Details for: SLC22A17

Gene ID: 51310

Symbol: SLC22A17

Ensembl ID: ENSG00000092096

Description: solute carrier family 22 member 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 239.6088
    Cell Significance Index: -37.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 144.5336
    Cell Significance Index: -36.6600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.4880
    Cell Significance Index: -28.2300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 30.2120
    Cell Significance Index: -37.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.5786
    Cell Significance Index: -28.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4778
    Cell Significance Index: -37.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8249
    Cell Significance Index: 366.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.7121
    Cell Significance Index: 29.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4574
    Cell Significance Index: 31.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.3808
    Cell Significance Index: 87.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3163
    Cell Significance Index: 472.1500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2913
    Cell Significance Index: 36.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2344
    Cell Significance Index: 64.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2166
    Cell Significance Index: 55.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0694
    Cell Significance Index: 203.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8595
    Cell Significance Index: 57.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8541
    Cell Significance Index: 39.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7216
    Cell Significance Index: 92.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6909
    Cell Significance Index: 22.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5553
    Cell Significance Index: 54.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5248
    Cell Significance Index: 473.8400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.4878
    Cell Significance Index: 6.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2877
    Cell Significance Index: 3.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2669
    Cell Significance Index: 43.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2441
    Cell Significance Index: 33.5200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1778
    Cell Significance Index: 13.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1257
    Cell Significance Index: 5.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1046
    Cell Significance Index: 1.7500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1037
    Cell Significance Index: 2.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0955
    Cell Significance Index: 10.3900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0634
    Cell Significance Index: 28.0200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0551
    Cell Significance Index: 0.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0512
    Cell Significance Index: 1.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0252
    Cell Significance Index: 47.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0168
    Cell Significance Index: 0.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0084
    Cell Significance Index: 0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0031
    Cell Significance Index: 0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0016
    Cell Significance Index: 1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0057
    Cell Significance Index: -8.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0141
    Cell Significance Index: -25.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0160
    Cell Significance Index: -10.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0166
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0237
    Cell Significance Index: -4.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0286
    Cell Significance Index: -38.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0303
    Cell Significance Index: -17.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0317
    Cell Significance Index: -5.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0318
    Cell Significance Index: -6.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0337
    Cell Significance Index: -0.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0378
    Cell Significance Index: -17.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0389
    Cell Significance Index: -28.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0452
    Cell Significance Index: -34.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0503
    Cell Significance Index: -10.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0542
    Cell Significance Index: -29.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0555
    Cell Significance Index: -6.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0802
    Cell Significance Index: -4.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0815
    Cell Significance Index: -5.6400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1101
    Cell Significance Index: -31.6900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1109
    Cell Significance Index: -1.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1200
    Cell Significance Index: -6.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1302
    Cell Significance Index: -16.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1318
    Cell Significance Index: -19.1600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1380
    Cell Significance Index: -2.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1843
    Cell Significance Index: -5.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1855
    Cell Significance Index: -1.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2002
    Cell Significance Index: -12.0200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2136
    Cell Significance Index: -24.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2172
    Cell Significance Index: -5.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2495
    Cell Significance Index: -6.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2524
    Cell Significance Index: -25.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2773
    Cell Significance Index: -31.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2860
    Cell Significance Index: -9.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2945
    Cell Significance Index: -34.7300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3223
    Cell Significance Index: -6.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3238
    Cell Significance Index: -33.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3528
    Cell Significance Index: -19.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3622
    Cell Significance Index: -18.8200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3661
    Cell Significance Index: -25.8900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3861
    Cell Significance Index: -5.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4020
    Cell Significance Index: -8.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4052
    Cell Significance Index: -32.0900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4393
    Cell Significance Index: -8.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4513
    Cell Significance Index: -21.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4730
    Cell Significance Index: -13.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4764
    Cell Significance Index: -36.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4916
    Cell Significance Index: -9.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5138
    Cell Significance Index: -11.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5157
    Cell Significance Index: -16.4300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5290
    Cell Significance Index: -17.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5323
    Cell Significance Index: -34.3400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5415
    Cell Significance Index: -5.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5707
    Cell Significance Index: -11.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5743
    Cell Significance Index: -35.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6090
    Cell Significance Index: -12.9700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.6130
    Cell Significance Index: -5.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6295
    Cell Significance Index: -13.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6576
    Cell Significance Index: -19.3700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.6780
    Cell Significance Index: -7.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7273
    Cell Significance Index: -25.4800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.8190
    Cell Significance Index: -11.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transmembrane Transporter**: SLC22A17 is a member of the solute carrier family 22, which is characterized by its ability to transport small molecules across cell membranes. This protein exhibits a unique structure, consisting of 10 transmembrane domains. 2. **Iron Homeostasis**: The primary function of SLC22A17 is to regulate iron uptake and transport, particularly in hematopoietic cells. It is involved in the transport of iron ions across the plasma membrane, influencing erythropoiesis and iron storage. 3. **Siderophore Transport**: SLC22A17 also plays a role in the transport of siderophores, which are iron-chelating compounds produced by microorganisms. This function is essential for the acquisition of iron from the environment. 4. **Protein Binding**: The protein exhibits high affinity for various ligands, including iron ions, siderophores, and other small molecules, allowing it to regulate its activity and interact with different cellular components. **Pathways and Functions** 1. **Intracellular Iron Ion Homeostasis**: SLC22A17 regulates the intracellular concentration of iron ions by controlling the uptake and efflux of iron from cells. This is crucial for maintaining proper iron homeostasis and preventing iron overload or deficiency. 2. **Iron Uptake and Transport**: The protein facilitates the transport of iron ions across the plasma membrane, enabling the uptake of iron from the bloodstream and subsequent storage or utilization in the body. 3. **Transmembrane Signaling**: SLC22A17 can interact with other transmembrane receptors and proteins, influencing signaling pathways involved in cell growth, differentiation, and survival. 4. **Vacuolar Membrane Transport**: The protein is also found in the vacuolar membrane, where it regulates the transport of small molecules, including iron ions, into the vacuole. **Clinical Significance** 1. **Iron Deficiency and Anemia**: Dysregulation of SLC22A17 has been implicated in iron deficiency and anemia, highlighting its importance in maintaining proper iron homeostasis. 2. **Hematological Disorders**: Mutations in the SLC22A17 gene have been associated with hematological disorders, such as anemia and leukemia, emphasizing the protein's role in maintaining normal hematopoiesis. 3. **Neurological Disorders**: The protein's expression in neurons suggests its potential involvement in neurological disorders, such as Parkinson's disease and Alzheimer's disease, where iron dysregulation is a key feature. 4. **Cancer**: SLC22A17 has been identified as a potential biomarker for cancer diagnosis and prognosis, given its expression in various types of cancer cells. In conclusion, SLC22A17 is a multifunctional protein that plays a critical role in maintaining iron homeostasis and regulating various cellular processes. Its dysregulation has been implicated in several diseases, highlighting the need for further research into its mechanisms of action and its potential therapeutic applications.

Genular Protein ID: 3957176159

Symbol: S22AH_HUMAN

Name: Solute carrier family 22 member 17

UniProtKB Accession Codes:

Q8WUG5 A0A1C7CYV9 A4UA13 A8MUT0 Q2TAB0 Q5BKY8 Q86U04 Q9H1D3 Q9NQD5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 6 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17253959

Title: A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells.

PubMed ID: 17253959

DOI: 10.1042/bj20060836

PubMed ID: 16377569

Title: A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake.

PubMed ID: 16377569

DOI: 10.1016/j.cell.2005.10.027

PubMed ID: 19229297

Title: Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R.

PubMed ID: 19229297

DOI: 10.1038/emboj.2009.35

Sequence Information:

  • Length: 649
  • Mass: 68619
  • Checksum: 203B6C38A451C44C
  • Sequence:
    • MAPRVATGTP EPNGGGGGKI DNTVEITPTS NGQVGTLGDA VPTEQLQGER EREREGEGDA 
GGDGLGSSLS LAVPPGPLSF EALLAQVGAL GGGQQLQLGL CCLPVLFVAL GMASDPIFTL 
APPLHCHYGA FPPNASGWEQ PPNASGVSVA SAALAASAAS RVATSTDPSC SGFAPPDFNH 
CLKDWDYNGL PVLTTNAIGQ WDLVCDLGWQ VILEQILFIL GFASGYLFLG YPADRFGRRG 
IVLLTLGLVG PCGVGGAAAG SSTGVMALRF LLGFLLAGVD LGVYLMRLEL CDPTQRLRVA 
LAGELVGVGG HFLFLGLALV SKDWRFLQRM ITAPCILFLF YGWPGLFLES ARWLIVKRQI 
EEAQSVLRIL AERNRPHGQM LGEEAQEALQ DLENTCPLPA TSSFSFASLL NYRNIWKNLL 
ILGFTNFIAH AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV DRFGRRGILL 
LSMTLTGIAS LVLLGLWDCE HPIFPTVWAQ QGNPNRDLNE AAITTFSVLG LFSSQAAAIL 
STLLAAEVIP TTVRGRGLGL IMALGALGGL SGPAQRLHMG HGAFLQHVVL AACALLCILS 
IMLLPETKRK LLPEVLRDGE LCRRPSLLRQ PPPTRCDHVP LLATPNPAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.