Details for: SLC25A37

Gene ID: 51312

Symbol: SLC25A37

Ensembl ID: ENSG00000147454

Description: solute carrier family 25 member 37

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 203.3170
    Cell Significance Index: -51.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.4489
    Cell Significance Index: -62.0600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 114.0002
    Cell Significance Index: -58.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.7838
    Cell Significance Index: -62.2600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.8223
    Cell Significance Index: -55.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.2107
    Cell Significance Index: -33.2900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.5462
    Cell Significance Index: -57.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.2701
    Cell Significance Index: -43.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4302
    Cell Significance Index: -12.8600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.3489
    Cell Significance Index: 85.8200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 5.1506
    Cell Significance Index: 45.7200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 3.2960
    Cell Significance Index: 20.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.0552
    Cell Significance Index: 143.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.5617
    Cell Significance Index: 298.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9833
    Cell Significance Index: 256.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6142
    Cell Significance Index: 323.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5034
    Cell Significance Index: 40.9200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4763
    Cell Significance Index: 68.8300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4457
    Cell Significance Index: 26.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4192
    Cell Significance Index: 194.8900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3222
    Cell Significance Index: 58.4900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.2726
    Cell Significance Index: 13.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2467
    Cell Significance Index: 27.0100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.1947
    Cell Significance Index: 45.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1119
    Cell Significance Index: 120.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0001
    Cell Significance Index: 27.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9509
    Cell Significance Index: 121.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9432
    Cell Significance Index: 72.3800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8407
    Cell Significance Index: 24.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7605
    Cell Significance Index: 150.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7034
    Cell Significance Index: 635.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6502
    Cell Significance Index: 355.1200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6202
    Cell Significance Index: 222.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6169
    Cell Significance Index: 272.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5698
    Cell Significance Index: 108.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5556
    Cell Significance Index: 38.4300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5352
    Cell Significance Index: 37.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4363
    Cell Significance Index: 78.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3982
    Cell Significance Index: 48.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3604
    Cell Significance Index: 9.6400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2704
    Cell Significance Index: 7.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2244
    Cell Significance Index: 10.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2162
    Cell Significance Index: 12.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1992
    Cell Significance Index: 137.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1787
    Cell Significance Index: 4.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1705
    Cell Significance Index: 8.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1688
    Cell Significance Index: 311.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1685
    Cell Significance Index: 28.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1390
    Cell Significance Index: 4.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1051
    Cell Significance Index: 10.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1028
    Cell Significance Index: 193.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0901
    Cell Significance Index: 138.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0803
    Cell Significance Index: 36.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0786
    Cell Significance Index: 49.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0452
    Cell Significance Index: 2.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0439
    Cell Significance Index: 3.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0313
    Cell Significance Index: -3.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0401
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0416
    Cell Significance Index: -30.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0468
    Cell Significance Index: -6.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0487
    Cell Significance Index: -36.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0500
    Cell Significance Index: -36.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0626
    Cell Significance Index: -39.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0634
    Cell Significance Index: -35.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0993
    Cell Significance Index: -5.1600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1026
    Cell Significance Index: -2.7400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1051
    Cell Significance Index: -10.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1394
    Cell Significance Index: -9.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1485
    Cell Significance Index: -2.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1656
    Cell Significance Index: -47.6600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1903
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2118
    Cell Significance Index: -44.6200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2188
    Cell Significance Index: -4.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2398
    Cell Significance Index: -8.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2986
    Cell Significance Index: -3.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3004
    Cell Significance Index: -1.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3187
    Cell Significance Index: -8.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3241
    Cell Significance Index: -37.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3350
    Cell Significance Index: -7.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3952
    Cell Significance Index: -41.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4105
    Cell Significance Index: -6.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4160
    Cell Significance Index: -26.2200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.4372
    Cell Significance Index: -3.1400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4565
    Cell Significance Index: -52.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.5030
    Cell Significance Index: -7.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5456
    Cell Significance Index: -11.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5612
    Cell Significance Index: -33.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6244
    Cell Significance Index: -17.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6301
    Cell Significance Index: -38.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6671
    Cell Significance Index: -16.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6910
    Cell Significance Index: -54.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7359
    Cell Significance Index: -13.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7678
    Cell Significance Index: -24.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8423
    Cell Significance Index: -51.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9593
    Cell Significance Index: -20.0800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9780
    Cell Significance Index: -11.1100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.0732
    Cell Significance Index: -15.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.1214
    Cell Significance Index: -15.3000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1518
    Cell Significance Index: -17.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Mitoferrin-1, encoded by the SLC25A37 gene, is a member of the solute carrier family 25. It is a ferrous iron transmembrane transporter that facilitates the uptake of iron into the mitochondrion, where it is utilized for energy production and storage. The protein exhibits high affinity for iron, allowing it to bind and transport iron ions across cell membranes. Mitoferrin-1 is also involved in the regulation of hemoglobin biosynthesis, suggesting a link between iron metabolism and erythropoiesis. **Pathways and Functions** Mitoferrin-1 is intricately involved in various cellular pathways, including: 1. **Iron import into the mitochondrion**: Mitoferrin-1 plays a critical role in regulating iron import into the mitochondrion, a process essential for maintaining cellular energy production and preventing oxidative stress. 2. **Iron ion transmembrane transporter activity**: As a ferrous iron transmembrane transporter, Mitoferrin-1 facilitates the transport of iron ions across cell membranes. 3. **Mitochondrial iron-sulfur cluster biogenesis**: Mitoferrin-1 is involved in the regulation of mitochondrial iron-sulfur cluster biogenesis, a process critical for maintaining mitochondrial function and preventing oxidative stress. 4. **Metabolism**: Mitoferrin-1 is also involved in metabolic pathways, including the regulation of hemoglobin biosynthesis. **Significantly Expressed Cells** Mitoferrin-1 is expressed in various cell types, including: 1. **Hematopoietic oligopotent progenitor cells**: These cells are responsible for the development of blood cells, and Mitoferrin-1 plays a crucial role in regulating iron homeostasis during hematopoiesis. 2. **Smooth muscle fibers of the ileum**: These cells are involved in the regulation of iron absorption in the gut. 3. **Peripheral blood mononuclear cells**: These cells are involved in immune responses, and Mitoferrin-1 plays a role in regulating iron homeostasis in these cells. 4. **Ileal goblet cells**: These cells are involved in the regulation of iron absorption in the gut. **Clinical Significance** Dysregulation of Mitoferrin-1 has been implicated in various immune-related disorders, including: 1. **Anemia**: Mitoferrin-1 plays a crucial role in regulating iron homeostasis during erythropoiesis, and dysregulation of Mitoferrin-1 has been implicated in anemia. 2. **Iron deficiency**: Mitoferrin-1 is involved in regulating iron absorption in the gut, and dysregulation of Mitoferrin-1 has been implicated in iron deficiency. 3. **Autoimmune disorders**: Mitoferrin-1 has been implicated in the regulation of immune responses, and dysregulation of Mitoferrin-1 has been implicated in autoimmune disorders such as rheumatoid arthritis and lupus. In conclusion, Mitoferrin-1, encoded by the SLC25A37 gene, is a critical player in the regulation of iron homeostasis and immune function. Its dysregulation has been implicated in various immune-related disorders, highlighting the need for further research into the mechanisms underlying Mitoferrin-1 function and its role in disease.

Genular Protein ID: 3821727777

Symbol: MFRN1_HUMAN

Name: Mitoferrin-1

UniProtKB Accession Codes:

Q9NYZ2 A2RU93 Q53FT7 Q69YJ8 Q969S1 Q9P0J2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 35513392

Title: Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS.

PubMed ID: 35513392

DOI: 10.1038/s41467-022-30126-9

Sequence Information:

  • Length: 338
  • Mass: 37323
  • Checksum: 14576DF1F1854FAA
  • Sequence:
    • MELRSGSVGS QAVARRMDGD SRDGGGGKDA TGSEDYENLP TSASVSTHMT AGAMAGILEH 
SVMYPVDSVK TRMQSLSPDP KAQYTSIYGA LKKIMRTEGF WRPLRGVNVM IMGAGPAHAM 
YFACYENMKR TLNDVFHHQG NSHLANGIAG SMATLLHDAV MNPAEVVKQR LQMYNSQHRS 
AISCIRTVWR TEGLGAFYRS YTTQLTMNIP FQSIHFITYE FLQEQVNPHR TYNPQSHIIS 
GGLAGALAAA ATTPLDVCKT LLNTQENVAL SLANISGRLS GMANAFRTVY QLNGLAGYFK 
GIQARVIYQM PSTAISWSVY EFFKYFLTKR QLENRAPY

Genular Protein ID: 2558408372

Symbol: Q71JB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q71JB2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 IntAct 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 4

Sequence Information:

  • Length: 113
  • Mass: 12511
  • Checksum: F03DD57260829CCC
  • Sequence:
    • MHTVPWGVDF ALIAMKNFIS QWSSFFRSGM GKSQTGYLPR VPREQPFAAG LWGLAAALSH 
LAVNAFSLLC PPLPKTSCSL NPHGDVESRK VHATVENVYI SALNLPWVRV KWC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.