Details for: PHF21A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 422.9638
Cell Significance Index: -65.7900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 256.0288
Cell Significance Index: -64.9400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 141.2557
Cell Significance Index: -66.6900 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 123.4440
Cell Significance Index: -50.1500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 116.9746
Cell Significance Index: -60.1700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 53.8057
Cell Significance Index: -66.3400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 52.6843
Cell Significance Index: -50.3000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.9426
Cell Significance Index: -61.4600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 21.2374
Cell Significance Index: -46.4800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 17.0044
Cell Significance Index: -67.1000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 4.5406
Cell Significance Index: 254.7900 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.7888
Cell Significance Index: 54.4300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.6122
Cell Significance Index: 200.4600 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.5708
Cell Significance Index: 22.8200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.4424
Cell Significance Index: 489.9500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.2932
Cell Significance Index: 140.9500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.1906
Cell Significance Index: 46.8300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.0572
Cell Significance Index: 737.8700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.0493
Cell Significance Index: 57.2700 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.0130
Cell Significance Index: 76.2300 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.9439
Cell Significance Index: 46.6200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9437
Cell Significance Index: 385.7300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.9431
Cell Significance Index: 85.9500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.9087
Cell Significance Index: 51.1500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.7876
Cell Significance Index: 45.9500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.2749
Cell Significance Index: 881.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.1991
Cell Significance Index: 80.6300 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1447
Cell Significance Index: 113.2400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8889
Cell Significance Index: 144.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.7284
Cell Significance Index: 37.9400 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.6385
Cell Significance Index: 7.9200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.5306
Cell Significance Index: 999.1300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.5118
Cell Significance Index: 787.9600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.4645
Cell Significance Index: 631.5400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.4545
Cell Significance Index: 288.6500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.4200
Cell Significance Index: 190.6300 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3802
Cell Significance Index: 701.2600 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.3344
Cell Significance Index: 5.7300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3289
Cell Significance Index: 35.7700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.2392
Cell Significance Index: 43.1300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2076
Cell Significance Index: 5.9300 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.1602
Cell Significance Index: 2.3000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1131
Cell Significance Index: 15.5400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0999
Cell Significance Index: 12.2800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0865
Cell Significance Index: 47.2600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0590
Cell Significance Index: 26.0800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0260
Cell Significance Index: 23.5000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0120
Cell Significance Index: -0.4200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0201
Cell Significance Index: -0.9100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0300
Cell Significance Index: -18.7600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0305
Cell Significance Index: -4.4300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0351
Cell Significance Index: -26.0000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0572
Cell Significance Index: -3.9600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0581
Cell Significance Index: -11.0500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0674
Cell Significance Index: -49.4500 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0849
Cell Significance Index: -64.2400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0958
Cell Significance Index: -54.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1729
Cell Significance Index: -29.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1963
Cell Significance Index: -56.4700 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1985
Cell Significance Index: -2.9300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1998
Cell Significance Index: -42.0900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2380
Cell Significance Index: -24.7800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2502
Cell Significance Index: -29.5100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2809
Cell Significance Index: -6.0900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3053
Cell Significance Index: -31.1900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.3228
Cell Significance Index: -41.3800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3328
Cell Significance Index: -8.1200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3773
Cell Significance Index: -43.9700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4346
Cell Significance Index: -49.7900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4407
Cell Significance Index: -56.9400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4707
Cell Significance Index: -30.3700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.5123
Cell Significance Index: -32.2900 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: -0.5300
Cell Significance Index: -3.2700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5321
Cell Significance Index: -25.0100 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.5371
Cell Significance Index: -7.5100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5621
Cell Significance Index: -26.2100 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5731
Cell Significance Index: -65.4200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.6185
Cell Significance Index: -32.1300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6309
Cell Significance Index: -15.7700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7150
Cell Significance Index: -56.6300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.7288
Cell Significance Index: -54.3200 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: -0.7441
Cell Significance Index: -11.3200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.7698
Cell Significance Index: -20.5600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.7751
Cell Significance Index: -54.8200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8143
Cell Significance Index: -4.9200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.8171
Cell Significance Index: -42.9000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.8212
Cell Significance Index: -17.0400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.9338
Cell Significance Index: -57.2500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9358
Cell Significance Index: -29.8100 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.9535
Cell Significance Index: -11.8900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.9609
Cell Significance Index: -19.0000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9618
Cell Significance Index: -31.4900 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -1.0235
Cell Significance Index: -14.7200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.0353
Cell Significance Index: -29.8300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.0490
Cell Significance Index: -22.9700 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.0546
Cell Significance Index: -8.6000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.0607
Cell Significance Index: -18.3400 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1741
Cell Significance Index: -24.9200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.1922
Cell Significance Index: -31.3500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.2586
Cell Significance Index: -43.7400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3066830652
Symbol: PF21A_HUMAN
Name: PHD finger protein 21A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12032298
Title: A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes.
PubMed ID: 12032298
PubMed ID: 11214970
Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 11214970
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 12493763
Title: A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.
PubMed ID: 12493763
PubMed ID: 15325272
Title: Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression.
PubMed ID: 15325272
PubMed ID: 16140033
Title: Regulation of LSD1 histone demethylase activity by its associated factors.
PubMed ID: 16140033
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 30487643
Title: De novo truncating variants in PHF21A cause intellectual disability and craniofacial anomalies.
PubMed ID: 30487643
PubMed ID: 31649809
Title: Disruption of PHF21A causes syndromic intellectual disability with craniofacial anomalies, epilepsy, hypotonia, and neurobehavioral problems including autism.
PubMed ID: 31649809
Sequence Information:
- Length: 680
- Mass: 74854
- Checksum: C7AF87EB2984A796
- Sequence:
MELQTLQEAL KVEIQVHQKL VAQMKQDPQN ADLKKQLHEL QAKITALSEK QKRVVEQLRK NLIVKQEQPD KFQIQPLPQS ENKLQTAQQQ PLQQLQQQQQ YHHHHAQQSA AASPNLTASQ KTVTTASMIT TKTLPLVLKA ATATMPASVV GQRPTIAMVT AINSQKAVLS TDVQNTPVNL QTSSKVTGPG AEAVQIVAKN TVTLVQATPP QPIKVPQFIP PPRLTPRPNF LPQVRPKPVA QNNIPIAPAP PPMLAAPQLI QRPVMLTKFT PTTLPTSQNS IHPVRVVNGQ TATIAKTFPM AQLTSIVIAT PGTRLAGPQT VQLSKPSLEK QTVKSHTETD EKQTESRTIT PPAAPKPKRE ENPQKLAFMV SLGLVTHDHL EEIQSKRQER KRRTTANPVY SGAVFEPERK KSAVTYLNST MHPGTRKRGR PPKYNAVLGF GALTPTSPQS SHPDSPENEK TETTFTFPAP VQPVSLPSPT STDGDIHEDF CSVCRKSGQL LMCDTCSRVY HLDCLDPPLK TIPKGMWICP RCQDQMLKKE EAIPWPGTLA IVHSYIAYKA AKEEEKQKLL KWSSDLKQER EQLEQKVKQL SNSISKCMEM KNTILARQKE MHSSLEKVKQ LIRLIHGIDL SKPVDSEATV GAISNGPDCT PPANAATSTP APSPSSQSCT ANCNQGEETK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.