Details for: GMPR2

Gene ID: 51292

Symbol: GMPR2

Ensembl ID: ENSG00000100938

Description: guanosine monophosphate reductase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 150.9529
    Cell Significance Index: -23.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.2207
    Cell Significance Index: -14.2600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.8329
    Cell Significance Index: -26.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.1160
    Cell Significance Index: -21.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 50.0403
    Cell Significance Index: -25.7400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.8598
    Cell Significance Index: -22.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.0250
    Cell Significance Index: -24.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2997
    Cell Significance Index: -19.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.3925
    Cell Significance Index: -25.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 5.4111
    Cell Significance Index: -16.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5653
    Cell Significance Index: 298.9600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8236
    Cell Significance Index: 109.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.4917
    Cell Significance Index: 11.9100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4725
    Cell Significance Index: 1329.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1820
    Cell Significance Index: 61.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1705
    Cell Significance Index: 15.9700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0989
    Cell Significance Index: 29.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7494
    Cell Significance Index: 51.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7149
    Cell Significance Index: 37.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6809
    Cell Significance Index: 83.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6664
    Cell Significance Index: 43.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6593
    Cell Significance Index: 7.4900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6471
    Cell Significance Index: 353.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6293
    Cell Significance Index: 113.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6194
    Cell Significance Index: 18.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4995
    Cell Significance Index: 68.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4596
    Cell Significance Index: 12.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4545
    Cell Significance Index: 53.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4485
    Cell Significance Index: 23.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4343
    Cell Significance Index: 20.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4079
    Cell Significance Index: 180.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3502
    Cell Significance Index: 24.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3348
    Cell Significance Index: 3.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3076
    Cell Significance Index: 10.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2987
    Cell Significance Index: 38.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2943
    Cell Significance Index: 6.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2816
    Cell Significance Index: 20.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2695
    Cell Significance Index: 34.5500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2580
    Cell Significance Index: 5.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2262
    Cell Significance Index: 4.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1983
    Cell Significance Index: 9.3200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1801
    Cell Significance Index: 36.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1671
    Cell Significance Index: 33.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1488
    Cell Significance Index: 1.3700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1460
    Cell Significance Index: 3.8400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1176
    Cell Significance Index: 81.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1160
    Cell Significance Index: 19.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1138
    Cell Significance Index: 5.1600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1072
    Cell Significance Index: 20.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0839
    Cell Significance Index: 4.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0790
    Cell Significance Index: 2.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0725
    Cell Significance Index: 2.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0694
    Cell Significance Index: 24.8900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0365
    Cell Significance Index: 3.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0188
    Cell Significance Index: 13.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0074
    Cell Significance Index: 5.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0056
    Cell Significance Index: -0.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0056
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0125
    Cell Significance Index: -0.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0131
    Cell Significance Index: -24.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0140
    Cell Significance Index: -8.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0151
    Cell Significance Index: -1.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0155
    Cell Significance Index: -23.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0158
    Cell Significance Index: -21.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0169
    Cell Significance Index: -9.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0258
    Cell Significance Index: -0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0267
    Cell Significance Index: -16.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0278
    Cell Significance Index: -0.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0485
    Cell Significance Index: -21.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0519
    Cell Significance Index: -10.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0724
    Cell Significance Index: -20.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0932
    Cell Significance Index: -10.6400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1012
    Cell Significance Index: -11.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1223
    Cell Significance Index: -2.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1460
    Cell Significance Index: -4.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1496
    Cell Significance Index: -21.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1536
    Cell Significance Index: -6.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1557
    Cell Significance Index: -12.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1736
    Cell Significance Index: -5.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1778
    Cell Significance Index: -1.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2389
    Cell Significance Index: -24.8800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2408
    Cell Significance Index: -18.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2915
    Cell Significance Index: -17.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3434
    Cell Significance Index: -19.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3548
    Cell Significance Index: -10.4500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3932
    Cell Significance Index: -4.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4372
    Cell Significance Index: -11.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4435
    Cell Significance Index: -5.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4436
    Cell Significance Index: -19.6200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4621
    Cell Significance Index: -11.5500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4753
    Cell Significance Index: -8.4000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4867
    Cell Significance Index: -17.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5146
    Cell Significance Index: -18.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5184
    Cell Significance Index: -6.1800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5216
    Cell Significance Index: -19.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5388
    Cell Significance Index: -17.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5439
    Cell Significance Index: -15.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5443
    Cell Significance Index: -13.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GMPR2 is a metal-dependent enzyme that catalyzes the reduction of guanosine monophosphate (GMP) to inosine monophosphate (IMP). This reaction is a crucial step in the salvage pathway of purine nucleotides, which is essential for maintaining the balance of nucleotides in the cell. GMPR2 is a homodimeric enzyme, composed of two identical subunits, each containing a metal ion-dependent reductase activity site. The enzyme is highly specific for GMP, with a Km value of 0.5 mM, indicating its high affinity for the substrate. **Pathways and Functions** GMPR2 is involved in several key pathways, including: 1. **GMP Metabolic Process**: GMPR2 catalyzes the reduction of GMP to IMP, which is then converted to other purine nucleotides, such as ATP, ADP, and AMP. 2. **GMP Reductase Activity**: GMPR2 is a metal-dependent enzyme that requires a metal ion cofactor to catalyze the reduction of GMP. 3. **GMP Reductase Complex**: GMPR2 is part of a complex that also includes GMP synthetase and other enzymes involved in the salvage pathway of purine nucleotides. 4. **Metabolism of Nucleotides**: GMPR2 is involved in the metabolism of nucleotides, including the conversion of GMP to IMP, which is then converted to other purine nucleotides. 5. **Metal Ion Binding**: GMPR2 requires a metal ion cofactor to catalyze the reduction of GMP. 6. **Nucleotide Salvage**: GMPR2 is involved in the salvage pathway of purine nucleotides, which is essential for maintaining the balance of nucleotides in the cell. 7. **Purine Nucleobase Metabolic Process**: GMPR2 is involved in the metabolism of purine nucleobases, including the conversion of GMP to IMP. 8. **Purine Salvage**: GMPR2 is involved in the salvage pathway of purine nucleotides, which is essential for maintaining the balance of nucleotides in the cell. **Clinical Significance** GMPR2 has significant clinical implications, particularly in the context of immune regulation and tissue homeostasis. Abnormalities in GMPR2 expression or function have been implicated in various diseases, including: 1. **Hematological disorders**: Mutations in GMPR2 have been associated with hematological disorders, such as anemia and leukemia. 2. **Immune system dysfunction**: Abnormalities in GMPR2 expression or function have been implicated in immune system dysfunction, including autoimmune diseases and cancer. 3. **Neurological disorders**: GMPR2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease**: Abnormalities in GMPR2 expression or function have been associated with cardiovascular disease, including hypertension and atherosclerosis. In conclusion, GMPR2 is a crucial enzyme involved in the salvage pathway of purine nucleotides, and its dysregulation has significant clinical implications. Further research is needed to fully understand the role of GMPR2 in immune regulation and tissue homeostasis, and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3005023966

Symbol: GMPR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P2T1 D3DS66 Q567T0 Q6IAJ8 Q86T14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 15 Ensembl 10 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12009299

Title: NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties.

PubMed ID: 12009299

DOI: 10.1016/s1357-2725(02)00024-9

PubMed ID: 12669231

Title: Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells.

PubMed ID: 12669231

DOI: 10.1007/s00432-002-0413-7

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16359702

Title: Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP.

PubMed ID: 16359702

DOI: 10.1016/j.jmb.2005.11.047

PubMed ID: 22037469

Title: Cofactor mobility determines reaction outcome in the IMPDH and GMPR (beta-alpha)8 barrel enzymes.

PubMed ID: 22037469

DOI: 10.1038/nchembio.693

Sequence Information:

  • Length: 348
  • Mass: 37874
  • Checksum: E7812A754C433E51
  • Sequence:
    • MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT 
FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI 
PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI 
GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM 
LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD 
VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC

Genular Protein ID: 3794416418

Symbol: H0YNJ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YNJ6

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 3 GO 6 Gene3D 1 GeneTree 1 HAMAP 1 HAMAP-Rule 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 1 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 427
  • Mass: 46938
  • Checksum: F6502E9031B42D0F
  • Sequence:
    • MTSCLPALRF IATPRLSAMP HIDNDVKLDF KDVLLRPKRS TLKSRSEVDL TRSFSFRNSK 
QTYSGVPIIA ANMDTVGTFE MAKVLCKFSL FTAVHKHYSL VQWQEFAGQN PDCLEHLAAS 
SGTGSSDFEQ LEQILEAIPQ VKYICLDVAN GYSEHFVEFV KDVRKRFPQH TIMAGNVVTG 
EMVEELILSG ADIIKVGIGP GSVCTTRKKT GVGYPQLSAV MECADAAHGL KGHIISDGGC 
SCPGDVAKAF GAGADFVMLG GMLAGHSESG GELIERDGKK YKLFYGMSSE MAMKKYAGGV 
AEYRYVWRPR SLVIVWRQNS WLLRGGWYSS QRSMVNRGSM LGSVEKSLGL RNPEGEDNKV 
FPTLRASEGK TVEVPFKGDV EHTIRDILGG IRSTCTYVGA AKLKELSRRT TFIRVTQQVN 
PIFSEAC

Genular Protein ID: 1350877384

Symbol: Q6PKC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PKC0

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 25 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 6 Gene3D 1 HAMAP 1 HAMAP-Rule 1 IntAct 1 InterPro 6 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PROSITE 1 PeptideAtlas 1 Pfam 2 PhylomeDB 1 ProteomicsDB 1 RefSeq 4 Rhea 1 RuleBase 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 409
  • Mass: 45008
  • Checksum: 73B70E7FA0BE4A57
  • Sequence:
    • MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT 
FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI 
PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI 
GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM 
LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRYVWR PRSLVIVWRQ 
NSWLLRGGWY SSQRSMVNRG SMLGSVEKSL GLRNPEGEDN KVFPTLRASE GKTVEVPFKG 
DVEHTIRDIL GGIRSTCTYV GAAKLKELSR RTTFIRVTQQ VNPIFSEAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.