Details for: PHF21A

Gene ID: 51317

Symbol: PHF21A

Ensembl ID: ENSG00000135365

Description: PHD finger protein 21A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 422.9638
    Cell Significance Index: -65.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 256.0288
    Cell Significance Index: -64.9400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 141.2557
    Cell Significance Index: -66.6900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 123.4440
    Cell Significance Index: -50.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 116.9746
    Cell Significance Index: -60.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.8057
    Cell Significance Index: -66.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.6843
    Cell Significance Index: -50.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9426
    Cell Significance Index: -61.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.2374
    Cell Significance Index: -46.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.0044
    Cell Significance Index: -67.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.5406
    Cell Significance Index: 254.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.7888
    Cell Significance Index: 54.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.6122
    Cell Significance Index: 200.4600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.5708
    Cell Significance Index: 22.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4424
    Cell Significance Index: 489.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.2932
    Cell Significance Index: 140.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.1906
    Cell Significance Index: 46.8300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0572
    Cell Significance Index: 737.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0493
    Cell Significance Index: 57.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0130
    Cell Significance Index: 76.2300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.9439
    Cell Significance Index: 46.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9437
    Cell Significance Index: 385.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.9431
    Cell Significance Index: 85.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9087
    Cell Significance Index: 51.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.7876
    Cell Significance Index: 45.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2749
    Cell Significance Index: 881.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1991
    Cell Significance Index: 80.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1447
    Cell Significance Index: 113.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8889
    Cell Significance Index: 144.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7284
    Cell Significance Index: 37.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6385
    Cell Significance Index: 7.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5306
    Cell Significance Index: 999.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5118
    Cell Significance Index: 787.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.4645
    Cell Significance Index: 631.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4545
    Cell Significance Index: 288.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4200
    Cell Significance Index: 190.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3802
    Cell Significance Index: 701.2600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3344
    Cell Significance Index: 5.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3289
    Cell Significance Index: 35.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2392
    Cell Significance Index: 43.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2076
    Cell Significance Index: 5.9300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.1602
    Cell Significance Index: 2.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1131
    Cell Significance Index: 15.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0999
    Cell Significance Index: 12.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0865
    Cell Significance Index: 47.2600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0590
    Cell Significance Index: 26.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0260
    Cell Significance Index: 23.5000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0120
    Cell Significance Index: -0.4200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0201
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0300
    Cell Significance Index: -18.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0305
    Cell Significance Index: -4.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0351
    Cell Significance Index: -26.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0572
    Cell Significance Index: -3.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0581
    Cell Significance Index: -11.0500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0674
    Cell Significance Index: -49.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0849
    Cell Significance Index: -64.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0958
    Cell Significance Index: -54.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1729
    Cell Significance Index: -29.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1963
    Cell Significance Index: -56.4700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1985
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1998
    Cell Significance Index: -42.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2380
    Cell Significance Index: -24.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2502
    Cell Significance Index: -29.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2809
    Cell Significance Index: -6.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3053
    Cell Significance Index: -31.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3228
    Cell Significance Index: -41.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3328
    Cell Significance Index: -8.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3773
    Cell Significance Index: -43.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4346
    Cell Significance Index: -49.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4407
    Cell Significance Index: -56.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4707
    Cell Significance Index: -30.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5123
    Cell Significance Index: -32.2900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.5300
    Cell Significance Index: -3.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5321
    Cell Significance Index: -25.0100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.5371
    Cell Significance Index: -7.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5621
    Cell Significance Index: -26.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5731
    Cell Significance Index: -65.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6185
    Cell Significance Index: -32.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6309
    Cell Significance Index: -15.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7150
    Cell Significance Index: -56.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7288
    Cell Significance Index: -54.3200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.7441
    Cell Significance Index: -11.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7698
    Cell Significance Index: -20.5600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7751
    Cell Significance Index: -54.8200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8143
    Cell Significance Index: -4.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8171
    Cell Significance Index: -42.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.8212
    Cell Significance Index: -17.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9338
    Cell Significance Index: -57.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9358
    Cell Significance Index: -29.8100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9535
    Cell Significance Index: -11.8900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9609
    Cell Significance Index: -19.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9618
    Cell Significance Index: -31.4900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.0235
    Cell Significance Index: -14.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0353
    Cell Significance Index: -29.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.0490
    Cell Significance Index: -22.9700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.0546
    Cell Significance Index: -8.6000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0607
    Cell Significance Index: -18.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1741
    Cell Significance Index: -24.9200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.1922
    Cell Significance Index: -31.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.2586
    Cell Significance Index: -43.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PHF21A exhibits a unique combination of characteristics that distinguish it from other genes. Its PHD domain enables it to interact with histones, thereby modulating chromatin structure and accessibility to transcriptional machinery. Additionally, PHF21A has been shown to interact with various proteins, including histone deacetylases, which are involved in the regulation of gene expression through the removal of acetyl groups from histones. These interactions suggest that PHF21A plays a crucial role in the regulation of gene expression and cellular homeostasis. **Pathways and Functions:** PHF21A is involved in multiple cellular pathways, including: 1. **Chromatin binding and modification:** PHF21A interacts with histone deacetylases, which are involved in the regulation of gene expression through the removal of acetyl groups from histones. 2. **DNA repair complex:** PHF21A has been implicated in the regulation of DNA repair pathways, particularly in the context of nucleotide excision repair. 3. **Histone deacetylase complex:** PHF21A interacts with histone deacetylases, which are involved in the regulation of gene expression through the removal of acetyl groups from histones. 4. **Infectious disease:** PHF21A has been implicated in the regulation of immune responses, particularly in the context of viral infections and hematopoiesis. **Clinical Significance:** The clinical significance of PHF21A is an area of active research. Recent studies have implicated PHF21A in the regulation of immune responses, particularly in the context of viral infections and hematopoiesis. For example, PHF21A has been shown to be involved in the regulation of T cell development and function, which is critical for the immune response to viral infections. Additionally, PHF21A has been implicated in the regulation of hematopoiesis, which is the process by which blood cells are produced. In the context of infectious diseases, PHF21A has been shown to play a critical role in the regulation of immune responses, particularly in the context of viral infections. For example, PHF21A has been implicated in the regulation of T cell development and function, which is critical for the immune response to viral infections. Additionally, PHF21A has been shown to be involved in the regulation of hematopoiesis, which is the process by which blood cells are produced. In conclusion, PHF21A is a gene of emerging interest in immunology and disease pathways. Its involvement in multiple cellular processes, including chromatin organization, DNA repair, and transcriptional regulation, positions PHF21A as a critical player in the regulation of gene expression and cellular homeostasis. Recent studies have also implicated PHF21A in the regulation of immune responses, particularly in the context of viral infections and hematopoiesis. Further research is needed to fully elucidate the clinical significance of PHF21A and its role in human disease.

Genular Protein ID: 3066830652

Symbol: PF21A_HUMAN

Name: PHD finger protein 21A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12032298

Title: A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.

PubMed ID: 12032298

DOI: 10.1073/pnas.112008599

PubMed ID: 11214970

Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11214970

DOI: 10.1093/dnares/7.6.347

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12493763

Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.

PubMed ID: 12493763

DOI: 10.1074/jbc.m208992200

PubMed ID: 15325272

Title: Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.

PubMed ID: 15325272

DOI: 10.1016/j.bbrc.2004.07.163

PubMed ID: 16140033

Title: Regulation of LSD1 histone demethylase activity by its associated factors.

PubMed ID: 16140033

DOI: 10.1016/j.molcel.2005.08.027

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 30487643

Title: De novo truncating variants in PHF21A cause intellectual disability and craniofacial anomalies.

PubMed ID: 30487643

DOI: 10.1038/s41431-018-0289-x

PubMed ID: 31649809

Title: Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism.

PubMed ID: 31649809

DOI: 10.1186/s13229-019-0286-0

Sequence Information:

  • Length: 680
  • Mass: 74854
  • Checksum: C7AF87EB2984A796
  • Sequence:
  • MELQTLQEAL KVEIQVHQKL VAQMKQDPQN ADLKKQLHEL QAKITALSEK QKRVVEQLRK 
    NLIVKQEQPD KFQIQPLPQS ENKLQTAQQQ PLQQLQQQQQ YHHHHAQQSA AASPNLTASQ 
    KTVTTASMIT TKTLPLVLKA ATATMPASVV GQRPTIAMVT AINSQKAVLS TDVQNTPVNL 
    QTSSKVTGPG AEAVQIVAKN TVTLVQATPP QPIKVPQFIP PPRLTPRPNF LPQVRPKPVA 
    QNNIPIAPAP PPMLAAPQLI QRPVMLTKFT PTTLPTSQNS IHPVRVVNGQ TATIAKTFPM 
    AQLTSIVIAT PGTRLAGPQT VQLSKPSLEK QTVKSHTETD EKQTESRTIT PPAAPKPKRE 
    ENPQKLAFMV SLGLVTHDHL EEIQSKRQER KRRTTANPVY SGAVFEPERK KSAVTYLNST 
    MHPGTRKRGR PPKYNAVLGF GALTPTSPQS SHPDSPENEK TETTFTFPAP VQPVSLPSPT 
    STDGDIHEDF CSVCRKSGQL LMCDTCSRVY HLDCLDPPLK TIPKGMWICP RCQDQMLKKE 
    EAIPWPGTLA IVHSYIAYKA AKEEEKQKLL KWSSDLKQER EQLEQKVKQL SNSISKCMEM 
    KNTILARQKE MHSSLEKVKQ LIRLIHGIDL SKPVDSEATV GAISNGPDCT PPANAATSTP 
    APSPSSQSCT ANCNQGEETK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.