Details for: NGRN

Gene ID: 51335

Symbol: NGRN

Ensembl ID: ENSG00000182768

Description: neugrin, neurite outgrowth associated

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.7898
    Cell Significance Index: -26.4100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 105.3448
    Cell Significance Index: -26.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.1423
    Cell Significance Index: -27.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.7121
    Cell Significance Index: -26.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.4111
    Cell Significance Index: -27.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8423
    Cell Significance Index: -27.0000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.3273
    Cell Significance Index: 20.5900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.2780
    Cell Significance Index: 41.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.8200
    Cell Significance Index: 195.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2410
    Cell Significance Index: 51.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1355
    Cell Significance Index: 19.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.0732
    Cell Significance Index: 254.9200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.0621
    Cell Significance Index: 14.8100
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.0256
    Cell Significance Index: 15.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.0146
    Cell Significance Index: 57.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6003
    Cell Significance Index: 321.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5294
    Cell Significance Index: 17.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4016
    Cell Significance Index: 86.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3336
    Cell Significance Index: 240.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2445
    Cell Significance Index: 16.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.1938
    Cell Significance Index: 28.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1227
    Cell Significance Index: 122.1200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.1110
    Cell Significance Index: 16.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0833
    Cell Significance Index: 138.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9468
    Cell Significance Index: 339.6100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8685
    Cell Significance Index: 784.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5756
    Cell Significance Index: 93.6200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5374
    Cell Significance Index: 63.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.5361
    Cell Significance Index: 13.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4170
    Cell Significance Index: 11.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3928
    Cell Significance Index: 4.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3587
    Cell Significance Index: 10.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3373
    Cell Significance Index: 8.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2492
    Cell Significance Index: 24.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2282
    Cell Significance Index: 14.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2264
    Cell Significance Index: 10.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2215
    Cell Significance Index: 63.7500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2199
    Cell Significance Index: 1.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2089
    Cell Significance Index: 39.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1950
    Cell Significance Index: 10.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1752
    Cell Significance Index: 24.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1542
    Cell Significance Index: 5.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1352
    Cell Significance Index: 2.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1268
    Cell Significance Index: 5.6100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0774
    Cell Significance Index: 34.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0699
    Cell Significance Index: 38.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0642
    Cell Significance Index: 2.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0540
    Cell Significance Index: 2.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0276
    Cell Significance Index: 3.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0173
    Cell Significance Index: 0.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0160
    Cell Significance Index: 0.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0087
    Cell Significance Index: 0.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0080
    Cell Significance Index: 0.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0084
    Cell Significance Index: -5.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0145
    Cell Significance Index: -0.5100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0146
    Cell Significance Index: -27.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0150
    Cell Significance Index: -0.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0241
    Cell Significance Index: -16.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0261
    Cell Significance Index: -19.7500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0272
    Cell Significance Index: -19.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0281
    Cell Significance Index: -4.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0337
    Cell Significance Index: -19.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0400
    Cell Significance Index: -4.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0411
    Cell Significance Index: -26.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0579
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0608
    Cell Significance Index: -12.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0647
    Cell Significance Index: -29.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0937
    Cell Significance Index: -4.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0989
    Cell Significance Index: -11.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1048
    Cell Significance Index: -12.2100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1052
    Cell Significance Index: -2.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1400
    Cell Significance Index: -18.0900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1557
    Cell Significance Index: -3.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1645
    Cell Significance Index: -8.6400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1727
    Cell Significance Index: -7.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1730
    Cell Significance Index: -12.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1783
    Cell Significance Index: -25.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1886
    Cell Significance Index: -5.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2213
    Cell Significance Index: -4.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2323
    Cell Significance Index: -7.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2394
    Cell Significance Index: -5.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2695
    Cell Significance Index: -12.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2827
    Cell Significance Index: -18.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2908
    Cell Significance Index: -20.5700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.2945
    Cell Significance Index: -1.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3119
    Cell Significance Index: -19.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3152
    Cell Significance Index: -24.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3233
    Cell Significance Index: -5.4100
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.3290
    Cell Significance Index: -1.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3311
    Cell Significance Index: -10.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3532
    Cell Significance Index: -11.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3555
    Cell Significance Index: -7.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3557
    Cell Significance Index: -4.2400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3894
    Cell Significance Index: -7.7000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3930
    Cell Significance Index: -7.8900
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.4589
    Cell Significance Index: -2.7500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.4812
    Cell Significance Index: -7.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5271
    Cell Significance Index: -14.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5327
    Cell Significance Index: -18.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NGRN exhibits a unique structure, consisting of two distinct domains: a mitochondrial ribosome assembly domain and a cytoplasmic domain. The former is involved in the regulation of mitochondrial translation, while the latter is responsible for binding to various proteins and RNAs. This dual functionality allows Neugrin to interact with multiple cellular components, thereby modulating various cellular processes. **Pathways and Functions:** Neugrin's involvement in multiple cellular pathways underscores its multifaceted role in maintaining cellular homeostasis. Some of the key pathways and functions associated with Neugrin include: 1. **Mitochondrial Translation:** Neugrin regulates the translation of mitochondrial mRNAs, which is essential for maintaining mitochondrial function and energy production. 2. **Protein Binding:** Neugrin interacts with various proteins, including RNA-binding proteins and mitochondrial proteins, to regulate protein expression and function. 3. **Immune Regulation:** Neugrin has been implicated in the regulation of immune responses, particularly in the context of hematopoietic cells. Its expression is increased in peripheral blood mononuclear cells, suggesting a role in immune cell development and function. 4. **Neuronal Differentiation:** Neugrin has been shown to play a role in neuronal differentiation, particularly in the context of neurite outgrowth. Its expression is increased in neuronal cells, suggesting a role in regulating neuronal development and function. **Clinical Significance:** Neugrin's involvement in various cellular pathways highlights its potential significance in human disease. Some potential clinical applications of Neugrin include: 1. **Mitochondrial Disorders:** Alterations in Neugrin expression have been linked to mitochondrial disorders, such as mitochondrial myopathies. Understanding Neugrin's role in mitochondrial function may lead to the development of novel therapeutic strategies for these disorders. 2. **Immune-Related Disorders:** Neugrin's regulation of immune responses suggests a potential role in immune-related disorders, such as autoimmune diseases. Further studies are needed to elucidate Neugrin's involvement in immune regulation and its potential therapeutic applications. 3. **Neurological Disorders:** Neugrin's involvement in neuronal differentiation and function suggests a potential role in neurological disorders, such as neurodegenerative diseases. Further studies are needed to elucidate Neugrin's role in neuronal development and function. In conclusion, Neugrin is a multifunctional protein that plays a crucial role in various cellular processes, including mitochondrial function, protein binding, and immune regulation. Further studies are needed to elucidate Neugrin's role in human disease and to explore its potential therapeutic applications.

Genular Protein ID: 1252304699

Symbol: NGRN_HUMAN

Name: Neugrin

UniProtKB Accession Codes:

Q9NPE2 B2R6M8 Q4V9L7 Q9HBL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 1 ExpressionAtlas 1 GO 13 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11118320

Title: Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells.

PubMed ID: 11118320

DOI: 10.1006/bbrc.2000.3971

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 27667664

Title: A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation.

PubMed ID: 27667664

DOI: 10.1016/j.cmet.2016.08.017

Sequence Information:

  • Length: 291
  • Mass: 32408
  • Checksum: F0480D6D94BE2ACE
  • Sequence:
    • MAVTLSLLLG GRVCAAVTRC GFATRGVAGP GPIGREPDPD SDWEPEEREL QEVESTLKRQ 
KQAIRFQKIR RQMEAPGAPP RTLTWEAMEQ IRYLHEEFPE SWSVPRLAEG FDVSTDVIRR 
VLKSKFLPTL EQKLKQDQKV LKKAGLAHSL QHLRGSGNTS KLLPAGHSVS GSLLMPGHEA 
SSKDPNHSTA LKVIESDTHR TNTPRRRKGR NKEIQDLEES FVPVAAPLGH PRELQKYSSD 
SESPRGTGSG ALPSGQKLEE LKAEEPDNFS SKVVQRGREF FDSNGNFLYR I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.