Details for: CDK16

Gene ID: 5127

Symbol: CDK16

Ensembl ID: ENSG00000102225

Description: cyclin dependent kinase 16

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 135.2661
    Cell Significance Index: -21.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.5746
    Cell Significance Index: -22.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.4138
    Cell Significance Index: -25.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.1560
    Cell Significance Index: -21.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.6795
    Cell Significance Index: -25.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.6763
    Cell Significance Index: -21.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.0599
    Cell Significance Index: -23.5000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.5040
    Cell Significance Index: -25.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2772
    Cell Significance Index: -19.2800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.1074
    Cell Significance Index: -24.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.5365
    Cell Significance Index: -7.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6892
    Cell Significance Index: 274.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4768
    Cell Significance Index: 1333.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1347
    Cell Significance Index: 30.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0888
    Cell Significance Index: 56.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0560
    Cell Significance Index: 114.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0112
    Cell Significance Index: 29.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7834
    Cell Significance Index: 35.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6990
    Cell Significance Index: 381.7200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.5944
    Cell Significance Index: 1.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5711
    Cell Significance Index: 70.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5700
    Cell Significance Index: 11.9300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5610
    Cell Significance Index: 12.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5487
    Cell Significance Index: 37.9500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5397
    Cell Significance Index: 28.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5067
    Cell Significance Index: 101.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5059
    Cell Significance Index: 50.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5036
    Cell Significance Index: 6.4500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4398
    Cell Significance Index: 6.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4300
    Cell Significance Index: 77.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4194
    Cell Significance Index: 19.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3803
    Cell Significance Index: 52.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3623
    Cell Significance Index: 16.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3550
    Cell Significance Index: 70.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3228
    Cell Significance Index: 9.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3206
    Cell Significance Index: 41.4300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3136
    Cell Significance Index: 138.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2983
    Cell Significance Index: 22.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2967
    Cell Significance Index: 19.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2822
    Cell Significance Index: 7.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2754
    Cell Significance Index: 47.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2280
    Cell Significance Index: 11.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2269
    Cell Significance Index: 6.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2218
    Cell Significance Index: 26.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2143
    Cell Significance Index: 2.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1963
    Cell Significance Index: 37.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1912
    Cell Significance Index: 68.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.1721
    Cell Significance Index: 3.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1586
    Cell Significance Index: 3.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1338
    Cell Significance Index: 2.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1192
    Cell Significance Index: 7.5100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1171
    Cell Significance Index: 3.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1106
    Cell Significance Index: 14.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1099
    Cell Significance Index: 3.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0916
    Cell Significance Index: 6.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0858
    Cell Significance Index: 0.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0837
    Cell Significance Index: 2.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0818
    Cell Significance Index: 56.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0518
    Cell Significance Index: 1.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0109
    Cell Significance Index: 0.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0050
    Cell Significance Index: 3.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0076
    Cell Significance Index: -4.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0116
    Cell Significance Index: -21.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0123
    Cell Significance Index: -9.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0136
    Cell Significance Index: -20.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0178
    Cell Significance Index: -24.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0189
    Cell Significance Index: -12.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0220
    Cell Significance Index: -2.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0331
    Cell Significance Index: -18.6400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0357
    Cell Significance Index: -0.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0386
    Cell Significance Index: -17.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0496
    Cell Significance Index: -3.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0505
    Cell Significance Index: -0.8700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0562
    Cell Significance Index: -4.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0565
    Cell Significance Index: -8.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0632
    Cell Significance Index: -13.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0657
    Cell Significance Index: -7.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0839
    Cell Significance Index: -5.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0864
    Cell Significance Index: -24.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0938
    Cell Significance Index: -10.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1107
    Cell Significance Index: -1.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1131
    Cell Significance Index: -12.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1312
    Cell Significance Index: -1.0700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1490
    Cell Significance Index: -2.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1750
    Cell Significance Index: -9.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1849
    Cell Significance Index: -2.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1963
    Cell Significance Index: -5.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2235
    Cell Significance Index: -23.2700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2236
    Cell Significance Index: -17.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2241
    Cell Significance Index: -3.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2889
    Cell Significance Index: -17.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3809
    Cell Significance Index: -16.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3820
    Cell Significance Index: -10.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3888
    Cell Significance Index: -11.4200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.4101
    Cell Significance Index: -7.5800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4619
    Cell Significance Index: -11.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4637
    Cell Significance Index: -17.5600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4667
    Cell Significance Index: -12.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CDK16 is a serine/threonine kinase that belongs to the cyclin-dependent kinase (CDK) family. It is characterized by its ability to phosphorylate and regulate the activity of downstream targets, thereby influencing various cellular processes. CDK16 is specifically expressed in certain cell types, including oogonial cells, bladder urothelial cells, Leydig cells, and primary sensory neurons. Its expression is also observed in other cell types, such as acinar cells of the salivary gland and squamous epithelial cells. **Pathways and Functions:** CDK16 is involved in several critical pathways, including: 1. **Cell Cycle Regulation:** CDK16 plays a key role in regulating the cell cycle, particularly in the G2/M phase. It phosphorylates and activates downstream targets, such as cyclin-dependent kinases and transcription factors, to drive cell cycle progression. 2. **Insulin Secretion:** CDK16 is involved in the regulation of insulin secretion in response to glucose stimuli. It phosphorylates and activates key proteins involved in insulin signaling, thereby modulating glucose metabolism. 3. **Spermatogenesis:** CDK16 is essential for the regulation of spermatogenesis, a critical process in male reproductive development. It phosphorylates and activates proteins involved in the meiotic process, ensuring proper sperm development. 4. **Neurotransmission:** CDK16 is also involved in the regulation of neurotransmission, particularly in the development and maturation of primary sensory neurons. It phosphorylates and activates key proteins involved in synaptic transmission, thereby modulating neuronal function. **Clinical Significance:** CDK16 has significant implications in various diseases and disorders, including: 1. **Cancer:** Dysregulation of CDK16 has been observed in several types of cancer, including breast, lung, and prostate cancer. Its overexpression can lead to uncontrolled cell proliferation and tumor formation. 2. **Diabetes:** Impaired insulin secretion and glucose metabolism have been linked to CDK16 dysregulation. Its inhibition may provide a novel therapeutic strategy for managing diabetes. 3. **Neurological Disorders:** CDK16 dysregulation has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. Its role in neuronal development and function makes it a potential target for neuroprotective therapies. 4. **Reproductive Disorders:** CDK16 dysregulation has been linked to male infertility and reproductive dysfunction. Its inhibition may provide a novel therapeutic strategy for addressing reproductive issues. In conclusion, CDK16 is a critical protein kinase that plays a pivotal role in regulating various cellular processes, including cell cycle progression, insulin secretion, and spermatogenesis. Its dysregulation has significant implications in various diseases and disorders, making it a promising target for therapeutic interventions. Further research is needed to fully elucidate the role of CDK16 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2031625513

Symbol: CDK16_HUMAN

Name: Cyclin-dependent kinase 16

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1639063

Title: A family of human cdc2-related protein kinases.

PubMed ID: 1639063

DOI: 10.1002/j.1460-2075.1992.tb05360.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22796189

Title: Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase.

PubMed ID: 22796189

DOI: 10.1016/j.cellsig.2012.06.018

PubMed ID: 22798068

Title: Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells.

PubMed ID: 22798068

DOI: 10.1074/jbc.m112.375618

PubMed ID: 22184064

Title: Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.

PubMed ID: 22184064

DOI: 10.1128/mcb.06261-11

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 496
  • Mass: 55716
  • Checksum: 9A5DDD34A5E5CBBB
  • Sequence:
  • MDRMKKIKRQ LSMTLRGGRG IDKTNGAPEQ IGLDESGGGG GSDPGEAPTR AAPGELRSAR 
    GPLSSAPEIV HEDLKMGSDG ESDQASATSS DEVQSPVRVR MRNHPPRKIS TEDINKRLSL 
    PADIRLPEGY LEKLTLNSPI FDKPLSRRLR RVSLSEIGFG KLETYIKLDK LGEGTYATVY 
    KGKSKLTDNL VALKEIRLEH EEGAPCTAIR EVSLLKDLKH ANIVTLHDII HTEKSLTLVF 
    EYLDKDLKQY LDDCGNIINM HNVKLFLFQL LRGLAYCHRQ KVLHRDLKPQ NLLINERGEL 
    KLADFGLARA KSIPTKTYSN EVVTLWYRPP DILLGSTDYS TQIDMWGVGC IFYEMATGRP 
    LFPGSTVEEQ LHFIFRILGT PTEETWPGIL SNEEFKTYNY PKYRAEALLS HAPRLDSDGA 
    DLLTKLLQFE GRNRISAEDA MKHPFFLSLG ERIHKLPDTT SIFALKEIQL QKEASLRSSS 
    MPDSGRPAFR VVDTEF

Genular Protein ID: 1681080765

Symbol: Q9BRL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 448
  • Mass: 51091
  • Checksum: 604E761BBD217D24
  • Sequence:
  • MDRMKKIKRQ LSMTLSSAPE IVHEDLKMGS DGESDQASAT SSDEVQSPVR VRMRNHPPRK 
    ISTEDINKRL SLPADIRLPE GYLEKLTLNS PIFDKPLSRR LRRVSLSEIG FGKLETYIKL 
    DKLGEGTYAT VYKGKSKLTD NLVALKEIRL EHEEGAPCTA IREVSLLKDL KHANIVTLHD 
    IIHTEKSLTL VFEYLDKDLK QYLDDCGNII NMHNVKLFLF QLLRGLAYCH RQKVLHRDLK 
    PQNLLINERG ELKLADFGLA RAKSIPTKTY SNEVVTLWYR PPDILLGSTD YSTQIDMWGV 
    GCIFYEMATG RPLFPGSTVE EQLHFIFRIL GTPTEETWPG ILSNEEFKTY NYPKYRAEAL 
    LSHAPRLDSD GADLLTKLLQ FEGRNRISAE DAMKHPFFLS LGERIHKLPD TTSIFALKEI 
    QLQKEASLRS SSMPDSGRPA FRVVDTEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.