Details for: SNX7

Gene ID: 51375

Symbol: SNX7

Ensembl ID: ENSG00000162627

Description: sorting nexin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 136.1754
    Cell Significance Index: -34.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 73.7308
    Cell Significance Index: -34.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.3480
    Cell Significance Index: -35.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7809
    Cell Significance Index: -34.6500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 6.8068
    Cell Significance Index: 109.2100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.1083
    Cell Significance Index: -11.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1925
    Cell Significance Index: 356.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.0508
    Cell Significance Index: 123.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.5954
    Cell Significance Index: 82.8800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.4048
    Cell Significance Index: 11.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2878
    Cell Significance Index: 17.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0443
    Cell Significance Index: 128.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.0155
    Cell Significance Index: 27.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0000
    Cell Significance Index: 180.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8390
    Cell Significance Index: 38.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7947
    Cell Significance Index: 285.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7666
    Cell Significance Index: 153.7700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.7457
    Cell Significance Index: 16.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7020
    Cell Significance Index: 139.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5333
    Cell Significance Index: 36.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5197
    Cell Significance Index: 14.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3745
    Cell Significance Index: 259.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3525
    Cell Significance Index: 11.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3407
    Cell Significance Index: 186.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3046
    Cell Significance Index: 21.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2919
    Cell Significance Index: 7.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2828
    Cell Significance Index: 15.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2642
    Cell Significance Index: 12.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2519
    Cell Significance Index: 34.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2073
    Cell Significance Index: 91.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1937
    Cell Significance Index: 24.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1841
    Cell Significance Index: 14.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1484
    Cell Significance Index: 14.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1436
    Cell Significance Index: 27.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1218
    Cell Significance Index: 2.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1210
    Cell Significance Index: 3.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0912
    Cell Significance Index: 1.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0757
    Cell Significance Index: 4.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0640
    Cell Significance Index: 120.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0368
    Cell Significance Index: 33.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0165
    Cell Significance Index: 0.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0120
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0083
    Cell Significance Index: -12.7600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0143
    Cell Significance Index: -9.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0186
    Cell Significance Index: -8.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0249
    Cell Significance Index: -33.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0282
    Cell Significance Index: -20.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0326
    Cell Significance Index: -4.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0334
    Cell Significance Index: -25.3100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0420
    Cell Significance Index: -31.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0528
    Cell Significance Index: -7.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0599
    Cell Significance Index: -33.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0600
    Cell Significance Index: -10.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0621
    Cell Significance Index: -1.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0638
    Cell Significance Index: -0.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0653
    Cell Significance Index: -6.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0704
    Cell Significance Index: -5.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0783
    Cell Significance Index: -48.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0927
    Cell Significance Index: -10.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1003
    Cell Significance Index: -3.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1058
    Cell Significance Index: -30.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1940
    Cell Significance Index: -40.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2066
    Cell Significance Index: -23.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2316
    Cell Significance Index: -5.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2398
    Cell Significance Index: -11.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2531
    Cell Significance Index: -27.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2671
    Cell Significance Index: -27.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2981
    Cell Significance Index: -7.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3011
    Cell Significance Index: -35.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3091
    Cell Significance Index: -15.6200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3138
    Cell Significance Index: -2.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3564
    Cell Significance Index: -28.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3822
    Cell Significance Index: -25.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4677
    Cell Significance Index: -24.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4708
    Cell Significance Index: -3.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4780
    Cell Significance Index: -5.4300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5083
    Cell Significance Index: -14.5700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5205
    Cell Significance Index: -11.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5377
    Cell Significance Index: -34.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5698
    Cell Significance Index: -34.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5761
    Cell Significance Index: -36.3100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5791
    Cell Significance Index: -18.9600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6251
    Cell Significance Index: -32.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6902
    Cell Significance Index: -30.5300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.7018
    Cell Significance Index: -16.8300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7157
    Cell Significance Index: -15.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7250
    Cell Significance Index: -20.6900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.7406
    Cell Significance Index: -10.3800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7567
    Cell Significance Index: -24.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7614
    Cell Significance Index: -4.6000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7635
    Cell Significance Index: -11.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8243
    Cell Significance Index: -30.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8369
    Cell Significance Index: -31.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.8427
    Cell Significance Index: -19.4700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8615
    Cell Significance Index: -30.1800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.8619
    Cell Significance Index: -13.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8663
    Cell Significance Index: -25.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.8839
    Cell Significance Index: -13.0500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.9395
    Cell Significance Index: -6.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SNX7 is predominantly expressed in hematopoietic cells, smooth muscle fibers, and epithelial cells, suggesting its involvement in immune cell development, tissue maintenance, and cellular homeostasis. 2. **Protein Interactions:** SNX7 interacts with various proteins, including phosphatidylinositol-binding proteins, to regulate endocytic recycling, autophagy, and protein transport. 3. **Pathway Involvement:** SNX7 is implicated in multiple cellular pathways, including early endosome formation, phagophore assembly, and positive regulation of autophagosome assembly. 4. **Cellular Context:** SNX7's role in cellular homeostasis is likely context-dependent, with varying levels of expression and activity in different cell types and tissues. **Pathways and Functions:** 1. **Endocytic Recycling:** SNX7 regulates the recycling of endosomes, allowing for the efficient exchange of membrane components and the maintenance of cellular homeostasis. 2. **Autophagy:** SNX7 is involved in the regulation of autophagosome assembly, a process essential for the degradation of damaged or dysfunctional cellular components. 3. **Phagophore Assembly:** SNX7 interacts with phosphatidylinositol-binding proteins to regulate the formation of phagophores, the structures that give rise to autophagosomes. 4. **Protein Transport:** SNX7 regulates the transport of proteins across cellular membranes, influencing cellular signaling and homeostasis. **Clinical Significance:** While the specific mechanisms by which SNX7 contributes to immune regulation and cellular homeostasis are not yet fully understood, its dysregulation has been implicated in various diseases, including: 1. **Immunodeficiency Disorders:** SNX7's role in immune cell development and function suggests its involvement in immunodeficiency disorders, such as primary immunodeficiency diseases. 2. **Cancer:** SNX7's regulation of autophagy and protein transport may influence cancer cell metabolism and survival, making it a potential therapeutic target. 3. **Neurological Disorders:** SNX7's involvement in cellular homeostasis and protein transport may also contribute to the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, SNX7 is a multifunctional protein that plays a complex and intriguing role in immune regulation and cellular homeostasis. Further research is needed to elucidate the precise mechanisms by which SNX7 contributes to these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 3788457036

Symbol: SNX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 32513819

Title: A heterodimeric SNX4--SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly.

PubMed ID: 32513819

DOI: 10.1242/jcs.246306

Sequence Information:

  • Length: 387
  • Mass: 45303
  • Checksum: E703B3EC6013DC1F
  • Sequence:
  • MDMNSFSPMM PTSPLSMINQ IKFEDEPDLK DLFITVDEPE SHVTTIETFI TYRIITKTSR 
    GEFDSSEFEV RRRYQDFLWL KGKLEEAHPT LIIPPLPEKF IVKGMVERFN DDFIETRRKA 
    LHKFLNRIAD HPTLTFNEDF KIFLTAQAWE LSSHKKQGPG LLSRMGQTVR AVASSMRGVK 
    NRPEEFMEMN NFIELFSQKI NLIDKISQRI YKEEREYFDE MKEYGPIHIL WSASEEDLVD 
    TLKDVASCID RCCKATEKRM SGLSEALLPV VHEYVLYSEM LMGVMKRRDQ IQAELDSKVE 
    VLTYKKADTD LLPEEIGKLE DKVECANNAL KADWERWKQN MQNDIKLAFT DMAEENIHYY 
    EQCLATWESF LTSQTNLHLE EASEDKP

Genular Protein ID: 775935481

Symbol: E9PNL2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 396
  • Mass: 45031
  • Checksum: 4443B027FA3D62AF
  • Sequence:
  • MEGERRASQA PSSGLPAGGA NGESPGGGAP FPGSSGSSAL LQAEVLDLDE DEDDLEVFSK 
    DASLMDMNSF SPMMPTSPLS MINQIKFEDE PDLKDLFITV DEPESHVTTI ETFITYRIIT 
    KTSRGEFDSS EFEVRRRYQD FLWLKGKLEE AHPTLIIPEL SSHKKQGPGL LSRMGQTVRA 
    VASSMRGVKN RPEEFMEMNN FIELFSQKIN LIDKISQRIY KEEREYFDEM KEYGPIHILW 
    SASEEDLVDT LKDVASCIDR CCKATEKRMS GLSEALLPVV HEYVLYSEML MGVMKRRDQI 
    QAELDSKVEV LTYKKADTDL LPEEIGKLED KVECANNALK ADWERWKQNM QNDIKLAFTD 
    MAEENIHYYE QCLATWESFL TSQTNLHLEE ASEDKP

Genular Protein ID: 3399422267

Symbol: B4DP69_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 332
  • Mass: 38714
  • Checksum: 4B1A8A1A92780FD3
  • Sequence:
  • MDMNSFSPMM PTSPLSMINQ IKFEDEPDLK DLFITVDEPE SHVTTIETFI TYRIITKTSR 
    GEFDSSEFEV RRRYQDFLWL KGKLEEAHPT LIIPELSSHK KQGPGLLSRM GQTVRAVASS 
    MRGVKNRPEE FMEMNNFIEL FSQKINLIDK ISQRIYKEER EYFDEMKEYG PIHILWSASE 
    EDLVDTLKDV ASCIDRCCKA TEKRMSGLSE ALLPVVHEYV LYSEMLMGVM KRRDQIQAEL 
    DSKVEVLTYK KADTDLLPEE IGKLEDKVEC ANNALKADWE RWKQNMQNDI KLAFTDMAEE 
    NIHYYEQCLA TWESFLTSQT NLHLEEASED KP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.