Details for: IER5

Gene ID: 51278

Symbol: IER5

Ensembl ID: ENSG00000162783

Description: immediate early response 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 232.9226
    Cell Significance Index: -36.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 151.3542
    Cell Significance Index: -38.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 92.5399
    Cell Significance Index: -37.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.5124
    Cell Significance Index: -40.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 60.6686
    Cell Significance Index: -40.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.3880
    Cell Significance Index: -38.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3643
    Cell Significance Index: -38.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.9416
    Cell Significance Index: -39.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.5069
    Cell Significance Index: -29.2000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.6303
    Cell Significance Index: 34.6500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6292
    Cell Significance Index: -12.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.4946
    Cell Significance Index: 100.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.9497
    Cell Significance Index: 52.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9187
    Cell Significance Index: 217.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6298
    Cell Significance Index: 136.6100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4925
    Cell Significance Index: 112.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9247
    Cell Significance Index: 52.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5483
    Cell Significance Index: 684.5300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.5095
    Cell Significance Index: 36.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3807
    Cell Significance Index: 64.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.3356
    Cell Significance Index: 92.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2170
    Cell Significance Index: 1098.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1624
    Cell Significance Index: 33.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1240
    Cell Significance Index: 72.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0215
    Cell Significance Index: 131.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.9093
    Cell Significance Index: 10.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.8807
    Cell Significance Index: 62.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7784
    Cell Significance Index: 126.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7622
    Cell Significance Index: 82.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7435
    Cell Significance Index: 91.4200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7016
    Cell Significance Index: 126.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6589
    Cell Significance Index: 65.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6436
    Cell Significance Index: 82.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6295
    Cell Significance Index: 11.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5265
    Cell Significance Index: 100.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5087
    Cell Significance Index: 7.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5063
    Cell Significance Index: 276.4800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.4561
    Cell Significance Index: 4.2000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.4363
    Cell Significance Index: 7.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3264
    Cell Significance Index: 8.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3145
    Cell Significance Index: 11.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2565
    Cell Significance Index: 30.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2563
    Cell Significance Index: 51.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1756
    Cell Significance Index: 24.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1505
    Cell Significance Index: 4.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1216
    Cell Significance Index: 13.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0933
    Cell Significance Index: 2.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0740
    Cell Significance Index: 1.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0206
    Cell Significance Index: 4.0900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0143
    Cell Significance Index: -4.1100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0194
    Cell Significance Index: -0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0201
    Cell Significance Index: -37.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0227
    Cell Significance Index: -17.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0263
    Cell Significance Index: -48.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0264
    Cell Significance Index: -19.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0306
    Cell Significance Index: -47.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0314
    Cell Significance Index: -19.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0341
    Cell Significance Index: -3.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0364
    Cell Significance Index: -49.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0396
    Cell Significance Index: -14.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0434
    Cell Significance Index: -7.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0455
    Cell Significance Index: -25.6500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0521
    Cell Significance Index: -1.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0526
    Cell Significance Index: -38.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0603
    Cell Significance Index: -38.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0854
    Cell Significance Index: -38.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1234
    Cell Significance Index: -25.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1447
    Cell Significance Index: -16.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1812
    Cell Significance Index: -20.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1822
    Cell Significance Index: -8.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1847
    Cell Significance Index: -2.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1897
    Cell Significance Index: -4.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2071
    Cell Significance Index: -4.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2288
    Cell Significance Index: -17.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2710
    Cell Significance Index: -39.3900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2711
    Cell Significance Index: -11.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2850
    Cell Significance Index: -19.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3056
    Cell Significance Index: -8.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3547
    Cell Significance Index: -17.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3807
    Cell Significance Index: -39.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4220
    Cell Significance Index: -25.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4297
    Cell Significance Index: -22.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4953
    Cell Significance Index: -31.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5008
    Cell Significance Index: -39.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5116
    Cell Significance Index: -28.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5140
    Cell Significance Index: -17.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5351
    Cell Significance Index: -14.0700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5369
    Cell Significance Index: -13.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5515
    Cell Significance Index: -33.9000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6207
    Cell Significance Index: -3.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6451
    Cell Significance Index: -20.6600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6716
    Cell Significance Index: -9.5600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6785
    Cell Significance Index: -5.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6850
    Cell Significance Index: -35.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7845
    Cell Significance Index: -13.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7875
    Cell Significance Index: -17.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8131
    Cell Significance Index: -29.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8531
    Cell Significance Index: -19.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8713
    Cell Significance Index: -38.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.8970
    Cell Significance Index: -9.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IER5 gene is characterized by its expression in multiple cell types, including polychromatophilic erythroblast, hematopoietic oligopotent progenitor cells, mucosal type mast cells, and peripheral blood mononuclear cells. The IER5 protein is a transcription factor that regulates the expression of various genes involved in cell proliferation, differentiation, and survival. The IER5 gene is also involved in the regulation of cellular responses to heat shock, oxidative stress, and other environmental stressors. **Pathways and Functions:** The IER5 gene is involved in several key pathways, including: 1. **Positive regulation of cellular response to heat**: IER5 regulates the expression of heat shock proteins, which are essential for protecting cells against heat shock. 2. **Positive regulation of transcription by RNA polymerase II**: IER5 acts as a transcriptional activator, regulating the expression of genes involved in cell proliferation and differentiation. 3. **Protein binding**: IER5 interacts with various proteins, including protein phosphatase type 2A complex, to regulate cell signaling pathways. 4. **Regulation of cell population proliferation**: IER5 regulates the expression of genes involved in cell proliferation, differentiation, and survival. **Clinical Significance:** The IER5 gene has significant implications for understanding immune homeostasis and responding to environmental stressors. Abnormal expression of IER5 has been implicated in various diseases, including: 1. **Immune disorders**: Dysregulation of IER5 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: IER5 has been implicated in the regulation of cell proliferation and differentiation in various cancer types, including leukemia and lymphoma. 3. **Neurological disorders**: Abnormal expression of IER5 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the IER5 gene is a critical component of the immune system, regulating cellular responses to various stimuli, including heat shock. Understanding the functions and pathways of the IER5 gene is essential for elucidating its role in maintaining immune homeostasis and responding to environmental stressors. Further research is needed to fully understand the clinical significance of the IER5 gene and its implications for human disease.

Genular Protein ID: 4021480986

Symbol: IER5_HUMAN

Name: Immediate early response gene 5 protein

UniProtKB Accession Codes:

Q5VY09 B2RBV3 Q8WY68 Q9NY49 Q9NZP9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 GO 9 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19238419

Title: Induced expression of the IER5 gene by gamma-ray irradiation and its involvement in cell cycle checkpoint control and survival.

PubMed ID: 19238419

DOI: 10.1007/s00411-009-0213-4

PubMed ID: 22132193

Title: Transcriptional repression of Cdc25B by IER5 inhibits the proliferation of leukemic progenitor cells through NF-YB and p300 in acute myeloid leukemia.

PubMed ID: 22132193

DOI: 10.1371/journal.pone.0028011

PubMed ID: 25355627

Title: Heat-induced expression of the immediate-early gene IER5 and its involvement in the proliferation of heat-shocked cells.

PubMed ID: 25355627

DOI: 10.1111/febs.13134

PubMed ID: 25816751

Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PubMed ID: 25816751

DOI: 10.1016/j.febslet.2015.03.019

PubMed ID: 26496226

Title: Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1.

PubMed ID: 26496226

DOI: 10.1016/j.febslet.2015.10.013

PubMed ID: 26754925

Title: IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

PubMed ID: 26754925

DOI: 10.1038/srep19174

Sequence Information:

  • Length: 327
  • Mass: 33704
  • Checksum: E841C5FAF6520A12
  • Sequence:
    • MEFKLEAHRI VSISLGKIYN SRVQRGGIKL HKNLLVSLVL RSARQVYLSD PCPGLYLAGP 
AGTPAPPPQQ QPGEPAAGPP AGWGEPPPPA ARASWPETEP QPERSSVSDA PRVGDEVPVA 
TVTGVGDVFQ GGEADATEAA WSRVEGPRQA AAREAEGTAG GWGVFPEVSR AARRPCGCPL 
GGEDPPGTPA ATPRAACCCA PQPAEDEPPA PPAVCPRKRC AAGVGGGPAG CPAPGSTPLK 
KPRRNLEQPP SGGEDDDAEE METGNVANLI SIFGSSFSGL LRKSPGGGRE EEEGEESGPE 
AAEPGQICCD KPVLRDMNPW STAIVAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.