Details for: ARMCX1

Gene ID: 51309

Symbol: ARMCX1

Ensembl ID: ENSG00000126947

Description: armadillo repeat containing X-linked 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.1458
    Cell Significance Index: -23.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.9157
    Cell Significance Index: -17.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 54.6892
    Cell Significance Index: -25.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.0022
    Cell Significance Index: -20.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9431
    Cell Significance Index: -20.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2951
    Cell Significance Index: -23.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.8512
    Cell Significance Index: -26.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0288
    Cell Significance Index: -23.7900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.3013
    Cell Significance Index: 13.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8950
    Cell Significance Index: 360.6300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4084
    Cell Significance Index: 11.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3209
    Cell Significance Index: 14.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.1303
    Cell Significance Index: 23.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0943
    Cell Significance Index: 57.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0696
    Cell Significance Index: 30.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7603
    Cell Significance Index: 525.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7477
    Cell Significance Index: 9.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6775
    Cell Significance Index: 86.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6760
    Cell Significance Index: 92.8400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5629
    Cell Significance Index: 508.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5595
    Cell Significance Index: 15.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4711
    Cell Significance Index: 28.2800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4381
    Cell Significance Index: 47.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3931
    Cell Significance Index: 63.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3726
    Cell Significance Index: 164.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3647
    Cell Significance Index: 19.1500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3544
    Cell Significance Index: 10.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3312
    Cell Significance Index: 8.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2877
    Cell Significance Index: 57.7200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2710
    Cell Significance Index: 4.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1808
    Cell Significance Index: 23.3600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1757
    Cell Significance Index: 1.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1666
    Cell Significance Index: 28.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1648
    Cell Significance Index: 11.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1581
    Cell Significance Index: 56.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1562
    Cell Significance Index: 2.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1492
    Cell Significance Index: 11.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1055
    Cell Significance Index: 57.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0871
    Cell Significance Index: 4.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0806
    Cell Significance Index: 2.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0778
    Cell Significance Index: 5.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0650
    Cell Significance Index: 6.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0585
    Cell Significance Index: 0.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0511
    Cell Significance Index: 3.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0507
    Cell Significance Index: 1.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0423
    Cell Significance Index: 7.6300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0242
    Cell Significance Index: 0.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0237
    Cell Significance Index: 1.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0180
    Cell Significance Index: 0.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -3.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0111
    Cell Significance Index: -8.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0153
    Cell Significance Index: -28.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0164
    Cell Significance Index: -25.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0168
    Cell Significance Index: -22.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0242
    Cell Significance Index: -13.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0270
    Cell Significance Index: -1.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0415
    Cell Significance Index: -18.8500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0441
    Cell Significance Index: -9.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0448
    Cell Significance Index: -2.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0485
    Cell Significance Index: -2.2000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0542
    Cell Significance Index: -1.1800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0556
    Cell Significance Index: -0.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0571
    Cell Significance Index: -5.8300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0792
    Cell Significance Index: -0.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0847
    Cell Significance Index: -9.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0889
    Cell Significance Index: -25.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0916
    Cell Significance Index: -18.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1070
    Cell Significance Index: -1.7900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1106
    Cell Significance Index: -12.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1134
    Cell Significance Index: -16.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1151
    Cell Significance Index: -3.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1164
    Cell Significance Index: -4.0900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1186
    Cell Significance Index: -13.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1433
    Cell Significance Index: -4.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1843
    Cell Significance Index: -5.1500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1953
    Cell Significance Index: -4.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2068
    Cell Significance Index: -15.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2157
    Cell Significance Index: -25.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2185
    Cell Significance Index: -4.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2227
    Cell Significance Index: -4.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2285
    Cell Significance Index: -23.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2388
    Cell Significance Index: -13.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2508
    Cell Significance Index: -16.8700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2595
    Cell Significance Index: -13.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2732
    Cell Significance Index: -6.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2739
    Cell Significance Index: -21.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3024
    Cell Significance Index: -18.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3151
    Cell Significance Index: -6.7400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3380
    Cell Significance Index: -2.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3583
    Cell Significance Index: -6.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3901
    Cell Significance Index: -17.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4287
    Cell Significance Index: -6.4600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4345
    Cell Significance Index: -7.1600
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.4458
    Cell Significance Index: -2.9000
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.4584
    Cell Significance Index: -2.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **X-linked gene**: ARMCX1 is located on the X chromosome, which is a common site for genes with X-linked disorders. 2. **Armadillo repeat-containing protein**: The ARMX1 protein is composed of armadillo repeats, which are involved in protein-protein interactions. 3. **High expression in hematopoietic cells**: ARMCX1 is significantly expressed in hematopoietic stem cells, oligopotent progenitor cells, and polychromatophilic erythroblasts, highlighting its role in hematopoiesis. 4. **Cellular localization**: ARMCX1 is also expressed in smooth muscle fibers, mucosal type mast cells, ciliated cells of the bronchus, and enteroendocrine cells of the colon. **Pathways and Functions** 1. **Hematopoietic stem cell homeostasis**: ARMCX1 plays a crucial role in maintaining the balance of hematopoietic stem cells, influencing their proliferation, differentiation, and survival. 2. **Mitochondrial outer membrane**: The ARMCX1 protein is involved in the regulation of mitochondrial outer membrane dynamics, which is essential for maintaining cellular energy homeostasis. 3. **Protein binding**: The armadillo repeats in ARMCX1 facilitate protein-protein interactions, which are critical for regulating various cellular processes, including signal transduction and cell signaling. 4. **Mitochondrial dynamics**: ARMCX1 is involved in the regulation of mitochondrial fission and fusion, which is essential for maintaining mitochondrial function and cellular homeostasis. **Clinical Significance** 1. **Hematological disorders**: Alterations in ARMCX1 expression have been linked to various hematological disorders, including anemia and leukemia. 2. **Mitochondrial diseases**: Mutations in ARMCX1 have been associated with mitochondrial diseases, such as mitochondrial myopathies and encephalopathies. 3. **Cancer**: The dysregulation of ARMCX1 has been implicated in various types of cancer, including leukemia and lymphoma. 4. **Neurological disorders**: ARMCX1 has also been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the ARMCX1 gene is a multifaceted component of the human genome that plays a critical role in maintaining cellular homeostasis, particularly in the context of hematopoiesis. Further research is necessary to fully elucidate the functions and clinical significance of ARMCX1, with the ultimate goal of developing novel therapeutic strategies for the treatment of associated diseases.

Genular Protein ID: 187982064

Symbol: ARMX1_HUMAN

Name: Armadillo repeat-containing X-linked protein 1

UniProtKB Accession Codes:

Q9P291 Q53HK2 Q9H2Q0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11162520

Title: ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.

PubMed ID: 11162520

DOI: 10.1006/bbrc.2000.4125

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 453
  • Mass: 49180
  • Checksum: 01BED98EC3F64672
  • Sequence:
    • MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI GVETVKGAKT 
NAGAGSGAKL QGDSEVKPEV SLGLEDCPGV KEKAHSGSHS GGGLEAKAKA LFNTLKEQAS 
AKAGKGARVG TISGNRTLAP SLPCPGGRGG GCHPTRSGSR AGGRASGKSK GKARSKSTRA 
PATTWPVRRG KFNFPYKIDD ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ 
NAIRELGGVP IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL 
DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL IINFTENPAM 
TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI KNEGLASSRK EFSRSSLFFL 
FKESGVCVKK IKALANHNDL VVKVKVLKVL TKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.