNPI NPSTNCNGLK ENPHCGGSVT 
MPPINLTNSN LMAANLSSNL FHPSVRLTER AKKRRTSSQS IGQVMPNSRQ EDPGPIQSQM 
EKGIFNERTG HSDQMANENK RKLNFSRSDR KEFHFPELPV TIQSKDTKGM EVKQIKMLKR 
ESKKTESSKI PTLLNVDQNQ EKQENTGNAQ TERKKNLPDV E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.